/* Generated by Cython 3.0.2 */

/* BEGIN: Cython Metadata
{
    "distutils": {
        "depends": [
            "/Users/runner/work/pysam/pysam/htslib/htslib/bgzf.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/cram.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/faidx.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/hfile.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/hts.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/kstring.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/sam.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/tbx.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/vcf.h",
            "/Users/runner/work/pysam/pysam/htslib/htslib/vcfutils.h",
            "/Users/runner/work/pysam/pysam/pysam/htslib_util.h",
            "/Users/runner/work/pysam/pysam/pysam/pysam_stream.h"
        ],
        "extra_compile_args": [
            "-Wno-unused",
            "-Wno-strict-prototypes",
            "-Wno-sign-compare",
            "-Wno-error=declaration-after-statement"
        ],
        "include_dirs": [
            "pysam",
            "/Users/runner/work/pysam/pysam/pysam",
            "/Users/runner/work/pysam/pysam/htslib",
            "/Users/runner/work/pysam/pysam/samtools",
            "/Users/runner/work/pysam/pysam/samtools/lz4",
            "/Users/runner/work/pysam/pysam/bcftools",
            "/Users/runner/work/pysam/pysam"
        ],
        "language": "c",
        "libraries": [
            "z",
            "lzma",
            "bz2",
            "z",
            "curl",
            "chtslib.cpython-39-darwin",
            "cutils.cpython-39-darwin"
        ],
        "library_dirs": [
            "/Users/runner/work/pysam/pysam/pysam",
            "/Users/runner/work/pysam/pysam"
        ],
        "name": "pysam.libctabix",
        "sources": [
            "pysam/libctabix.pyx"
        ]
    },
    "module_name": "pysam.libctabix"
}
END: Cython Metadata */

#ifndef PY_SSIZE_T_CLEAN
#define PY_SSIZE_T_CLEAN
#endif /* PY_SSIZE_T_CLEAN */
#if defined(CYTHON_LIMITED_API) && 0
  #ifndef Py_LIMITED_API
    #if CYTHON_LIMITED_API+0 > 0x03030000
      #define Py_LIMITED_API CYTHON_LIMITED_API
    #else
      #define Py_LIMITED_API 0x03030000
    #endif
  #endif
#endif

#include "Python.h"

    #if PY_MAJOR_VERSION >= 3
      #define __Pyx_PyFloat_FromString(obj)  PyFloat_FromString(obj)
    #else
      #define __Pyx_PyFloat_FromString(obj)  PyFloat_FromString(obj, NULL)
    #endif
    

    #if PY_MAJOR_VERSION <= 2
    #define PyDict_GetItemWithError _PyDict_GetItemWithError
    #endif
    

    #if (PY_VERSION_HEX < 0x030700b1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM < 0x07030600)) && !defined(PyContextVar_Get)
    #define PyContextVar_Get(var, d, v)         ((d) ?             ((void)(var), Py_INCREF(d), (v)[0] = (d), 0) :             ((v)[0] = NULL, 0)         )
    #endif
    
#ifndef Py_PYTHON_H
    #error Python headers needed to compile C extensions, please install development version of Python.
#elif PY_VERSION_HEX < 0x02070000 || (0x03000000 <= PY_VERSION_HEX && PY_VERSION_HEX < 0x03030000)
    #error Cython requires Python 2.7+ or Python 3.3+.
#else
#if CYTHON_LIMITED_API
#define __PYX_EXTRA_ABI_MODULE_NAME "limited"
#else
#define __PYX_EXTRA_ABI_MODULE_NAME ""
#endif
#define CYTHON_ABI "3_0_2" __PYX_EXTRA_ABI_MODULE_NAME
#define __PYX_ABI_MODULE_NAME "_cython_" CYTHON_ABI
#define __PYX_TYPE_MODULE_PREFIX __PYX_ABI_MODULE_NAME "."
#define CYTHON_HEX_VERSION 0x030002F0
#define CYTHON_FUTURE_DIVISION 1
#include <stddef.h>
#ifndef offsetof
  #define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
#endif
#if !defined(_WIN32) && !defined(WIN32) && !defined(MS_WINDOWS)
  #ifndef __stdcall
    #define __stdcall
  #endif
  #ifndef __cdecl
    #define __cdecl
  #endif
  #ifndef __fastcall
    #define __fastcall
  #endif
#endif
#ifndef DL_IMPORT
  #define DL_IMPORT(t) t
#endif
#ifndef DL_EXPORT
  #define DL_EXPORT(t) t
#endif
#define __PYX_COMMA ,
#ifndef HAVE_LONG_LONG
  #define HAVE_LONG_LONG
#endif
#ifndef PY_LONG_LONG
  #define PY_LONG_LONG LONG_LONG
#endif
#ifndef Py_HUGE_VAL
  #define Py_HUGE_VAL HUGE_VAL
#endif
#define __PYX_LIMITED_VERSION_HEX PY_VERSION_HEX
#if defined(GRAALVM_PYTHON)
  /* For very preliminary testing purposes. Most variables are set the same as PyPy.
     The existence of this section does not imply that anything works or is even tested */
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #define CYTHON_COMPILING_IN_LIMITED_API 0
  #define CYTHON_COMPILING_IN_GRAAL 1
  #define CYTHON_COMPILING_IN_NOGIL 0
  #undef CYTHON_USE_TYPE_SLOTS
  #define CYTHON_USE_TYPE_SLOTS 0
  #undef CYTHON_USE_TYPE_SPECS
  #define CYTHON_USE_TYPE_SPECS 0
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #if PY_VERSION_HEX < 0x03050000
    #undef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 0
  #elif !defined(CYTHON_USE_ASYNC_SLOTS)
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #undef CYTHON_USE_UNICODE_INTERNALS
  #define CYTHON_USE_UNICODE_INTERNALS 0
  #undef CYTHON_USE_UNICODE_WRITER
  #define CYTHON_USE_UNICODE_WRITER 0
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #undef CYTHON_AVOID_BORROWED_REFS
  #define CYTHON_AVOID_BORROWED_REFS 1
  #undef CYTHON_ASSUME_SAFE_MACROS
  #define CYTHON_ASSUME_SAFE_MACROS 0
  #undef CYTHON_UNPACK_METHODS
  #define CYTHON_UNPACK_METHODS 0
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_GIL
  #define CYTHON_FAST_GIL 0
  #undef CYTHON_METH_FASTCALL
  #define CYTHON_METH_FASTCALL 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #ifndef CYTHON_PEP487_INIT_SUBCLASS
    #define CYTHON_PEP487_INIT_SUBCLASS (PY_MAJOR_VERSION >= 3)
  #endif
  #undef CYTHON_PEP489_MULTI_PHASE_INIT
  #define CYTHON_PEP489_MULTI_PHASE_INIT 1
  #undef CYTHON_USE_MODULE_STATE
  #define CYTHON_USE_MODULE_STATE 0
  #undef CYTHON_USE_TP_FINALIZE
  #define CYTHON_USE_TP_FINALIZE 0
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
  #ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
    #define CYTHON_UPDATE_DESCRIPTOR_DOC 0
  #endif
#elif defined(PYPY_VERSION)
  #define CYTHON_COMPILING_IN_PYPY 1
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #define CYTHON_COMPILING_IN_LIMITED_API 0
  #define CYTHON_COMPILING_IN_GRAAL 0
  #define CYTHON_COMPILING_IN_NOGIL 0
  #undef CYTHON_USE_TYPE_SLOTS
  #define CYTHON_USE_TYPE_SLOTS 0
  #ifndef CYTHON_USE_TYPE_SPECS
    #define CYTHON_USE_TYPE_SPECS 0
  #endif
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #if PY_VERSION_HEX < 0x03050000
    #undef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 0
  #elif !defined(CYTHON_USE_ASYNC_SLOTS)
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #undef CYTHON_USE_UNICODE_INTERNALS
  #define CYTHON_USE_UNICODE_INTERNALS 0
  #undef CYTHON_USE_UNICODE_WRITER
  #define CYTHON_USE_UNICODE_WRITER 0
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #undef CYTHON_AVOID_BORROWED_REFS
  #define CYTHON_AVOID_BORROWED_REFS 1
  #undef CYTHON_ASSUME_SAFE_MACROS
  #define CYTHON_ASSUME_SAFE_MACROS 0
  #undef CYTHON_UNPACK_METHODS
  #define CYTHON_UNPACK_METHODS 0
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_GIL
  #define CYTHON_FAST_GIL 0
  #undef CYTHON_METH_FASTCALL
  #define CYTHON_METH_FASTCALL 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #ifndef CYTHON_PEP487_INIT_SUBCLASS
    #define CYTHON_PEP487_INIT_SUBCLASS (PY_MAJOR_VERSION >= 3)
  #endif
  #if PY_VERSION_HEX < 0x03090000
    #undef CYTHON_PEP489_MULTI_PHASE_INIT
    #define CYTHON_PEP489_MULTI_PHASE_INIT 0
  #elif !defined(CYTHON_PEP489_MULTI_PHASE_INIT)
    #define CYTHON_PEP489_MULTI_PHASE_INIT 1
  #endif
  #undef CYTHON_USE_MODULE_STATE
  #define CYTHON_USE_MODULE_STATE 0
  #undef CYTHON_USE_TP_FINALIZE
  #define CYTHON_USE_TP_FINALIZE (PY_VERSION_HEX >= 0x030400a1 && PYPY_VERSION_NUM >= 0x07030C00)
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
  #ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
    #define CYTHON_UPDATE_DESCRIPTOR_DOC 0
  #endif
#elif defined(CYTHON_LIMITED_API)
  #ifdef Py_LIMITED_API
    #undef __PYX_LIMITED_VERSION_HEX
    #define __PYX_LIMITED_VERSION_HEX Py_LIMITED_API
  #endif
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #define CYTHON_COMPILING_IN_LIMITED_API 1
  #define CYTHON_COMPILING_IN_GRAAL 0
  #define CYTHON_COMPILING_IN_NOGIL 0
  #undef CYTHON_CLINE_IN_TRACEBACK
  #define CYTHON_CLINE_IN_TRACEBACK 0
  #undef CYTHON_USE_TYPE_SLOTS
  #define CYTHON_USE_TYPE_SLOTS 0
  #undef CYTHON_USE_TYPE_SPECS
  #define CYTHON_USE_TYPE_SPECS 1
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #undef CYTHON_USE_ASYNC_SLOTS
  #define CYTHON_USE_ASYNC_SLOTS 0
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #undef CYTHON_USE_UNICODE_INTERNALS
  #define CYTHON_USE_UNICODE_INTERNALS 0
  #ifndef CYTHON_USE_UNICODE_WRITER
    #define CYTHON_USE_UNICODE_WRITER 0
  #endif
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #ifndef CYTHON_AVOID_BORROWED_REFS
    #define CYTHON_AVOID_BORROWED_REFS 0
  #endif
  #undef CYTHON_ASSUME_SAFE_MACROS
  #define CYTHON_ASSUME_SAFE_MACROS 0
  #undef CYTHON_UNPACK_METHODS
  #define CYTHON_UNPACK_METHODS 0
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_GIL
  #define CYTHON_FAST_GIL 0
  #undef CYTHON_METH_FASTCALL
  #define CYTHON_METH_FASTCALL 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #ifndef CYTHON_PEP487_INIT_SUBCLASS
    #define CYTHON_PEP487_INIT_SUBCLASS 1
  #endif
  #undef CYTHON_PEP489_MULTI_PHASE_INIT
  #define CYTHON_PEP489_MULTI_PHASE_INIT 0
  #undef CYTHON_USE_MODULE_STATE
  #define CYTHON_USE_MODULE_STATE 1
  #ifndef CYTHON_USE_TP_FINALIZE
    #define CYTHON_USE_TP_FINALIZE 0
  #endif
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
  #ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
    #define CYTHON_UPDATE_DESCRIPTOR_DOC 0
  #endif
#elif defined(PY_NOGIL)
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #define CYTHON_COMPILING_IN_LIMITED_API 0
  #define CYTHON_COMPILING_IN_GRAAL 0
  #define CYTHON_COMPILING_IN_NOGIL 1
  #ifndef CYTHON_USE_TYPE_SLOTS
    #define CYTHON_USE_TYPE_SLOTS 1
  #endif
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #ifndef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #ifndef CYTHON_USE_UNICODE_INTERNALS
    #define CYTHON_USE_UNICODE_INTERNALS 1
  #endif
  #undef CYTHON_USE_UNICODE_WRITER
  #define CYTHON_USE_UNICODE_WRITER 0
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #ifndef CYTHON_AVOID_BORROWED_REFS
    #define CYTHON_AVOID_BORROWED_REFS 0
  #endif
  #ifndef CYTHON_ASSUME_SAFE_MACROS
    #define CYTHON_ASSUME_SAFE_MACROS 1
  #endif
  #ifndef CYTHON_UNPACK_METHODS
    #define CYTHON_UNPACK_METHODS 1
  #endif
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #ifndef CYTHON_PEP489_MULTI_PHASE_INIT
    #define CYTHON_PEP489_MULTI_PHASE_INIT 1
  #endif
  #ifndef CYTHON_USE_TP_FINALIZE
    #define CYTHON_USE_TP_FINALIZE 1
  #endif
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
#else
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_CPYTHON 1
  #define CYTHON_COMPILING_IN_LIMITED_API 0
  #define CYTHON_COMPILING_IN_GRAAL 0
  #define CYTHON_COMPILING_IN_NOGIL 0
  #ifndef CYTHON_USE_TYPE_SLOTS
    #define CYTHON_USE_TYPE_SLOTS 1
  #endif
  #ifndef CYTHON_USE_TYPE_SPECS
    #define CYTHON_USE_TYPE_SPECS 0
  #endif
  #ifndef CYTHON_USE_PYTYPE_LOOKUP
    #define CYTHON_USE_PYTYPE_LOOKUP 1
  #endif
  #if PY_MAJOR_VERSION < 3
    #undef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 0
  #elif !defined(CYTHON_USE_ASYNC_SLOTS)
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #ifndef CYTHON_USE_PYLONG_INTERNALS
    #define CYTHON_USE_PYLONG_INTERNALS 1
  #endif
  #ifndef CYTHON_USE_PYLIST_INTERNALS
    #define CYTHON_USE_PYLIST_INTERNALS 1
  #endif
  #ifndef CYTHON_USE_UNICODE_INTERNALS
    #define CYTHON_USE_UNICODE_INTERNALS 1
  #endif
  #if PY_VERSION_HEX < 0x030300F0 || PY_VERSION_HEX >= 0x030B00A2
    #undef CYTHON_USE_UNICODE_WRITER
    #define CYTHON_USE_UNICODE_WRITER 0
  #elif !defined(CYTHON_USE_UNICODE_WRITER)
    #define CYTHON_USE_UNICODE_WRITER 1
  #endif
  #ifndef CYTHON_AVOID_BORROWED_REFS
    #define CYTHON_AVOID_BORROWED_REFS 0
  #endif
  #ifndef CYTHON_ASSUME_SAFE_MACROS
    #define CYTHON_ASSUME_SAFE_MACROS 1
  #endif
  #ifndef CYTHON_UNPACK_METHODS
    #define CYTHON_UNPACK_METHODS 1
  #endif
  #ifndef CYTHON_FAST_THREAD_STATE
    #define CYTHON_FAST_THREAD_STATE 1
  #endif
  #ifndef CYTHON_FAST_GIL
    #define CYTHON_FAST_GIL (PY_MAJOR_VERSION < 3 || PY_VERSION_HEX >= 0x03060000 && PY_VERSION_HEX < 0x030C00A6)
  #endif
  #ifndef CYTHON_METH_FASTCALL
    #define CYTHON_METH_FASTCALL (PY_VERSION_HEX >= 0x030700A1)
  #endif
  #ifndef CYTHON_FAST_PYCALL
    #define CYTHON_FAST_PYCALL 1
  #endif
  #ifndef CYTHON_PEP487_INIT_SUBCLASS
    #define CYTHON_PEP487_INIT_SUBCLASS 1
  #endif
  #if PY_VERSION_HEX < 0x03050000
    #undef CYTHON_PEP489_MULTI_PHASE_INIT
    #define CYTHON_PEP489_MULTI_PHASE_INIT 0
  #elif !defined(CYTHON_PEP489_MULTI_PHASE_INIT)
    #define CYTHON_PEP489_MULTI_PHASE_INIT 1
  #endif
  #ifndef CYTHON_USE_MODULE_STATE
    #define CYTHON_USE_MODULE_STATE 0
  #endif
  #if PY_VERSION_HEX < 0x030400a1
    #undef CYTHON_USE_TP_FINALIZE
    #define CYTHON_USE_TP_FINALIZE 0
  #elif !defined(CYTHON_USE_TP_FINALIZE)
    #define CYTHON_USE_TP_FINALIZE 1
  #endif
  #if PY_VERSION_HEX < 0x030600B1
    #undef CYTHON_USE_DICT_VERSIONS
    #define CYTHON_USE_DICT_VERSIONS 0
  #elif !defined(CYTHON_USE_DICT_VERSIONS)
    #define CYTHON_USE_DICT_VERSIONS  (PY_VERSION_HEX < 0x030C00A5)
  #endif
  #if PY_VERSION_HEX < 0x030700A3
    #undef CYTHON_USE_EXC_INFO_STACK
    #define CYTHON_USE_EXC_INFO_STACK 0
  #elif !defined(CYTHON_USE_EXC_INFO_STACK)
    #define CYTHON_USE_EXC_INFO_STACK 1
  #endif
  #ifndef CYTHON_UPDATE_DESCRIPTOR_DOC
    #define CYTHON_UPDATE_DESCRIPTOR_DOC 1
  #endif
#endif
#if !defined(CYTHON_FAST_PYCCALL)
#define CYTHON_FAST_PYCCALL  (CYTHON_FAST_PYCALL && PY_VERSION_HEX >= 0x030600B1)
#endif
#if !defined(CYTHON_VECTORCALL)
#define CYTHON_VECTORCALL  (CYTHON_FAST_PYCCALL && PY_VERSION_HEX >= 0x030800B1)
#endif
#define CYTHON_BACKPORT_VECTORCALL (CYTHON_METH_FASTCALL && PY_VERSION_HEX < 0x030800B1)
#if CYTHON_USE_PYLONG_INTERNALS
  #if PY_MAJOR_VERSION < 3
    #include "longintrepr.h"
  #endif
  #undef SHIFT
  #undef BASE
  #undef MASK
  #ifdef SIZEOF_VOID_P
    enum { __pyx_check_sizeof_voidp = 1 / (int)(SIZEOF_VOID_P == sizeof(void*)) };
  #endif
#endif
#ifndef __has_attribute
  #define __has_attribute(x) 0
#endif
#ifndef __has_cpp_attribute
  #define __has_cpp_attribute(x) 0
#endif
#ifndef CYTHON_RESTRICT
  #if defined(__GNUC__)
    #define CYTHON_RESTRICT __restrict__
  #elif defined(_MSC_VER) && _MSC_VER >= 1400
    #define CYTHON_RESTRICT __restrict
  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define CYTHON_RESTRICT restrict
  #else
    #define CYTHON_RESTRICT
  #endif
#endif
#ifndef CYTHON_UNUSED
  #if defined(__cplusplus)
    /* for clang __has_cpp_attribute(maybe_unused) is true even before C++17
     * but leads to warnings with -pedantic, since it is a C++17 feature */
    #if ((defined(_MSVC_LANG) && _MSVC_LANG >= 201703L) || __cplusplus >= 201703L)
      #if __has_cpp_attribute(maybe_unused)
        #define CYTHON_UNUSED [[maybe_unused]]
      #endif
    #endif
  #endif
#endif
#ifndef CYTHON_UNUSED
# if defined(__GNUC__)
#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
#     define CYTHON_UNUSED __attribute__ ((__unused__))
#   else
#     define CYTHON_UNUSED
#   endif
# elif defined(__ICC) || (defined(__INTEL_COMPILER) && !defined(_MSC_VER))
#   define CYTHON_UNUSED __attribute__ ((__unused__))
# else
#   define CYTHON_UNUSED
# endif
#endif
#ifndef CYTHON_UNUSED_VAR
#  if defined(__cplusplus)
     template<class T> void CYTHON_UNUSED_VAR( const T& ) { }
#  else
#    define CYTHON_UNUSED_VAR(x) (void)(x)
#  endif
#endif
#ifndef CYTHON_MAYBE_UNUSED_VAR
  #define CYTHON_MAYBE_UNUSED_VAR(x) CYTHON_UNUSED_VAR(x)
#endif
#ifndef CYTHON_NCP_UNUSED
# if CYTHON_COMPILING_IN_CPYTHON
#  define CYTHON_NCP_UNUSED
# else
#  define CYTHON_NCP_UNUSED CYTHON_UNUSED
# endif
#endif
#ifndef CYTHON_USE_CPP_STD_MOVE
  #if defined(__cplusplus) && (\
    __cplusplus >= 201103L || (defined(_MSC_VER) && _MSC_VER >= 1600))
    #define CYTHON_USE_CPP_STD_MOVE 1
  #else
    #define CYTHON_USE_CPP_STD_MOVE 0
  #endif
#endif
#define __Pyx_void_to_None(void_result) ((void)(void_result), Py_INCREF(Py_None), Py_None)
#ifdef _MSC_VER
    #ifndef _MSC_STDINT_H_
        #if _MSC_VER < 1300
            typedef unsigned char     uint8_t;
            typedef unsigned short    uint16_t;
            typedef unsigned int      uint32_t;
        #else
            typedef unsigned __int8   uint8_t;
            typedef unsigned __int16  uint16_t;
            typedef unsigned __int32  uint32_t;
        #endif
    #endif
    #if _MSC_VER < 1300
        #ifdef _WIN64
            typedef unsigned long long  __pyx_uintptr_t;
        #else
            typedef unsigned int        __pyx_uintptr_t;
        #endif
    #else
        #ifdef _WIN64
            typedef unsigned __int64    __pyx_uintptr_t;
        #else
            typedef unsigned __int32    __pyx_uintptr_t;
        #endif
    #endif
#else
    #include <stdint.h>
    typedef uintptr_t  __pyx_uintptr_t;
#endif
#ifndef CYTHON_FALLTHROUGH
  #if defined(__cplusplus)
    /* for clang __has_cpp_attribute(fallthrough) is true even before C++17
     * but leads to warnings with -pedantic, since it is a C++17 feature */
    #if ((defined(_MSVC_LANG) && _MSVC_LANG >= 201703L) || __cplusplus >= 201703L)
      #if __has_cpp_attribute(fallthrough)
        #define CYTHON_FALLTHROUGH [[fallthrough]]
      #endif
    #endif
    #ifndef CYTHON_FALLTHROUGH
      #if __has_cpp_attribute(clang::fallthrough)
        #define CYTHON_FALLTHROUGH [[clang::fallthrough]]
      #elif __has_cpp_attribute(gnu::fallthrough)
        #define CYTHON_FALLTHROUGH [[gnu::fallthrough]]
      #endif
    #endif
  #endif
  #ifndef CYTHON_FALLTHROUGH
    #if __has_attribute(fallthrough)
      #define CYTHON_FALLTHROUGH __attribute__((fallthrough))
    #else
      #define CYTHON_FALLTHROUGH
    #endif
  #endif
  #if defined(__clang__) && defined(__apple_build_version__)
    #if __apple_build_version__ < 7000000
      #undef  CYTHON_FALLTHROUGH
      #define CYTHON_FALLTHROUGH
    #endif
  #endif
#endif
#ifdef __cplusplus
  template <typename T>
  struct __PYX_IS_UNSIGNED_IMPL {static const bool value = T(0) < T(-1);};
  #define __PYX_IS_UNSIGNED(type) (__PYX_IS_UNSIGNED_IMPL<type>::value)
#else
  #define __PYX_IS_UNSIGNED(type) (((type)-1) > 0)
#endif
#if CYTHON_COMPILING_IN_PYPY == 1
  #define __PYX_NEED_TP_PRINT_SLOT  (PY_VERSION_HEX >= 0x030800b4 && PY_VERSION_HEX < 0x030A0000)
#else
  #define __PYX_NEED_TP_PRINT_SLOT  (PY_VERSION_HEX >= 0x030800b4 && PY_VERSION_HEX < 0x03090000)
#endif
#define __PYX_REINTERPRET_FUNCION(func_pointer, other_pointer) ((func_pointer)(void(*)(void))(other_pointer))

#ifndef CYTHON_INLINE
  #if defined(__clang__)
    #define CYTHON_INLINE __inline__ __attribute__ ((__unused__))
  #elif defined(__GNUC__)
    #define CYTHON_INLINE __inline__
  #elif defined(_MSC_VER)
    #define CYTHON_INLINE __inline
  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define CYTHON_INLINE inline
  #else
    #define CYTHON_INLINE
  #endif
#endif

#define __PYX_BUILD_PY_SSIZE_T "n"
#define CYTHON_FORMAT_SSIZE_T "z"
#if PY_MAJOR_VERSION < 3
  #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
  #define __Pyx_DefaultClassType PyClass_Type
  #define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_New(a+k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
#else
  #define __Pyx_BUILTIN_MODULE_NAME "builtins"
  #define __Pyx_DefaultClassType PyType_Type
#if CYTHON_COMPILING_IN_LIMITED_API
    static CYTHON_INLINE PyObject* __Pyx_PyCode_New(int a, int p, int k, int l, int s, int f,
                                                    PyObject *code, PyObject *c, PyObject* n, PyObject *v,
                                                    PyObject *fv, PyObject *cell, PyObject* fn,
                                                    PyObject *name, int fline, PyObject *lnos) {
        PyObject *exception_table = NULL;
        PyObject *types_module=NULL, *code_type=NULL, *result=NULL;
        PyObject *version_info; // borrowed
        PyObject *py_minor_version = NULL;
        long minor_version = 0;
        PyObject *type, *value, *traceback;
        PyErr_Fetch(&type, &value, &traceback);
        #if __PYX_LIMITED_VERSION_HEX >= 0x030B0000
        minor_version = 11; // we don't yet need to distinguish between versions > 11
        #else
        if (!(version_info = PySys_GetObject("version_info"))) goto end;
        if (!(py_minor_version = PySequence_GetItem(version_info, 1))) goto end;
        minor_version = PyLong_AsLong(py_minor_version);
        if (minor_version == -1 && PyErr_Occurred()) goto end;
        #endif
        if (!(types_module = PyImport_ImportModule("types"))) goto end;
        if (!(code_type = PyObject_GetAttrString(types_module, "CodeType"))) goto end;
        if (minor_version <= 7) {
            (void)p;
            result = PyObject_CallFunction(code_type, "iiiiiOOOOOOiOO", a, k, l, s, f, code,
                          c, n, v, fn, name, fline, lnos, fv, cell);
        } else if (minor_version <= 10) {
            result = PyObject_CallFunction(code_type, "iiiiiiOOOOOOiOO", a,p, k, l, s, f, code,
                          c, n, v, fn, name, fline, lnos, fv, cell);
        } else {
            if (!(exception_table = PyBytes_FromStringAndSize(NULL, 0))) goto end;
            result = PyObject_CallFunction(code_type, "iiiiiiOOOOOOOiOO", a,p, k, l, s, f, code,
                          c, n, v, fn, name, name, fline, lnos, exception_table, fv, cell);
        }
    end:
        Py_XDECREF(code_type);
        Py_XDECREF(exception_table);
        Py_XDECREF(types_module);
        Py_XDECREF(py_minor_version);
        if (type) {
            PyErr_Restore(type, value, traceback);
        }
        return result;
    }
    #ifndef CO_OPTIMIZED
    #define CO_OPTIMIZED 0x0001
    #endif
    #ifndef CO_NEWLOCALS
    #define CO_NEWLOCALS 0x0002
    #endif
    #ifndef CO_VARARGS
    #define CO_VARARGS 0x0004
    #endif
    #ifndef CO_VARKEYWORDS
    #define CO_VARKEYWORDS 0x0008
    #endif
    #ifndef CO_ASYNC_GENERATOR
    #define CO_ASYNC_GENERATOR 0x0200
    #endif
    #ifndef CO_GENERATOR
    #define CO_GENERATOR 0x0020
    #endif
    #ifndef CO_COROUTINE
    #define CO_COROUTINE 0x0080
    #endif
#elif PY_VERSION_HEX >= 0x030B0000
  static CYTHON_INLINE PyCodeObject* __Pyx_PyCode_New(int a, int p, int k, int l, int s, int f,
                                                    PyObject *code, PyObject *c, PyObject* n, PyObject *v,
                                                    PyObject *fv, PyObject *cell, PyObject* fn,
                                                    PyObject *name, int fline, PyObject *lnos) {
    PyCodeObject *result;
    PyObject *empty_bytes = PyBytes_FromStringAndSize("", 0);  // we don't have access to __pyx_empty_bytes here
    if (!empty_bytes) return NULL;
    result =
      #if PY_VERSION_HEX >= 0x030C0000
        PyUnstable_Code_NewWithPosOnlyArgs
      #else
        PyCode_NewWithPosOnlyArgs
      #endif
        (a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, name, fline, lnos, empty_bytes);
    Py_DECREF(empty_bytes);
    return result;
  }
#elif PY_VERSION_HEX >= 0x030800B2 && !CYTHON_COMPILING_IN_PYPY
  #define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_NewWithPosOnlyArgs(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
#else
  #define __Pyx_PyCode_New(a, p, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
#endif
#endif
#if PY_VERSION_HEX >= 0x030900A4 || defined(Py_IS_TYPE)
  #define __Pyx_IS_TYPE(ob, type) Py_IS_TYPE(ob, type)
#else
  #define __Pyx_IS_TYPE(ob, type) (((const PyObject*)ob)->ob_type == (type))
#endif
#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_Is)
  #define __Pyx_Py_Is(x, y)  Py_Is(x, y)
#else
  #define __Pyx_Py_Is(x, y) ((x) == (y))
#endif
#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsNone)
  #define __Pyx_Py_IsNone(ob) Py_IsNone(ob)
#else
  #define __Pyx_Py_IsNone(ob) __Pyx_Py_Is((ob), Py_None)
#endif
#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsTrue)
  #define __Pyx_Py_IsTrue(ob) Py_IsTrue(ob)
#else
  #define __Pyx_Py_IsTrue(ob) __Pyx_Py_Is((ob), Py_True)
#endif
#if PY_VERSION_HEX >= 0x030A00B1 || defined(Py_IsFalse)
  #define __Pyx_Py_IsFalse(ob) Py_IsFalse(ob)
#else
  #define __Pyx_Py_IsFalse(ob) __Pyx_Py_Is((ob), Py_False)
#endif
#define __Pyx_NoneAsNull(obj)  (__Pyx_Py_IsNone(obj) ? NULL : (obj))
#if PY_VERSION_HEX >= 0x030900F0 && !CYTHON_COMPILING_IN_PYPY
  #define __Pyx_PyObject_GC_IsFinalized(o) PyObject_GC_IsFinalized(o)
#else
  #define __Pyx_PyObject_GC_IsFinalized(o) _PyGC_FINALIZED(o)
#endif
#ifndef CO_COROUTINE
  #define CO_COROUTINE 0x80
#endif
#ifndef CO_ASYNC_GENERATOR
  #define CO_ASYNC_GENERATOR 0x200
#endif
#ifndef Py_TPFLAGS_CHECKTYPES
  #define Py_TPFLAGS_CHECKTYPES 0
#endif
#ifndef Py_TPFLAGS_HAVE_INDEX
  #define Py_TPFLAGS_HAVE_INDEX 0
#endif
#ifndef Py_TPFLAGS_HAVE_NEWBUFFER
  #define Py_TPFLAGS_HAVE_NEWBUFFER 0
#endif
#ifndef Py_TPFLAGS_HAVE_FINALIZE
  #define Py_TPFLAGS_HAVE_FINALIZE 0
#endif
#ifndef Py_TPFLAGS_SEQUENCE
  #define Py_TPFLAGS_SEQUENCE 0
#endif
#ifndef Py_TPFLAGS_MAPPING
  #define Py_TPFLAGS_MAPPING 0
#endif
#ifndef METH_STACKLESS
  #define METH_STACKLESS 0
#endif
#if PY_VERSION_HEX <= 0x030700A3 || !defined(METH_FASTCALL)
  #ifndef METH_FASTCALL
     #define METH_FASTCALL 0x80
  #endif
  typedef PyObject *(*__Pyx_PyCFunctionFast) (PyObject *self, PyObject *const *args, Py_ssize_t nargs);
  typedef PyObject *(*__Pyx_PyCFunctionFastWithKeywords) (PyObject *self, PyObject *const *args,
                                                          Py_ssize_t nargs, PyObject *kwnames);
#else
  #define __Pyx_PyCFunctionFast _PyCFunctionFast
  #define __Pyx_PyCFunctionFastWithKeywords _PyCFunctionFastWithKeywords
#endif
#if CYTHON_METH_FASTCALL
  #define __Pyx_METH_FASTCALL METH_FASTCALL
  #define __Pyx_PyCFunction_FastCall __Pyx_PyCFunctionFast
  #define __Pyx_PyCFunction_FastCallWithKeywords __Pyx_PyCFunctionFastWithKeywords
#else
  #define __Pyx_METH_FASTCALL METH_VARARGS
  #define __Pyx_PyCFunction_FastCall PyCFunction
  #define __Pyx_PyCFunction_FastCallWithKeywords PyCFunctionWithKeywords
#endif
#if CYTHON_VECTORCALL
  #define __pyx_vectorcallfunc vectorcallfunc
  #define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  PY_VECTORCALL_ARGUMENTS_OFFSET
  #define __Pyx_PyVectorcall_NARGS(n)  PyVectorcall_NARGS((size_t)(n))
#elif CYTHON_BACKPORT_VECTORCALL
  typedef PyObject *(*__pyx_vectorcallfunc)(PyObject *callable, PyObject *const *args,
                                            size_t nargsf, PyObject *kwnames);
  #define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  ((size_t)1 << (8 * sizeof(size_t) - 1))
  #define __Pyx_PyVectorcall_NARGS(n)  ((Py_ssize_t)(((size_t)(n)) & ~__Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET))
#else
  #define __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET  0
  #define __Pyx_PyVectorcall_NARGS(n)  ((Py_ssize_t)(n))
#endif
#if __PYX_LIMITED_VERSION_HEX < 0x030900B1
  #define __Pyx_PyType_FromModuleAndSpec(m, s, b)  ((void)m, PyType_FromSpecWithBases(s, b))
  typedef PyObject *(*__Pyx_PyCMethod)(PyObject *, PyTypeObject *, PyObject *const *, size_t, PyObject *);
#else
  #define __Pyx_PyType_FromModuleAndSpec(m, s, b)  PyType_FromModuleAndSpec(m, s, b)
  #define __Pyx_PyCMethod  PyCMethod
#endif
#ifndef METH_METHOD
  #define METH_METHOD 0x200
#endif
#if CYTHON_COMPILING_IN_PYPY && !defined(PyObject_Malloc)
  #define PyObject_Malloc(s)   PyMem_Malloc(s)
  #define PyObject_Free(p)     PyMem_Free(p)
  #define PyObject_Realloc(p)  PyMem_Realloc(p)
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
  #define __Pyx_PyCode_HasFreeVars(co)  (PyCode_GetNumFree(co) > 0)
  #define __Pyx_PyFrame_SetLineNumber(frame, lineno)
#else
  #define __Pyx_PyCode_HasFreeVars(co)  (PyCode_GetNumFree(co) > 0)
  #define __Pyx_PyFrame_SetLineNumber(frame, lineno)  (frame)->f_lineno = (lineno)
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
  #define __Pyx_PyThreadState_Current PyThreadState_Get()
#elif !CYTHON_FAST_THREAD_STATE
  #define __Pyx_PyThreadState_Current PyThreadState_GET()
#elif PY_VERSION_HEX >= 0x03060000
  #define __Pyx_PyThreadState_Current _PyThreadState_UncheckedGet()
#elif PY_VERSION_HEX >= 0x03000000
  #define __Pyx_PyThreadState_Current PyThreadState_GET()
#else
  #define __Pyx_PyThreadState_Current _PyThreadState_Current
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
static CYTHON_INLINE void *__Pyx_PyModule_GetState(PyObject *op)
{
    void *result;
    result = PyModule_GetState(op);
    if (!result)
        Py_FatalError("Couldn't find the module state");
    return result;
}
#endif
#define __Pyx_PyObject_GetSlot(obj, name, func_ctype)  __Pyx_PyType_GetSlot(Py_TYPE(obj), name, func_ctype)
#if CYTHON_COMPILING_IN_LIMITED_API
  #define __Pyx_PyType_GetSlot(type, name, func_ctype)  ((func_ctype) PyType_GetSlot((type), Py_##name))
#else
  #define __Pyx_PyType_GetSlot(type, name, func_ctype)  ((type)->name)
#endif
#if PY_VERSION_HEX < 0x030700A2 && !defined(PyThread_tss_create) && !defined(Py_tss_NEEDS_INIT)
#include "pythread.h"
#define Py_tss_NEEDS_INIT 0
typedef int Py_tss_t;
static CYTHON_INLINE int PyThread_tss_create(Py_tss_t *key) {
  *key = PyThread_create_key();
  return 0;
}
static CYTHON_INLINE Py_tss_t * PyThread_tss_alloc(void) {
  Py_tss_t *key = (Py_tss_t *)PyObject_Malloc(sizeof(Py_tss_t));
  *key = Py_tss_NEEDS_INIT;
  return key;
}
static CYTHON_INLINE void PyThread_tss_free(Py_tss_t *key) {
  PyObject_Free(key);
}
static CYTHON_INLINE int PyThread_tss_is_created(Py_tss_t *key) {
  return *key != Py_tss_NEEDS_INIT;
}
static CYTHON_INLINE void PyThread_tss_delete(Py_tss_t *key) {
  PyThread_delete_key(*key);
  *key = Py_tss_NEEDS_INIT;
}
static CYTHON_INLINE int PyThread_tss_set(Py_tss_t *key, void *value) {
  return PyThread_set_key_value(*key, value);
}
static CYTHON_INLINE void * PyThread_tss_get(Py_tss_t *key) {
  return PyThread_get_key_value(*key);
}
#endif
#if PY_MAJOR_VERSION < 3
    #if CYTHON_COMPILING_IN_PYPY
        #if PYPY_VERSION_NUM < 0x07030600
            #if defined(__cplusplus) && __cplusplus >= 201402L
                [[deprecated("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6")]]
            #elif defined(__GNUC__) || defined(__clang__)
                __attribute__ ((__deprecated__("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6")))
            #elif defined(_MSC_VER)
                __declspec(deprecated("`with nogil:` inside a nogil function will not release the GIL in PyPy2 < 7.3.6"))
            #endif
            static CYTHON_INLINE int PyGILState_Check(void) {
                return 0;
            }
        #else  // PYPY_VERSION_NUM < 0x07030600
        #endif  // PYPY_VERSION_NUM < 0x07030600
    #else
        static CYTHON_INLINE int PyGILState_Check(void) {
            PyThreadState * tstate = _PyThreadState_Current;
            return tstate && (tstate == PyGILState_GetThisThreadState());
        }
    #endif
#endif
#if CYTHON_COMPILING_IN_CPYTHON || defined(_PyDict_NewPresized)
#define __Pyx_PyDict_NewPresized(n)  ((n <= 8) ? PyDict_New() : _PyDict_NewPresized(n))
#else
#define __Pyx_PyDict_NewPresized(n)  PyDict_New()
#endif
#if PY_MAJOR_VERSION >= 3 || CYTHON_FUTURE_DIVISION
  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
#else
  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX > 0x030600B4 && CYTHON_USE_UNICODE_INTERNALS
#define __Pyx_PyDict_GetItemStrWithError(dict, name)  _PyDict_GetItem_KnownHash(dict, name, ((PyASCIIObject *) name)->hash)
static CYTHON_INLINE PyObject * __Pyx_PyDict_GetItemStr(PyObject *dict, PyObject *name) {
    PyObject *res = __Pyx_PyDict_GetItemStrWithError(dict, name);
    if (res == NULL) PyErr_Clear();
    return res;
}
#elif PY_MAJOR_VERSION >= 3 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07020000)
#define __Pyx_PyDict_GetItemStrWithError  PyDict_GetItemWithError
#define __Pyx_PyDict_GetItemStr           PyDict_GetItem
#else
static CYTHON_INLINE PyObject * __Pyx_PyDict_GetItemStrWithError(PyObject *dict, PyObject *name) {
#if CYTHON_COMPILING_IN_PYPY
    return PyDict_GetItem(dict, name);
#else
    PyDictEntry *ep;
    PyDictObject *mp = (PyDictObject*) dict;
    long hash = ((PyStringObject *) name)->ob_shash;
    assert(hash != -1);
    ep = (mp->ma_lookup)(mp, name, hash);
    if (ep == NULL) {
        return NULL;
    }
    return ep->me_value;
#endif
}
#define __Pyx_PyDict_GetItemStr           PyDict_GetItem
#endif
#if CYTHON_USE_TYPE_SLOTS
  #define __Pyx_PyType_GetFlags(tp)   (((PyTypeObject *)tp)->tp_flags)
  #define __Pyx_PyType_HasFeature(type, feature)  ((__Pyx_PyType_GetFlags(type) & (feature)) != 0)
  #define __Pyx_PyObject_GetIterNextFunc(obj)  (Py_TYPE(obj)->tp_iternext)
#else
  #define __Pyx_PyType_GetFlags(tp)   (PyType_GetFlags((PyTypeObject *)tp))
  #define __Pyx_PyType_HasFeature(type, feature)  PyType_HasFeature(type, feature)
  #define __Pyx_PyObject_GetIterNextFunc(obj)  PyIter_Next
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
  #define __Pyx_SetItemOnTypeDict(tp, k, v) PyObject_GenericSetAttr((PyObject*)tp, k, v)
#else
  #define __Pyx_SetItemOnTypeDict(tp, k, v) PyDict_SetItem(tp->tp_dict, k, v)
#endif
#if CYTHON_USE_TYPE_SPECS && PY_VERSION_HEX >= 0x03080000
#define __Pyx_PyHeapTypeObject_GC_Del(obj)  {\
    PyTypeObject *type = Py_TYPE(obj);\
    assert(__Pyx_PyType_HasFeature(type, Py_TPFLAGS_HEAPTYPE));\
    PyObject_GC_Del(obj);\
    Py_DECREF(type);\
}
#else
#define __Pyx_PyHeapTypeObject_GC_Del(obj)  PyObject_GC_Del(obj)
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
  #define CYTHON_PEP393_ENABLED 1
  #define __Pyx_PyUnicode_READY(op)       (0)
  #define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GetLength(u)
  #define __Pyx_PyUnicode_READ_CHAR(u, i) PyUnicode_ReadChar(u, i)
  #define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   ((void)u, 1114111U)
  #define __Pyx_PyUnicode_KIND(u)         ((void)u, (0))
  #define __Pyx_PyUnicode_DATA(u)         ((void*)u)
  #define __Pyx_PyUnicode_READ(k, d, i)   ((void)k, PyUnicode_ReadChar((PyObject*)(d), i))
  #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GetLength(u))
#elif PY_VERSION_HEX > 0x03030000 && defined(PyUnicode_KIND)
  #define CYTHON_PEP393_ENABLED 1
  #if PY_VERSION_HEX >= 0x030C0000
    #define __Pyx_PyUnicode_READY(op)       (0)
  #else
    #define __Pyx_PyUnicode_READY(op)       (likely(PyUnicode_IS_READY(op)) ?\
                                                0 : _PyUnicode_Ready((PyObject *)(op)))
  #endif
  #define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_LENGTH(u)
  #define __Pyx_PyUnicode_READ_CHAR(u, i) PyUnicode_READ_CHAR(u, i)
  #define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   PyUnicode_MAX_CHAR_VALUE(u)
  #define __Pyx_PyUnicode_KIND(u)         ((int)PyUnicode_KIND(u))
  #define __Pyx_PyUnicode_DATA(u)         PyUnicode_DATA(u)
  #define __Pyx_PyUnicode_READ(k, d, i)   PyUnicode_READ(k, d, i)
  #define __Pyx_PyUnicode_WRITE(k, d, i, ch)  PyUnicode_WRITE(k, d, i, (Py_UCS4) ch)
  #if PY_VERSION_HEX >= 0x030C0000
    #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GET_LENGTH(u))
  #else
    #if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x03090000
    #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != (likely(PyUnicode_IS_READY(u)) ? PyUnicode_GET_LENGTH(u) : ((PyCompactUnicodeObject *)(u))->wstr_length))
    #else
    #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != (likely(PyUnicode_IS_READY(u)) ? PyUnicode_GET_LENGTH(u) : PyUnicode_GET_SIZE(u)))
    #endif
  #endif
#else
  #define CYTHON_PEP393_ENABLED 0
  #define PyUnicode_1BYTE_KIND  1
  #define PyUnicode_2BYTE_KIND  2
  #define PyUnicode_4BYTE_KIND  4
  #define __Pyx_PyUnicode_READY(op)       (0)
  #define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_SIZE(u)
  #define __Pyx_PyUnicode_READ_CHAR(u, i) ((Py_UCS4)(PyUnicode_AS_UNICODE(u)[i]))
  #define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   ((sizeof(Py_UNICODE) == 2) ? 65535U : 1114111U)
  #define __Pyx_PyUnicode_KIND(u)         ((int)sizeof(Py_UNICODE))
  #define __Pyx_PyUnicode_DATA(u)         ((void*)PyUnicode_AS_UNICODE(u))
  #define __Pyx_PyUnicode_READ(k, d, i)   ((void)(k), (Py_UCS4)(((Py_UNICODE*)d)[i]))
  #define __Pyx_PyUnicode_WRITE(k, d, i, ch)  (((void)(k)), ((Py_UNICODE*)d)[i] = (Py_UNICODE) ch)
  #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GET_SIZE(u))
#endif
#if CYTHON_COMPILING_IN_PYPY
  #define __Pyx_PyUnicode_Concat(a, b)      PyNumber_Add(a, b)
  #define __Pyx_PyUnicode_ConcatSafe(a, b)  PyNumber_Add(a, b)
#else
  #define __Pyx_PyUnicode_Concat(a, b)      PyUnicode_Concat(a, b)
  #define __Pyx_PyUnicode_ConcatSafe(a, b)  ((unlikely((a) == Py_None) || unlikely((b) == Py_None)) ?\
      PyNumber_Add(a, b) : __Pyx_PyUnicode_Concat(a, b))
#endif
#if CYTHON_COMPILING_IN_PYPY
  #if !defined(PyUnicode_DecodeUnicodeEscape)
    #define PyUnicode_DecodeUnicodeEscape(s, size, errors)  PyUnicode_Decode(s, size, "unicode_escape", errors)
  #endif
  #if !defined(PyUnicode_Contains) || (PY_MAJOR_VERSION == 2 && PYPY_VERSION_NUM < 0x07030500)
    #undef PyUnicode_Contains
    #define PyUnicode_Contains(u, s)  PySequence_Contains(u, s)
  #endif
  #if !defined(PyByteArray_Check)
    #define PyByteArray_Check(obj)  PyObject_TypeCheck(obj, &PyByteArray_Type)
  #endif
  #if !defined(PyObject_Format)
    #define PyObject_Format(obj, fmt)  PyObject_CallMethod(obj, "__format__", "O", fmt)
  #endif
#endif
#define __Pyx_PyString_FormatSafe(a, b)   ((unlikely((a) == Py_None || (PyString_Check(b) && !PyString_CheckExact(b)))) ? PyNumber_Remainder(a, b) : __Pyx_PyString_Format(a, b))
#define __Pyx_PyUnicode_FormatSafe(a, b)  ((unlikely((a) == Py_None || (PyUnicode_Check(b) && !PyUnicode_CheckExact(b)))) ? PyNumber_Remainder(a, b) : PyUnicode_Format(a, b))
#if PY_MAJOR_VERSION >= 3
  #define __Pyx_PyString_Format(a, b)  PyUnicode_Format(a, b)
#else
  #define __Pyx_PyString_Format(a, b)  PyString_Format(a, b)
#endif
#if PY_MAJOR_VERSION < 3 && !defined(PyObject_ASCII)
  #define PyObject_ASCII(o)            PyObject_Repr(o)
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyBaseString_Type            PyUnicode_Type
  #define PyStringObject               PyUnicodeObject
  #define PyString_Type                PyUnicode_Type
  #define PyString_Check               PyUnicode_Check
  #define PyString_CheckExact          PyUnicode_CheckExact
#ifndef PyObject_Unicode
  #define PyObject_Unicode             PyObject_Str
#endif
#endif
#if PY_MAJOR_VERSION >= 3
  #define __Pyx_PyBaseString_Check(obj) PyUnicode_Check(obj)
  #define __Pyx_PyBaseString_CheckExact(obj) PyUnicode_CheckExact(obj)
#else
  #define __Pyx_PyBaseString_Check(obj) (PyString_Check(obj) || PyUnicode_Check(obj))
  #define __Pyx_PyBaseString_CheckExact(obj) (PyString_CheckExact(obj) || PyUnicode_CheckExact(obj))
#endif
#if CYTHON_COMPILING_IN_CPYTHON
  #define __Pyx_PySequence_ListKeepNew(obj)\
    (likely(PyList_CheckExact(obj) && Py_REFCNT(obj) == 1) ? __Pyx_NewRef(obj) : PySequence_List(obj))
#else
  #define __Pyx_PySequence_ListKeepNew(obj)  PySequence_List(obj)
#endif
#ifndef PySet_CheckExact
  #define PySet_CheckExact(obj)        __Pyx_IS_TYPE(obj, &PySet_Type)
#endif
#if PY_VERSION_HEX >= 0x030900A4
  #define __Pyx_SET_REFCNT(obj, refcnt) Py_SET_REFCNT(obj, refcnt)
  #define __Pyx_SET_SIZE(obj, size) Py_SET_SIZE(obj, size)
#else
  #define __Pyx_SET_REFCNT(obj, refcnt) Py_REFCNT(obj) = (refcnt)
  #define __Pyx_SET_SIZE(obj, size) Py_SIZE(obj) = (size)
#endif
#if CYTHON_ASSUME_SAFE_MACROS
  #define __Pyx_PySequence_ITEM(o, i) PySequence_ITEM(o, i)
  #define __Pyx_PySequence_SIZE(seq)  Py_SIZE(seq)
  #define __Pyx_PyTuple_SET_ITEM(o, i, v) (PyTuple_SET_ITEM(o, i, v), (0))
  #define __Pyx_PyList_SET_ITEM(o, i, v) (PyList_SET_ITEM(o, i, v), (0))
  #define __Pyx_PyTuple_GET_SIZE(o) PyTuple_GET_SIZE(o)
  #define __Pyx_PyList_GET_SIZE(o) PyList_GET_SIZE(o)
  #define __Pyx_PySet_GET_SIZE(o) PySet_GET_SIZE(o)
  #define __Pyx_PyBytes_GET_SIZE(o) PyBytes_GET_SIZE(o)
  #define __Pyx_PyByteArray_GET_SIZE(o) PyByteArray_GET_SIZE(o)
#else
  #define __Pyx_PySequence_ITEM(o, i) PySequence_GetItem(o, i)
  #define __Pyx_PySequence_SIZE(seq)  PySequence_Size(seq)
  #define __Pyx_PyTuple_SET_ITEM(o, i, v) PyTuple_SetItem(o, i, v)
  #define __Pyx_PyList_SET_ITEM(o, i, v) PyList_SetItem(o, i, v)
  #define __Pyx_PyTuple_GET_SIZE(o) PyTuple_Size(o)
  #define __Pyx_PyList_GET_SIZE(o) PyList_Size(o)
  #define __Pyx_PySet_GET_SIZE(o) PySet_Size(o)
  #define __Pyx_PyBytes_GET_SIZE(o) PyBytes_Size(o)
  #define __Pyx_PyByteArray_GET_SIZE(o) PyByteArray_Size(o)
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyIntObject                  PyLongObject
  #define PyInt_Type                   PyLong_Type
  #define PyInt_Check(op)              PyLong_Check(op)
  #define PyInt_CheckExact(op)         PyLong_CheckExact(op)
  #define __Pyx_Py3Int_Check(op)       PyLong_Check(op)
  #define __Pyx_Py3Int_CheckExact(op)  PyLong_CheckExact(op)
  #define PyInt_FromString             PyLong_FromString
  #define PyInt_FromUnicode            PyLong_FromUnicode
  #define PyInt_FromLong               PyLong_FromLong
  #define PyInt_FromSize_t             PyLong_FromSize_t
  #define PyInt_FromSsize_t            PyLong_FromSsize_t
  #define PyInt_AsLong                 PyLong_AsLong
  #define PyInt_AS_LONG                PyLong_AS_LONG
  #define PyInt_AsSsize_t              PyLong_AsSsize_t
  #define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
  #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
  #define PyNumber_Int                 PyNumber_Long
#else
  #define __Pyx_Py3Int_Check(op)       (PyLong_Check(op) || PyInt_Check(op))
  #define __Pyx_Py3Int_CheckExact(op)  (PyLong_CheckExact(op) || PyInt_CheckExact(op))
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyBoolObject                 PyLongObject
#endif
#if PY_MAJOR_VERSION >= 3 && CYTHON_COMPILING_IN_PYPY
  #ifndef PyUnicode_InternFromString
    #define PyUnicode_InternFromString(s) PyUnicode_FromString(s)
  #endif
#endif
#if PY_VERSION_HEX < 0x030200A4
  typedef long Py_hash_t;
  #define __Pyx_PyInt_FromHash_t PyInt_FromLong
  #define __Pyx_PyInt_AsHash_t   __Pyx_PyIndex_AsHash_t
#else
  #define __Pyx_PyInt_FromHash_t PyInt_FromSsize_t
  #define __Pyx_PyInt_AsHash_t   __Pyx_PyIndex_AsSsize_t
#endif
#if CYTHON_USE_ASYNC_SLOTS
  #if PY_VERSION_HEX >= 0x030500B1
    #define __Pyx_PyAsyncMethodsStruct PyAsyncMethods
    #define __Pyx_PyType_AsAsync(obj) (Py_TYPE(obj)->tp_as_async)
  #else
    #define __Pyx_PyType_AsAsync(obj) ((__Pyx_PyAsyncMethodsStruct*) (Py_TYPE(obj)->tp_reserved))
  #endif
#else
  #define __Pyx_PyType_AsAsync(obj) NULL
#endif
#ifndef __Pyx_PyAsyncMethodsStruct
    typedef struct {
        unaryfunc am_await;
        unaryfunc am_aiter;
        unaryfunc am_anext;
    } __Pyx_PyAsyncMethodsStruct;
#endif

#if defined(_WIN32) || defined(WIN32) || defined(MS_WINDOWS)
  #if !defined(_USE_MATH_DEFINES)
    #define _USE_MATH_DEFINES
  #endif
#endif
#include <math.h>
#ifdef NAN
#define __PYX_NAN() ((float) NAN)
#else
static CYTHON_INLINE float __PYX_NAN() {
  float value;
  memset(&value, 0xFF, sizeof(value));
  return value;
}
#endif
#if defined(__CYGWIN__) && defined(_LDBL_EQ_DBL)
#define __Pyx_truncl trunc
#else
#define __Pyx_truncl truncl
#endif

#define __PYX_MARK_ERR_POS(f_index, lineno) \
    { __pyx_filename = __pyx_f[f_index]; (void)__pyx_filename; __pyx_lineno = lineno; (void)__pyx_lineno; __pyx_clineno = __LINE__; (void)__pyx_clineno; }
#define __PYX_ERR(f_index, lineno, Ln_error) \
    { __PYX_MARK_ERR_POS(f_index, lineno) goto Ln_error; }

#ifdef CYTHON_EXTERN_C
    #undef __PYX_EXTERN_C
    #define __PYX_EXTERN_C CYTHON_EXTERN_C
#elif defined(__PYX_EXTERN_C)
    #ifdef _MSC_VER
    #pragma message ("Please do not define the '__PYX_EXTERN_C' macro externally. Use 'CYTHON_EXTERN_C' instead.")
    #else
    #warning Please do not define the '__PYX_EXTERN_C' macro externally. Use 'CYTHON_EXTERN_C' instead.
    #endif
#else
  #ifdef __cplusplus
    #define __PYX_EXTERN_C extern "C"
  #else
    #define __PYX_EXTERN_C extern
  #endif
#endif

#define __PYX_HAVE__pysam__libctabix
#define __PYX_HAVE_API__pysam__libctabix
/* Early includes */
#include <stdint.h>
#include <string.h>
#include <stdlib.h>
#include <stdio.h>
#include "fcntl.h"
#include "unistd.h"
#include <sys/types.h>
#include "stdarg.h"
#include "htslib/kstring.h"
#include "htslib_util.h"
#include "htslib/hfile.h"
#include "htslib/bgzf.h"
#include "htslib/hts.h"
#include "htslib/sam.h"
#include "htslib/faidx.h"
#include "htslib/tbx.h"
#include "htslib/vcf.h"
#include "htslib/vcfutils.h"
#include "htslib/cram.h"
#include "pysam_stream.h"
#include <errno.h>
#include <unistd.h>
#include "pythread.h"

    #if CYTHON_COMPILING_IN_PYPY
    #ifdef _MSC_VER
    #pragma message ("This module uses CPython specific internals of 'array.array', which are not available in PyPy.")
    #else
    #warning This module uses CPython specific internals of 'array.array', which are not available in PyPy.
    #endif
    #endif
    
#ifdef _OPENMP
#include <omp.h>
#endif /* _OPENMP */

#if defined(PYREX_WITHOUT_ASSERTIONS) && !defined(CYTHON_WITHOUT_ASSERTIONS)
#define CYTHON_WITHOUT_ASSERTIONS
#endif

typedef struct {PyObject **p; const char *s; const Py_ssize_t n; const char* encoding;
                const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry;

#define __PYX_DEFAULT_STRING_ENCODING_IS_ASCII 0
#define __PYX_DEFAULT_STRING_ENCODING_IS_UTF8 0
#define __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT (PY_MAJOR_VERSION >= 3 && __PYX_DEFAULT_STRING_ENCODING_IS_UTF8)
#define __PYX_DEFAULT_STRING_ENCODING ""
#define __Pyx_PyObject_FromString __Pyx_PyBytes_FromString
#define __Pyx_PyObject_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
#define __Pyx_uchar_cast(c) ((unsigned char)c)
#define __Pyx_long_cast(x) ((long)x)
#define __Pyx_fits_Py_ssize_t(v, type, is_signed)  (\
    (sizeof(type) < sizeof(Py_ssize_t))  ||\
    (sizeof(type) > sizeof(Py_ssize_t) &&\
          likely(v < (type)PY_SSIZE_T_MAX ||\
                 v == (type)PY_SSIZE_T_MAX)  &&\
          (!is_signed || likely(v > (type)PY_SSIZE_T_MIN ||\
                                v == (type)PY_SSIZE_T_MIN)))  ||\
    (sizeof(type) == sizeof(Py_ssize_t) &&\
          (is_signed || likely(v < (type)PY_SSIZE_T_MAX ||\
                               v == (type)PY_SSIZE_T_MAX)))  )
static CYTHON_INLINE int __Pyx_is_valid_index(Py_ssize_t i, Py_ssize_t limit) {
    return (size_t) i < (size_t) limit;
}
#if defined (__cplusplus) && __cplusplus >= 201103L
    #include <cstdlib>
    #define __Pyx_sst_abs(value) std::abs(value)
#elif SIZEOF_INT >= SIZEOF_SIZE_T
    #define __Pyx_sst_abs(value) abs(value)
#elif SIZEOF_LONG >= SIZEOF_SIZE_T
    #define __Pyx_sst_abs(value) labs(value)
#elif defined (_MSC_VER)
    #define __Pyx_sst_abs(value) ((Py_ssize_t)_abs64(value))
#elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define __Pyx_sst_abs(value) llabs(value)
#elif defined (__GNUC__)
    #define __Pyx_sst_abs(value) __builtin_llabs(value)
#else
    #define __Pyx_sst_abs(value) ((value<0) ? -value : value)
#endif
static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject*);
static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject*, Py_ssize_t* length);
#define __Pyx_PyByteArray_FromString(s) PyByteArray_FromStringAndSize((const char*)s, strlen((const char*)s))
#define __Pyx_PyByteArray_FromStringAndSize(s, l) PyByteArray_FromStringAndSize((const char*)s, l)
#define __Pyx_PyBytes_FromString        PyBytes_FromString
#define __Pyx_PyBytes_FromStringAndSize PyBytes_FromStringAndSize
static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char*);
#if PY_MAJOR_VERSION < 3
    #define __Pyx_PyStr_FromString        __Pyx_PyBytes_FromString
    #define __Pyx_PyStr_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
#else
    #define __Pyx_PyStr_FromString        __Pyx_PyUnicode_FromString
    #define __Pyx_PyStr_FromStringAndSize __Pyx_PyUnicode_FromStringAndSize
#endif
#define __Pyx_PyBytes_AsWritableString(s)     ((char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsWritableSString(s)    ((signed char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsWritableUString(s)    ((unsigned char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsString(s)     ((const char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsSString(s)    ((const signed char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsUString(s)    ((const unsigned char*) PyBytes_AS_STRING(s))
#define __Pyx_PyObject_AsWritableString(s)    ((char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsWritableSString(s)    ((signed char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsWritableUString(s)    ((unsigned char*)(__pyx_uintptr_t) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsSString(s)    ((const signed char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsUString(s)    ((const unsigned char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_FromCString(s)  __Pyx_PyObject_FromString((const char*)s)
#define __Pyx_PyBytes_FromCString(s)   __Pyx_PyBytes_FromString((const char*)s)
#define __Pyx_PyByteArray_FromCString(s)   __Pyx_PyByteArray_FromString((const char*)s)
#define __Pyx_PyStr_FromCString(s)     __Pyx_PyStr_FromString((const char*)s)
#define __Pyx_PyUnicode_FromCString(s) __Pyx_PyUnicode_FromString((const char*)s)
#if CYTHON_COMPILING_IN_LIMITED_API
static CYTHON_INLINE size_t __Pyx_Py_UNICODE_strlen(const wchar_t *u)
{
    const wchar_t *u_end = u;
    while (*u_end++) ;
    return (size_t)(u_end - u - 1);
}
#else
static CYTHON_INLINE size_t __Pyx_Py_UNICODE_strlen(const Py_UNICODE *u)
{
    const Py_UNICODE *u_end = u;
    while (*u_end++) ;
    return (size_t)(u_end - u - 1);
}
#endif
#define __Pyx_PyUnicode_FromOrdinal(o)       PyUnicode_FromOrdinal((int)o)
#define __Pyx_PyUnicode_FromUnicode(u)       PyUnicode_FromUnicode(u, __Pyx_Py_UNICODE_strlen(u))
#define __Pyx_PyUnicode_FromUnicodeAndLength PyUnicode_FromUnicode
#define __Pyx_PyUnicode_AsUnicode            PyUnicode_AsUnicode
#define __Pyx_NewRef(obj) (Py_INCREF(obj), obj)
#define __Pyx_Owned_Py_None(b) __Pyx_NewRef(Py_None)
static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b);
static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject*);
static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x);
#define __Pyx_PySequence_Tuple(obj)\
    (likely(PyTuple_CheckExact(obj)) ? __Pyx_NewRef(obj) : PySequence_Tuple(obj))
static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
static CYTHON_INLINE Py_hash_t __Pyx_PyIndex_AsHash_t(PyObject*);
#if CYTHON_ASSUME_SAFE_MACROS
#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
#else
#define __pyx_PyFloat_AsDouble(x) PyFloat_AsDouble(x)
#endif
#define __pyx_PyFloat_AsFloat(x) ((float) __pyx_PyFloat_AsDouble(x))
#if PY_MAJOR_VERSION >= 3
#define __Pyx_PyNumber_Int(x) (PyLong_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Long(x))
#else
#define __Pyx_PyNumber_Int(x) (PyInt_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Int(x))
#endif
#if CYTHON_USE_PYLONG_INTERNALS
  #if PY_VERSION_HEX >= 0x030C00A7
  #ifndef _PyLong_SIGN_MASK
    #define _PyLong_SIGN_MASK 3
  #endif
  #ifndef _PyLong_NON_SIZE_BITS
    #define _PyLong_NON_SIZE_BITS 3
  #endif
  #define __Pyx_PyLong_Sign(x)  (((PyLongObject*)x)->long_value.lv_tag & _PyLong_SIGN_MASK)
  #define __Pyx_PyLong_IsNeg(x)  ((__Pyx_PyLong_Sign(x) & 2) != 0)
  #define __Pyx_PyLong_IsNonNeg(x)  (!__Pyx_PyLong_IsNeg(x))
  #define __Pyx_PyLong_IsZero(x)  (__Pyx_PyLong_Sign(x) & 1)
  #define __Pyx_PyLong_IsPos(x)  (__Pyx_PyLong_Sign(x) == 0)
  #define __Pyx_PyLong_CompactValueUnsigned(x)  (__Pyx_PyLong_Digits(x)[0])
  #define __Pyx_PyLong_DigitCount(x)  ((Py_ssize_t) (((PyLongObject*)x)->long_value.lv_tag >> _PyLong_NON_SIZE_BITS))
  #define __Pyx_PyLong_SignedDigitCount(x)\
        ((1 - (Py_ssize_t) __Pyx_PyLong_Sign(x)) * __Pyx_PyLong_DigitCount(x))
  #if defined(PyUnstable_Long_IsCompact) && defined(PyUnstable_Long_CompactValue)
    #define __Pyx_PyLong_IsCompact(x)     PyUnstable_Long_IsCompact((PyLongObject*) x)
    #define __Pyx_PyLong_CompactValue(x)  PyUnstable_Long_CompactValue((PyLongObject*) x)
  #else
    #define __Pyx_PyLong_IsCompact(x)     (((PyLongObject*)x)->long_value.lv_tag < (2 << _PyLong_NON_SIZE_BITS))
    #define __Pyx_PyLong_CompactValue(x)  ((1 - (Py_ssize_t) __Pyx_PyLong_Sign(x)) * (Py_ssize_t) __Pyx_PyLong_Digits(x)[0])
  #endif
  typedef Py_ssize_t  __Pyx_compact_pylong;
  typedef size_t  __Pyx_compact_upylong;
  #else  // Py < 3.12
  #define __Pyx_PyLong_IsNeg(x)  (Py_SIZE(x) < 0)
  #define __Pyx_PyLong_IsNonNeg(x)  (Py_SIZE(x) >= 0)
  #define __Pyx_PyLong_IsZero(x)  (Py_SIZE(x) == 0)
  #define __Pyx_PyLong_IsPos(x)  (Py_SIZE(x) > 0)
  #define __Pyx_PyLong_CompactValueUnsigned(x)  ((Py_SIZE(x) == 0) ? 0 : __Pyx_PyLong_Digits(x)[0])
  #define __Pyx_PyLong_DigitCount(x)  __Pyx_sst_abs(Py_SIZE(x))
  #define __Pyx_PyLong_SignedDigitCount(x)  Py_SIZE(x)
  #define __Pyx_PyLong_IsCompact(x)  (Py_SIZE(x) == 0 || Py_SIZE(x) == 1 || Py_SIZE(x) == -1)
  #define __Pyx_PyLong_CompactValue(x)\
        ((Py_SIZE(x) == 0) ? (sdigit) 0 : ((Py_SIZE(x) < 0) ? -(sdigit)__Pyx_PyLong_Digits(x)[0] : (sdigit)__Pyx_PyLong_Digits(x)[0]))
  typedef sdigit  __Pyx_compact_pylong;
  typedef digit  __Pyx_compact_upylong;
  #endif
  #if PY_VERSION_HEX >= 0x030C00A5
  #define __Pyx_PyLong_Digits(x)  (((PyLongObject*)x)->long_value.ob_digit)
  #else
  #define __Pyx_PyLong_Digits(x)  (((PyLongObject*)x)->ob_digit)
  #endif
#endif
#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
static int __Pyx_sys_getdefaultencoding_not_ascii;
static int __Pyx_init_sys_getdefaultencoding_params(void) {
    PyObject* sys;
    PyObject* default_encoding = NULL;
    PyObject* ascii_chars_u = NULL;
    PyObject* ascii_chars_b = NULL;
    const char* default_encoding_c;
    sys = PyImport_ImportModule("sys");
    if (!sys) goto bad;
    default_encoding = PyObject_CallMethod(sys, (char*) "getdefaultencoding", NULL);
    Py_DECREF(sys);
    if (!default_encoding) goto bad;
    default_encoding_c = PyBytes_AsString(default_encoding);
    if (!default_encoding_c) goto bad;
    if (strcmp(default_encoding_c, "ascii") == 0) {
        __Pyx_sys_getdefaultencoding_not_ascii = 0;
    } else {
        char ascii_chars[128];
        int c;
        for (c = 0; c < 128; c++) {
            ascii_chars[c] = (char) c;
        }
        __Pyx_sys_getdefaultencoding_not_ascii = 1;
        ascii_chars_u = PyUnicode_DecodeASCII(ascii_chars, 128, NULL);
        if (!ascii_chars_u) goto bad;
        ascii_chars_b = PyUnicode_AsEncodedString(ascii_chars_u, default_encoding_c, NULL);
        if (!ascii_chars_b || !PyBytes_Check(ascii_chars_b) || memcmp(ascii_chars, PyBytes_AS_STRING(ascii_chars_b), 128) != 0) {
            PyErr_Format(
                PyExc_ValueError,
                "This module compiled with c_string_encoding=ascii, but default encoding '%.200s' is not a superset of ascii.",
                default_encoding_c);
            goto bad;
        }
        Py_DECREF(ascii_chars_u);
        Py_DECREF(ascii_chars_b);
    }
    Py_DECREF(default_encoding);
    return 0;
bad:
    Py_XDECREF(default_encoding);
    Py_XDECREF(ascii_chars_u);
    Py_XDECREF(ascii_chars_b);
    return -1;
}
#endif
#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT && PY_MAJOR_VERSION >= 3
#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_DecodeUTF8(c_str, size, NULL)
#else
#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_Decode(c_str, size, __PYX_DEFAULT_STRING_ENCODING, NULL)
#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
static char* __PYX_DEFAULT_STRING_ENCODING;
static int __Pyx_init_sys_getdefaultencoding_params(void) {
    PyObject* sys;
    PyObject* default_encoding = NULL;
    char* default_encoding_c;
    sys = PyImport_ImportModule("sys");
    if (!sys) goto bad;
    default_encoding = PyObject_CallMethod(sys, (char*) (const char*) "getdefaultencoding", NULL);
    Py_DECREF(sys);
    if (!default_encoding) goto bad;
    default_encoding_c = PyBytes_AsString(default_encoding);
    if (!default_encoding_c) goto bad;
    __PYX_DEFAULT_STRING_ENCODING = (char*) malloc(strlen(default_encoding_c) + 1);
    if (!__PYX_DEFAULT_STRING_ENCODING) goto bad;
    strcpy(__PYX_DEFAULT_STRING_ENCODING, default_encoding_c);
    Py_DECREF(default_encoding);
    return 0;
bad:
    Py_XDECREF(default_encoding);
    return -1;
}
#endif
#endif


/* Test for GCC > 2.95 */
#if defined(__GNUC__)     && (__GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)))
  #define likely(x)   __builtin_expect(!!(x), 1)
  #define unlikely(x) __builtin_expect(!!(x), 0)
#else /* !__GNUC__ or GCC < 2.95 */
  #define likely(x)   (x)
  #define unlikely(x) (x)
#endif /* __GNUC__ */
static CYTHON_INLINE void __Pyx_pretend_to_initialize(void* ptr) { (void)ptr; }

#if !CYTHON_USE_MODULE_STATE
static PyObject *__pyx_m = NULL;
#endif
static int __pyx_lineno;
static int __pyx_clineno = 0;
static const char * __pyx_cfilenm = __FILE__;
static const char *__pyx_filename;

/* #### Code section: filename_table ### */

static const char *__pyx_f[] = {
  "pysam/libctabix.pyx",
  "<stringsource>",
  "contextvars.pxd",
  "array.pxd",
  "pysam/libctabix.pxd",
  "type.pxd",
  "bool.pxd",
  "complex.pxd",
  "pysam/libctabixproxies.pxd",
};
/* #### Code section: utility_code_proto_before_types ### */
/* NoFastGil.proto */
#define __Pyx_PyGILState_Ensure PyGILState_Ensure
#define __Pyx_PyGILState_Release PyGILState_Release
#define __Pyx_FastGIL_Remember()
#define __Pyx_FastGIL_Forget()
#define __Pyx_FastGilFuncInit()

/* ForceInitThreads.proto */
#ifndef __PYX_FORCE_INIT_THREADS
  #define __PYX_FORCE_INIT_THREADS 0
#endif

/* #### Code section: numeric_typedefs ### */
/* #### Code section: complex_type_declarations ### */
/* #### Code section: type_declarations ### */

/*--- Type declarations ---*/
#ifndef _ARRAYARRAY_H
struct arrayobject;
typedef struct arrayobject arrayobject;
#endif
struct __pyx_obj_5pysam_10libchtslib_HTSFile;
struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy;
struct __pyx_obj_5pysam_16libctabixproxies_TupleProxyIterator;
struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy;
struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy;
struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy;
struct __pyx_obj_5pysam_16libctabixproxies_BedProxy;
struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy;
struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator;
struct __pyx_obj_5pysam_9libctabix_TabixFile;
struct __pyx_obj_5pysam_9libctabix_Parser;
struct __pyx_obj_5pysam_9libctabix_asTuple;
struct __pyx_obj_5pysam_9libctabix_asGTF;
struct __pyx_obj_5pysam_9libctabix_asGFF3;
struct __pyx_obj_5pysam_9libctabix_asBed;
struct __pyx_obj_5pysam_9libctabix_asVCF;
struct __pyx_obj_5pysam_9libctabix_TabixIterator;
struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed;
struct __pyx_obj_5pysam_9libctabix_GZIterator;
struct __pyx_obj_5pysam_9libctabix_GZIteratorHead;
struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed;
struct __pyx_obj_5pysam_9libctabix_Tabixfile;
struct __pyx_opt_args_7cpython_11contextvars_get_value;
struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default;

/* "cpython/contextvars.pxd":112
 * 
 * 
 * cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the default value of the context variable,
 */
struct __pyx_opt_args_7cpython_11contextvars_get_value {
  int __pyx_n;
  PyObject *default_value;
};

/* "cpython/contextvars.pxd":129
 * 
 * 
 * cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the provided default value if no such value was found.
 */
struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default {
  int __pyx_n;
  PyObject *default_value;
};
struct __pyx_opt_args_5pysam_16libctabixproxies_10TupleProxy_copy;

/* "pysam/libctabixproxies.pxd":23
 *     cdef take(self, char * buffer, size_t nbytes)
 *     cdef present(self, char * buffer, size_t nbytes)
 *     cdef copy(self, char * buffer, size_t nbytes, bint reset=*)             # <<<<<<<<<<<<<<
 *     cdef update(self, char * buffer, size_t nbytes)
 * 
 */
struct __pyx_opt_args_5pysam_16libctabixproxies_10TupleProxy_copy {
  int __pyx_n;
  int reset;
};
struct __pyx_opt_args_5pysam_9libcutils_parse_region;
struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array;
struct __pyx_opt_args_5pysam_9libcutils_array_to_qualitystring;
struct __pyx_opt_args_5pysam_9libcutils_qualities_to_qualitystring;
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str;
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_bytes;
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str_w_len;
struct __pyx_opt_args_5pysam_9libcutils_force_str;
struct __pyx_opt_args_5pysam_9libcutils_force_bytes;
struct __pyx_opt_args_5pysam_9libcutils_decode_bytes;

/* "pysam/libcutils.pxd":8
 * from cpython cimport array as c_array
 * 
 * cpdef parse_region(contig=*, start=*, stop=*, region=*, reference=*, end=*)             # <<<<<<<<<<<<<<
 * 
 * cdef int libc_whence_from_io(int whence)
 */
struct __pyx_opt_args_5pysam_9libcutils_parse_region {
  int __pyx_n;
  PyObject *contig;
  PyObject *start;
  PyObject *stop;
  PyObject *region;
  PyObject *reference;
  PyObject *end;
};

/* "pysam/libcutils.pxd":15
 * # Utility functions for quality string conversions
 * 
 * cpdef c_array.array qualitystring_to_array(input_str, int offset=*)             # <<<<<<<<<<<<<<
 * cpdef array_to_qualitystring(c_array.array arr, int offset=*)
 * cpdef qualities_to_qualitystring(qualities, int offset=*)
 */
struct __pyx_opt_args_5pysam_9libcutils_qualitystring_to_array {
  int __pyx_n;
  int offset;
};

/* "pysam/libcutils.pxd":16
 * 
 * cpdef c_array.array qualitystring_to_array(input_str, int offset=*)
 * cpdef array_to_qualitystring(c_array.array arr, int offset=*)             # <<<<<<<<<<<<<<
 * cpdef qualities_to_qualitystring(qualities, int offset=*)
 * 
 */
struct __pyx_opt_args_5pysam_9libcutils_array_to_qualitystring {
  int __pyx_n;
  int offset;
};

/* "pysam/libcutils.pxd":17
 * cpdef c_array.array qualitystring_to_array(input_str, int offset=*)
 * cpdef array_to_qualitystring(c_array.array arr, int offset=*)
 * cpdef qualities_to_qualitystring(qualities, int offset=*)             # <<<<<<<<<<<<<<
 * 
 * ########################################################################
 */
struct __pyx_opt_args_5pysam_9libcutils_qualities_to_qualitystring {
  int __pyx_n;
  int offset;
};

/* "pysam/libcutils.pxd":29
 * ## Python 3 compatibility functions
 * ########################################################################
 * cdef charptr_to_str(const char *s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
 * cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
 */
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libcutils.pxd":30
 * ########################################################################
 * cdef charptr_to_str(const char *s, encoding=*, errors=*)
 * cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
 * cdef force_str(object s, encoding=*, errors=*)
 */
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_bytes {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libcutils.pxd":31
 * cdef charptr_to_str(const char *s, encoding=*, errors=*)
 * cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
 * cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef force_str(object s, encoding=*, errors=*)
 * cdef bytes force_bytes(object s, encoding=*, errors=*)
 */
struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str_w_len {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libcutils.pxd":32
 * cdef bytes charptr_to_bytes(const char *s, encoding=*, errors=*)
 * cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
 * cdef force_str(object s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef bytes force_bytes(object s, encoding=*, errors=*)
 * cdef decode_bytes(bytes s, encoding=*, errors=*)
 */
struct __pyx_opt_args_5pysam_9libcutils_force_str {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libcutils.pxd":33
 * cdef charptr_to_str_w_len(const char* s, size_t n, encoding=*, errors=*)
 * cdef force_str(object s, encoding=*, errors=*)
 * cdef bytes force_bytes(object s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef decode_bytes(bytes s, encoding=*, errors=*)
 * cdef bytes encode_filename(object filename)
 */
struct __pyx_opt_args_5pysam_9libcutils_force_bytes {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libcutils.pxd":34
 * cdef force_str(object s, encoding=*, errors=*)
 * cdef bytes force_bytes(object s, encoding=*, errors=*)
 * cdef decode_bytes(bytes s, encoding=*, errors=*)             # <<<<<<<<<<<<<<
 * cdef bytes encode_filename(object filename)
 * cdef from_string_and_size(const char *s, size_t length)
 */
struct __pyx_opt_args_5pysam_9libcutils_decode_bytes {
  int __pyx_n;
  PyObject *encoding;
  PyObject *errors;
};

/* "pysam/libchtslib.pxd":2700
 * 
 * 
 * cdef class HTSFile(object):             # <<<<<<<<<<<<<<
 *     cdef          htsFile *htsfile       # pointer to htsFile structure
 *     cdef          int64_t start_offset   # BGZF offset of first record
 */
struct __pyx_obj_5pysam_10libchtslib_HTSFile {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile *__pyx_vtab;
  htsFile *htsfile;
  int64_t start_offset;
  PyObject *filename;
  PyObject *mode;
  PyObject *threads;
  PyObject *index_filename;
  int is_stream;
  int is_remote;
  int duplicate_filehandle;
};


/* "pysam/libctabixproxies.pxd":5
 * from libc.stdint cimport uint8_t, int32_t, uint32_t, int64_t, uint64_t
 * 
 * cdef class TupleProxy:             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */
struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy *__pyx_vtab;
  char *data;
  char **fields;
  int nfields;
  int nbytes;
  int offset;
  int is_modified;
  PyObject *encoding;
};


/* "pysam/libctabixproxies.pxd":27
 * 
 * 
 * cdef class TupleProxyIterator:             # <<<<<<<<<<<<<<
 *     cdef TupleProxy proxy
 *     cdef int index
 */
struct __pyx_obj_5pysam_16libctabixproxies_TupleProxyIterator {
  PyObject_HEAD
  struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *proxy;
  int index;
};


/* "pysam/libctabixproxies.pxd":32
 * 
 * 
 * cdef class NamedTupleProxy(TupleProxy):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy {
  struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy __pyx_base;
};


/* "pysam/libctabixproxies.pxd":36
 * 
 * 
 * cdef class GTFProxy(NamedTupleProxy):             # <<<<<<<<<<<<<<
 *     cdef object attribute_dict
 *     cpdef int getMaxFields(self)
 */
struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy {
  struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
  PyObject *attribute_dict;
};


/* "pysam/libctabixproxies.pxd":42
 * 
 * 
 * cdef class GFF3Proxy(GTFProxy):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy {
  struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy __pyx_base;
};


/* "pysam/libctabixproxies.pxd":46
 * 
 * 
 * cdef class BedProxy(NamedTupleProxy):             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */
struct __pyx_obj_5pysam_16libctabixproxies_BedProxy {
  struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
  char *contig;
  uint32_t start;
  uint32_t end;
  int bedfields;
};


/* "pysam/libctabixproxies.pxd":58
 *     cdef update(self, char * buffer, size_t nbytes)
 * 
 * cdef class VCFProxy(NamedTupleProxy) :             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */
struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy {
  struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
  char *contig;
  uint32_t pos;
};


/* "pysam/libctabix.pxd":48
 * 
 * 
 * cdef class tabix_file_iterator:             # <<<<<<<<<<<<<<
 *     cdef BGZF * fh
 *     cdef kstream_t * kstream
 */
struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_9libctabix_tabix_file_iterator *__pyx_vtab;
  BGZF *fh;
  kstream_t *kstream;
  kstring_t buffer;
  size_t size;
  struct __pyx_obj_5pysam_9libctabix_Parser *parser;
  int fd;
  int duplicated_fd;
  PyObject *infile;
};


/* "pysam/libctabix.pxd":61
 * 
 * 
 * cdef class TabixFile(HTSFile):             # <<<<<<<<<<<<<<
 *     # pointer to index structure
 *     cdef tbx_t * index
 */
struct __pyx_obj_5pysam_9libctabix_TabixFile {
  struct __pyx_obj_5pysam_10libchtslib_HTSFile __pyx_base;
  tbx_t *index;
  PyObject *filename_index;
  struct __pyx_obj_5pysam_9libctabix_Parser *parser;
  PyObject *encoding;
};


/* "pysam/libctabix.pxd":72
 * 
 * 
 * cdef class Parser:             # <<<<<<<<<<<<<<
 *     cdef encoding
 *     cdef parse(self, char * buffer, int len)
 */
struct __pyx_obj_5pysam_9libctabix_Parser {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser *__pyx_vtab;
  PyObject *encoding;
};


/* "pysam/libctabix.pxd":77
 * 
 * 
 * cdef class asTuple(Parser):             # <<<<<<<<<<<<<<
 *     cdef parse(self, char * buffer, int len)
 * 
 */
struct __pyx_obj_5pysam_9libctabix_asTuple {
  struct __pyx_obj_5pysam_9libctabix_Parser __pyx_base;
};


/* "pysam/libctabix.pxd":81
 * 
 * 
 * cdef class asGTF(Parser):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_9libctabix_asGTF {
  struct __pyx_obj_5pysam_9libctabix_Parser __pyx_base;
};


/* "pysam/libctabix.pxd":85
 * 
 * 
 * cdef class asGFF3(Parser):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_9libctabix_asGFF3 {
  struct __pyx_obj_5pysam_9libctabix_Parser __pyx_base;
};


/* "pysam/libctabix.pxd":89
 * 
 * 
 * cdef class asBed(Parser):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_9libctabix_asBed {
  struct __pyx_obj_5pysam_9libctabix_Parser __pyx_base;
};


/* "pysam/libctabix.pxd":93
 * 
 * 
 * cdef class asVCF(Parser):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_9libctabix_asVCF {
  struct __pyx_obj_5pysam_9libctabix_Parser __pyx_base;
};


/* "pysam/libctabix.pxd":97
 * 
 * 
 * cdef class TabixIterator:             # <<<<<<<<<<<<<<
 *     cdef hts_itr_t * iterator
 *     cdef TabixFile tabixfile
 */
struct __pyx_obj_5pysam_9libctabix_TabixIterator {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator *__pyx_vtab;
  hts_itr_t *iterator;
  struct __pyx_obj_5pysam_9libctabix_TabixFile *tabixfile;
  kstring_t buffer;
  PyObject *encoding;
};


/* "pysam/libctabix.pxd":105
 * 
 * 
 * cdef class TabixIteratorParsed(TabixIterator):             # <<<<<<<<<<<<<<
 *     cdef Parser parser
 * 
 */
struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed {
  struct __pyx_obj_5pysam_9libctabix_TabixIterator __pyx_base;
  struct __pyx_obj_5pysam_9libctabix_Parser *parser;
};


/* "pysam/libctabix.pxd":109
 * 
 * 
 * cdef class GZIterator:             # <<<<<<<<<<<<<<
 *     cdef object _filename
 *     cdef BGZF * gzipfile
 */
struct __pyx_obj_5pysam_9libctabix_GZIterator {
  PyObject_HEAD
  struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator *__pyx_vtab;
  PyObject *_filename;
  BGZF *gzipfile;
  kstream_t *kstream;
  kstring_t buffer;
  PyObject *encoding;
};


/* "pysam/libctabix.pxd":118
 * 
 * 
 * cdef class GZIteratorHead(GZIterator):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */
struct __pyx_obj_5pysam_9libctabix_GZIteratorHead {
  struct __pyx_obj_5pysam_9libctabix_GZIterator __pyx_base;
};


/* "pysam/libctabix.pxd":122
 * 
 * 
 * cdef class GZIteratorParsed(GZIterator):             # <<<<<<<<<<<<<<
 *     cdef Parser parser
 * 
 */
struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed {
  struct __pyx_obj_5pysam_9libctabix_GZIterator __pyx_base;
  struct __pyx_obj_5pysam_9libctabix_Parser *parser;
};


/* "pysam/libctabix.pxd":127
 * 
 * # Compatibility Layer for pysam < 0.8
 * cdef class Tabixfile(TabixFile):             # <<<<<<<<<<<<<<
 *     pass
 */
struct __pyx_obj_5pysam_9libctabix_Tabixfile {
  struct __pyx_obj_5pysam_9libctabix_TabixFile __pyx_base;
};



/* "pysam/libchtslib.pxd":2700
 * 
 * 
 * cdef class HTSFile(object):             # <<<<<<<<<<<<<<
 *     cdef          htsFile *htsfile       # pointer to htsFile structure
 *     cdef          int64_t start_offset   # BGZF offset of first record
 */

struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile {
  htsFile *(*_open_htsfile)(struct __pyx_obj_5pysam_10libchtslib_HTSFile *);
};
static struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile *__pyx_vtabptr_5pysam_10libchtslib_HTSFile;


/* "pysam/libctabixproxies.pxd":5
 * from libc.stdint cimport uint8_t, int32_t, uint32_t, int64_t, uint64_t
 * 
 * cdef class TupleProxy:             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy {
  int (*getMaxFields)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, int __pyx_skip_dispatch);
  int (*getMinFields)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, int __pyx_skip_dispatch);
  PyObject *(*take)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, char *, size_t);
  PyObject *(*present)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, char *, size_t);
  PyObject *(*copy)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, char *, size_t, struct __pyx_opt_args_5pysam_16libctabixproxies_10TupleProxy_copy *__pyx_optional_args);
  PyObject *(*update)(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *, char *, size_t);
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy *__pyx_vtabptr_5pysam_16libctabixproxies_TupleProxy;


/* "pysam/libctabixproxies.pxd":32
 * 
 * 
 * cdef class NamedTupleProxy(TupleProxy):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy {
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy *__pyx_vtabptr_5pysam_16libctabixproxies_NamedTupleProxy;


/* "pysam/libctabixproxies.pxd":36
 * 
 * 
 * cdef class GTFProxy(NamedTupleProxy):             # <<<<<<<<<<<<<<
 *     cdef object attribute_dict
 *     cpdef int getMaxFields(self)
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_GTFProxy {
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_GTFProxy *__pyx_vtabptr_5pysam_16libctabixproxies_GTFProxy;


/* "pysam/libctabixproxies.pxd":42
 * 
 * 
 * cdef class GFF3Proxy(GTFProxy):             # <<<<<<<<<<<<<<
 *     pass
 * 
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_GFF3Proxy {
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_GTFProxy __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_GFF3Proxy *__pyx_vtabptr_5pysam_16libctabixproxies_GFF3Proxy;


/* "pysam/libctabixproxies.pxd":46
 * 
 * 
 * cdef class BedProxy(NamedTupleProxy):             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_BedProxy {
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_BedProxy *__pyx_vtabptr_5pysam_16libctabixproxies_BedProxy;


/* "pysam/libctabixproxies.pxd":58
 *     cdef update(self, char * buffer, size_t nbytes)
 * 
 * cdef class VCFProxy(NamedTupleProxy) :             # <<<<<<<<<<<<<<
 * 
 *     cdef:
 */

struct __pyx_vtabstruct_5pysam_16libctabixproxies_VCFProxy {
  struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_16libctabixproxies_VCFProxy *__pyx_vtabptr_5pysam_16libctabixproxies_VCFProxy;


/* "pysam/libctabix.pyx":1100
 * 
 * 
 * cdef class tabix_file_iterator:             # <<<<<<<<<<<<<<
 *     '''iterate over a compressed or uncompressed ``infile``.
 *     '''
 */

struct __pyx_vtabstruct_5pysam_9libctabix_tabix_file_iterator {
  PyObject *(*__pyx___cnext__)(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *);
};
static struct __pyx_vtabstruct_5pysam_9libctabix_tabix_file_iterator *__pyx_vtabptr_5pysam_9libctabix_tabix_file_iterator;


/* "pysam/libctabix.pyx":287
 * 
 * 
 * cdef class TabixFile:             # <<<<<<<<<<<<<<
 *     """Random access to bgzf formatted files that
 *     have been indexed by :term:`tabix`.
 */

struct __pyx_vtabstruct_5pysam_9libctabix_TabixFile {
  struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixFile *__pyx_vtabptr_5pysam_9libctabix_TabixFile;


/* "pysam/libctabix.pyx":82
 * from pysam.libcutils cimport encode_filename, from_string_and_size
 * 
 * cdef class Parser:             # <<<<<<<<<<<<<<
 * 
 *     def __init__(self, encoding="ascii"):
 */

struct __pyx_vtabstruct_5pysam_9libctabix_Parser {
  PyObject *(*parse)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int);
};
static struct __pyx_vtabstruct_5pysam_9libctabix_Parser *__pyx_vtabptr_5pysam_9libctabix_Parser;


/* "pysam/libctabix.pyx":101
 * 
 * 
 * cdef class asTuple(Parser):             # <<<<<<<<<<<<<<
 *     '''converts a :term:`tabix row` into a python tuple.
 * 
 */

struct __pyx_vtabstruct_5pysam_9libctabix_asTuple {
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_asTuple *__pyx_vtabptr_5pysam_9libctabix_asTuple;


/* "pysam/libctabix.pyx":151
 * 
 * 
 * cdef class asGTF(Parser):             # <<<<<<<<<<<<<<
 *     '''converts a :term:`tabix row` into a GTF record with the following
 *     fields:
 */

struct __pyx_vtabstruct_5pysam_9libctabix_asGTF {
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_asGTF *__pyx_vtabptr_5pysam_9libctabix_asGTF;


/* "pysam/libctabix.pyx":115
 * 
 * 
 * cdef class asGFF3(Parser):             # <<<<<<<<<<<<<<
 *     '''converts a :term:`tabix row` into a GFF record with the following
 *     fields:
 */

struct __pyx_vtabstruct_5pysam_9libctabix_asGFF3 {
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_asGFF3 *__pyx_vtabptr_5pysam_9libctabix_asGFF3;


/* "pysam/libctabix.pyx":198
 * 
 * 
 * cdef class asBed(Parser):             # <<<<<<<<<<<<<<
 *     '''converts a :term:`tabix row` into a bed record
 *     with the following fields:
 */

struct __pyx_vtabstruct_5pysam_9libctabix_asBed {
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_asBed *__pyx_vtabptr_5pysam_9libctabix_asBed;


/* "pysam/libctabix.pyx":246
 * 
 * 
 * cdef class asVCF(Parser):             # <<<<<<<<<<<<<<
 *     '''converts a :term:`tabix row` into a VCF record with
 *     the following fields:
 */

struct __pyx_vtabstruct_5pysam_9libctabix_asVCF {
  struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_asVCF *__pyx_vtabptr_5pysam_9libctabix_asVCF;


/* "pysam/libctabix.pyx":619
 * 
 * 
 * cdef class TabixIterator:             # <<<<<<<<<<<<<<
 *     """iterates over rows in *tabixfile* in region
 *     given by *tid*, *start* and *end*.
 */

struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator {
  int (*__pyx___cnext__)(struct __pyx_obj_5pysam_9libctabix_TabixIterator *);
};
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator *__pyx_vtabptr_5pysam_9libctabix_TabixIterator;


/* "pysam/libctabix.pyx":692
 * 
 * 
 * cdef class TabixIteratorParsed(TabixIterator):             # <<<<<<<<<<<<<<
 *     """iterates over mapped reads in a region.
 * 
 */

struct __pyx_vtabstruct_5pysam_9libctabix_TabixIteratorParsed {
  struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixIteratorParsed *__pyx_vtabptr_5pysam_9libctabix_TabixIteratorParsed;


/* "pysam/libctabix.pyx":722
 * 
 * 
 * cdef class GZIterator:             # <<<<<<<<<<<<<<
 *     def __init__(self, filename, int buffer_size=65536, encoding="ascii"):
 *         '''iterate line-by-line through gzip (or bgzip)
 */

struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator {
  int (*__pyx___cnext__)(struct __pyx_obj_5pysam_9libctabix_GZIterator *);
};
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator *__pyx_vtabptr_5pysam_9libctabix_GZIterator;


/* "pysam/libctabix.pyx":777
 * 
 * 
 * cdef class GZIteratorHead(GZIterator):             # <<<<<<<<<<<<<<
 *     '''iterate line-by-line through gzip (or bgzip)
 *     compressed file returning comments at top of file.
 */

struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorHead {
  struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorHead *__pyx_vtabptr_5pysam_9libctabix_GZIteratorHead;


/* "pysam/libctabix.pyx":794
 * 
 * 
 * cdef class GZIteratorParsed(GZIterator):             # <<<<<<<<<<<<<<
 *     '''iterate line-by-line through gzip (or bgzip)
 *     compressed file returning comments at top of file.
 */

struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorParsed {
  struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorParsed *__pyx_vtabptr_5pysam_9libctabix_GZIteratorParsed;


/* "pysam/libctabix.pyx":1253
 * 
 * 
 * cdef class Tabixfile(TabixFile):             # <<<<<<<<<<<<<<
 *     """Tabixfile is deprecated: use TabixFile instead"""
 *     pass
 */

struct __pyx_vtabstruct_5pysam_9libctabix_Tabixfile {
  struct __pyx_vtabstruct_5pysam_9libctabix_TabixFile __pyx_base;
};
static struct __pyx_vtabstruct_5pysam_9libctabix_Tabixfile *__pyx_vtabptr_5pysam_9libctabix_Tabixfile;
/* #### Code section: utility_code_proto ### */

/* --- Runtime support code (head) --- */
/* Refnanny.proto */
#ifndef CYTHON_REFNANNY
  #define CYTHON_REFNANNY 0
#endif
#if CYTHON_REFNANNY
  typedef struct {
    void (*INCREF)(void*, PyObject*, Py_ssize_t);
    void (*DECREF)(void*, PyObject*, Py_ssize_t);
    void (*GOTREF)(void*, PyObject*, Py_ssize_t);
    void (*GIVEREF)(void*, PyObject*, Py_ssize_t);
    void* (*SetupContext)(const char*, Py_ssize_t, const char*);
    void (*FinishContext)(void**);
  } __Pyx_RefNannyAPIStruct;
  static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
  static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname);
  #define __Pyx_RefNannyDeclarations void *__pyx_refnanny = NULL;
#ifdef WITH_THREAD
  #define __Pyx_RefNannySetupContext(name, acquire_gil)\
          if (acquire_gil) {\
              PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
              __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__));\
              PyGILState_Release(__pyx_gilstate_save);\
          } else {\
              __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__));\
          }
  #define __Pyx_RefNannyFinishContextNogil() {\
              PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
              __Pyx_RefNannyFinishContext();\
              PyGILState_Release(__pyx_gilstate_save);\
          }
#else
  #define __Pyx_RefNannySetupContext(name, acquire_gil)\
          __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), (__LINE__), (__FILE__))
  #define __Pyx_RefNannyFinishContextNogil() __Pyx_RefNannyFinishContext()
#endif
  #define __Pyx_RefNannyFinishContextNogil() {\
              PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
              __Pyx_RefNannyFinishContext();\
              PyGILState_Release(__pyx_gilstate_save);\
          }
  #define __Pyx_RefNannyFinishContext()\
          __Pyx_RefNanny->FinishContext(&__pyx_refnanny)
  #define __Pyx_INCREF(r)  __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
  #define __Pyx_DECREF(r)  __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
  #define __Pyx_GOTREF(r)  __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
  #define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), (__LINE__))
  #define __Pyx_XINCREF(r)  do { if((r) == NULL); else {__Pyx_INCREF(r); }} while(0)
  #define __Pyx_XDECREF(r)  do { if((r) == NULL); else {__Pyx_DECREF(r); }} while(0)
  #define __Pyx_XGOTREF(r)  do { if((r) == NULL); else {__Pyx_GOTREF(r); }} while(0)
  #define __Pyx_XGIVEREF(r) do { if((r) == NULL); else {__Pyx_GIVEREF(r);}} while(0)
#else
  #define __Pyx_RefNannyDeclarations
  #define __Pyx_RefNannySetupContext(name, acquire_gil)
  #define __Pyx_RefNannyFinishContextNogil()
  #define __Pyx_RefNannyFinishContext()
  #define __Pyx_INCREF(r) Py_INCREF(r)
  #define __Pyx_DECREF(r) Py_DECREF(r)
  #define __Pyx_GOTREF(r)
  #define __Pyx_GIVEREF(r)
  #define __Pyx_XINCREF(r) Py_XINCREF(r)
  #define __Pyx_XDECREF(r) Py_XDECREF(r)
  #define __Pyx_XGOTREF(r)
  #define __Pyx_XGIVEREF(r)
#endif
#define __Pyx_Py_XDECREF_SET(r, v) do {\
        PyObject *tmp = (PyObject *) r;\
        r = v; Py_XDECREF(tmp);\
    } while (0)
#define __Pyx_XDECREF_SET(r, v) do {\
        PyObject *tmp = (PyObject *) r;\
        r = v; __Pyx_XDECREF(tmp);\
    } while (0)
#define __Pyx_DECREF_SET(r, v) do {\
        PyObject *tmp = (PyObject *) r;\
        r = v; __Pyx_DECREF(tmp);\
    } while (0)
#define __Pyx_CLEAR(r)    do { PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);} while(0)
#define __Pyx_XCLEAR(r)   do { if((r) != NULL) {PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);}} while(0)

/* PyErrExceptionMatches.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyErr_ExceptionMatches(err) __Pyx_PyErr_ExceptionMatchesInState(__pyx_tstate, err)
static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err);
#else
#define __Pyx_PyErr_ExceptionMatches(err)  PyErr_ExceptionMatches(err)
#endif

/* PyThreadStateGet.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyThreadState_declare  PyThreadState *__pyx_tstate;
#define __Pyx_PyThreadState_assign  __pyx_tstate = __Pyx_PyThreadState_Current;
#if PY_VERSION_HEX >= 0x030C00A6
#define __Pyx_PyErr_Occurred()  (__pyx_tstate->current_exception != NULL)
#define __Pyx_PyErr_CurrentExceptionType()  (__pyx_tstate->current_exception ? (PyObject*) Py_TYPE(__pyx_tstate->current_exception) : (PyObject*) NULL)
#else
#define __Pyx_PyErr_Occurred()  (__pyx_tstate->curexc_type != NULL)
#define __Pyx_PyErr_CurrentExceptionType()  (__pyx_tstate->curexc_type)
#endif
#else
#define __Pyx_PyThreadState_declare
#define __Pyx_PyThreadState_assign
#define __Pyx_PyErr_Occurred()  (PyErr_Occurred() != NULL)
#define __Pyx_PyErr_CurrentExceptionType()  PyErr_Occurred()
#endif

/* PyErrFetchRestore.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyErr_Clear() __Pyx_ErrRestore(NULL, NULL, NULL)
#define __Pyx_ErrRestoreWithState(type, value, tb)  __Pyx_ErrRestoreInState(PyThreadState_GET(), type, value, tb)
#define __Pyx_ErrFetchWithState(type, value, tb)    __Pyx_ErrFetchInState(PyThreadState_GET(), type, value, tb)
#define __Pyx_ErrRestore(type, value, tb)  __Pyx_ErrRestoreInState(__pyx_tstate, type, value, tb)
#define __Pyx_ErrFetch(type, value, tb)    __Pyx_ErrFetchInState(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A6
#define __Pyx_PyErr_SetNone(exc) (Py_INCREF(exc), __Pyx_ErrRestore((exc), NULL, NULL))
#else
#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
#endif
#else
#define __Pyx_PyErr_Clear() PyErr_Clear()
#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
#define __Pyx_ErrRestoreWithState(type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetchWithState(type, value, tb)  PyErr_Fetch(type, value, tb)
#define __Pyx_ErrRestoreInState(tstate, type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetchInState(tstate, type, value, tb)  PyErr_Fetch(type, value, tb)
#define __Pyx_ErrRestore(type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetch(type, value, tb)  PyErr_Fetch(type, value, tb)
#endif

/* PyObjectGetAttrStr.proto */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GetAttrStr(o,n) PyObject_GetAttr(o,n)
#endif

/* PyObjectGetAttrStrNoError.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStrNoError(PyObject* obj, PyObject* attr_name);

/* GetBuiltinName.proto */
static PyObject *__Pyx_GetBuiltinName(PyObject *name);

/* TupleAndListFromArray.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyList_FromArray(PyObject *const *src, Py_ssize_t n);
static CYTHON_INLINE PyObject* __Pyx_PyTuple_FromArray(PyObject *const *src, Py_ssize_t n);
#endif

/* IncludeStringH.proto */
#include <string.h>

/* BytesEquals.proto */
static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals);

/* UnicodeEquals.proto */
static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals);

/* fastcall.proto */
#if CYTHON_AVOID_BORROWED_REFS
    #define __Pyx_Arg_VARARGS(args, i) PySequence_GetItem(args, i)
#elif CYTHON_ASSUME_SAFE_MACROS
    #define __Pyx_Arg_VARARGS(args, i) PyTuple_GET_ITEM(args, i)
#else
    #define __Pyx_Arg_VARARGS(args, i) PyTuple_GetItem(args, i)
#endif
#if CYTHON_AVOID_BORROWED_REFS
    #define __Pyx_Arg_NewRef_VARARGS(arg) __Pyx_NewRef(arg)
    #define __Pyx_Arg_XDECREF_VARARGS(arg) Py_XDECREF(arg)
#else
    #define __Pyx_Arg_NewRef_VARARGS(arg) arg // no-op
    #define __Pyx_Arg_XDECREF_VARARGS(arg) // no-op - arg is borrowed
#endif
#define __Pyx_NumKwargs_VARARGS(kwds) PyDict_Size(kwds)
#define __Pyx_KwValues_VARARGS(args, nargs) NULL
#define __Pyx_GetKwValue_VARARGS(kw, kwvalues, s) __Pyx_PyDict_GetItemStrWithError(kw, s)
#define __Pyx_KwargsAsDict_VARARGS(kw, kwvalues) PyDict_Copy(kw)
#if CYTHON_METH_FASTCALL
    #define __Pyx_Arg_FASTCALL(args, i) args[i]
    #define __Pyx_NumKwargs_FASTCALL(kwds) PyTuple_GET_SIZE(kwds)
    #define __Pyx_KwValues_FASTCALL(args, nargs) ((args) + (nargs))
    static CYTHON_INLINE PyObject * __Pyx_GetKwValue_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues, PyObject *s);
    #define __Pyx_KwargsAsDict_FASTCALL(kw, kwvalues) _PyStack_AsDict(kwvalues, kw)
    #define __Pyx_Arg_NewRef_FASTCALL(arg) arg // no-op, __Pyx_Arg_FASTCALL is direct and this needs
    #define __Pyx_Arg_XDECREF_FASTCALL(arg)  // no-op - arg was returned from array
#else
    #define __Pyx_Arg_FASTCALL __Pyx_Arg_VARARGS
    #define __Pyx_NumKwargs_FASTCALL __Pyx_NumKwargs_VARARGS
    #define __Pyx_KwValues_FASTCALL __Pyx_KwValues_VARARGS
    #define __Pyx_GetKwValue_FASTCALL __Pyx_GetKwValue_VARARGS
    #define __Pyx_KwargsAsDict_FASTCALL __Pyx_KwargsAsDict_VARARGS
    #define __Pyx_Arg_NewRef_FASTCALL(arg) __Pyx_Arg_NewRef_VARARGS(arg)
    #define __Pyx_Arg_XDECREF_FASTCALL(arg) __Pyx_Arg_XDECREF_VARARGS(arg)
#endif
#if CYTHON_COMPILING_IN_CPYTHON && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
#define __Pyx_ArgsSlice_VARARGS(args, start, stop) __Pyx_PyTuple_FromArray(&__Pyx_Arg_VARARGS(args, start), stop - start)
#define __Pyx_ArgsSlice_FASTCALL(args, start, stop) __Pyx_PyTuple_FromArray(&__Pyx_Arg_FASTCALL(args, start), stop - start)
#else
#define __Pyx_ArgsSlice_VARARGS(args, start, stop) PyTuple_GetSlice(args, start, stop)
#define __Pyx_ArgsSlice_FASTCALL(args, start, stop) PyTuple_GetSlice(args, start, stop)
#endif

/* RaiseDoubleKeywords.proto */
static void __Pyx_RaiseDoubleKeywordsError(const char* func_name, PyObject* kw_name);

/* ParseKeywords.proto */
static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject *const *kwvalues,
    PyObject **argnames[],
    PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args,
    const char* function_name);

/* RaiseArgTupleInvalid.proto */
static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
    Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found);

/* Profile.proto */
#ifndef CYTHON_PROFILE
#if CYTHON_COMPILING_IN_LIMITED_API || CYTHON_COMPILING_IN_PYPY
  #define CYTHON_PROFILE 0
#else
  #define CYTHON_PROFILE 1
#endif
#endif
#ifndef CYTHON_TRACE_NOGIL
  #define CYTHON_TRACE_NOGIL 0
#else
  #if CYTHON_TRACE_NOGIL && !defined(CYTHON_TRACE)
    #define CYTHON_TRACE 1
  #endif
#endif
#ifndef CYTHON_TRACE
  #define CYTHON_TRACE 0
#endif
#if CYTHON_TRACE
  #undef CYTHON_PROFILE_REUSE_FRAME
#endif
#ifndef CYTHON_PROFILE_REUSE_FRAME
  #define CYTHON_PROFILE_REUSE_FRAME 0
#endif
#if CYTHON_PROFILE || CYTHON_TRACE
  #include "compile.h"
  #include "frameobject.h"
  #include "traceback.h"
#if PY_VERSION_HEX >= 0x030b00a6
  #ifndef Py_BUILD_CORE
    #define Py_BUILD_CORE 1
  #endif
  #include "internal/pycore_frame.h"
#endif
  #if CYTHON_PROFILE_REUSE_FRAME
    #define CYTHON_FRAME_MODIFIER static
    #define CYTHON_FRAME_DEL(frame)
  #else
    #define CYTHON_FRAME_MODIFIER
    #define CYTHON_FRAME_DEL(frame) Py_CLEAR(frame)
  #endif
  #define __Pyx_TraceDeclarations\
      static PyCodeObject *__pyx_frame_code = NULL;\
      CYTHON_FRAME_MODIFIER PyFrameObject *__pyx_frame = NULL;\
      int __Pyx_use_tracing = 0;
  #define __Pyx_TraceFrameInit(codeobj)\
      if (codeobj) __pyx_frame_code = (PyCodeObject*) codeobj;
#if PY_VERSION_HEX >= 0x030b00a2
  #if PY_VERSION_HEX >= 0x030C00b1
  #define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
     ((!(check_tracing) || !(tstate)->tracing) &&\
         (!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
  #else
  #define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
     (unlikely((tstate)->cframe->use_tracing) &&\
         (!(check_tracing) || !(tstate)->tracing) &&\
         (!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
  #endif
  #define __Pyx_EnterTracing(tstate)  PyThreadState_EnterTracing(tstate)
  #define __Pyx_LeaveTracing(tstate)  PyThreadState_LeaveTracing(tstate)
#elif PY_VERSION_HEX >= 0x030a00b1
  #define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
     (unlikely((tstate)->cframe->use_tracing) &&\
         (!(check_tracing) || !(tstate)->tracing) &&\
         (!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
  #define __Pyx_EnterTracing(tstate)\
      do { tstate->tracing++; tstate->cframe->use_tracing = 0; } while (0)
  #define __Pyx_LeaveTracing(tstate)\
      do {\
          tstate->tracing--;\
          tstate->cframe->use_tracing = ((CYTHON_TRACE && tstate->c_tracefunc != NULL)\
                                 || tstate->c_profilefunc != NULL);\
      } while (0)
#else
  #define __Pyx_IsTracing(tstate, check_tracing, check_funcs)\
     (unlikely((tstate)->use_tracing) &&\
         (!(check_tracing) || !(tstate)->tracing) &&\
         (!(check_funcs) || (tstate)->c_profilefunc || (CYTHON_TRACE && (tstate)->c_tracefunc)))
  #define __Pyx_EnterTracing(tstate)\
      do { tstate->tracing++; tstate->use_tracing = 0; } while (0)
  #define __Pyx_LeaveTracing(tstate)\
      do {\
          tstate->tracing--;\
          tstate->use_tracing = ((CYTHON_TRACE && tstate->c_tracefunc != NULL)\
                                         || tstate->c_profilefunc != NULL);\
      } while (0)
#endif
  #ifdef WITH_THREAD
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
  if (nogil) {\
      if (CYTHON_TRACE_NOGIL) {\
          PyThreadState *tstate;\
          PyGILState_STATE state = PyGILState_Ensure();\
          tstate = __Pyx_PyThreadState_Current;\
          if (__Pyx_IsTracing(tstate, 1, 1)) {\
              __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          }\
          PyGILState_Release(state);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  } else {\
      PyThreadState* tstate = PyThreadState_GET();\
      if (__Pyx_IsTracing(tstate, 1, 1)) {\
          __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  }
  #else
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
  {   PyThreadState* tstate = PyThreadState_GET();\
      if (__Pyx_IsTracing(tstate, 1, 1)) {\
          __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  }
  #endif
  #define __Pyx_TraceException()\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (__Pyx_IsTracing(tstate, 0, 1)) {\
          __Pyx_EnterTracing(tstate);\
          PyObject *exc_info = __Pyx_GetExceptionTuple(tstate);\
          if (exc_info) {\
              if (CYTHON_TRACE && tstate->c_tracefunc)\
                  tstate->c_tracefunc(\
                      tstate->c_traceobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
              tstate->c_profilefunc(\
                  tstate->c_profileobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
              Py_DECREF(exc_info);\
          }\
          __Pyx_LeaveTracing(tstate);\
      }\
  }
  static void __Pyx_call_return_trace_func(PyThreadState *tstate, PyFrameObject *frame, PyObject *result) {
      PyObject *type, *value, *traceback;
      __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
      __Pyx_EnterTracing(tstate);
      if (CYTHON_TRACE && tstate->c_tracefunc)
          tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_RETURN, result);
      if (tstate->c_profilefunc)
          tstate->c_profilefunc(tstate->c_profileobj, frame, PyTrace_RETURN, result);
      CYTHON_FRAME_DEL(frame);
      __Pyx_LeaveTracing(tstate);
      __Pyx_ErrRestoreInState(tstate, type, value, traceback);
  }
  #ifdef WITH_THREAD
  #define __Pyx_TraceReturn(result, nogil)\
  if (likely(!__Pyx_use_tracing)); else {\
      if (nogil) {\
          if (CYTHON_TRACE_NOGIL) {\
              PyThreadState *tstate;\
              PyGILState_STATE state = PyGILState_Ensure();\
              tstate = __Pyx_PyThreadState_Current;\
              if (__Pyx_IsTracing(tstate, 0, 0)) {\
                  __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
              }\
              PyGILState_Release(state);\
          }\
      } else {\
          PyThreadState* tstate = __Pyx_PyThreadState_Current;\
          if (__Pyx_IsTracing(tstate, 0, 0)) {\
              __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
          }\
      }\
  }
  #else
  #define __Pyx_TraceReturn(result, nogil)\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (__Pyx_IsTracing(tstate, 0, 0)) {\
          __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
      }\
  }
  #endif
  static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno);
  static int __Pyx_TraceSetupAndCall(PyCodeObject** code, PyFrameObject** frame, PyThreadState* tstate, const char *funcname, const char *srcfile, int firstlineno);
#else
  #define __Pyx_TraceDeclarations
  #define __Pyx_TraceFrameInit(codeobj)
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)   if ((1)); else goto_error;
  #define __Pyx_TraceException()
  #define __Pyx_TraceReturn(result, nogil)
#endif
#if CYTHON_TRACE
  static int __Pyx_call_line_trace_func(PyThreadState *tstate, PyFrameObject *frame, int lineno) {
      int ret;
      PyObject *type, *value, *traceback;
      __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
      __Pyx_PyFrame_SetLineNumber(frame, lineno);
      __Pyx_EnterTracing(tstate);
      ret = tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_LINE, NULL);
      __Pyx_LeaveTracing(tstate);
      if (likely(!ret)) {
          __Pyx_ErrRestoreInState(tstate, type, value, traceback);
      } else {
          Py_XDECREF(type);
          Py_XDECREF(value);
          Py_XDECREF(traceback);
      }
      return ret;
  }
  #ifdef WITH_THREAD
  #define __Pyx_TraceLine(lineno, nogil, goto_error)\
  if (likely(!__Pyx_use_tracing)); else {\
      if (nogil) {\
          if (CYTHON_TRACE_NOGIL) {\
              int ret = 0;\
              PyThreadState *tstate;\
              PyGILState_STATE state = __Pyx_PyGILState_Ensure();\
              tstate = __Pyx_PyThreadState_Current;\
              if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
                  ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
              }\
              __Pyx_PyGILState_Release(state);\
              if (unlikely(ret)) goto_error;\
          }\
      } else {\
          PyThreadState* tstate = __Pyx_PyThreadState_Current;\
          if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
              int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
              if (unlikely(ret)) goto_error;\
          }\
      }\
  }
  #else
  #define __Pyx_TraceLine(lineno, nogil, goto_error)\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (__Pyx_IsTracing(tstate, 0, 0) && tstate->c_tracefunc && __pyx_frame->f_trace) {\
          int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
          if (unlikely(ret)) goto_error;\
      }\
  }
  #endif
#else
  #define __Pyx_TraceLine(lineno, nogil, goto_error)   if ((1)); else goto_error;
#endif

/* KeywordStringCheck.proto */
static int __Pyx_CheckKeywordStrings(PyObject *kw, const char* function_name, int kw_allowed);

/* PyObject_Str.proto */
#define __Pyx_PyObject_Str(obj)\
    (likely(PyString_CheckExact(obj)) ? __Pyx_NewRef(obj) : PyObject_Str(obj))

/* PyFunctionFastCall.proto */
#if CYTHON_FAST_PYCALL
#if !CYTHON_VECTORCALL
#define __Pyx_PyFunction_FastCall(func, args, nargs)\
    __Pyx_PyFunction_FastCallDict((func), (args), (nargs), NULL)
static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs);
#endif
#define __Pyx_BUILD_ASSERT_EXPR(cond)\
    (sizeof(char [1 - 2*!(cond)]) - 1)
#ifndef Py_MEMBER_SIZE
#define Py_MEMBER_SIZE(type, member) sizeof(((type *)0)->member)
#endif
#if !CYTHON_VECTORCALL
#if PY_VERSION_HEX >= 0x03080000
  #include "frameobject.h"
#if PY_VERSION_HEX >= 0x030b00a6 && !CYTHON_COMPILING_IN_LIMITED_API
  #ifndef Py_BUILD_CORE
    #define Py_BUILD_CORE 1
  #endif
  #include "internal/pycore_frame.h"
#endif
  #define __Pxy_PyFrame_Initialize_Offsets()
  #define __Pyx_PyFrame_GetLocalsplus(frame)  ((frame)->f_localsplus)
#else
  static size_t __pyx_pyframe_localsplus_offset = 0;
  #include "frameobject.h"
  #define __Pxy_PyFrame_Initialize_Offsets()\
    ((void)__Pyx_BUILD_ASSERT_EXPR(sizeof(PyFrameObject) == offsetof(PyFrameObject, f_localsplus) + Py_MEMBER_SIZE(PyFrameObject, f_localsplus)),\
     (void)(__pyx_pyframe_localsplus_offset = ((size_t)PyFrame_Type.tp_basicsize) - Py_MEMBER_SIZE(PyFrameObject, f_localsplus)))
  #define __Pyx_PyFrame_GetLocalsplus(frame)\
    (assert(__pyx_pyframe_localsplus_offset), (PyObject **)(((char *)(frame)) + __pyx_pyframe_localsplus_offset))
#endif
#endif
#endif

/* PyObjectCall.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw);
#else
#define __Pyx_PyObject_Call(func, arg, kw) PyObject_Call(func, arg, kw)
#endif

/* PyObjectCallMethO.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg);
#endif

/* PyObjectFastCall.proto */
#define __Pyx_PyObject_FastCall(func, args, nargs)  __Pyx_PyObject_FastCallDict(func, args, (size_t)(nargs), NULL)
static CYTHON_INLINE PyObject* __Pyx_PyObject_FastCallDict(PyObject *func, PyObject **args, size_t nargs, PyObject *kwargs);

/* PyObjectCallOneArg.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg);

/* RaiseException.proto */
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause);

/* GetAttr3.proto */
static CYTHON_INLINE PyObject *__Pyx_GetAttr3(PyObject *, PyObject *, PyObject *);

/* PyDictVersioning.proto */
#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
#define __PYX_DICT_VERSION_INIT  ((PY_UINT64_T) -1)
#define __PYX_GET_DICT_VERSION(dict)  (((PyDictObject*)(dict))->ma_version_tag)
#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)\
    (version_var) = __PYX_GET_DICT_VERSION(dict);\
    (cache_var) = (value);
#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP) {\
    static PY_UINT64_T __pyx_dict_version = 0;\
    static PyObject *__pyx_dict_cached_value = NULL;\
    if (likely(__PYX_GET_DICT_VERSION(DICT) == __pyx_dict_version)) {\
        (VAR) = __pyx_dict_cached_value;\
    } else {\
        (VAR) = __pyx_dict_cached_value = (LOOKUP);\
        __pyx_dict_version = __PYX_GET_DICT_VERSION(DICT);\
    }\
}
static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj);
static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj);
static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version);
#else
#define __PYX_GET_DICT_VERSION(dict)  (0)
#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)
#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP)  (VAR) = (LOOKUP);
#endif

/* GetModuleGlobalName.proto */
#if CYTHON_USE_DICT_VERSIONS
#define __Pyx_GetModuleGlobalName(var, name)  do {\
    static PY_UINT64_T __pyx_dict_version = 0;\
    static PyObject *__pyx_dict_cached_value = NULL;\
    (var) = (likely(__pyx_dict_version == __PYX_GET_DICT_VERSION(__pyx_d))) ?\
        (likely(__pyx_dict_cached_value) ? __Pyx_NewRef(__pyx_dict_cached_value) : __Pyx_GetBuiltinName(name)) :\
        __Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
} while(0)
#define __Pyx_GetModuleGlobalNameUncached(var, name)  do {\
    PY_UINT64_T __pyx_dict_version;\
    PyObject *__pyx_dict_cached_value;\
    (var) = __Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
} while(0)
static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value);
#else
#define __Pyx_GetModuleGlobalName(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
#define __Pyx_GetModuleGlobalNameUncached(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name);
#endif

/* RaiseUnexpectedTypeError.proto */
static int __Pyx_RaiseUnexpectedTypeError(const char *expected, PyObject *obj);

/* ExtTypeTest.proto */
static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type);

/* PyIntBinop.proto */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_AddObjC(PyObject *op1, PyObject *op2, long intval, int inplace, int zerodivision_check);
#else
#define __Pyx_PyInt_AddObjC(op1, op2, intval, inplace, zerodivision_check)\
    (inplace ? PyNumber_InPlaceAdd(op1, op2) : PyNumber_Add(op1, op2))
#endif

/* ListAppend.proto */
#if CYTHON_USE_PYLIST_INTERNALS && CYTHON_ASSUME_SAFE_MACROS
static CYTHON_INLINE int __Pyx_PyList_Append(PyObject* list, PyObject* x) {
    PyListObject* L = (PyListObject*) list;
    Py_ssize_t len = Py_SIZE(list);
    if (likely(L->allocated > len) & likely(len > (L->allocated >> 1))) {
        Py_INCREF(x);
        PyList_SET_ITEM(list, len, x);
        __Pyx_SET_SIZE(list, len + 1);
        return 0;
    }
    return PyList_Append(list, x);
}
#else
#define __Pyx_PyList_Append(L,x) PyList_Append(L,x)
#endif

/* WriteUnraisableException.proto */
static void __Pyx_WriteUnraisable(const char *name, int clineno,
                                  int lineno, const char *filename,
                                  int full_traceback, int nogil);

/* PyObjectCallNoArg.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func);

/* ArgTypeTest.proto */
#define __Pyx_ArgTypeTest(obj, type, none_allowed, name, exact)\
    ((likely(__Pyx_IS_TYPE(obj, type) | (none_allowed && (obj == Py_None)))) ? 1 :\
        __Pyx__ArgTypeTest(obj, type, name, exact))
static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact);

/* PyObjectFormatAndDecref.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatSimpleAndDecref(PyObject* s, PyObject* f);
static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatAndDecref(PyObject* s, PyObject* f);

/* JoinPyUnicode.proto */
static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
                                      Py_UCS4 max_char);

/* DictGetItem.proto */
#if PY_MAJOR_VERSION >= 3 && !CYTHON_COMPILING_IN_PYPY
static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key);
#define __Pyx_PyObject_Dict_GetItem(obj, name)\
    (likely(PyDict_CheckExact(obj)) ?\
     __Pyx_PyDict_GetItem(obj, name) : PyObject_GetItem(obj, name))
#else
#define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
#define __Pyx_PyObject_Dict_GetItem(obj, name)  PyObject_GetItem(obj, name)
#endif

/* GetTopmostException.proto */
#if CYTHON_USE_EXC_INFO_STACK && CYTHON_FAST_THREAD_STATE
static _PyErr_StackItem * __Pyx_PyErr_GetTopmostException(PyThreadState *tstate);
#endif

/* SaveResetException.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_ExceptionSave(type, value, tb)  __Pyx__ExceptionSave(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#define __Pyx_ExceptionReset(type, value, tb)  __Pyx__ExceptionReset(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
#else
#define __Pyx_ExceptionSave(type, value, tb)   PyErr_GetExcInfo(type, value, tb)
#define __Pyx_ExceptionReset(type, value, tb)  PyErr_SetExcInfo(type, value, tb)
#endif

/* GetException.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_GetException(type, value, tb)  __Pyx__GetException(__pyx_tstate, type, value, tb)
static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#else
static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb);
#endif

/* py_dict_keys.proto */
static CYTHON_INLINE PyObject* __Pyx_PyDict_Keys(PyObject* d);

/* UnpackUnboundCMethod.proto */
typedef struct {
    PyObject *type;
    PyObject **method_name;
    PyCFunction func;
    PyObject *method;
    int flag;
} __Pyx_CachedCFunction;

/* CallUnboundCMethod0.proto */
static PyObject* __Pyx__CallUnboundCMethod0(__Pyx_CachedCFunction* cfunc, PyObject* self);
#if CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_CallUnboundCMethod0(cfunc, self)\
    (likely((cfunc)->func) ?\
        (likely((cfunc)->flag == METH_NOARGS) ?  (*((cfunc)->func))(self, NULL) :\
         (PY_VERSION_HEX >= 0x030600B1 && likely((cfunc)->flag == METH_FASTCALL) ?\
            (PY_VERSION_HEX >= 0x030700A0 ?\
                (*(__Pyx_PyCFunctionFast)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0) :\
                (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0, NULL)) :\
          (PY_VERSION_HEX >= 0x030700A0 && (cfunc)->flag == (METH_FASTCALL | METH_KEYWORDS) ?\
            (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0, NULL) :\
            (likely((cfunc)->flag == (METH_VARARGS | METH_KEYWORDS)) ?  ((*(PyCFunctionWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, __pyx_empty_tuple, NULL)) :\
               ((cfunc)->flag == METH_VARARGS ?  (*((cfunc)->func))(self, __pyx_empty_tuple) :\
               __Pyx__CallUnboundCMethod0(cfunc, self)))))) :\
        __Pyx__CallUnboundCMethod0(cfunc, self))
#else
#define __Pyx_CallUnboundCMethod0(cfunc, self)  __Pyx__CallUnboundCMethod0(cfunc, self)
#endif

/* UnicodeAsUCS4.proto */
static CYTHON_INLINE Py_UCS4 __Pyx_PyUnicode_AsPy_UCS4(PyObject*);

/* object_ord.proto */
#if PY_MAJOR_VERSION >= 3
#define __Pyx_PyObject_Ord(c)\
    (likely(PyUnicode_Check(c)) ? (long)__Pyx_PyUnicode_AsPy_UCS4(c) : __Pyx__PyObject_Ord(c))
#else
#define __Pyx_PyObject_Ord(c) __Pyx__PyObject_Ord(c)
#endif
static long __Pyx__PyObject_Ord(PyObject* c);

/* RaiseTooManyValuesToUnpack.proto */
static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);

/* RaiseNeedMoreValuesToUnpack.proto */
static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);

/* IterFinish.proto */
static CYTHON_INLINE int __Pyx_IterFinish(void);

/* UnpackItemEndCheck.proto */
static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected);

/* PyObjectSetAttrStr.proto */
#if CYTHON_USE_TYPE_SLOTS
#define __Pyx_PyObject_DelAttrStr(o,n) __Pyx_PyObject_SetAttrStr(o, n, NULL)
static CYTHON_INLINE int __Pyx_PyObject_SetAttrStr(PyObject* obj, PyObject* attr_name, PyObject* value);
#else
#define __Pyx_PyObject_DelAttrStr(o,n)   PyObject_DelAttr(o,n)
#define __Pyx_PyObject_SetAttrStr(o,n,v) PyObject_SetAttr(o,n,v)
#endif

/* AssertionsEnabled.proto */
#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX < 0x02070600 && !defined(Py_OptimizeFlag)
  #define __Pyx_init_assertions_enabled()  (0)
  #define __pyx_assertions_enabled()  (1)
#elif CYTHON_COMPILING_IN_LIMITED_API  ||  (CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030C0000)
  static int __pyx_assertions_enabled_flag;
  #define __pyx_assertions_enabled() (__pyx_assertions_enabled_flag)
  static int __Pyx_init_assertions_enabled(void) {
    PyObject *builtins, *debug, *debug_str;
    int flag;
    builtins = PyEval_GetBuiltins();
    if (!builtins) goto bad;
    debug_str = PyUnicode_FromStringAndSize("__debug__", 9);
    if (!debug_str) goto bad;
    debug = PyObject_GetItem(builtins, debug_str);
    Py_DECREF(debug_str);
    if (!debug) goto bad;
    flag = PyObject_IsTrue(debug);
    Py_DECREF(debug);
    if (flag == -1) goto bad;
    __pyx_assertions_enabled_flag = flag;
    return 0;
  bad:
    __pyx_assertions_enabled_flag = 1;
    return -1;
  }
#else
  #define __Pyx_init_assertions_enabled()  (0)
  #define __pyx_assertions_enabled()  (!Py_OptimizeFlag)
#endif

/* PySequenceContains.proto */
static CYTHON_INLINE int __Pyx_PySequence_ContainsTF(PyObject* item, PyObject* seq, int eq) {
    int result = PySequence_Contains(seq, item);
    return unlikely(result < 0) ? result : (result == (eq == Py_EQ));
}

/* Import.proto */
static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level);

/* ImportFrom.proto */
static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name);

/* GetItemInt.proto */
#define __Pyx_GetItemInt(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_Fast(o, (Py_ssize_t)i, is_list, wraparound, boundscheck) :\
    (is_list ? (PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL) :\
               __Pyx_GetItemInt_Generic(o, to_py_func(i))))
#define __Pyx_GetItemInt_List(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_List_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
    (PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL))
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
                                                              int wraparound, int boundscheck);
#define __Pyx_GetItemInt_Tuple(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_Tuple_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
    (PyErr_SetString(PyExc_IndexError, "tuple index out of range"), (PyObject*)NULL))
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
                                                              int wraparound, int boundscheck);
static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j);
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i,
                                                     int is_list, int wraparound, int boundscheck);

/* GetAttr.proto */
static CYTHON_INLINE PyObject *__Pyx_GetAttr(PyObject *, PyObject *);

/* HasAttr.proto */
static CYTHON_INLINE int __Pyx_HasAttr(PyObject *, PyObject *);

/* CallNextTpDealloc.proto */
static void __Pyx_call_next_tp_dealloc(PyObject* obj, destructor current_tp_dealloc);

/* CallNextTpTraverse.proto */
static int __Pyx_call_next_tp_traverse(PyObject* obj, visitproc v, void *a, traverseproc current_tp_traverse);

/* CallNextTpClear.proto */
static void __Pyx_call_next_tp_clear(PyObject* obj, inquiry current_tp_clear);

/* IncludeStructmemberH.proto */
#include <structmember.h>

/* FixUpExtensionType.proto */
#if CYTHON_USE_TYPE_SPECS
static int __Pyx_fix_up_extension_type_from_spec(PyType_Spec *spec, PyTypeObject *type);
#endif

/* PyObjectGetMethod.proto */
static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method);

/* PyObjectCallMethod0.proto */
static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name);

/* ValidateBasesTuple.proto */
#if CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API || CYTHON_USE_TYPE_SPECS
static int __Pyx_validate_bases_tuple(const char *type_name, Py_ssize_t dictoffset, PyObject *bases);
#endif

/* PyType_Ready.proto */
CYTHON_UNUSED static int __Pyx_PyType_Ready(PyTypeObject *t);

/* PyObject_GenericGetAttrNoDict.proto */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GenericGetAttrNoDict PyObject_GenericGetAttr
#endif

/* PyObject_GenericGetAttr.proto */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GenericGetAttr PyObject_GenericGetAttr
#endif

/* SetVTable.proto */
static int __Pyx_SetVtable(PyTypeObject* typeptr , void* vtable);

/* GetVTable.proto */
static void* __Pyx_GetVtable(PyTypeObject *type);

/* MergeVTables.proto */
#if !CYTHON_COMPILING_IN_LIMITED_API
static int __Pyx_MergeVtables(PyTypeObject *type);
#endif

/* SetupReduce.proto */
#if !CYTHON_COMPILING_IN_LIMITED_API
static int __Pyx_setup_reduce(PyObject* type_obj);
#endif

/* TypeImport.proto */
#ifndef __PYX_HAVE_RT_ImportType_proto_3_0_2
#define __PYX_HAVE_RT_ImportType_proto_3_0_2
#if defined (__STDC_VERSION__) && __STDC_VERSION__ >= 201112L
#include <stdalign.h>
#endif
#if (defined (__STDC_VERSION__) && __STDC_VERSION__ >= 201112L) || __cplusplus >= 201103L
#define __PYX_GET_STRUCT_ALIGNMENT_3_0_2(s) alignof(s)
#else
#define __PYX_GET_STRUCT_ALIGNMENT_3_0_2(s) sizeof(void*)
#endif
enum __Pyx_ImportType_CheckSize_3_0_2 {
   __Pyx_ImportType_CheckSize_Error_3_0_2 = 0,
   __Pyx_ImportType_CheckSize_Warn_3_0_2 = 1,
   __Pyx_ImportType_CheckSize_Ignore_3_0_2 = 2
};
static PyTypeObject *__Pyx_ImportType_3_0_2(PyObject* module, const char *module_name, const char *class_name, size_t size, size_t alignment, enum __Pyx_ImportType_CheckSize_3_0_2 check_size);
#endif

/* ImportDottedModule.proto */
static PyObject *__Pyx_ImportDottedModule(PyObject *name, PyObject *parts_tuple);
#if PY_MAJOR_VERSION >= 3
static PyObject *__Pyx_ImportDottedModule_WalkParts(PyObject *module, PyObject *name, PyObject *parts_tuple);
#endif

/* FetchSharedCythonModule.proto */
static PyObject *__Pyx_FetchSharedCythonABIModule(void);

/* FetchCommonType.proto */
#if !CYTHON_USE_TYPE_SPECS
static PyTypeObject* __Pyx_FetchCommonType(PyTypeObject* type);
#else
static PyTypeObject* __Pyx_FetchCommonTypeFromSpec(PyObject *module, PyType_Spec *spec, PyObject *bases);
#endif

/* PyMethodNew.proto */
#if CYTHON_COMPILING_IN_LIMITED_API
static PyObject *__Pyx_PyMethod_New(PyObject *func, PyObject *self, PyObject *typ) {
    PyObject *typesModule=NULL, *methodType=NULL, *result=NULL;
    CYTHON_UNUSED_VAR(typ);
    if (!self)
        return __Pyx_NewRef(func);
    typesModule = PyImport_ImportModule("types");
    if (!typesModule) return NULL;
    methodType = PyObject_GetAttrString(typesModule, "MethodType");
    Py_DECREF(typesModule);
    if (!methodType) return NULL;
    result = PyObject_CallFunctionObjArgs(methodType, func, self, NULL);
    Py_DECREF(methodType);
    return result;
}
#elif PY_MAJOR_VERSION >= 3
static PyObject *__Pyx_PyMethod_New(PyObject *func, PyObject *self, PyObject *typ) {
    CYTHON_UNUSED_VAR(typ);
    if (!self)
        return __Pyx_NewRef(func);
    return PyMethod_New(func, self);
}
#else
    #define __Pyx_PyMethod_New PyMethod_New
#endif

/* PyVectorcallFastCallDict.proto */
#if CYTHON_METH_FASTCALL
static CYTHON_INLINE PyObject *__Pyx_PyVectorcall_FastCallDict(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw);
#endif

/* CythonFunctionShared.proto */
#define __Pyx_CyFunction_USED
#define __Pyx_CYFUNCTION_STATICMETHOD  0x01
#define __Pyx_CYFUNCTION_CLASSMETHOD   0x02
#define __Pyx_CYFUNCTION_CCLASS        0x04
#define __Pyx_CYFUNCTION_COROUTINE     0x08
#define __Pyx_CyFunction_GetClosure(f)\
    (((__pyx_CyFunctionObject *) (f))->func_closure)
#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
  #define __Pyx_CyFunction_GetClassObj(f)\
      (((__pyx_CyFunctionObject *) (f))->func_classobj)
#else
  #define __Pyx_CyFunction_GetClassObj(f)\
      ((PyObject*) ((PyCMethodObject *) (f))->mm_class)
#endif
#define __Pyx_CyFunction_SetClassObj(f, classobj)\
    __Pyx__CyFunction_SetClassObj((__pyx_CyFunctionObject *) (f), (classobj))
#define __Pyx_CyFunction_Defaults(type, f)\
    ((type *)(((__pyx_CyFunctionObject *) (f))->defaults))
#define __Pyx_CyFunction_SetDefaultsGetter(f, g)\
    ((__pyx_CyFunctionObject *) (f))->defaults_getter = (g)
typedef struct {
#if CYTHON_COMPILING_IN_LIMITED_API
    PyObject_HEAD
    PyObject *func;
#elif PY_VERSION_HEX < 0x030900B1
    PyCFunctionObject func;
#else
    PyCMethodObject func;
#endif
#if CYTHON_BACKPORT_VECTORCALL
    __pyx_vectorcallfunc func_vectorcall;
#endif
#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
    PyObject *func_weakreflist;
#endif
    PyObject *func_dict;
    PyObject *func_name;
    PyObject *func_qualname;
    PyObject *func_doc;
    PyObject *func_globals;
    PyObject *func_code;
    PyObject *func_closure;
#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
    PyObject *func_classobj;
#endif
    void *defaults;
    int defaults_pyobjects;
    size_t defaults_size;  // used by FusedFunction for copying defaults
    int flags;
    PyObject *defaults_tuple;
    PyObject *defaults_kwdict;
    PyObject *(*defaults_getter)(PyObject *);
    PyObject *func_annotations;
    PyObject *func_is_coroutine;
} __pyx_CyFunctionObject;
#define __Pyx_CyFunction_Check(obj)  __Pyx_TypeCheck(obj, __pyx_CyFunctionType)
#define __Pyx_IsCyOrPyCFunction(obj)  __Pyx_TypeCheck2(obj, __pyx_CyFunctionType, &PyCFunction_Type)
#define __Pyx_CyFunction_CheckExact(obj)  __Pyx_IS_TYPE(obj, __pyx_CyFunctionType)
static PyObject *__Pyx_CyFunction_Init(__pyx_CyFunctionObject* op, PyMethodDef *ml,
                                      int flags, PyObject* qualname,
                                      PyObject *closure,
                                      PyObject *module, PyObject *globals,
                                      PyObject* code);
static CYTHON_INLINE void __Pyx__CyFunction_SetClassObj(__pyx_CyFunctionObject* f, PyObject* classobj);
static CYTHON_INLINE void *__Pyx_CyFunction_InitDefaults(PyObject *m,
                                                         size_t size,
                                                         int pyobjects);
static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsTuple(PyObject *m,
                                                            PyObject *tuple);
static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsKwDict(PyObject *m,
                                                             PyObject *dict);
static CYTHON_INLINE void __Pyx_CyFunction_SetAnnotationsDict(PyObject *m,
                                                              PyObject *dict);
static int __pyx_CyFunction_init(PyObject *module);
#if CYTHON_METH_FASTCALL
static PyObject * __Pyx_CyFunction_Vectorcall_NOARGS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
static PyObject * __Pyx_CyFunction_Vectorcall_O(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames);
#if CYTHON_BACKPORT_VECTORCALL
#define __Pyx_CyFunction_func_vectorcall(f) (((__pyx_CyFunctionObject*)f)->func_vectorcall)
#else
#define __Pyx_CyFunction_func_vectorcall(f) (((PyCFunctionObject*)f)->vectorcall)
#endif
#endif

/* CythonFunction.proto */
static PyObject *__Pyx_CyFunction_New(PyMethodDef *ml,
                                      int flags, PyObject* qualname,
                                      PyObject *closure,
                                      PyObject *module, PyObject *globals,
                                      PyObject* code);

/* SetNameInClass.proto */
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030500A1
#define __Pyx_SetNameInClass(ns, name, value)\
    (likely(PyDict_CheckExact(ns)) ? _PyDict_SetItem_KnownHash(ns, name, value, ((PyASCIIObject *) name)->hash) : PyObject_SetItem(ns, name, value))
#elif CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_SetNameInClass(ns, name, value)\
    (likely(PyDict_CheckExact(ns)) ? PyDict_SetItem(ns, name, value) : PyObject_SetItem(ns, name, value))
#else
#define __Pyx_SetNameInClass(ns, name, value)  PyObject_SetItem(ns, name, value)
#endif

/* CalculateMetaclass.proto */
static PyObject *__Pyx_CalculateMetaclass(PyTypeObject *metaclass, PyObject *bases);

/* PyObjectCall2Args.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2);

/* PyObjectLookupSpecial.proto */
#if CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
#define __Pyx_PyObject_LookupSpecialNoError(obj, attr_name)  __Pyx__PyObject_LookupSpecial(obj, attr_name, 0)
#define __Pyx_PyObject_LookupSpecial(obj, attr_name)  __Pyx__PyObject_LookupSpecial(obj, attr_name, 1)
static CYTHON_INLINE PyObject* __Pyx__PyObject_LookupSpecial(PyObject* obj, PyObject* attr_name, int with_error);
#else
#define __Pyx_PyObject_LookupSpecialNoError(o,n) __Pyx_PyObject_GetAttrStrNoError(o,n)
#define __Pyx_PyObject_LookupSpecial(o,n) __Pyx_PyObject_GetAttrStr(o,n)
#endif

/* Py3ClassCreate.proto */
static PyObject *__Pyx_Py3MetaclassPrepare(PyObject *metaclass, PyObject *bases, PyObject *name, PyObject *qualname,
                                           PyObject *mkw, PyObject *modname, PyObject *doc);
static PyObject *__Pyx_Py3ClassCreate(PyObject *metaclass, PyObject *name, PyObject *bases, PyObject *dict,
                                      PyObject *mkw, int calculate_metaclass, int allow_py2_metaclass);

/* CLineInTraceback.proto */
#ifdef CYTHON_CLINE_IN_TRACEBACK
#define __Pyx_CLineForTraceback(tstate, c_line)  (((CYTHON_CLINE_IN_TRACEBACK)) ? c_line : 0)
#else
static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line);
#endif

/* CodeObjectCache.proto */
#if !CYTHON_COMPILING_IN_LIMITED_API
typedef struct {
    PyCodeObject* code_object;
    int code_line;
} __Pyx_CodeObjectCacheEntry;
struct __Pyx_CodeObjectCache {
    int count;
    int max_count;
    __Pyx_CodeObjectCacheEntry* entries;
};
static struct __Pyx_CodeObjectCache __pyx_code_cache = {0,0,NULL};
static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line);
static PyCodeObject *__pyx_find_code_object(int code_line);
static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object);
#endif

/* AddTraceback.proto */
static void __Pyx_AddTraceback(const char *funcname, int c_line,
                               int py_line, const char *filename);

/* GCCDiagnostics.proto */
#if !defined(__INTEL_COMPILER) && defined(__GNUC__) && (__GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR__ >= 6))
#define __Pyx_HAS_GCC_DIAGNOSTIC
#endif

/* ArrayAPI.proto */
#ifndef _ARRAYARRAY_H
#define _ARRAYARRAY_H
typedef struct arraydescr {
    int typecode;
    int itemsize;
    PyObject * (*getitem)(struct arrayobject *, Py_ssize_t);
    int (*setitem)(struct arrayobject *, Py_ssize_t, PyObject *);
#if PY_MAJOR_VERSION >= 3
    char *formats;
#endif
} arraydescr;
struct arrayobject {
    PyObject_HEAD
    Py_ssize_t ob_size;
    union {
        char *ob_item;
        float *as_floats;
        double *as_doubles;
        int *as_ints;
        unsigned int *as_uints;
        unsigned char *as_uchars;
        signed char *as_schars;
        char *as_chars;
        unsigned long *as_ulongs;
        long *as_longs;
#if PY_MAJOR_VERSION >= 3
        unsigned long long *as_ulonglongs;
        long long *as_longlongs;
#endif
        short *as_shorts;
        unsigned short *as_ushorts;
        Py_UNICODE *as_pyunicodes;
        void *as_voidptr;
    } data;
    Py_ssize_t allocated;
    struct arraydescr *ob_descr;
    PyObject *weakreflist;
#if PY_MAJOR_VERSION >= 3
        int ob_exports;
#endif
};
#ifndef NO_NEWARRAY_INLINE
static CYTHON_INLINE PyObject * newarrayobject(PyTypeObject *type, Py_ssize_t size,
    struct arraydescr *descr) {
    arrayobject *op;
    size_t nbytes;
    if (size < 0) {
        PyErr_BadInternalCall();
        return NULL;
    }
    nbytes = size * descr->itemsize;
    if (nbytes / descr->itemsize != (size_t)size) {
        return PyErr_NoMemory();
    }
    op = (arrayobject *) type->tp_alloc(type, 0);
    if (op == NULL) {
        return NULL;
    }
    op->ob_descr = descr;
    op->allocated = size;
    op->weakreflist = NULL;
    __Pyx_SET_SIZE(op, size);
    if (size <= 0) {
        op->data.ob_item = NULL;
    }
    else {
        op->data.ob_item = PyMem_NEW(char, nbytes);
        if (op->data.ob_item == NULL) {
            Py_DECREF(op);
            return PyErr_NoMemory();
        }
    }
    return (PyObject *) op;
}
#else
PyObject* newarrayobject(PyTypeObject *type, Py_ssize_t size,
    struct arraydescr *descr);
#endif
static CYTHON_INLINE int resize(arrayobject *self, Py_ssize_t n) {
    void *items = (void*) self->data.ob_item;
    PyMem_Resize(items, char, (size_t)(n * self->ob_descr->itemsize));
    if (items == NULL) {
        PyErr_NoMemory();
        return -1;
    }
    self->data.ob_item = (char*) items;
    __Pyx_SET_SIZE(self, n);
    self->allocated = n;
    return 0;
}
static CYTHON_INLINE int resize_smart(arrayobject *self, Py_ssize_t n) {
    void *items = (void*) self->data.ob_item;
    Py_ssize_t newsize;
    if (n < self->allocated && n*4 > self->allocated) {
        __Pyx_SET_SIZE(self, n);
        return 0;
    }
    newsize = n + (n / 2) + 1;
    if (newsize <= n) {
        PyErr_NoMemory();
        return -1;
    }
    PyMem_Resize(items, char, (size_t)(newsize * self->ob_descr->itemsize));
    if (items == NULL) {
        PyErr_NoMemory();
        return -1;
    }
    self->data.ob_item = (char*) items;
    __Pyx_SET_SIZE(self, n);
    self->allocated = newsize;
    return 0;
}
#endif

/* CIntFromPy.proto */
static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value);

/* CIntFromPy.proto */
static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *);

/* CIntFromPy.proto */
static CYTHON_INLINE int64_t __Pyx_PyInt_As_int64_t(PyObject *);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int32_t(int32_t value);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value);

/* CIntFromPy.proto */
static CYTHON_INLINE int32_t __Pyx_PyInt_As_int32_t(PyObject *);

/* FormatTypeName.proto */
#if CYTHON_COMPILING_IN_LIMITED_API
typedef PyObject *__Pyx_TypeName;
#define __Pyx_FMT_TYPENAME "%U"
static __Pyx_TypeName __Pyx_PyType_GetName(PyTypeObject* tp);
#define __Pyx_DECREF_TypeName(obj) Py_XDECREF(obj)
#else
typedef const char *__Pyx_TypeName;
#define __Pyx_FMT_TYPENAME "%.200s"
#define __Pyx_PyType_GetName(tp) ((tp)->tp_name)
#define __Pyx_DECREF_TypeName(obj)
#endif

/* FastTypeChecks.proto */
#if CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_TypeCheck(obj, type) __Pyx_IsSubtype(Py_TYPE(obj), (PyTypeObject *)type)
#define __Pyx_TypeCheck2(obj, type1, type2) __Pyx_IsAnySubtype2(Py_TYPE(obj), (PyTypeObject *)type1, (PyTypeObject *)type2)
static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b);
static CYTHON_INLINE int __Pyx_IsAnySubtype2(PyTypeObject *cls, PyTypeObject *a, PyTypeObject *b);
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject *type);
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *type1, PyObject *type2);
#else
#define __Pyx_TypeCheck(obj, type) PyObject_TypeCheck(obj, (PyTypeObject *)type)
#define __Pyx_TypeCheck2(obj, type1, type2) (PyObject_TypeCheck(obj, (PyTypeObject *)type1) || PyObject_TypeCheck(obj, (PyTypeObject *)type2))
#define __Pyx_PyErr_GivenExceptionMatches(err, type) PyErr_GivenExceptionMatches(err, type)
#define __Pyx_PyErr_GivenExceptionMatches2(err, type1, type2) (PyErr_GivenExceptionMatches(err, type1) || PyErr_GivenExceptionMatches(err, type2))
#endif
#define __Pyx_PyErr_ExceptionMatches2(err1, err2)  __Pyx_PyErr_GivenExceptionMatches2(__Pyx_PyErr_CurrentExceptionType(), err1, err2)
#define __Pyx_PyException_Check(obj) __Pyx_TypeCheck(obj, PyExc_Exception)

/* CheckBinaryVersion.proto */
static int __Pyx_check_binary_version(void);

/* FunctionImport.proto */
static int __Pyx_ImportFunction_3_0_2(PyObject *module, const char *funcname, void (**f)(void), const char *sig);

/* InitStrings.proto */
static int __Pyx_InitStrings(__Pyx_StringTabEntry *t);

/* #### Code section: module_declarations ### */
static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4real_real(PyComplexObject *__pyx_v_self); /* proto*/
static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4imag_imag(PyComplexObject *__pyx_v_self); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_6Parser_parse(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, CYTHON_UNUSED char *__pyx_v_buffer, CYTHON_UNUSED int __pyx_v_length); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_7asTuple_parse(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_6asGFF3_parse(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_5asGTF_parse(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_5asBed_parse(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_5asVCF_parse(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len); /* proto*/
static int __pyx_f_5pysam_9libctabix_13TabixIterator___cnext__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self); /* proto*/
static int __pyx_f_5pysam_9libctabix_10GZIterator___cnext__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self); /* proto*/
static PyObject *__pyx_f_5pysam_9libctabix_19tabix_file_iterator___cnext__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self); /* proto*/

/* Module declarations from "libc.stdint" */

/* Module declarations from "libc.string" */

/* Module declarations from "libc.stdlib" */

/* Module declarations from "libc.stdio" */

/* Module declarations from "posix.types" */

/* Module declarations from "pysam.libchtslib" */

/* Module declarations from "libc.errno" */

/* Module declarations from "posix.unistd" */

/* Module declarations from "cpython.version" */

/* Module declarations from "__builtin__" */

/* Module declarations from "cpython.type" */

/* Module declarations from "cpython.object" */

/* Module declarations from "cpython.ref" */

/* Module declarations from "cpython.exc" */

/* Module declarations from "cpython.module" */

/* Module declarations from "cpython.mem" */

/* Module declarations from "cpython.tuple" */

/* Module declarations from "cpython.list" */

/* Module declarations from "cpython.sequence" */

/* Module declarations from "cpython.mapping" */

/* Module declarations from "cpython.iterator" */

/* Module declarations from "cpython.number" */

/* Module declarations from "cpython.int" */

/* Module declarations from "__builtin__" */

/* Module declarations from "cpython.bool" */

/* Module declarations from "cpython.long" */

/* Module declarations from "cpython.float" */

/* Module declarations from "__builtin__" */

/* Module declarations from "cpython.complex" */

/* Module declarations from "cpython.string" */

/* Module declarations from "cpython.unicode" */

/* Module declarations from "cpython.pyport" */

/* Module declarations from "cpython.dict" */

/* Module declarations from "cpython.instance" */

/* Module declarations from "cpython.function" */

/* Module declarations from "cpython.method" */

/* Module declarations from "cpython.weakref" */

/* Module declarations from "cpython.getargs" */

/* Module declarations from "cpython.pythread" */

/* Module declarations from "cpython.pystate" */

/* Module declarations from "cpython.cobject" */

/* Module declarations from "cpython.oldbuffer" */

/* Module declarations from "cpython.set" */

/* Module declarations from "cpython.buffer" */

/* Module declarations from "cpython.bytes" */

/* Module declarations from "cpython.pycapsule" */

/* Module declarations from "cpython.contextvars" */

/* Module declarations from "cpython" */

/* Module declarations from "pysam.libctabixproxies" */

/* Module declarations from "cython" */

/* Module declarations from "array" */

/* Module declarations from "cpython.array" */
static CYTHON_INLINE int __pyx_f_7cpython_5array_extend_buffer(arrayobject *, char *, Py_ssize_t); /*proto*/

/* Module declarations from "pysam.libcutils" */
static PyObject *(*__pyx_f_5pysam_9libcutils_charptr_to_str)(char const *, struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str *__pyx_optional_args); /*proto*/
static PyObject *(*__pyx_f_5pysam_9libcutils_force_str)(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_str *__pyx_optional_args); /*proto*/
static PyObject *(*__pyx_f_5pysam_9libcutils_force_bytes)(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_bytes *__pyx_optional_args); /*proto*/
static PyObject *(*__pyx_f_5pysam_9libcutils_encode_filename)(PyObject *); /*proto*/
static PyObject *(*__pyx_f_5pysam_9libcutils_from_string_and_size)(char const *, size_t); /*proto*/

/* Module declarations from "pysam.libctabix" */
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_Parser__set_state(struct __pyx_obj_5pysam_9libctabix_Parser *, PyObject *); /*proto*/
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asTuple__set_state(struct __pyx_obj_5pysam_9libctabix_asTuple *, PyObject *); /*proto*/
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asGFF3__set_state(struct __pyx_obj_5pysam_9libctabix_asGFF3 *, PyObject *); /*proto*/
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asGTF__set_state(struct __pyx_obj_5pysam_9libctabix_asGTF *, PyObject *); /*proto*/
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asBed__set_state(struct __pyx_obj_5pysam_9libctabix_asBed *, PyObject *); /*proto*/
static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asVCF__set_state(struct __pyx_obj_5pysam_9libctabix_asVCF *, PyObject *); /*proto*/
/* #### Code section: typeinfo ### */
/* #### Code section: before_global_var ### */
#define __Pyx_MODULE_NAME "pysam.libctabix"
extern int __pyx_module_is_main_pysam__libctabix;
int __pyx_module_is_main_pysam__libctabix = 0;

/* Implementation of "pysam.libctabix" */
/* #### Code section: global_var ### */
static PyObject *__pyx_builtin_NotImplementedError;
static PyObject *__pyx_builtin_ValueError;
static PyObject *__pyx_builtin_IOError;
static PyObject *__pyx_builtin_OSError;
static PyObject *__pyx_builtin_TypeError;
static PyObject *__pyx_builtin_StopIteration;
static PyObject *__pyx_builtin_KeyError;
static PyObject *__pyx_builtin_AssertionError;
static PyObject *__pyx_builtin_MemoryError;
/* #### Code section: string_decls ### */
static const char __pyx_k_a[] = "a";
static const char __pyx_k_b[] = "b";
static const char __pyx_k_c[] = "c";
static const char __pyx_k_r[] = "r";
static const char __pyx_k_s[] = "%s";
static const char __pyx_k_fn[] = "fn";
static const char __pyx_k_fp[] = "fp";
static const char __pyx_k_gc[] = "gc";
static const char __pyx_k_gz[] = ".gz";
static const char __pyx_k_os[] = "os";
static const char __pyx_k__16[] = "-";
static const char __pyx_k__39[] = "#";
static const char __pyx_k__42[] = "': ";
static const char __pyx_k__43[] = ",";
static const char __pyx_k__44[] = "'";
static const char __pyx_k__56[] = ".";
static const char __pyx_k__62[] = "*";
static const char __pyx_k__78[] = "?";
static const char __pyx_k_all[] = "__all__";
static const char __pyx_k_bcf[] = "bcf";
static const char __pyx_k_bed[] = "bed";
static const char __pyx_k_cfn[] = "cfn";
static const char __pyx_k_cpy[] = "cpy";
static const char __pyx_k_csi[] = "csi";
static const char __pyx_k_doc[] = "__doc__";
static const char __pyx_k_dup[] = "_dup";
static const char __pyx_k_end[] = "end";
static const char __pyx_k_fmt[] = "fmt";
static const char __pyx_k_gff[] = "gff";
static const char __pyx_k_itr[] = "itr";
static const char __pyx_k_new[] = "__new__";
static const char __pyx_k_s_2[] = "s";
static const char __pyx_k_s_i[] = "%s:%i";
static const char __pyx_k_sam[] = "sam";
static const char __pyx_k_sys[] = "sys";
static const char __pyx_k_tbi[] = ".tbi";
static const char __pyx_k_vcf[] = "vcf";
static const char __pyx_k_conf[] = "conf";
static const char __pyx_k_cstr[] = "cstr";
static const char __pyx_k_dict[] = "__dict__";
static const char __pyx_k_init[] = "__init__";
static const char __pyx_k_iter[] = "__iter__";
static const char __pyx_k_keys[] = "keys";
static const char __pyx_k_line[] = "line";
static const char __pyx_k_main[] = "__main__";
static const char __pyx_k_mode[] = "mode";
static const char __pyx_k_name[] = "__name__";
static const char __pyx_k_next[] = "__next__";
static const char __pyx_k_open[] = "_open";
static const char __pyx_k_path[] = "path";
static const char __pyx_k_self[] = "self";
static const char __pyx_k_spec[] = "__spec__";
static const char __pyx_k_tell[] = "tell";
static const char __pyx_k_test[] = "__test__";
static const char __pyx_k_asBed[] = "asBed";
static const char __pyx_k_asGTF[] = "asGTF";
static const char __pyx_k_asVCF[] = "asVCF";
static const char __pyx_k_ascii[] = "ascii";
static const char __pyx_k_close[] = "close";
static const char __pyx_k_csi_2[] = ".csi";
static const char __pyx_k_fetch[] = "fetch";
static const char __pyx_k_fnidx[] = "fnidx";
static const char __pyx_k_force[] = "force";
static const char __pyx_k_index[] = "index";
static const char __pyx_k_s_i_i[] = "%s:%i-%i";
static const char __pyx_k_start[] = "start";
static const char __pyx_k_state[] = "state";
static const char __pyx_k_super[] = "super";
static const char __pyx_k_Parser[] = "Parser";
static const char __pyx_k_asGFF3[] = "asGFF3";
static const char __pyx_k_buffer[] = "buffer";
static const char __pyx_k_closed[] = "closed";
static const char __pyx_k_dict_2[] = "_dict";
static const char __pyx_k_enable[] = "enable";
static const char __pyx_k_exists[] = "exists";
static const char __pyx_k_fd_src[] = "fd_src";
static const char __pyx_k_format[] = "format";
static const char __pyx_k_import[] = "__import__";
static const char __pyx_k_infile[] = "infile";
static const char __pyx_k_length[] = "length";
static const char __pyx_k_module[] = "__module__";
static const char __pyx_k_nbytes[] = "nbytes";
static const char __pyx_k_parser[] = "parser";
static const char __pyx_k_pickle[] = "pickle";
static const char __pyx_k_preset[] = "preset";
static const char __pyx_k_psltbl[] = "psltbl";
static const char __pyx_k_reduce[] = "__reduce__";
static const char __pyx_k_region[] = "region";
static const char __pyx_k_retval[] = "retval";
static const char __pyx_k_suffix[] = "suffix";
static const char __pyx_k_unlink[] = "unlink";
static const char __pyx_k_update[] = "update";
static const char __pyx_k_IOError[] = "IOError";
static const char __pyx_k_OSError[] = "OSError";
static const char __pyx_k_asTuple[] = "asTuple";
static const char __pyx_k_contigs[] = "contigs";
static const char __pyx_k_disable[] = "disable";
static const char __pyx_k_end_col[] = "end_col";
static const char __pyx_k_fileobj[] = "fileobj";
static const char __pyx_k_is_open[] = "is_open";
static const char __pyx_k_prepare[] = "__prepare__";
static const char __pyx_k_seq_col[] = "seq_col";
static const char __pyx_k_threads[] = "threads";
static const char __pyx_k_KeyError[] = "KeyError";
static const char __pyx_k_O_RDONLY[] = "O_RDONLY";
static const char __pyx_k_encoding[] = "encoding";
static const char __pyx_k_filename[] = "filename";
static const char __pyx_k_fn_index[] = "fn_index";
static const char __pyx_k_getstate[] = "__getstate__";
static const char __pyx_k_is_empty[] = "is_empty";
static const char __pyx_k_pyx_type[] = "__pyx_type";
static const char __pyx_k_qualname[] = "__qualname__";
static const char __pyx_k_readline[] = "readline";
static const char __pyx_k_set_name[] = "__set_name__";
static const char __pyx_k_setstate[] = "__setstate__";
static const char __pyx_k_TabixFile[] = "TabixFile";
static const char __pyx_k_Tabixfile[] = "Tabixfile";
static const char __pyx_k_TypeError[] = "TypeError";
static const char __pyx_k_bytes_cpy[] = "bytes_cpy";
static const char __pyx_k_cfilename[] = "cfilename";
static const char __pyx_k_conf_data[] = "conf_data";
static const char __pyx_k_isenabled[] = "isenabled";
static const char __pyx_k_line_skip[] = "line_skip";
static const char __pyx_k_meta_char[] = "meta_char";
static const char __pyx_k_metaclass[] = "__metaclass__";
static const char __pyx_k_min_shift[] = "min_shift";
static const char __pyx_k_pyx_state[] = "__pyx_state";
static const char __pyx_k_reduce_ex[] = "__reduce_ex__";
static const char __pyx_k_reference[] = "reference";
static const char __pyx_k_start_col[] = "start_col";
static const char __pyx_k_zerobased[] = "zerobased";
static const char __pyx_k_GZIterator[] = "GZIterator";
static const char __pyx_k_ValueError[] = "ValueError";
static const char __pyx_k_pyx_result[] = "__pyx_result";
static const char __pyx_k_pyx_vtable[] = "__pyx_vtable__";
static const char __pyx_k_MemoryError[] = "MemoryError";
static const char __pyx_k_PickleError[] = "PickleError";
static const char __pyx_k_WINDOW_SIZE[] = "WINDOW_SIZE";
static const char __pyx_k_buffer_size[] = "buffer_size";
static const char __pyx_k_filename_in[] = "filename_in";
static const char __pyx_k_preset2conf[] = "preset2conf";
static const char __pyx_k_tabix_index[] = "tabix_index";
static const char __pyx_k_filename_out[] = "filename_out";
static const char __pyx_k_get_encoding[] = "get_encoding";
static const char __pyx_k_initializing[] = "_initializing";
static const char __pyx_k_is_coroutine[] = "_is_coroutine";
static const char __pyx_k_pyx_checksum[] = "__pyx_checksum";
static const char __pyx_k_set_encoding[] = "set_encoding";
static const char __pyx_k_stringsource[] = "<stringsource>";
static const char __pyx_k_use_setstate[] = "use_setstate";
static const char __pyx_k_EmptyIterator[] = "EmptyIterator";
static const char __pyx_k_StopIteration[] = "StopIteration";
static const char __pyx_k_TabixIterator[] = "TabixIterator";
static const char __pyx_k_init_subclass[] = "__init_subclass__";
static const char __pyx_k_keep_original[] = "keep_original";
static const char __pyx_k_reduce_cython[] = "__reduce_cython__";
static const char __pyx_k_start_i_end_i[] = "start (%i) >= end (%i)";
static const char __pyx_k_AssertionError[] = "AssertionError";
static const char __pyx_k_GZIteratorHead[] = "GZIteratorHead";
static const char __pyx_k_TabixFile__dup[] = "TabixFile._dup";
static const char __pyx_k_empty_iterator[] = "empty iterator";
static const char __pyx_k_filename_index[] = "filename_index";
static const char __pyx_k_tabix_compress[] = "tabix_compress";
static const char __pyx_k_tabix_iterator[] = "tabix_iterator";
static const char __pyx_k_unknown_preset[] = "unknown preset '";
static const char __pyx_k_writing_failed[] = "writing failed";
static const char __pyx_k_TabixFile__open[] = "TabixFile._open";
static const char __pyx_k_TabixFile_close[] = "TabixFile.close";
static const char __pyx_k_TabixFile_fetch[] = "TabixFile.fetch";
static const char __pyx_k_cfilename_index[] = "cfilename_index";
static const char __pyx_k_pysam_libctabix[] = "pysam.libctabix";
static const char __pyx_k_pyx_PickleError[] = "__pyx_PickleError";
static const char __pyx_k_setstate_cython[] = "__setstate_cython__";
static const char __pyx_k_GZIteratorParsed[] = "GZIteratorParsed";
static const char __pyx_k_file_s_not_found[] = "file `%s` not found";
static const char __pyx_k_index_s_not_found[] = "index `%s` not found";
static const char __pyx_k_valid_presets_are[] = "', valid presets are '";
static const char __pyx_k_asyncio_coroutines[] = "asyncio.coroutines";
static const char __pyx_k_cline_in_traceback[] = "cline_in_traceback";
static const char __pyx_k_end_out_of_range_i[] = "end out of range (%i)";
static const char __pyx_k_multiple_iterators[] = "multiple_iterators";
static const char __pyx_k_pyx_unpickle_asBed[] = "__pyx_unpickle_asBed";
static const char __pyx_k_pyx_unpickle_asGTF[] = "__pyx_unpickle_asGTF";
static const char __pyx_k_pyx_unpickle_asVCF[] = "__pyx_unpickle_asVCF";
static const char __pyx_k_Could_not_open_file[] = "Could not open file '";
static const char __pyx_k_NotImplementedError[] = "NotImplementedError";
static const char __pyx_k_Parser_get_encoding[] = "Parser.get_encoding";
static const char __pyx_k_Parser_set_encoding[] = "Parser.set_encoding";
static const char __pyx_k_TabixIteratorParsed[] = "TabixIteratorParsed";
static const char __pyx_k_pysam_libctabix_pyx[] = "pysam/libctabix.pyx";
static const char __pyx_k_pyx_unpickle_Parser[] = "__pyx_unpickle_Parser";
static const char __pyx_k_pyx_unpickle_asGFF3[] = "__pyx_unpickle_asGFF3";
static const char __pyx_k_tabix_file_iterator[] = "tabix_file_iterator";
static const char __pyx_k_EmptyIterator___iter[] = "EmptyIterator.__iter__";
static const char __pyx_k_EmptyIterator___next[] = "EmptyIterator.__next__";
static const char __pyx_k_incomplete_line_at_s[] = "incomplete line at %s";
static const char __pyx_k_pyx_unpickle_asTuple[] = "__pyx_unpickle_asTuple";
static const char __pyx_k_start_out_of_range_i[] = "start out of range (%i)";
static const char __pyx_k_asBed___reduce_cython[] = "asBed.__reduce_cython__";
static const char __pyx_k_asGTF___reduce_cython[] = "asGTF.__reduce_cython__";
static const char __pyx_k_asVCF___reduce_cython[] = "asVCF.__reduce_cython__";
static const char __pyx_k_could_not_open_file_s[] = "could not open file `%s`";
static const char __pyx_k_Parser___reduce_cython[] = "Parser.__reduce_cython__";
static const char __pyx_k_asGFF3___reduce_cython[] = "asGFF3.__reduce_cython__";
static const char __pyx_k_tabix_generic_iterator[] = "tabix_generic_iterator";
static const char __pyx_k_asBed___setstate_cython[] = "asBed.__setstate_cython__";
static const char __pyx_k_asGTF___setstate_cython[] = "asGTF.__setstate_cython__";
static const char __pyx_k_asTuple___reduce_cython[] = "asTuple.__reduce_cython__";
static const char __pyx_k_asVCF___setstate_cython[] = "asVCF.__setstate_cython__";
static const char __pyx_k_Parser___setstate_cython[] = "Parser.__setstate_cython__";
static const char __pyx_k_asGFF3___setstate_cython[] = "asGFF3.__setstate_cython__";
static const char __pyx_k_iteration_on_closed_file[] = "iteration on closed file";
static const char __pyx_k_TabixFile___reduce_cython[] = "TabixFile.__reduce_cython__";
static const char __pyx_k_Tabixfile___reduce_cython[] = "Tabixfile.__reduce_cython__";
static const char __pyx_k_asTuple___setstate_cython[] = "asTuple.__setstate_cython__";
static const char __pyx_k_GZIterator___reduce_cython[] = "GZIterator.__reduce_cython__";
static const char __pyx_k_could_not_open_index_for_s[] = "could not open index for `%s`";
static const char __pyx_k_No_such_file_or_directory_s[] = "No such file or directory: %s";
static const char __pyx_k_TabixFile___setstate_cython[] = "TabixFile.__setstate_cython__";
static const char __pyx_k_Tabixfile___setstate_cython[] = "Tabixfile.__setstate_cython__";
static const char __pyx_k_error_i_when_closing_file_s[] = "error %i when closing file %s";
static const char __pyx_k_invalid_file_opening_mode_s[] = "invalid file opening mode `%s`";
static const char __pyx_k_GZIterator___setstate_cython[] = "GZIterator.__setstate_cython__";
static const char __pyx_k_I_O_operation_on_closed_file[] = "I/O operation on closed file";
static const char __pyx_k_building_of_index_for_failed[] = "building of index for {} failed";
static const char __pyx_k_could_not_open_s_for_reading[] = "could not open '%s' for reading";
static const char __pyx_k_could_not_open_s_for_writing[] = "could not open '%s' for writing";
static const char __pyx_k_TabixIterator___reduce_cython[] = "TabixIterator.__reduce_cython__";
static const char __pyx_k_tabix_generic_iterator___init[] = "tabix_generic_iterator.__init__";
static const char __pyx_k_tabix_generic_iterator___iter[] = "tabix_generic_iterator.__iter__";
static const char __pyx_k_tabix_generic_iterator___next[] = "tabix_generic_iterator.__next__";
static const char __pyx_k_GZIteratorHead___reduce_cython[] = "GZIteratorHead.__reduce_cython__";
static const char __pyx_k_I_O_operation_on_closed_file_2[] = "I/O operation on closed file.";
static const char __pyx_k_error_i_when_writing_to_file_s[] = "error %i when writing to file %s";
static const char __pyx_k_TabixIterator___setstate_cython[] = "TabixIterator.__setstate_cython__";
static const char __pyx_k_could_not_load_tbi_csi_index_of[] = "could not load .tbi/.csi index of {}";
static const char __pyx_k_iterate_over_infile_Permits_the[] = "iterate over ``infile``.\n    \n    Permits the use of file-like objects for example from the gzip module.\n    ";
static const char __pyx_k_Filename_s_already_exists_use_fo[] = "Filename '%s' already exists, use *force* to overwrite";
static const char __pyx_k_GZIteratorHead___setstate_cython[] = "GZIteratorHead.__setstate_cython__";
static const char __pyx_k_GZIteratorParsed___reduce_cython[] = "GZIteratorParsed.__reduce_cython__";
static const char __pyx_k_GZIteratorParsed___setstate_cyth[] = "GZIteratorParsed.__setstate_cython__";
static const char __pyx_k_Incompatible_checksums_0x_x_vs_0[] = "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))";
static const char __pyx_k_TabixIteratorParsed___reduce_cyt[] = "TabixIteratorParsed.__reduce_cython__";
static const char __pyx_k_TabixIteratorParsed___setstate_c[] = "TabixIteratorParsed.__setstate_cython__";
static const char __pyx_k_could_not_create_iterator_for_re[] = "could not create iterator for region '%s'";
static const char __pyx_k_could_not_create_iterator_possib[] = "could not create iterator, possible tabix version mismatch";
static const char __pyx_k_could_not_open_for_reading_heade[] = "could not open {} for reading header";
static const char __pyx_k_filename_s_already_exists_use_fo[] = "filename '%s' already exists, use *force* to overwrite";
static const char __pyx_k_neither_preset_nor_seq_col_start[] = "neither preset nor seq_col,start_col and end_col given";
static const char __pyx_k_no_default___reduce___due_to_non[] = "no default __reduce__ due to non-trivial __cinit__";
static const char __pyx_k_parse_method_of_s_not_implemente[] = "parse method of %s not implemented";
static const char __pyx_k_self_gzipfile_self_kstream_canno[] = "self.gzipfile,self.kstream cannot be converted to a Python object for pickling";
static const char __pyx_k_self_iterator_cannot_be_converte[] = "self.iterator cannot be converted to a Python object for pickling";
static const char __pyx_k_tabix_file_iterator___reduce_cyt[] = "tabix_file_iterator.__reduce_cython__";
static const char __pyx_k_tabix_file_iterator___setstate_c[] = "tabix_file_iterator.__setstate_cython__";
/* #### Code section: decls ### */
static int __pyx_pf_7cpython_5array_5array___getbuffer__(arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info, CYTHON_UNUSED int __pyx_v_flags); /* proto */
static void __pyx_pf_7cpython_5array_5array_2__releasebuffer__(CYTHON_UNUSED arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info); /* proto */
static int __pyx_pf_5pysam_9libctabix_6Parser___init__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v_encoding); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_2set_encoding(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v_encoding); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_4get_encoding(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_6__call__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_length); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_8__reduce_cython__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_10__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_7asTuple___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_7asTuple_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6asGFF3___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6asGFF3_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asGTF___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asGTF_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asBed___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asBed_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asVCF___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_5asVCF_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self, PyObject *__pyx_v___pyx_state); /* proto */
static int __pyx_pf_5pysam_9libctabix_9TabixFile___cinit__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_mode, PyObject *__pyx_v_parser, PyObject *__pyx_v_index, PyObject *__pyx_v_encoding, PyObject *__pyx_v_threads, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_2_open(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_mode, PyObject *__pyx_v_index, PyObject *__pyx_v_threads); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_4_dup(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_6fetch(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_reference, PyObject *__pyx_v_start, PyObject *__pyx_v_end, PyObject *__pyx_v_region, PyObject *__pyx_v_parser, PyObject *__pyx_v_multiple_iterators); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_6header___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_7contigs___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_8close(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static void __pyx_pf_5pysam_9libctabix_9TabixFile_10__dealloc__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_14filename_index___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_12__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_14__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static int __pyx_pf_5pysam_9libctabix_13TabixIterator___init__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self, PyObject *__pyx_v_encoding); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_2__iter__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_4__next__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self); /* proto */
static void __pyx_pf_5pysam_9libctabix_13TabixIterator_6__dealloc__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13EmptyIterator___iter__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_13EmptyIterator_2__next__(CYTHON_UNUSED PyObject *__pyx_self, CYTHON_UNUSED PyObject *__pyx_v_self); /* proto */
static int __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed___init__(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self, struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_2__next__(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static int __pyx_pf_5pysam_9libctabix_10GZIterator___init__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self, PyObject *__pyx_v_filename, int __pyx_v_buffer_size, PyObject *__pyx_v_encoding); /* proto */
static void __pyx_pf_5pysam_9libctabix_10GZIterator_2__dealloc__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_4__iter__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_6__next__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead___next__(struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static int __pyx_pf_5pysam_9libctabix_16GZIteratorParsed___init__(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self, PyObject *__pyx_v_parser); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_2__next__(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_tabix_compress(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_filename_in, PyObject *__pyx_v_filename_out, PyObject *__pyx_v_force); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_2tabix_index(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_force, PyObject *__pyx_v_seq_col, PyObject *__pyx_v_start_col, PyObject *__pyx_v_end_col, PyObject *__pyx_v_preset, PyObject *__pyx_v_meta_char, int __pyx_v_line_skip, PyObject *__pyx_v_zerobased, int __pyx_v_min_shift, PyObject *__pyx_v_index, PyObject *__pyx_v_keep_original, PyObject *__pyx_v_csi); /* proto */
static int __pyx_pf_5pysam_9libctabix_19tabix_file_iterator___cinit__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self, PyObject *__pyx_v_infile, struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser, int __pyx_v_buffer_size); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_2__iter__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self); /* proto */
static void __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_4__dealloc__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_6__next__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator___init__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self, PyObject *__pyx_v_infile, PyObject *__pyx_v_parser); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_2__iter__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_4__next__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_4tabix_iterator(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_infile, PyObject *__pyx_v_parser); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9Tabixfile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_Tabixfile *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_9Tabixfile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_Tabixfile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_6__pyx_unpickle_Parser(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_8__pyx_unpickle_asTuple(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_10__pyx_unpickle_asGFF3(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_12__pyx_unpickle_asGTF(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_14__pyx_unpickle_asBed(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_pf_5pysam_9libctabix_16__pyx_unpickle_asVCF(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state); /* proto */
static PyObject *__pyx_tp_new_5pysam_9libctabix_tabix_file_iterator(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixFile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_Parser(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_asTuple(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_asGTF(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_asGFF3(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_asBed(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_asVCF(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixIterator(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIterator(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIteratorHead(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static PyObject *__pyx_tp_new_5pysam_9libctabix_Tabixfile(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static __Pyx_CachedCFunction __pyx_umethod_PyDict_Type_keys = {0, 0, 0, 0, 0};
/* #### Code section: late_includes ### */
/* #### Code section: module_state ### */
typedef struct {
  PyObject *__pyx_d;
  PyObject *__pyx_b;
  PyObject *__pyx_cython_runtime;
  PyObject *__pyx_empty_tuple;
  PyObject *__pyx_empty_bytes;
  PyObject *__pyx_empty_unicode;
  #ifdef __Pyx_CyFunction_USED
  PyTypeObject *__pyx_CyFunctionType;
  #endif
  #ifdef __Pyx_FusedFunction_USED
  PyTypeObject *__pyx_FusedFunctionType;
  #endif
  #ifdef __Pyx_Generator_USED
  PyTypeObject *__pyx_GeneratorType;
  #endif
  #ifdef __Pyx_IterableCoroutine_USED
  PyTypeObject *__pyx_IterableCoroutineType;
  #endif
  #ifdef __Pyx_Coroutine_USED
  PyTypeObject *__pyx_CoroutineAwaitType;
  #endif
  #ifdef __Pyx_Coroutine_USED
  PyTypeObject *__pyx_CoroutineType;
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_5pysam_10libchtslib_HTSFile;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_7cpython_4type_type;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_7cpython_4bool_bool;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_7cpython_7complex_complex;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_TupleProxy;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_GTFProxy;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_BedProxy;
  PyTypeObject *__pyx_ptype_5pysam_16libctabixproxies_VCFProxy;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  #endif
  PyTypeObject *__pyx_ptype_7cpython_5array_array;
  #if CYTHON_USE_MODULE_STATE
  #endif
  #if CYTHON_USE_MODULE_STATE
  PyObject *__pyx_type_5pysam_9libctabix_tabix_file_iterator;
  PyObject *__pyx_type_5pysam_9libctabix_TabixFile;
  PyObject *__pyx_type_5pysam_9libctabix_Parser;
  PyObject *__pyx_type_5pysam_9libctabix_asTuple;
  PyObject *__pyx_type_5pysam_9libctabix_asGTF;
  PyObject *__pyx_type_5pysam_9libctabix_asGFF3;
  PyObject *__pyx_type_5pysam_9libctabix_asBed;
  PyObject *__pyx_type_5pysam_9libctabix_asVCF;
  PyObject *__pyx_type_5pysam_9libctabix_TabixIterator;
  PyObject *__pyx_type_5pysam_9libctabix_TabixIteratorParsed;
  PyObject *__pyx_type_5pysam_9libctabix_GZIterator;
  PyObject *__pyx_type_5pysam_9libctabix_GZIteratorHead;
  PyObject *__pyx_type_5pysam_9libctabix_GZIteratorParsed;
  PyObject *__pyx_type_5pysam_9libctabix_Tabixfile;
  #endif
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_tabix_file_iterator;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_TabixFile;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_Parser;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_asTuple;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_asGTF;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_asGFF3;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_asBed;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_asVCF;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_TabixIterator;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_GZIterator;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_GZIteratorHead;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_GZIteratorParsed;
  PyTypeObject *__pyx_ptype_5pysam_9libctabix_Tabixfile;
  PyObject *__pyx_n_s_AssertionError;
  PyObject *__pyx_kp_u_Could_not_open_file;
  PyObject *__pyx_n_s_EmptyIterator;
  PyObject *__pyx_n_s_EmptyIterator___iter;
  PyObject *__pyx_n_s_EmptyIterator___next;
  PyObject *__pyx_kp_u_Filename_s_already_exists_use_fo;
  PyObject *__pyx_n_s_GZIterator;
  PyObject *__pyx_n_u_GZIterator;
  PyObject *__pyx_n_s_GZIteratorHead;
  PyObject *__pyx_n_u_GZIteratorHead;
  PyObject *__pyx_n_s_GZIteratorHead___reduce_cython;
  PyObject *__pyx_n_s_GZIteratorHead___setstate_cython;
  PyObject *__pyx_n_s_GZIteratorParsed;
  PyObject *__pyx_n_s_GZIteratorParsed___reduce_cython;
  PyObject *__pyx_n_s_GZIteratorParsed___setstate_cyth;
  PyObject *__pyx_n_s_GZIterator___reduce_cython;
  PyObject *__pyx_n_s_GZIterator___setstate_cython;
  PyObject *__pyx_n_s_IOError;
  PyObject *__pyx_kp_u_I_O_operation_on_closed_file;
  PyObject *__pyx_kp_u_I_O_operation_on_closed_file_2;
  PyObject *__pyx_kp_s_Incompatible_checksums_0x_x_vs_0;
  PyObject *__pyx_n_s_KeyError;
  PyObject *__pyx_n_s_MemoryError;
  PyObject *__pyx_kp_u_No_such_file_or_directory_s;
  PyObject *__pyx_n_s_NotImplementedError;
  PyObject *__pyx_n_s_OSError;
  PyObject *__pyx_n_s_O_RDONLY;
  PyObject *__pyx_n_s_Parser;
  PyObject *__pyx_n_s_Parser___reduce_cython;
  PyObject *__pyx_n_s_Parser___setstate_cython;
  PyObject *__pyx_n_s_Parser_get_encoding;
  PyObject *__pyx_n_s_Parser_set_encoding;
  PyObject *__pyx_n_s_PickleError;
  PyObject *__pyx_n_s_StopIteration;
  PyObject *__pyx_n_s_TabixFile;
  PyObject *__pyx_n_u_TabixFile;
  PyObject *__pyx_n_s_TabixFile___reduce_cython;
  PyObject *__pyx_n_s_TabixFile___setstate_cython;
  PyObject *__pyx_n_s_TabixFile__dup;
  PyObject *__pyx_n_s_TabixFile__open;
  PyObject *__pyx_n_s_TabixFile_close;
  PyObject *__pyx_n_s_TabixFile_fetch;
  PyObject *__pyx_n_s_TabixIterator;
  PyObject *__pyx_n_s_TabixIteratorParsed;
  PyObject *__pyx_n_s_TabixIteratorParsed___reduce_cyt;
  PyObject *__pyx_n_s_TabixIteratorParsed___setstate_c;
  PyObject *__pyx_n_s_TabixIterator___reduce_cython;
  PyObject *__pyx_n_s_TabixIterator___setstate_cython;
  PyObject *__pyx_n_s_Tabixfile;
  PyObject *__pyx_n_u_Tabixfile;
  PyObject *__pyx_n_s_Tabixfile___reduce_cython;
  PyObject *__pyx_n_s_Tabixfile___setstate_cython;
  PyObject *__pyx_n_s_TypeError;
  PyObject *__pyx_n_s_ValueError;
  PyObject *__pyx_n_s_WINDOW_SIZE;
  PyObject *__pyx_kp_b__16;
  PyObject *__pyx_kp_u__39;
  PyObject *__pyx_kp_u__42;
  PyObject *__pyx_kp_u__43;
  PyObject *__pyx_kp_u__44;
  PyObject *__pyx_kp_u__56;
  PyObject *__pyx_n_s__62;
  PyObject *__pyx_n_s__78;
  PyObject *__pyx_n_s_a;
  PyObject *__pyx_n_s_all;
  PyObject *__pyx_n_s_asBed;
  PyObject *__pyx_n_u_asBed;
  PyObject *__pyx_n_s_asBed___reduce_cython;
  PyObject *__pyx_n_s_asBed___setstate_cython;
  PyObject *__pyx_n_s_asGFF3;
  PyObject *__pyx_n_u_asGFF3;
  PyObject *__pyx_n_s_asGFF3___reduce_cython;
  PyObject *__pyx_n_s_asGFF3___setstate_cython;
  PyObject *__pyx_n_s_asGTF;
  PyObject *__pyx_n_u_asGTF;
  PyObject *__pyx_n_s_asGTF___reduce_cython;
  PyObject *__pyx_n_s_asGTF___setstate_cython;
  PyObject *__pyx_n_s_asTuple;
  PyObject *__pyx_n_u_asTuple;
  PyObject *__pyx_n_s_asTuple___reduce_cython;
  PyObject *__pyx_n_s_asTuple___setstate_cython;
  PyObject *__pyx_n_s_asVCF;
  PyObject *__pyx_n_u_asVCF;
  PyObject *__pyx_n_s_asVCF___reduce_cython;
  PyObject *__pyx_n_s_asVCF___setstate_cython;
  PyObject *__pyx_n_u_ascii;
  PyObject *__pyx_n_s_asyncio_coroutines;
  PyObject *__pyx_n_s_b;
  PyObject *__pyx_n_u_bcf;
  PyObject *__pyx_n_u_bed;
  PyObject *__pyx_n_s_buffer;
  PyObject *__pyx_n_s_buffer_size;
  PyObject *__pyx_kp_u_building_of_index_for_failed;
  PyObject *__pyx_n_s_bytes_cpy;
  PyObject *__pyx_n_s_c;
  PyObject *__pyx_n_s_cfilename;
  PyObject *__pyx_n_s_cfilename_index;
  PyObject *__pyx_n_s_cfn;
  PyObject *__pyx_n_s_cline_in_traceback;
  PyObject *__pyx_n_s_close;
  PyObject *__pyx_n_s_closed;
  PyObject *__pyx_n_s_conf;
  PyObject *__pyx_n_s_conf_data;
  PyObject *__pyx_n_s_contigs;
  PyObject *__pyx_kp_u_could_not_create_iterator_for_re;
  PyObject *__pyx_kp_u_could_not_create_iterator_possib;
  PyObject *__pyx_kp_u_could_not_load_tbi_csi_index_of;
  PyObject *__pyx_kp_u_could_not_open_file_s;
  PyObject *__pyx_kp_u_could_not_open_for_reading_heade;
  PyObject *__pyx_kp_u_could_not_open_index_for_s;
  PyObject *__pyx_kp_u_could_not_open_s_for_reading;
  PyObject *__pyx_kp_u_could_not_open_s_for_writing;
  PyObject *__pyx_n_s_cpy;
  PyObject *__pyx_n_s_csi;
  PyObject *__pyx_kp_u_csi_2;
  PyObject *__pyx_n_s_cstr;
  PyObject *__pyx_n_s_dict;
  PyObject *__pyx_n_s_dict_2;
  PyObject *__pyx_kp_u_disable;
  PyObject *__pyx_n_s_doc;
  PyObject *__pyx_n_s_dup;
  PyObject *__pyx_kp_s_empty_iterator;
  PyObject *__pyx_kp_u_enable;
  PyObject *__pyx_n_s_encoding;
  PyObject *__pyx_n_s_end;
  PyObject *__pyx_n_s_end_col;
  PyObject *__pyx_kp_u_end_out_of_range_i;
  PyObject *__pyx_kp_u_error_i_when_closing_file_s;
  PyObject *__pyx_kp_u_error_i_when_writing_to_file_s;
  PyObject *__pyx_n_s_exists;
  PyObject *__pyx_n_s_fd_src;
  PyObject *__pyx_n_s_fetch;
  PyObject *__pyx_kp_u_file_s_not_found;
  PyObject *__pyx_n_s_filename;
  PyObject *__pyx_n_s_filename_in;
  PyObject *__pyx_n_s_filename_index;
  PyObject *__pyx_n_s_filename_out;
  PyObject *__pyx_kp_u_filename_s_already_exists_use_fo;
  PyObject *__pyx_n_s_fileobj;
  PyObject *__pyx_n_s_fmt;
  PyObject *__pyx_n_s_fn;
  PyObject *__pyx_n_s_fn_index;
  PyObject *__pyx_n_s_fnidx;
  PyObject *__pyx_n_s_force;
  PyObject *__pyx_n_s_format;
  PyObject *__pyx_n_s_fp;
  PyObject *__pyx_kp_u_gc;
  PyObject *__pyx_n_s_get_encoding;
  PyObject *__pyx_n_s_getstate;
  PyObject *__pyx_n_u_gff;
  PyObject *__pyx_kp_u_gz;
  PyObject *__pyx_n_s_import;
  PyObject *__pyx_kp_u_incomplete_line_at_s;
  PyObject *__pyx_n_s_index;
  PyObject *__pyx_kp_u_index_s_not_found;
  PyObject *__pyx_n_s_infile;
  PyObject *__pyx_n_s_init;
  PyObject *__pyx_n_s_init_subclass;
  PyObject *__pyx_n_s_initializing;
  PyObject *__pyx_kp_u_invalid_file_opening_mode_s;
  PyObject *__pyx_n_s_is_coroutine;
  PyObject *__pyx_n_s_is_empty;
  PyObject *__pyx_n_s_is_open;
  PyObject *__pyx_kp_u_isenabled;
  PyObject *__pyx_n_s_iter;
  PyObject *__pyx_kp_s_iterate_over_infile_Permits_the;
  PyObject *__pyx_kp_u_iteration_on_closed_file;
  PyObject *__pyx_n_s_itr;
  PyObject *__pyx_n_s_keep_original;
  PyObject *__pyx_n_s_keys;
  PyObject *__pyx_n_s_length;
  PyObject *__pyx_n_s_line;
  PyObject *__pyx_n_s_line_skip;
  PyObject *__pyx_n_s_main;
  PyObject *__pyx_n_s_meta_char;
  PyObject *__pyx_n_s_metaclass;
  PyObject *__pyx_n_s_min_shift;
  PyObject *__pyx_n_s_mode;
  PyObject *__pyx_n_s_module;
  PyObject *__pyx_n_s_multiple_iterators;
  PyObject *__pyx_n_s_name;
  PyObject *__pyx_n_s_nbytes;
  PyObject *__pyx_kp_u_neither_preset_nor_seq_col_start;
  PyObject *__pyx_n_s_new;
  PyObject *__pyx_n_s_next;
  PyObject *__pyx_kp_s_no_default___reduce___due_to_non;
  PyObject *__pyx_n_s_open;
  PyObject *__pyx_n_s_os;
  PyObject *__pyx_kp_u_parse_method_of_s_not_implemente;
  PyObject *__pyx_n_s_parser;
  PyObject *__pyx_n_s_path;
  PyObject *__pyx_n_s_pickle;
  PyObject *__pyx_n_s_prepare;
  PyObject *__pyx_n_s_preset;
  PyObject *__pyx_n_s_preset2conf;
  PyObject *__pyx_n_u_psltbl;
  PyObject *__pyx_n_s_pysam_libctabix;
  PyObject *__pyx_kp_s_pysam_libctabix_pyx;
  PyObject *__pyx_n_s_pyx_PickleError;
  PyObject *__pyx_n_s_pyx_checksum;
  PyObject *__pyx_n_s_pyx_result;
  PyObject *__pyx_n_s_pyx_state;
  PyObject *__pyx_n_s_pyx_type;
  PyObject *__pyx_n_s_pyx_unpickle_Parser;
  PyObject *__pyx_n_s_pyx_unpickle_asBed;
  PyObject *__pyx_n_s_pyx_unpickle_asGFF3;
  PyObject *__pyx_n_s_pyx_unpickle_asGTF;
  PyObject *__pyx_n_s_pyx_unpickle_asTuple;
  PyObject *__pyx_n_s_pyx_unpickle_asVCF;
  PyObject *__pyx_n_s_pyx_vtable;
  PyObject *__pyx_n_s_qualname;
  PyObject *__pyx_n_s_r;
  PyObject *__pyx_n_u_r;
  PyObject *__pyx_n_s_readline;
  PyObject *__pyx_n_s_reduce;
  PyObject *__pyx_n_s_reduce_cython;
  PyObject *__pyx_n_s_reduce_ex;
  PyObject *__pyx_n_s_reference;
  PyObject *__pyx_n_s_region;
  PyObject *__pyx_n_s_retval;
  PyObject *__pyx_kp_u_s;
  PyObject *__pyx_n_s_s_2;
  PyObject *__pyx_kp_u_s_i;
  PyObject *__pyx_kp_u_s_i_i;
  PyObject *__pyx_n_u_sam;
  PyObject *__pyx_n_s_self;
  PyObject *__pyx_kp_s_self_gzipfile_self_kstream_canno;
  PyObject *__pyx_kp_s_self_iterator_cannot_be_converte;
  PyObject *__pyx_n_s_seq_col;
  PyObject *__pyx_n_s_set_encoding;
  PyObject *__pyx_n_s_set_name;
  PyObject *__pyx_n_s_setstate;
  PyObject *__pyx_n_s_setstate_cython;
  PyObject *__pyx_n_s_spec;
  PyObject *__pyx_n_s_start;
  PyObject *__pyx_n_s_start_col;
  PyObject *__pyx_kp_u_start_i_end_i;
  PyObject *__pyx_kp_u_start_out_of_range_i;
  PyObject *__pyx_n_s_state;
  PyObject *__pyx_kp_s_stringsource;
  PyObject *__pyx_n_s_suffix;
  PyObject *__pyx_n_s_super;
  PyObject *__pyx_n_s_sys;
  PyObject *__pyx_n_s_tabix_compress;
  PyObject *__pyx_n_u_tabix_compress;
  PyObject *__pyx_n_s_tabix_file_iterator;
  PyObject *__pyx_n_u_tabix_file_iterator;
  PyObject *__pyx_n_s_tabix_file_iterator___reduce_cyt;
  PyObject *__pyx_n_s_tabix_file_iterator___setstate_c;
  PyObject *__pyx_n_s_tabix_generic_iterator;
  PyObject *__pyx_n_u_tabix_generic_iterator;
  PyObject *__pyx_n_s_tabix_generic_iterator___init;
  PyObject *__pyx_n_s_tabix_generic_iterator___iter;
  PyObject *__pyx_n_s_tabix_generic_iterator___next;
  PyObject *__pyx_n_s_tabix_index;
  PyObject *__pyx_n_u_tabix_index;
  PyObject *__pyx_n_s_tabix_iterator;
  PyObject *__pyx_n_u_tabix_iterator;
  PyObject *__pyx_kp_u_tbi;
  PyObject *__pyx_n_s_tell;
  PyObject *__pyx_n_s_test;
  PyObject *__pyx_n_s_threads;
  PyObject *__pyx_kp_u_unknown_preset;
  PyObject *__pyx_n_s_unlink;
  PyObject *__pyx_n_s_update;
  PyObject *__pyx_n_s_use_setstate;
  PyObject *__pyx_kp_u_valid_presets_are;
  PyObject *__pyx_n_u_vcf;
  PyObject *__pyx_kp_u_writing_failed;
  PyObject *__pyx_n_s_zerobased;
  PyObject *__pyx_int_0;
  PyObject *__pyx_int_1;
  PyObject *__pyx_int_2;
  PyObject *__pyx_int_3;
  PyObject *__pyx_int_4;
  PyObject *__pyx_int_5;
  PyObject *__pyx_int_15;
  PyObject *__pyx_int_17;
  PyObject *__pyx_int_18;
  PyObject *__pyx_int_35;
  PyObject *__pyx_int_64;
  PyObject *__pyx_int_21667264;
  PyObject *__pyx_int_139192863;
  PyObject *__pyx_int_243541226;
  PyObject *__pyx_int_neg_1;
  PyObject *__pyx_codeobj_;
  PyObject *__pyx_tuple__19;
  PyObject *__pyx_tuple__20;
  PyObject *__pyx_tuple__24;
  PyObject *__pyx_tuple__38;
  PyObject *__pyx_tuple__41;
  PyObject *__pyx_tuple__45;
  PyObject *__pyx_tuple__55;
  PyObject *__pyx_tuple__63;
  PyObject *__pyx_tuple__64;
  PyObject *__pyx_tuple__65;
  PyObject *__pyx_tuple__66;
  PyObject *__pyx_tuple__67;
  PyObject *__pyx_tuple__68;
  PyObject *__pyx_tuple__69;
  PyObject *__pyx_tuple__70;
  PyObject *__pyx_tuple__71;
  PyObject *__pyx_tuple__72;
  PyObject *__pyx_tuple__73;
  PyObject *__pyx_tuple__74;
  PyObject *__pyx_tuple__75;
  PyObject *__pyx_tuple__76;
  PyObject *__pyx_tuple__77;
  PyObject *__pyx_codeobj__2;
  PyObject *__pyx_codeobj__3;
  PyObject *__pyx_codeobj__4;
  PyObject *__pyx_codeobj__5;
  PyObject *__pyx_codeobj__6;
  PyObject *__pyx_codeobj__7;
  PyObject *__pyx_codeobj__8;
  PyObject *__pyx_codeobj__9;
  PyObject *__pyx_codeobj__10;
  PyObject *__pyx_codeobj__11;
  PyObject *__pyx_codeobj__12;
  PyObject *__pyx_codeobj__13;
  PyObject *__pyx_codeobj__14;
  PyObject *__pyx_codeobj__15;
  PyObject *__pyx_codeobj__17;
  PyObject *__pyx_codeobj__18;
  PyObject *__pyx_codeobj__21;
  PyObject *__pyx_codeobj__22;
  PyObject *__pyx_codeobj__23;
  PyObject *__pyx_codeobj__25;
  PyObject *__pyx_codeobj__26;
  PyObject *__pyx_codeobj__27;
  PyObject *__pyx_codeobj__28;
  PyObject *__pyx_codeobj__29;
  PyObject *__pyx_codeobj__30;
  PyObject *__pyx_codeobj__31;
  PyObject *__pyx_codeobj__32;
  PyObject *__pyx_codeobj__33;
  PyObject *__pyx_codeobj__34;
  PyObject *__pyx_codeobj__35;
  PyObject *__pyx_codeobj__36;
  PyObject *__pyx_codeobj__37;
  PyObject *__pyx_codeobj__40;
  PyObject *__pyx_codeobj__46;
  PyObject *__pyx_codeobj__47;
  PyObject *__pyx_codeobj__48;
  PyObject *__pyx_codeobj__49;
  PyObject *__pyx_codeobj__50;
  PyObject *__pyx_codeobj__51;
  PyObject *__pyx_codeobj__52;
  PyObject *__pyx_codeobj__53;
  PyObject *__pyx_codeobj__54;
  PyObject *__pyx_codeobj__57;
  PyObject *__pyx_codeobj__58;
  PyObject *__pyx_codeobj__59;
  PyObject *__pyx_codeobj__60;
  PyObject *__pyx_codeobj__61;
} __pyx_mstate;

#if CYTHON_USE_MODULE_STATE
#ifdef __cplusplus
namespace {
  extern struct PyModuleDef __pyx_moduledef;
} /* anonymous namespace */
#else
static struct PyModuleDef __pyx_moduledef;
#endif

#define __pyx_mstate(o) ((__pyx_mstate *)__Pyx_PyModule_GetState(o))

#define __pyx_mstate_global (__pyx_mstate(PyState_FindModule(&__pyx_moduledef)))

#define __pyx_m (PyState_FindModule(&__pyx_moduledef))
#else
static __pyx_mstate __pyx_mstate_global_static =
#ifdef __cplusplus
    {};
#else
    {0};
#endif
static __pyx_mstate *__pyx_mstate_global = &__pyx_mstate_global_static;
#endif
/* #### Code section: module_state_clear ### */
#if CYTHON_USE_MODULE_STATE
static int __pyx_m_clear(PyObject *m) {
  __pyx_mstate *clear_module_state = __pyx_mstate(m);
  if (!clear_module_state) return 0;
  Py_CLEAR(clear_module_state->__pyx_d);
  Py_CLEAR(clear_module_state->__pyx_b);
  Py_CLEAR(clear_module_state->__pyx_cython_runtime);
  Py_CLEAR(clear_module_state->__pyx_empty_tuple);
  Py_CLEAR(clear_module_state->__pyx_empty_bytes);
  Py_CLEAR(clear_module_state->__pyx_empty_unicode);
  #ifdef __Pyx_CyFunction_USED
  Py_CLEAR(clear_module_state->__pyx_CyFunctionType);
  #endif
  #ifdef __Pyx_FusedFunction_USED
  Py_CLEAR(clear_module_state->__pyx_FusedFunctionType);
  #endif
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_10libchtslib_HTSFile);
  Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_4type_type);
  Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_4bool_bool);
  Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_7complex_complex);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_TupleProxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_GTFProxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_BedProxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_16libctabixproxies_VCFProxy);
  Py_CLEAR(clear_module_state->__pyx_ptype_7cpython_5array_array);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_tabix_file_iterator);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_tabix_file_iterator);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_TabixFile);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_TabixFile);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_Parser);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_Parser);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_asTuple);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_asTuple);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_asGTF);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_asGTF);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_asGFF3);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_asGFF3);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_asBed);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_asBed);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_asVCF);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_asVCF);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_TabixIterator);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_TabixIterator);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_TabixIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_GZIterator);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_GZIterator);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_GZIteratorHead);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_GZIteratorHead);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_GZIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_GZIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_ptype_5pysam_9libctabix_Tabixfile);
  Py_CLEAR(clear_module_state->__pyx_type_5pysam_9libctabix_Tabixfile);
  Py_CLEAR(clear_module_state->__pyx_n_s_AssertionError);
  Py_CLEAR(clear_module_state->__pyx_kp_u_Could_not_open_file);
  Py_CLEAR(clear_module_state->__pyx_n_s_EmptyIterator);
  Py_CLEAR(clear_module_state->__pyx_n_s_EmptyIterator___iter);
  Py_CLEAR(clear_module_state->__pyx_n_s_EmptyIterator___next);
  Py_CLEAR(clear_module_state->__pyx_kp_u_Filename_s_already_exists_use_fo);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIterator);
  Py_CLEAR(clear_module_state->__pyx_n_u_GZIterator);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorHead);
  Py_CLEAR(clear_module_state->__pyx_n_u_GZIteratorHead);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorHead___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorHead___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorParsed___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIteratorParsed___setstate_cyth);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIterator___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_GZIterator___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_IOError);
  Py_CLEAR(clear_module_state->__pyx_kp_u_I_O_operation_on_closed_file);
  Py_CLEAR(clear_module_state->__pyx_kp_u_I_O_operation_on_closed_file_2);
  Py_CLEAR(clear_module_state->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0);
  Py_CLEAR(clear_module_state->__pyx_n_s_KeyError);
  Py_CLEAR(clear_module_state->__pyx_n_s_MemoryError);
  Py_CLEAR(clear_module_state->__pyx_kp_u_No_such_file_or_directory_s);
  Py_CLEAR(clear_module_state->__pyx_n_s_NotImplementedError);
  Py_CLEAR(clear_module_state->__pyx_n_s_OSError);
  Py_CLEAR(clear_module_state->__pyx_n_s_O_RDONLY);
  Py_CLEAR(clear_module_state->__pyx_n_s_Parser);
  Py_CLEAR(clear_module_state->__pyx_n_s_Parser___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_Parser___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_Parser_get_encoding);
  Py_CLEAR(clear_module_state->__pyx_n_s_Parser_set_encoding);
  Py_CLEAR(clear_module_state->__pyx_n_s_PickleError);
  Py_CLEAR(clear_module_state->__pyx_n_s_StopIteration);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile);
  Py_CLEAR(clear_module_state->__pyx_n_u_TabixFile);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile__dup);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile__open);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile_close);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixFile_fetch);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIterator);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIteratorParsed);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIteratorParsed___reduce_cyt);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIteratorParsed___setstate_c);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIterator___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_TabixIterator___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_Tabixfile);
  Py_CLEAR(clear_module_state->__pyx_n_u_Tabixfile);
  Py_CLEAR(clear_module_state->__pyx_n_s_Tabixfile___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_Tabixfile___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_TypeError);
  Py_CLEAR(clear_module_state->__pyx_n_s_ValueError);
  Py_CLEAR(clear_module_state->__pyx_n_s_WINDOW_SIZE);
  Py_CLEAR(clear_module_state->__pyx_kp_b__16);
  Py_CLEAR(clear_module_state->__pyx_kp_u__39);
  Py_CLEAR(clear_module_state->__pyx_kp_u__42);
  Py_CLEAR(clear_module_state->__pyx_kp_u__43);
  Py_CLEAR(clear_module_state->__pyx_kp_u__44);
  Py_CLEAR(clear_module_state->__pyx_kp_u__56);
  Py_CLEAR(clear_module_state->__pyx_n_s__62);
  Py_CLEAR(clear_module_state->__pyx_n_s__78);
  Py_CLEAR(clear_module_state->__pyx_n_s_a);
  Py_CLEAR(clear_module_state->__pyx_n_s_all);
  Py_CLEAR(clear_module_state->__pyx_n_s_asBed);
  Py_CLEAR(clear_module_state->__pyx_n_u_asBed);
  Py_CLEAR(clear_module_state->__pyx_n_s_asBed___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asBed___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGFF3);
  Py_CLEAR(clear_module_state->__pyx_n_u_asGFF3);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGFF3___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGFF3___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGTF);
  Py_CLEAR(clear_module_state->__pyx_n_u_asGTF);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGTF___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asGTF___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asTuple);
  Py_CLEAR(clear_module_state->__pyx_n_u_asTuple);
  Py_CLEAR(clear_module_state->__pyx_n_s_asTuple___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asTuple___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asVCF);
  Py_CLEAR(clear_module_state->__pyx_n_u_asVCF);
  Py_CLEAR(clear_module_state->__pyx_n_s_asVCF___reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_asVCF___setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_u_ascii);
  Py_CLEAR(clear_module_state->__pyx_n_s_asyncio_coroutines);
  Py_CLEAR(clear_module_state->__pyx_n_s_b);
  Py_CLEAR(clear_module_state->__pyx_n_u_bcf);
  Py_CLEAR(clear_module_state->__pyx_n_u_bed);
  Py_CLEAR(clear_module_state->__pyx_n_s_buffer);
  Py_CLEAR(clear_module_state->__pyx_n_s_buffer_size);
  Py_CLEAR(clear_module_state->__pyx_kp_u_building_of_index_for_failed);
  Py_CLEAR(clear_module_state->__pyx_n_s_bytes_cpy);
  Py_CLEAR(clear_module_state->__pyx_n_s_c);
  Py_CLEAR(clear_module_state->__pyx_n_s_cfilename);
  Py_CLEAR(clear_module_state->__pyx_n_s_cfilename_index);
  Py_CLEAR(clear_module_state->__pyx_n_s_cfn);
  Py_CLEAR(clear_module_state->__pyx_n_s_cline_in_traceback);
  Py_CLEAR(clear_module_state->__pyx_n_s_close);
  Py_CLEAR(clear_module_state->__pyx_n_s_closed);
  Py_CLEAR(clear_module_state->__pyx_n_s_conf);
  Py_CLEAR(clear_module_state->__pyx_n_s_conf_data);
  Py_CLEAR(clear_module_state->__pyx_n_s_contigs);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_create_iterator_for_re);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_create_iterator_possib);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_load_tbi_csi_index_of);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_open_file_s);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_open_for_reading_heade);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_open_index_for_s);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_open_s_for_reading);
  Py_CLEAR(clear_module_state->__pyx_kp_u_could_not_open_s_for_writing);
  Py_CLEAR(clear_module_state->__pyx_n_s_cpy);
  Py_CLEAR(clear_module_state->__pyx_n_s_csi);
  Py_CLEAR(clear_module_state->__pyx_kp_u_csi_2);
  Py_CLEAR(clear_module_state->__pyx_n_s_cstr);
  Py_CLEAR(clear_module_state->__pyx_n_s_dict);
  Py_CLEAR(clear_module_state->__pyx_n_s_dict_2);
  Py_CLEAR(clear_module_state->__pyx_kp_u_disable);
  Py_CLEAR(clear_module_state->__pyx_n_s_doc);
  Py_CLEAR(clear_module_state->__pyx_n_s_dup);
  Py_CLEAR(clear_module_state->__pyx_kp_s_empty_iterator);
  Py_CLEAR(clear_module_state->__pyx_kp_u_enable);
  Py_CLEAR(clear_module_state->__pyx_n_s_encoding);
  Py_CLEAR(clear_module_state->__pyx_n_s_end);
  Py_CLEAR(clear_module_state->__pyx_n_s_end_col);
  Py_CLEAR(clear_module_state->__pyx_kp_u_end_out_of_range_i);
  Py_CLEAR(clear_module_state->__pyx_kp_u_error_i_when_closing_file_s);
  Py_CLEAR(clear_module_state->__pyx_kp_u_error_i_when_writing_to_file_s);
  Py_CLEAR(clear_module_state->__pyx_n_s_exists);
  Py_CLEAR(clear_module_state->__pyx_n_s_fd_src);
  Py_CLEAR(clear_module_state->__pyx_n_s_fetch);
  Py_CLEAR(clear_module_state->__pyx_kp_u_file_s_not_found);
  Py_CLEAR(clear_module_state->__pyx_n_s_filename);
  Py_CLEAR(clear_module_state->__pyx_n_s_filename_in);
  Py_CLEAR(clear_module_state->__pyx_n_s_filename_index);
  Py_CLEAR(clear_module_state->__pyx_n_s_filename_out);
  Py_CLEAR(clear_module_state->__pyx_kp_u_filename_s_already_exists_use_fo);
  Py_CLEAR(clear_module_state->__pyx_n_s_fileobj);
  Py_CLEAR(clear_module_state->__pyx_n_s_fmt);
  Py_CLEAR(clear_module_state->__pyx_n_s_fn);
  Py_CLEAR(clear_module_state->__pyx_n_s_fn_index);
  Py_CLEAR(clear_module_state->__pyx_n_s_fnidx);
  Py_CLEAR(clear_module_state->__pyx_n_s_force);
  Py_CLEAR(clear_module_state->__pyx_n_s_format);
  Py_CLEAR(clear_module_state->__pyx_n_s_fp);
  Py_CLEAR(clear_module_state->__pyx_kp_u_gc);
  Py_CLEAR(clear_module_state->__pyx_n_s_get_encoding);
  Py_CLEAR(clear_module_state->__pyx_n_s_getstate);
  Py_CLEAR(clear_module_state->__pyx_n_u_gff);
  Py_CLEAR(clear_module_state->__pyx_kp_u_gz);
  Py_CLEAR(clear_module_state->__pyx_n_s_import);
  Py_CLEAR(clear_module_state->__pyx_kp_u_incomplete_line_at_s);
  Py_CLEAR(clear_module_state->__pyx_n_s_index);
  Py_CLEAR(clear_module_state->__pyx_kp_u_index_s_not_found);
  Py_CLEAR(clear_module_state->__pyx_n_s_infile);
  Py_CLEAR(clear_module_state->__pyx_n_s_init);
  Py_CLEAR(clear_module_state->__pyx_n_s_init_subclass);
  Py_CLEAR(clear_module_state->__pyx_n_s_initializing);
  Py_CLEAR(clear_module_state->__pyx_kp_u_invalid_file_opening_mode_s);
  Py_CLEAR(clear_module_state->__pyx_n_s_is_coroutine);
  Py_CLEAR(clear_module_state->__pyx_n_s_is_empty);
  Py_CLEAR(clear_module_state->__pyx_n_s_is_open);
  Py_CLEAR(clear_module_state->__pyx_kp_u_isenabled);
  Py_CLEAR(clear_module_state->__pyx_n_s_iter);
  Py_CLEAR(clear_module_state->__pyx_kp_s_iterate_over_infile_Permits_the);
  Py_CLEAR(clear_module_state->__pyx_kp_u_iteration_on_closed_file);
  Py_CLEAR(clear_module_state->__pyx_n_s_itr);
  Py_CLEAR(clear_module_state->__pyx_n_s_keep_original);
  Py_CLEAR(clear_module_state->__pyx_n_s_keys);
  Py_CLEAR(clear_module_state->__pyx_n_s_length);
  Py_CLEAR(clear_module_state->__pyx_n_s_line);
  Py_CLEAR(clear_module_state->__pyx_n_s_line_skip);
  Py_CLEAR(clear_module_state->__pyx_n_s_main);
  Py_CLEAR(clear_module_state->__pyx_n_s_meta_char);
  Py_CLEAR(clear_module_state->__pyx_n_s_metaclass);
  Py_CLEAR(clear_module_state->__pyx_n_s_min_shift);
  Py_CLEAR(clear_module_state->__pyx_n_s_mode);
  Py_CLEAR(clear_module_state->__pyx_n_s_module);
  Py_CLEAR(clear_module_state->__pyx_n_s_multiple_iterators);
  Py_CLEAR(clear_module_state->__pyx_n_s_name);
  Py_CLEAR(clear_module_state->__pyx_n_s_nbytes);
  Py_CLEAR(clear_module_state->__pyx_kp_u_neither_preset_nor_seq_col_start);
  Py_CLEAR(clear_module_state->__pyx_n_s_new);
  Py_CLEAR(clear_module_state->__pyx_n_s_next);
  Py_CLEAR(clear_module_state->__pyx_kp_s_no_default___reduce___due_to_non);
  Py_CLEAR(clear_module_state->__pyx_n_s_open);
  Py_CLEAR(clear_module_state->__pyx_n_s_os);
  Py_CLEAR(clear_module_state->__pyx_kp_u_parse_method_of_s_not_implemente);
  Py_CLEAR(clear_module_state->__pyx_n_s_parser);
  Py_CLEAR(clear_module_state->__pyx_n_s_path);
  Py_CLEAR(clear_module_state->__pyx_n_s_pickle);
  Py_CLEAR(clear_module_state->__pyx_n_s_prepare);
  Py_CLEAR(clear_module_state->__pyx_n_s_preset);
  Py_CLEAR(clear_module_state->__pyx_n_s_preset2conf);
  Py_CLEAR(clear_module_state->__pyx_n_u_psltbl);
  Py_CLEAR(clear_module_state->__pyx_n_s_pysam_libctabix);
  Py_CLEAR(clear_module_state->__pyx_kp_s_pysam_libctabix_pyx);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_PickleError);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_checksum);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_result);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_state);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_type);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_Parser);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_asBed);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_asGFF3);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_asGTF);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_asTuple);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_unpickle_asVCF);
  Py_CLEAR(clear_module_state->__pyx_n_s_pyx_vtable);
  Py_CLEAR(clear_module_state->__pyx_n_s_qualname);
  Py_CLEAR(clear_module_state->__pyx_n_s_r);
  Py_CLEAR(clear_module_state->__pyx_n_u_r);
  Py_CLEAR(clear_module_state->__pyx_n_s_readline);
  Py_CLEAR(clear_module_state->__pyx_n_s_reduce);
  Py_CLEAR(clear_module_state->__pyx_n_s_reduce_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_reduce_ex);
  Py_CLEAR(clear_module_state->__pyx_n_s_reference);
  Py_CLEAR(clear_module_state->__pyx_n_s_region);
  Py_CLEAR(clear_module_state->__pyx_n_s_retval);
  Py_CLEAR(clear_module_state->__pyx_kp_u_s);
  Py_CLEAR(clear_module_state->__pyx_n_s_s_2);
  Py_CLEAR(clear_module_state->__pyx_kp_u_s_i);
  Py_CLEAR(clear_module_state->__pyx_kp_u_s_i_i);
  Py_CLEAR(clear_module_state->__pyx_n_u_sam);
  Py_CLEAR(clear_module_state->__pyx_n_s_self);
  Py_CLEAR(clear_module_state->__pyx_kp_s_self_gzipfile_self_kstream_canno);
  Py_CLEAR(clear_module_state->__pyx_kp_s_self_iterator_cannot_be_converte);
  Py_CLEAR(clear_module_state->__pyx_n_s_seq_col);
  Py_CLEAR(clear_module_state->__pyx_n_s_set_encoding);
  Py_CLEAR(clear_module_state->__pyx_n_s_set_name);
  Py_CLEAR(clear_module_state->__pyx_n_s_setstate);
  Py_CLEAR(clear_module_state->__pyx_n_s_setstate_cython);
  Py_CLEAR(clear_module_state->__pyx_n_s_spec);
  Py_CLEAR(clear_module_state->__pyx_n_s_start);
  Py_CLEAR(clear_module_state->__pyx_n_s_start_col);
  Py_CLEAR(clear_module_state->__pyx_kp_u_start_i_end_i);
  Py_CLEAR(clear_module_state->__pyx_kp_u_start_out_of_range_i);
  Py_CLEAR(clear_module_state->__pyx_n_s_state);
  Py_CLEAR(clear_module_state->__pyx_kp_s_stringsource);
  Py_CLEAR(clear_module_state->__pyx_n_s_suffix);
  Py_CLEAR(clear_module_state->__pyx_n_s_super);
  Py_CLEAR(clear_module_state->__pyx_n_s_sys);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_compress);
  Py_CLEAR(clear_module_state->__pyx_n_u_tabix_compress);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_file_iterator);
  Py_CLEAR(clear_module_state->__pyx_n_u_tabix_file_iterator);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_file_iterator___reduce_cyt);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_file_iterator___setstate_c);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_generic_iterator);
  Py_CLEAR(clear_module_state->__pyx_n_u_tabix_generic_iterator);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_generic_iterator___init);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_generic_iterator___iter);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_generic_iterator___next);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_index);
  Py_CLEAR(clear_module_state->__pyx_n_u_tabix_index);
  Py_CLEAR(clear_module_state->__pyx_n_s_tabix_iterator);
  Py_CLEAR(clear_module_state->__pyx_n_u_tabix_iterator);
  Py_CLEAR(clear_module_state->__pyx_kp_u_tbi);
  Py_CLEAR(clear_module_state->__pyx_n_s_tell);
  Py_CLEAR(clear_module_state->__pyx_n_s_test);
  Py_CLEAR(clear_module_state->__pyx_n_s_threads);
  Py_CLEAR(clear_module_state->__pyx_kp_u_unknown_preset);
  Py_CLEAR(clear_module_state->__pyx_n_s_unlink);
  Py_CLEAR(clear_module_state->__pyx_n_s_update);
  Py_CLEAR(clear_module_state->__pyx_n_s_use_setstate);
  Py_CLEAR(clear_module_state->__pyx_kp_u_valid_presets_are);
  Py_CLEAR(clear_module_state->__pyx_n_u_vcf);
  Py_CLEAR(clear_module_state->__pyx_kp_u_writing_failed);
  Py_CLEAR(clear_module_state->__pyx_n_s_zerobased);
  Py_CLEAR(clear_module_state->__pyx_int_0);
  Py_CLEAR(clear_module_state->__pyx_int_1);
  Py_CLEAR(clear_module_state->__pyx_int_2);
  Py_CLEAR(clear_module_state->__pyx_int_3);
  Py_CLEAR(clear_module_state->__pyx_int_4);
  Py_CLEAR(clear_module_state->__pyx_int_5);
  Py_CLEAR(clear_module_state->__pyx_int_15);
  Py_CLEAR(clear_module_state->__pyx_int_17);
  Py_CLEAR(clear_module_state->__pyx_int_18);
  Py_CLEAR(clear_module_state->__pyx_int_35);
  Py_CLEAR(clear_module_state->__pyx_int_64);
  Py_CLEAR(clear_module_state->__pyx_int_21667264);
  Py_CLEAR(clear_module_state->__pyx_int_139192863);
  Py_CLEAR(clear_module_state->__pyx_int_243541226);
  Py_CLEAR(clear_module_state->__pyx_int_neg_1);
  Py_CLEAR(clear_module_state->__pyx_codeobj_);
  Py_CLEAR(clear_module_state->__pyx_tuple__19);
  Py_CLEAR(clear_module_state->__pyx_tuple__20);
  Py_CLEAR(clear_module_state->__pyx_tuple__24);
  Py_CLEAR(clear_module_state->__pyx_tuple__38);
  Py_CLEAR(clear_module_state->__pyx_tuple__41);
  Py_CLEAR(clear_module_state->__pyx_tuple__45);
  Py_CLEAR(clear_module_state->__pyx_tuple__55);
  Py_CLEAR(clear_module_state->__pyx_tuple__63);
  Py_CLEAR(clear_module_state->__pyx_tuple__64);
  Py_CLEAR(clear_module_state->__pyx_tuple__65);
  Py_CLEAR(clear_module_state->__pyx_tuple__66);
  Py_CLEAR(clear_module_state->__pyx_tuple__67);
  Py_CLEAR(clear_module_state->__pyx_tuple__68);
  Py_CLEAR(clear_module_state->__pyx_tuple__69);
  Py_CLEAR(clear_module_state->__pyx_tuple__70);
  Py_CLEAR(clear_module_state->__pyx_tuple__71);
  Py_CLEAR(clear_module_state->__pyx_tuple__72);
  Py_CLEAR(clear_module_state->__pyx_tuple__73);
  Py_CLEAR(clear_module_state->__pyx_tuple__74);
  Py_CLEAR(clear_module_state->__pyx_tuple__75);
  Py_CLEAR(clear_module_state->__pyx_tuple__76);
  Py_CLEAR(clear_module_state->__pyx_tuple__77);
  Py_CLEAR(clear_module_state->__pyx_codeobj__2);
  Py_CLEAR(clear_module_state->__pyx_codeobj__3);
  Py_CLEAR(clear_module_state->__pyx_codeobj__4);
  Py_CLEAR(clear_module_state->__pyx_codeobj__5);
  Py_CLEAR(clear_module_state->__pyx_codeobj__6);
  Py_CLEAR(clear_module_state->__pyx_codeobj__7);
  Py_CLEAR(clear_module_state->__pyx_codeobj__8);
  Py_CLEAR(clear_module_state->__pyx_codeobj__9);
  Py_CLEAR(clear_module_state->__pyx_codeobj__10);
  Py_CLEAR(clear_module_state->__pyx_codeobj__11);
  Py_CLEAR(clear_module_state->__pyx_codeobj__12);
  Py_CLEAR(clear_module_state->__pyx_codeobj__13);
  Py_CLEAR(clear_module_state->__pyx_codeobj__14);
  Py_CLEAR(clear_module_state->__pyx_codeobj__15);
  Py_CLEAR(clear_module_state->__pyx_codeobj__17);
  Py_CLEAR(clear_module_state->__pyx_codeobj__18);
  Py_CLEAR(clear_module_state->__pyx_codeobj__21);
  Py_CLEAR(clear_module_state->__pyx_codeobj__22);
  Py_CLEAR(clear_module_state->__pyx_codeobj__23);
  Py_CLEAR(clear_module_state->__pyx_codeobj__25);
  Py_CLEAR(clear_module_state->__pyx_codeobj__26);
  Py_CLEAR(clear_module_state->__pyx_codeobj__27);
  Py_CLEAR(clear_module_state->__pyx_codeobj__28);
  Py_CLEAR(clear_module_state->__pyx_codeobj__29);
  Py_CLEAR(clear_module_state->__pyx_codeobj__30);
  Py_CLEAR(clear_module_state->__pyx_codeobj__31);
  Py_CLEAR(clear_module_state->__pyx_codeobj__32);
  Py_CLEAR(clear_module_state->__pyx_codeobj__33);
  Py_CLEAR(clear_module_state->__pyx_codeobj__34);
  Py_CLEAR(clear_module_state->__pyx_codeobj__35);
  Py_CLEAR(clear_module_state->__pyx_codeobj__36);
  Py_CLEAR(clear_module_state->__pyx_codeobj__37);
  Py_CLEAR(clear_module_state->__pyx_codeobj__40);
  Py_CLEAR(clear_module_state->__pyx_codeobj__46);
  Py_CLEAR(clear_module_state->__pyx_codeobj__47);
  Py_CLEAR(clear_module_state->__pyx_codeobj__48);
  Py_CLEAR(clear_module_state->__pyx_codeobj__49);
  Py_CLEAR(clear_module_state->__pyx_codeobj__50);
  Py_CLEAR(clear_module_state->__pyx_codeobj__51);
  Py_CLEAR(clear_module_state->__pyx_codeobj__52);
  Py_CLEAR(clear_module_state->__pyx_codeobj__53);
  Py_CLEAR(clear_module_state->__pyx_codeobj__54);
  Py_CLEAR(clear_module_state->__pyx_codeobj__57);
  Py_CLEAR(clear_module_state->__pyx_codeobj__58);
  Py_CLEAR(clear_module_state->__pyx_codeobj__59);
  Py_CLEAR(clear_module_state->__pyx_codeobj__60);
  Py_CLEAR(clear_module_state->__pyx_codeobj__61);
  return 0;
}
#endif
/* #### Code section: module_state_traverse ### */
#if CYTHON_USE_MODULE_STATE
static int __pyx_m_traverse(PyObject *m, visitproc visit, void *arg) {
  __pyx_mstate *traverse_module_state = __pyx_mstate(m);
  if (!traverse_module_state) return 0;
  Py_VISIT(traverse_module_state->__pyx_d);
  Py_VISIT(traverse_module_state->__pyx_b);
  Py_VISIT(traverse_module_state->__pyx_cython_runtime);
  Py_VISIT(traverse_module_state->__pyx_empty_tuple);
  Py_VISIT(traverse_module_state->__pyx_empty_bytes);
  Py_VISIT(traverse_module_state->__pyx_empty_unicode);
  #ifdef __Pyx_CyFunction_USED
  Py_VISIT(traverse_module_state->__pyx_CyFunctionType);
  #endif
  #ifdef __Pyx_FusedFunction_USED
  Py_VISIT(traverse_module_state->__pyx_FusedFunctionType);
  #endif
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_10libchtslib_HTSFile);
  Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_4type_type);
  Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_4bool_bool);
  Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_7complex_complex);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_TupleProxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_GTFProxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_BedProxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_16libctabixproxies_VCFProxy);
  Py_VISIT(traverse_module_state->__pyx_ptype_7cpython_5array_array);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_tabix_file_iterator);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_tabix_file_iterator);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_TabixFile);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_TabixFile);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_Parser);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_Parser);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_asTuple);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_asTuple);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_asGTF);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_asGTF);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_asGFF3);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_asGFF3);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_asBed);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_asBed);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_asVCF);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_asVCF);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_TabixIterator);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_TabixIterator);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_TabixIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_GZIterator);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_GZIterator);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_GZIteratorHead);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_GZIteratorHead);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_GZIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_GZIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_ptype_5pysam_9libctabix_Tabixfile);
  Py_VISIT(traverse_module_state->__pyx_type_5pysam_9libctabix_Tabixfile);
  Py_VISIT(traverse_module_state->__pyx_n_s_AssertionError);
  Py_VISIT(traverse_module_state->__pyx_kp_u_Could_not_open_file);
  Py_VISIT(traverse_module_state->__pyx_n_s_EmptyIterator);
  Py_VISIT(traverse_module_state->__pyx_n_s_EmptyIterator___iter);
  Py_VISIT(traverse_module_state->__pyx_n_s_EmptyIterator___next);
  Py_VISIT(traverse_module_state->__pyx_kp_u_Filename_s_already_exists_use_fo);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIterator);
  Py_VISIT(traverse_module_state->__pyx_n_u_GZIterator);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorHead);
  Py_VISIT(traverse_module_state->__pyx_n_u_GZIteratorHead);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorHead___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorHead___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorParsed___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIteratorParsed___setstate_cyth);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIterator___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_GZIterator___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_IOError);
  Py_VISIT(traverse_module_state->__pyx_kp_u_I_O_operation_on_closed_file);
  Py_VISIT(traverse_module_state->__pyx_kp_u_I_O_operation_on_closed_file_2);
  Py_VISIT(traverse_module_state->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0);
  Py_VISIT(traverse_module_state->__pyx_n_s_KeyError);
  Py_VISIT(traverse_module_state->__pyx_n_s_MemoryError);
  Py_VISIT(traverse_module_state->__pyx_kp_u_No_such_file_or_directory_s);
  Py_VISIT(traverse_module_state->__pyx_n_s_NotImplementedError);
  Py_VISIT(traverse_module_state->__pyx_n_s_OSError);
  Py_VISIT(traverse_module_state->__pyx_n_s_O_RDONLY);
  Py_VISIT(traverse_module_state->__pyx_n_s_Parser);
  Py_VISIT(traverse_module_state->__pyx_n_s_Parser___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_Parser___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_Parser_get_encoding);
  Py_VISIT(traverse_module_state->__pyx_n_s_Parser_set_encoding);
  Py_VISIT(traverse_module_state->__pyx_n_s_PickleError);
  Py_VISIT(traverse_module_state->__pyx_n_s_StopIteration);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile);
  Py_VISIT(traverse_module_state->__pyx_n_u_TabixFile);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile__dup);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile__open);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile_close);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixFile_fetch);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIterator);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIteratorParsed);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIteratorParsed___reduce_cyt);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIteratorParsed___setstate_c);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIterator___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_TabixIterator___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_Tabixfile);
  Py_VISIT(traverse_module_state->__pyx_n_u_Tabixfile);
  Py_VISIT(traverse_module_state->__pyx_n_s_Tabixfile___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_Tabixfile___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_TypeError);
  Py_VISIT(traverse_module_state->__pyx_n_s_ValueError);
  Py_VISIT(traverse_module_state->__pyx_n_s_WINDOW_SIZE);
  Py_VISIT(traverse_module_state->__pyx_kp_b__16);
  Py_VISIT(traverse_module_state->__pyx_kp_u__39);
  Py_VISIT(traverse_module_state->__pyx_kp_u__42);
  Py_VISIT(traverse_module_state->__pyx_kp_u__43);
  Py_VISIT(traverse_module_state->__pyx_kp_u__44);
  Py_VISIT(traverse_module_state->__pyx_kp_u__56);
  Py_VISIT(traverse_module_state->__pyx_n_s__62);
  Py_VISIT(traverse_module_state->__pyx_n_s__78);
  Py_VISIT(traverse_module_state->__pyx_n_s_a);
  Py_VISIT(traverse_module_state->__pyx_n_s_all);
  Py_VISIT(traverse_module_state->__pyx_n_s_asBed);
  Py_VISIT(traverse_module_state->__pyx_n_u_asBed);
  Py_VISIT(traverse_module_state->__pyx_n_s_asBed___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asBed___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGFF3);
  Py_VISIT(traverse_module_state->__pyx_n_u_asGFF3);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGFF3___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGFF3___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGTF);
  Py_VISIT(traverse_module_state->__pyx_n_u_asGTF);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGTF___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asGTF___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asTuple);
  Py_VISIT(traverse_module_state->__pyx_n_u_asTuple);
  Py_VISIT(traverse_module_state->__pyx_n_s_asTuple___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asTuple___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asVCF);
  Py_VISIT(traverse_module_state->__pyx_n_u_asVCF);
  Py_VISIT(traverse_module_state->__pyx_n_s_asVCF___reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_asVCF___setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_u_ascii);
  Py_VISIT(traverse_module_state->__pyx_n_s_asyncio_coroutines);
  Py_VISIT(traverse_module_state->__pyx_n_s_b);
  Py_VISIT(traverse_module_state->__pyx_n_u_bcf);
  Py_VISIT(traverse_module_state->__pyx_n_u_bed);
  Py_VISIT(traverse_module_state->__pyx_n_s_buffer);
  Py_VISIT(traverse_module_state->__pyx_n_s_buffer_size);
  Py_VISIT(traverse_module_state->__pyx_kp_u_building_of_index_for_failed);
  Py_VISIT(traverse_module_state->__pyx_n_s_bytes_cpy);
  Py_VISIT(traverse_module_state->__pyx_n_s_c);
  Py_VISIT(traverse_module_state->__pyx_n_s_cfilename);
  Py_VISIT(traverse_module_state->__pyx_n_s_cfilename_index);
  Py_VISIT(traverse_module_state->__pyx_n_s_cfn);
  Py_VISIT(traverse_module_state->__pyx_n_s_cline_in_traceback);
  Py_VISIT(traverse_module_state->__pyx_n_s_close);
  Py_VISIT(traverse_module_state->__pyx_n_s_closed);
  Py_VISIT(traverse_module_state->__pyx_n_s_conf);
  Py_VISIT(traverse_module_state->__pyx_n_s_conf_data);
  Py_VISIT(traverse_module_state->__pyx_n_s_contigs);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_create_iterator_for_re);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_create_iterator_possib);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_load_tbi_csi_index_of);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_open_file_s);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_open_for_reading_heade);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_open_index_for_s);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_open_s_for_reading);
  Py_VISIT(traverse_module_state->__pyx_kp_u_could_not_open_s_for_writing);
  Py_VISIT(traverse_module_state->__pyx_n_s_cpy);
  Py_VISIT(traverse_module_state->__pyx_n_s_csi);
  Py_VISIT(traverse_module_state->__pyx_kp_u_csi_2);
  Py_VISIT(traverse_module_state->__pyx_n_s_cstr);
  Py_VISIT(traverse_module_state->__pyx_n_s_dict);
  Py_VISIT(traverse_module_state->__pyx_n_s_dict_2);
  Py_VISIT(traverse_module_state->__pyx_kp_u_disable);
  Py_VISIT(traverse_module_state->__pyx_n_s_doc);
  Py_VISIT(traverse_module_state->__pyx_n_s_dup);
  Py_VISIT(traverse_module_state->__pyx_kp_s_empty_iterator);
  Py_VISIT(traverse_module_state->__pyx_kp_u_enable);
  Py_VISIT(traverse_module_state->__pyx_n_s_encoding);
  Py_VISIT(traverse_module_state->__pyx_n_s_end);
  Py_VISIT(traverse_module_state->__pyx_n_s_end_col);
  Py_VISIT(traverse_module_state->__pyx_kp_u_end_out_of_range_i);
  Py_VISIT(traverse_module_state->__pyx_kp_u_error_i_when_closing_file_s);
  Py_VISIT(traverse_module_state->__pyx_kp_u_error_i_when_writing_to_file_s);
  Py_VISIT(traverse_module_state->__pyx_n_s_exists);
  Py_VISIT(traverse_module_state->__pyx_n_s_fd_src);
  Py_VISIT(traverse_module_state->__pyx_n_s_fetch);
  Py_VISIT(traverse_module_state->__pyx_kp_u_file_s_not_found);
  Py_VISIT(traverse_module_state->__pyx_n_s_filename);
  Py_VISIT(traverse_module_state->__pyx_n_s_filename_in);
  Py_VISIT(traverse_module_state->__pyx_n_s_filename_index);
  Py_VISIT(traverse_module_state->__pyx_n_s_filename_out);
  Py_VISIT(traverse_module_state->__pyx_kp_u_filename_s_already_exists_use_fo);
  Py_VISIT(traverse_module_state->__pyx_n_s_fileobj);
  Py_VISIT(traverse_module_state->__pyx_n_s_fmt);
  Py_VISIT(traverse_module_state->__pyx_n_s_fn);
  Py_VISIT(traverse_module_state->__pyx_n_s_fn_index);
  Py_VISIT(traverse_module_state->__pyx_n_s_fnidx);
  Py_VISIT(traverse_module_state->__pyx_n_s_force);
  Py_VISIT(traverse_module_state->__pyx_n_s_format);
  Py_VISIT(traverse_module_state->__pyx_n_s_fp);
  Py_VISIT(traverse_module_state->__pyx_kp_u_gc);
  Py_VISIT(traverse_module_state->__pyx_n_s_get_encoding);
  Py_VISIT(traverse_module_state->__pyx_n_s_getstate);
  Py_VISIT(traverse_module_state->__pyx_n_u_gff);
  Py_VISIT(traverse_module_state->__pyx_kp_u_gz);
  Py_VISIT(traverse_module_state->__pyx_n_s_import);
  Py_VISIT(traverse_module_state->__pyx_kp_u_incomplete_line_at_s);
  Py_VISIT(traverse_module_state->__pyx_n_s_index);
  Py_VISIT(traverse_module_state->__pyx_kp_u_index_s_not_found);
  Py_VISIT(traverse_module_state->__pyx_n_s_infile);
  Py_VISIT(traverse_module_state->__pyx_n_s_init);
  Py_VISIT(traverse_module_state->__pyx_n_s_init_subclass);
  Py_VISIT(traverse_module_state->__pyx_n_s_initializing);
  Py_VISIT(traverse_module_state->__pyx_kp_u_invalid_file_opening_mode_s);
  Py_VISIT(traverse_module_state->__pyx_n_s_is_coroutine);
  Py_VISIT(traverse_module_state->__pyx_n_s_is_empty);
  Py_VISIT(traverse_module_state->__pyx_n_s_is_open);
  Py_VISIT(traverse_module_state->__pyx_kp_u_isenabled);
  Py_VISIT(traverse_module_state->__pyx_n_s_iter);
  Py_VISIT(traverse_module_state->__pyx_kp_s_iterate_over_infile_Permits_the);
  Py_VISIT(traverse_module_state->__pyx_kp_u_iteration_on_closed_file);
  Py_VISIT(traverse_module_state->__pyx_n_s_itr);
  Py_VISIT(traverse_module_state->__pyx_n_s_keep_original);
  Py_VISIT(traverse_module_state->__pyx_n_s_keys);
  Py_VISIT(traverse_module_state->__pyx_n_s_length);
  Py_VISIT(traverse_module_state->__pyx_n_s_line);
  Py_VISIT(traverse_module_state->__pyx_n_s_line_skip);
  Py_VISIT(traverse_module_state->__pyx_n_s_main);
  Py_VISIT(traverse_module_state->__pyx_n_s_meta_char);
  Py_VISIT(traverse_module_state->__pyx_n_s_metaclass);
  Py_VISIT(traverse_module_state->__pyx_n_s_min_shift);
  Py_VISIT(traverse_module_state->__pyx_n_s_mode);
  Py_VISIT(traverse_module_state->__pyx_n_s_module);
  Py_VISIT(traverse_module_state->__pyx_n_s_multiple_iterators);
  Py_VISIT(traverse_module_state->__pyx_n_s_name);
  Py_VISIT(traverse_module_state->__pyx_n_s_nbytes);
  Py_VISIT(traverse_module_state->__pyx_kp_u_neither_preset_nor_seq_col_start);
  Py_VISIT(traverse_module_state->__pyx_n_s_new);
  Py_VISIT(traverse_module_state->__pyx_n_s_next);
  Py_VISIT(traverse_module_state->__pyx_kp_s_no_default___reduce___due_to_non);
  Py_VISIT(traverse_module_state->__pyx_n_s_open);
  Py_VISIT(traverse_module_state->__pyx_n_s_os);
  Py_VISIT(traverse_module_state->__pyx_kp_u_parse_method_of_s_not_implemente);
  Py_VISIT(traverse_module_state->__pyx_n_s_parser);
  Py_VISIT(traverse_module_state->__pyx_n_s_path);
  Py_VISIT(traverse_module_state->__pyx_n_s_pickle);
  Py_VISIT(traverse_module_state->__pyx_n_s_prepare);
  Py_VISIT(traverse_module_state->__pyx_n_s_preset);
  Py_VISIT(traverse_module_state->__pyx_n_s_preset2conf);
  Py_VISIT(traverse_module_state->__pyx_n_u_psltbl);
  Py_VISIT(traverse_module_state->__pyx_n_s_pysam_libctabix);
  Py_VISIT(traverse_module_state->__pyx_kp_s_pysam_libctabix_pyx);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_PickleError);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_checksum);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_result);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_state);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_type);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_Parser);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_asBed);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_asGFF3);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_asGTF);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_asTuple);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_unpickle_asVCF);
  Py_VISIT(traverse_module_state->__pyx_n_s_pyx_vtable);
  Py_VISIT(traverse_module_state->__pyx_n_s_qualname);
  Py_VISIT(traverse_module_state->__pyx_n_s_r);
  Py_VISIT(traverse_module_state->__pyx_n_u_r);
  Py_VISIT(traverse_module_state->__pyx_n_s_readline);
  Py_VISIT(traverse_module_state->__pyx_n_s_reduce);
  Py_VISIT(traverse_module_state->__pyx_n_s_reduce_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_reduce_ex);
  Py_VISIT(traverse_module_state->__pyx_n_s_reference);
  Py_VISIT(traverse_module_state->__pyx_n_s_region);
  Py_VISIT(traverse_module_state->__pyx_n_s_retval);
  Py_VISIT(traverse_module_state->__pyx_kp_u_s);
  Py_VISIT(traverse_module_state->__pyx_n_s_s_2);
  Py_VISIT(traverse_module_state->__pyx_kp_u_s_i);
  Py_VISIT(traverse_module_state->__pyx_kp_u_s_i_i);
  Py_VISIT(traverse_module_state->__pyx_n_u_sam);
  Py_VISIT(traverse_module_state->__pyx_n_s_self);
  Py_VISIT(traverse_module_state->__pyx_kp_s_self_gzipfile_self_kstream_canno);
  Py_VISIT(traverse_module_state->__pyx_kp_s_self_iterator_cannot_be_converte);
  Py_VISIT(traverse_module_state->__pyx_n_s_seq_col);
  Py_VISIT(traverse_module_state->__pyx_n_s_set_encoding);
  Py_VISIT(traverse_module_state->__pyx_n_s_set_name);
  Py_VISIT(traverse_module_state->__pyx_n_s_setstate);
  Py_VISIT(traverse_module_state->__pyx_n_s_setstate_cython);
  Py_VISIT(traverse_module_state->__pyx_n_s_spec);
  Py_VISIT(traverse_module_state->__pyx_n_s_start);
  Py_VISIT(traverse_module_state->__pyx_n_s_start_col);
  Py_VISIT(traverse_module_state->__pyx_kp_u_start_i_end_i);
  Py_VISIT(traverse_module_state->__pyx_kp_u_start_out_of_range_i);
  Py_VISIT(traverse_module_state->__pyx_n_s_state);
  Py_VISIT(traverse_module_state->__pyx_kp_s_stringsource);
  Py_VISIT(traverse_module_state->__pyx_n_s_suffix);
  Py_VISIT(traverse_module_state->__pyx_n_s_super);
  Py_VISIT(traverse_module_state->__pyx_n_s_sys);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_compress);
  Py_VISIT(traverse_module_state->__pyx_n_u_tabix_compress);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_file_iterator);
  Py_VISIT(traverse_module_state->__pyx_n_u_tabix_file_iterator);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_file_iterator___reduce_cyt);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_file_iterator___setstate_c);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_generic_iterator);
  Py_VISIT(traverse_module_state->__pyx_n_u_tabix_generic_iterator);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_generic_iterator___init);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_generic_iterator___iter);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_generic_iterator___next);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_index);
  Py_VISIT(traverse_module_state->__pyx_n_u_tabix_index);
  Py_VISIT(traverse_module_state->__pyx_n_s_tabix_iterator);
  Py_VISIT(traverse_module_state->__pyx_n_u_tabix_iterator);
  Py_VISIT(traverse_module_state->__pyx_kp_u_tbi);
  Py_VISIT(traverse_module_state->__pyx_n_s_tell);
  Py_VISIT(traverse_module_state->__pyx_n_s_test);
  Py_VISIT(traverse_module_state->__pyx_n_s_threads);
  Py_VISIT(traverse_module_state->__pyx_kp_u_unknown_preset);
  Py_VISIT(traverse_module_state->__pyx_n_s_unlink);
  Py_VISIT(traverse_module_state->__pyx_n_s_update);
  Py_VISIT(traverse_module_state->__pyx_n_s_use_setstate);
  Py_VISIT(traverse_module_state->__pyx_kp_u_valid_presets_are);
  Py_VISIT(traverse_module_state->__pyx_n_u_vcf);
  Py_VISIT(traverse_module_state->__pyx_kp_u_writing_failed);
  Py_VISIT(traverse_module_state->__pyx_n_s_zerobased);
  Py_VISIT(traverse_module_state->__pyx_int_0);
  Py_VISIT(traverse_module_state->__pyx_int_1);
  Py_VISIT(traverse_module_state->__pyx_int_2);
  Py_VISIT(traverse_module_state->__pyx_int_3);
  Py_VISIT(traverse_module_state->__pyx_int_4);
  Py_VISIT(traverse_module_state->__pyx_int_5);
  Py_VISIT(traverse_module_state->__pyx_int_15);
  Py_VISIT(traverse_module_state->__pyx_int_17);
  Py_VISIT(traverse_module_state->__pyx_int_18);
  Py_VISIT(traverse_module_state->__pyx_int_35);
  Py_VISIT(traverse_module_state->__pyx_int_64);
  Py_VISIT(traverse_module_state->__pyx_int_21667264);
  Py_VISIT(traverse_module_state->__pyx_int_139192863);
  Py_VISIT(traverse_module_state->__pyx_int_243541226);
  Py_VISIT(traverse_module_state->__pyx_int_neg_1);
  Py_VISIT(traverse_module_state->__pyx_codeobj_);
  Py_VISIT(traverse_module_state->__pyx_tuple__19);
  Py_VISIT(traverse_module_state->__pyx_tuple__20);
  Py_VISIT(traverse_module_state->__pyx_tuple__24);
  Py_VISIT(traverse_module_state->__pyx_tuple__38);
  Py_VISIT(traverse_module_state->__pyx_tuple__41);
  Py_VISIT(traverse_module_state->__pyx_tuple__45);
  Py_VISIT(traverse_module_state->__pyx_tuple__55);
  Py_VISIT(traverse_module_state->__pyx_tuple__63);
  Py_VISIT(traverse_module_state->__pyx_tuple__64);
  Py_VISIT(traverse_module_state->__pyx_tuple__65);
  Py_VISIT(traverse_module_state->__pyx_tuple__66);
  Py_VISIT(traverse_module_state->__pyx_tuple__67);
  Py_VISIT(traverse_module_state->__pyx_tuple__68);
  Py_VISIT(traverse_module_state->__pyx_tuple__69);
  Py_VISIT(traverse_module_state->__pyx_tuple__70);
  Py_VISIT(traverse_module_state->__pyx_tuple__71);
  Py_VISIT(traverse_module_state->__pyx_tuple__72);
  Py_VISIT(traverse_module_state->__pyx_tuple__73);
  Py_VISIT(traverse_module_state->__pyx_tuple__74);
  Py_VISIT(traverse_module_state->__pyx_tuple__75);
  Py_VISIT(traverse_module_state->__pyx_tuple__76);
  Py_VISIT(traverse_module_state->__pyx_tuple__77);
  Py_VISIT(traverse_module_state->__pyx_codeobj__2);
  Py_VISIT(traverse_module_state->__pyx_codeobj__3);
  Py_VISIT(traverse_module_state->__pyx_codeobj__4);
  Py_VISIT(traverse_module_state->__pyx_codeobj__5);
  Py_VISIT(traverse_module_state->__pyx_codeobj__6);
  Py_VISIT(traverse_module_state->__pyx_codeobj__7);
  Py_VISIT(traverse_module_state->__pyx_codeobj__8);
  Py_VISIT(traverse_module_state->__pyx_codeobj__9);
  Py_VISIT(traverse_module_state->__pyx_codeobj__10);
  Py_VISIT(traverse_module_state->__pyx_codeobj__11);
  Py_VISIT(traverse_module_state->__pyx_codeobj__12);
  Py_VISIT(traverse_module_state->__pyx_codeobj__13);
  Py_VISIT(traverse_module_state->__pyx_codeobj__14);
  Py_VISIT(traverse_module_state->__pyx_codeobj__15);
  Py_VISIT(traverse_module_state->__pyx_codeobj__17);
  Py_VISIT(traverse_module_state->__pyx_codeobj__18);
  Py_VISIT(traverse_module_state->__pyx_codeobj__21);
  Py_VISIT(traverse_module_state->__pyx_codeobj__22);
  Py_VISIT(traverse_module_state->__pyx_codeobj__23);
  Py_VISIT(traverse_module_state->__pyx_codeobj__25);
  Py_VISIT(traverse_module_state->__pyx_codeobj__26);
  Py_VISIT(traverse_module_state->__pyx_codeobj__27);
  Py_VISIT(traverse_module_state->__pyx_codeobj__28);
  Py_VISIT(traverse_module_state->__pyx_codeobj__29);
  Py_VISIT(traverse_module_state->__pyx_codeobj__30);
  Py_VISIT(traverse_module_state->__pyx_codeobj__31);
  Py_VISIT(traverse_module_state->__pyx_codeobj__32);
  Py_VISIT(traverse_module_state->__pyx_codeobj__33);
  Py_VISIT(traverse_module_state->__pyx_codeobj__34);
  Py_VISIT(traverse_module_state->__pyx_codeobj__35);
  Py_VISIT(traverse_module_state->__pyx_codeobj__36);
  Py_VISIT(traverse_module_state->__pyx_codeobj__37);
  Py_VISIT(traverse_module_state->__pyx_codeobj__40);
  Py_VISIT(traverse_module_state->__pyx_codeobj__46);
  Py_VISIT(traverse_module_state->__pyx_codeobj__47);
  Py_VISIT(traverse_module_state->__pyx_codeobj__48);
  Py_VISIT(traverse_module_state->__pyx_codeobj__49);
  Py_VISIT(traverse_module_state->__pyx_codeobj__50);
  Py_VISIT(traverse_module_state->__pyx_codeobj__51);
  Py_VISIT(traverse_module_state->__pyx_codeobj__52);
  Py_VISIT(traverse_module_state->__pyx_codeobj__53);
  Py_VISIT(traverse_module_state->__pyx_codeobj__54);
  Py_VISIT(traverse_module_state->__pyx_codeobj__57);
  Py_VISIT(traverse_module_state->__pyx_codeobj__58);
  Py_VISIT(traverse_module_state->__pyx_codeobj__59);
  Py_VISIT(traverse_module_state->__pyx_codeobj__60);
  Py_VISIT(traverse_module_state->__pyx_codeobj__61);
  return 0;
}
#endif
/* #### Code section: module_state_defines ### */
#define __pyx_d __pyx_mstate_global->__pyx_d
#define __pyx_b __pyx_mstate_global->__pyx_b
#define __pyx_cython_runtime __pyx_mstate_global->__pyx_cython_runtime
#define __pyx_empty_tuple __pyx_mstate_global->__pyx_empty_tuple
#define __pyx_empty_bytes __pyx_mstate_global->__pyx_empty_bytes
#define __pyx_empty_unicode __pyx_mstate_global->__pyx_empty_unicode
#ifdef __Pyx_CyFunction_USED
#define __pyx_CyFunctionType __pyx_mstate_global->__pyx_CyFunctionType
#endif
#ifdef __Pyx_FusedFunction_USED
#define __pyx_FusedFunctionType __pyx_mstate_global->__pyx_FusedFunctionType
#endif
#ifdef __Pyx_Generator_USED
#define __pyx_GeneratorType __pyx_mstate_global->__pyx_GeneratorType
#endif
#ifdef __Pyx_IterableCoroutine_USED
#define __pyx_IterableCoroutineType __pyx_mstate_global->__pyx_IterableCoroutineType
#endif
#ifdef __Pyx_Coroutine_USED
#define __pyx_CoroutineAwaitType __pyx_mstate_global->__pyx_CoroutineAwaitType
#endif
#ifdef __Pyx_Coroutine_USED
#define __pyx_CoroutineType __pyx_mstate_global->__pyx_CoroutineType
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_5pysam_10libchtslib_HTSFile __pyx_mstate_global->__pyx_ptype_5pysam_10libchtslib_HTSFile
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_7cpython_4type_type __pyx_mstate_global->__pyx_ptype_7cpython_4type_type
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_7cpython_4bool_bool __pyx_mstate_global->__pyx_ptype_7cpython_4bool_bool
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_7cpython_7complex_complex __pyx_mstate_global->__pyx_ptype_7cpython_7complex_complex
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_5pysam_16libctabixproxies_TupleProxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_TupleProxy
#define __pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator
#define __pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy
#define __pyx_ptype_5pysam_16libctabixproxies_GTFProxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_GTFProxy
#define __pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy
#define __pyx_ptype_5pysam_16libctabixproxies_BedProxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_BedProxy
#define __pyx_ptype_5pysam_16libctabixproxies_VCFProxy __pyx_mstate_global->__pyx_ptype_5pysam_16libctabixproxies_VCFProxy
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#endif
#define __pyx_ptype_7cpython_5array_array __pyx_mstate_global->__pyx_ptype_7cpython_5array_array
#if CYTHON_USE_MODULE_STATE
#endif
#if CYTHON_USE_MODULE_STATE
#define __pyx_type_5pysam_9libctabix_tabix_file_iterator __pyx_mstate_global->__pyx_type_5pysam_9libctabix_tabix_file_iterator
#define __pyx_type_5pysam_9libctabix_TabixFile __pyx_mstate_global->__pyx_type_5pysam_9libctabix_TabixFile
#define __pyx_type_5pysam_9libctabix_Parser __pyx_mstate_global->__pyx_type_5pysam_9libctabix_Parser
#define __pyx_type_5pysam_9libctabix_asTuple __pyx_mstate_global->__pyx_type_5pysam_9libctabix_asTuple
#define __pyx_type_5pysam_9libctabix_asGTF __pyx_mstate_global->__pyx_type_5pysam_9libctabix_asGTF
#define __pyx_type_5pysam_9libctabix_asGFF3 __pyx_mstate_global->__pyx_type_5pysam_9libctabix_asGFF3
#define __pyx_type_5pysam_9libctabix_asBed __pyx_mstate_global->__pyx_type_5pysam_9libctabix_asBed
#define __pyx_type_5pysam_9libctabix_asVCF __pyx_mstate_global->__pyx_type_5pysam_9libctabix_asVCF
#define __pyx_type_5pysam_9libctabix_TabixIterator __pyx_mstate_global->__pyx_type_5pysam_9libctabix_TabixIterator
#define __pyx_type_5pysam_9libctabix_TabixIteratorParsed __pyx_mstate_global->__pyx_type_5pysam_9libctabix_TabixIteratorParsed
#define __pyx_type_5pysam_9libctabix_GZIterator __pyx_mstate_global->__pyx_type_5pysam_9libctabix_GZIterator
#define __pyx_type_5pysam_9libctabix_GZIteratorHead __pyx_mstate_global->__pyx_type_5pysam_9libctabix_GZIteratorHead
#define __pyx_type_5pysam_9libctabix_GZIteratorParsed __pyx_mstate_global->__pyx_type_5pysam_9libctabix_GZIteratorParsed
#define __pyx_type_5pysam_9libctabix_Tabixfile __pyx_mstate_global->__pyx_type_5pysam_9libctabix_Tabixfile
#endif
#define __pyx_ptype_5pysam_9libctabix_tabix_file_iterator __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_tabix_file_iterator
#define __pyx_ptype_5pysam_9libctabix_TabixFile __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_TabixFile
#define __pyx_ptype_5pysam_9libctabix_Parser __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_Parser
#define __pyx_ptype_5pysam_9libctabix_asTuple __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_asTuple
#define __pyx_ptype_5pysam_9libctabix_asGTF __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_asGTF
#define __pyx_ptype_5pysam_9libctabix_asGFF3 __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_asGFF3
#define __pyx_ptype_5pysam_9libctabix_asBed __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_asBed
#define __pyx_ptype_5pysam_9libctabix_asVCF __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_asVCF
#define __pyx_ptype_5pysam_9libctabix_TabixIterator __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_TabixIterator
#define __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed
#define __pyx_ptype_5pysam_9libctabix_GZIterator __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_GZIterator
#define __pyx_ptype_5pysam_9libctabix_GZIteratorHead __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_GZIteratorHead
#define __pyx_ptype_5pysam_9libctabix_GZIteratorParsed __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_GZIteratorParsed
#define __pyx_ptype_5pysam_9libctabix_Tabixfile __pyx_mstate_global->__pyx_ptype_5pysam_9libctabix_Tabixfile
#define __pyx_n_s_AssertionError __pyx_mstate_global->__pyx_n_s_AssertionError
#define __pyx_kp_u_Could_not_open_file __pyx_mstate_global->__pyx_kp_u_Could_not_open_file
#define __pyx_n_s_EmptyIterator __pyx_mstate_global->__pyx_n_s_EmptyIterator
#define __pyx_n_s_EmptyIterator___iter __pyx_mstate_global->__pyx_n_s_EmptyIterator___iter
#define __pyx_n_s_EmptyIterator___next __pyx_mstate_global->__pyx_n_s_EmptyIterator___next
#define __pyx_kp_u_Filename_s_already_exists_use_fo __pyx_mstate_global->__pyx_kp_u_Filename_s_already_exists_use_fo
#define __pyx_n_s_GZIterator __pyx_mstate_global->__pyx_n_s_GZIterator
#define __pyx_n_u_GZIterator __pyx_mstate_global->__pyx_n_u_GZIterator
#define __pyx_n_s_GZIteratorHead __pyx_mstate_global->__pyx_n_s_GZIteratorHead
#define __pyx_n_u_GZIteratorHead __pyx_mstate_global->__pyx_n_u_GZIteratorHead
#define __pyx_n_s_GZIteratorHead___reduce_cython __pyx_mstate_global->__pyx_n_s_GZIteratorHead___reduce_cython
#define __pyx_n_s_GZIteratorHead___setstate_cython __pyx_mstate_global->__pyx_n_s_GZIteratorHead___setstate_cython
#define __pyx_n_s_GZIteratorParsed __pyx_mstate_global->__pyx_n_s_GZIteratorParsed
#define __pyx_n_s_GZIteratorParsed___reduce_cython __pyx_mstate_global->__pyx_n_s_GZIteratorParsed___reduce_cython
#define __pyx_n_s_GZIteratorParsed___setstate_cyth __pyx_mstate_global->__pyx_n_s_GZIteratorParsed___setstate_cyth
#define __pyx_n_s_GZIterator___reduce_cython __pyx_mstate_global->__pyx_n_s_GZIterator___reduce_cython
#define __pyx_n_s_GZIterator___setstate_cython __pyx_mstate_global->__pyx_n_s_GZIterator___setstate_cython
#define __pyx_n_s_IOError __pyx_mstate_global->__pyx_n_s_IOError
#define __pyx_kp_u_I_O_operation_on_closed_file __pyx_mstate_global->__pyx_kp_u_I_O_operation_on_closed_file
#define __pyx_kp_u_I_O_operation_on_closed_file_2 __pyx_mstate_global->__pyx_kp_u_I_O_operation_on_closed_file_2
#define __pyx_kp_s_Incompatible_checksums_0x_x_vs_0 __pyx_mstate_global->__pyx_kp_s_Incompatible_checksums_0x_x_vs_0
#define __pyx_n_s_KeyError __pyx_mstate_global->__pyx_n_s_KeyError
#define __pyx_n_s_MemoryError __pyx_mstate_global->__pyx_n_s_MemoryError
#define __pyx_kp_u_No_such_file_or_directory_s __pyx_mstate_global->__pyx_kp_u_No_such_file_or_directory_s
#define __pyx_n_s_NotImplementedError __pyx_mstate_global->__pyx_n_s_NotImplementedError
#define __pyx_n_s_OSError __pyx_mstate_global->__pyx_n_s_OSError
#define __pyx_n_s_O_RDONLY __pyx_mstate_global->__pyx_n_s_O_RDONLY
#define __pyx_n_s_Parser __pyx_mstate_global->__pyx_n_s_Parser
#define __pyx_n_s_Parser___reduce_cython __pyx_mstate_global->__pyx_n_s_Parser___reduce_cython
#define __pyx_n_s_Parser___setstate_cython __pyx_mstate_global->__pyx_n_s_Parser___setstate_cython
#define __pyx_n_s_Parser_get_encoding __pyx_mstate_global->__pyx_n_s_Parser_get_encoding
#define __pyx_n_s_Parser_set_encoding __pyx_mstate_global->__pyx_n_s_Parser_set_encoding
#define __pyx_n_s_PickleError __pyx_mstate_global->__pyx_n_s_PickleError
#define __pyx_n_s_StopIteration __pyx_mstate_global->__pyx_n_s_StopIteration
#define __pyx_n_s_TabixFile __pyx_mstate_global->__pyx_n_s_TabixFile
#define __pyx_n_u_TabixFile __pyx_mstate_global->__pyx_n_u_TabixFile
#define __pyx_n_s_TabixFile___reduce_cython __pyx_mstate_global->__pyx_n_s_TabixFile___reduce_cython
#define __pyx_n_s_TabixFile___setstate_cython __pyx_mstate_global->__pyx_n_s_TabixFile___setstate_cython
#define __pyx_n_s_TabixFile__dup __pyx_mstate_global->__pyx_n_s_TabixFile__dup
#define __pyx_n_s_TabixFile__open __pyx_mstate_global->__pyx_n_s_TabixFile__open
#define __pyx_n_s_TabixFile_close __pyx_mstate_global->__pyx_n_s_TabixFile_close
#define __pyx_n_s_TabixFile_fetch __pyx_mstate_global->__pyx_n_s_TabixFile_fetch
#define __pyx_n_s_TabixIterator __pyx_mstate_global->__pyx_n_s_TabixIterator
#define __pyx_n_s_TabixIteratorParsed __pyx_mstate_global->__pyx_n_s_TabixIteratorParsed
#define __pyx_n_s_TabixIteratorParsed___reduce_cyt __pyx_mstate_global->__pyx_n_s_TabixIteratorParsed___reduce_cyt
#define __pyx_n_s_TabixIteratorParsed___setstate_c __pyx_mstate_global->__pyx_n_s_TabixIteratorParsed___setstate_c
#define __pyx_n_s_TabixIterator___reduce_cython __pyx_mstate_global->__pyx_n_s_TabixIterator___reduce_cython
#define __pyx_n_s_TabixIterator___setstate_cython __pyx_mstate_global->__pyx_n_s_TabixIterator___setstate_cython
#define __pyx_n_s_Tabixfile __pyx_mstate_global->__pyx_n_s_Tabixfile
#define __pyx_n_u_Tabixfile __pyx_mstate_global->__pyx_n_u_Tabixfile
#define __pyx_n_s_Tabixfile___reduce_cython __pyx_mstate_global->__pyx_n_s_Tabixfile___reduce_cython
#define __pyx_n_s_Tabixfile___setstate_cython __pyx_mstate_global->__pyx_n_s_Tabixfile___setstate_cython
#define __pyx_n_s_TypeError __pyx_mstate_global->__pyx_n_s_TypeError
#define __pyx_n_s_ValueError __pyx_mstate_global->__pyx_n_s_ValueError
#define __pyx_n_s_WINDOW_SIZE __pyx_mstate_global->__pyx_n_s_WINDOW_SIZE
#define __pyx_kp_b__16 __pyx_mstate_global->__pyx_kp_b__16
#define __pyx_kp_u__39 __pyx_mstate_global->__pyx_kp_u__39
#define __pyx_kp_u__42 __pyx_mstate_global->__pyx_kp_u__42
#define __pyx_kp_u__43 __pyx_mstate_global->__pyx_kp_u__43
#define __pyx_kp_u__44 __pyx_mstate_global->__pyx_kp_u__44
#define __pyx_kp_u__56 __pyx_mstate_global->__pyx_kp_u__56
#define __pyx_n_s__62 __pyx_mstate_global->__pyx_n_s__62
#define __pyx_n_s__78 __pyx_mstate_global->__pyx_n_s__78
#define __pyx_n_s_a __pyx_mstate_global->__pyx_n_s_a
#define __pyx_n_s_all __pyx_mstate_global->__pyx_n_s_all
#define __pyx_n_s_asBed __pyx_mstate_global->__pyx_n_s_asBed
#define __pyx_n_u_asBed __pyx_mstate_global->__pyx_n_u_asBed
#define __pyx_n_s_asBed___reduce_cython __pyx_mstate_global->__pyx_n_s_asBed___reduce_cython
#define __pyx_n_s_asBed___setstate_cython __pyx_mstate_global->__pyx_n_s_asBed___setstate_cython
#define __pyx_n_s_asGFF3 __pyx_mstate_global->__pyx_n_s_asGFF3
#define __pyx_n_u_asGFF3 __pyx_mstate_global->__pyx_n_u_asGFF3
#define __pyx_n_s_asGFF3___reduce_cython __pyx_mstate_global->__pyx_n_s_asGFF3___reduce_cython
#define __pyx_n_s_asGFF3___setstate_cython __pyx_mstate_global->__pyx_n_s_asGFF3___setstate_cython
#define __pyx_n_s_asGTF __pyx_mstate_global->__pyx_n_s_asGTF
#define __pyx_n_u_asGTF __pyx_mstate_global->__pyx_n_u_asGTF
#define __pyx_n_s_asGTF___reduce_cython __pyx_mstate_global->__pyx_n_s_asGTF___reduce_cython
#define __pyx_n_s_asGTF___setstate_cython __pyx_mstate_global->__pyx_n_s_asGTF___setstate_cython
#define __pyx_n_s_asTuple __pyx_mstate_global->__pyx_n_s_asTuple
#define __pyx_n_u_asTuple __pyx_mstate_global->__pyx_n_u_asTuple
#define __pyx_n_s_asTuple___reduce_cython __pyx_mstate_global->__pyx_n_s_asTuple___reduce_cython
#define __pyx_n_s_asTuple___setstate_cython __pyx_mstate_global->__pyx_n_s_asTuple___setstate_cython
#define __pyx_n_s_asVCF __pyx_mstate_global->__pyx_n_s_asVCF
#define __pyx_n_u_asVCF __pyx_mstate_global->__pyx_n_u_asVCF
#define __pyx_n_s_asVCF___reduce_cython __pyx_mstate_global->__pyx_n_s_asVCF___reduce_cython
#define __pyx_n_s_asVCF___setstate_cython __pyx_mstate_global->__pyx_n_s_asVCF___setstate_cython
#define __pyx_n_u_ascii __pyx_mstate_global->__pyx_n_u_ascii
#define __pyx_n_s_asyncio_coroutines __pyx_mstate_global->__pyx_n_s_asyncio_coroutines
#define __pyx_n_s_b __pyx_mstate_global->__pyx_n_s_b
#define __pyx_n_u_bcf __pyx_mstate_global->__pyx_n_u_bcf
#define __pyx_n_u_bed __pyx_mstate_global->__pyx_n_u_bed
#define __pyx_n_s_buffer __pyx_mstate_global->__pyx_n_s_buffer
#define __pyx_n_s_buffer_size __pyx_mstate_global->__pyx_n_s_buffer_size
#define __pyx_kp_u_building_of_index_for_failed __pyx_mstate_global->__pyx_kp_u_building_of_index_for_failed
#define __pyx_n_s_bytes_cpy __pyx_mstate_global->__pyx_n_s_bytes_cpy
#define __pyx_n_s_c __pyx_mstate_global->__pyx_n_s_c
#define __pyx_n_s_cfilename __pyx_mstate_global->__pyx_n_s_cfilename
#define __pyx_n_s_cfilename_index __pyx_mstate_global->__pyx_n_s_cfilename_index
#define __pyx_n_s_cfn __pyx_mstate_global->__pyx_n_s_cfn
#define __pyx_n_s_cline_in_traceback __pyx_mstate_global->__pyx_n_s_cline_in_traceback
#define __pyx_n_s_close __pyx_mstate_global->__pyx_n_s_close
#define __pyx_n_s_closed __pyx_mstate_global->__pyx_n_s_closed
#define __pyx_n_s_conf __pyx_mstate_global->__pyx_n_s_conf
#define __pyx_n_s_conf_data __pyx_mstate_global->__pyx_n_s_conf_data
#define __pyx_n_s_contigs __pyx_mstate_global->__pyx_n_s_contigs
#define __pyx_kp_u_could_not_create_iterator_for_re __pyx_mstate_global->__pyx_kp_u_could_not_create_iterator_for_re
#define __pyx_kp_u_could_not_create_iterator_possib __pyx_mstate_global->__pyx_kp_u_could_not_create_iterator_possib
#define __pyx_kp_u_could_not_load_tbi_csi_index_of __pyx_mstate_global->__pyx_kp_u_could_not_load_tbi_csi_index_of
#define __pyx_kp_u_could_not_open_file_s __pyx_mstate_global->__pyx_kp_u_could_not_open_file_s
#define __pyx_kp_u_could_not_open_for_reading_heade __pyx_mstate_global->__pyx_kp_u_could_not_open_for_reading_heade
#define __pyx_kp_u_could_not_open_index_for_s __pyx_mstate_global->__pyx_kp_u_could_not_open_index_for_s
#define __pyx_kp_u_could_not_open_s_for_reading __pyx_mstate_global->__pyx_kp_u_could_not_open_s_for_reading
#define __pyx_kp_u_could_not_open_s_for_writing __pyx_mstate_global->__pyx_kp_u_could_not_open_s_for_writing
#define __pyx_n_s_cpy __pyx_mstate_global->__pyx_n_s_cpy
#define __pyx_n_s_csi __pyx_mstate_global->__pyx_n_s_csi
#define __pyx_kp_u_csi_2 __pyx_mstate_global->__pyx_kp_u_csi_2
#define __pyx_n_s_cstr __pyx_mstate_global->__pyx_n_s_cstr
#define __pyx_n_s_dict __pyx_mstate_global->__pyx_n_s_dict
#define __pyx_n_s_dict_2 __pyx_mstate_global->__pyx_n_s_dict_2
#define __pyx_kp_u_disable __pyx_mstate_global->__pyx_kp_u_disable
#define __pyx_n_s_doc __pyx_mstate_global->__pyx_n_s_doc
#define __pyx_n_s_dup __pyx_mstate_global->__pyx_n_s_dup
#define __pyx_kp_s_empty_iterator __pyx_mstate_global->__pyx_kp_s_empty_iterator
#define __pyx_kp_u_enable __pyx_mstate_global->__pyx_kp_u_enable
#define __pyx_n_s_encoding __pyx_mstate_global->__pyx_n_s_encoding
#define __pyx_n_s_end __pyx_mstate_global->__pyx_n_s_end
#define __pyx_n_s_end_col __pyx_mstate_global->__pyx_n_s_end_col
#define __pyx_kp_u_end_out_of_range_i __pyx_mstate_global->__pyx_kp_u_end_out_of_range_i
#define __pyx_kp_u_error_i_when_closing_file_s __pyx_mstate_global->__pyx_kp_u_error_i_when_closing_file_s
#define __pyx_kp_u_error_i_when_writing_to_file_s __pyx_mstate_global->__pyx_kp_u_error_i_when_writing_to_file_s
#define __pyx_n_s_exists __pyx_mstate_global->__pyx_n_s_exists
#define __pyx_n_s_fd_src __pyx_mstate_global->__pyx_n_s_fd_src
#define __pyx_n_s_fetch __pyx_mstate_global->__pyx_n_s_fetch
#define __pyx_kp_u_file_s_not_found __pyx_mstate_global->__pyx_kp_u_file_s_not_found
#define __pyx_n_s_filename __pyx_mstate_global->__pyx_n_s_filename
#define __pyx_n_s_filename_in __pyx_mstate_global->__pyx_n_s_filename_in
#define __pyx_n_s_filename_index __pyx_mstate_global->__pyx_n_s_filename_index
#define __pyx_n_s_filename_out __pyx_mstate_global->__pyx_n_s_filename_out
#define __pyx_kp_u_filename_s_already_exists_use_fo __pyx_mstate_global->__pyx_kp_u_filename_s_already_exists_use_fo
#define __pyx_n_s_fileobj __pyx_mstate_global->__pyx_n_s_fileobj
#define __pyx_n_s_fmt __pyx_mstate_global->__pyx_n_s_fmt
#define __pyx_n_s_fn __pyx_mstate_global->__pyx_n_s_fn
#define __pyx_n_s_fn_index __pyx_mstate_global->__pyx_n_s_fn_index
#define __pyx_n_s_fnidx __pyx_mstate_global->__pyx_n_s_fnidx
#define __pyx_n_s_force __pyx_mstate_global->__pyx_n_s_force
#define __pyx_n_s_format __pyx_mstate_global->__pyx_n_s_format
#define __pyx_n_s_fp __pyx_mstate_global->__pyx_n_s_fp
#define __pyx_kp_u_gc __pyx_mstate_global->__pyx_kp_u_gc
#define __pyx_n_s_get_encoding __pyx_mstate_global->__pyx_n_s_get_encoding
#define __pyx_n_s_getstate __pyx_mstate_global->__pyx_n_s_getstate
#define __pyx_n_u_gff __pyx_mstate_global->__pyx_n_u_gff
#define __pyx_kp_u_gz __pyx_mstate_global->__pyx_kp_u_gz
#define __pyx_n_s_import __pyx_mstate_global->__pyx_n_s_import
#define __pyx_kp_u_incomplete_line_at_s __pyx_mstate_global->__pyx_kp_u_incomplete_line_at_s
#define __pyx_n_s_index __pyx_mstate_global->__pyx_n_s_index
#define __pyx_kp_u_index_s_not_found __pyx_mstate_global->__pyx_kp_u_index_s_not_found
#define __pyx_n_s_infile __pyx_mstate_global->__pyx_n_s_infile
#define __pyx_n_s_init __pyx_mstate_global->__pyx_n_s_init
#define __pyx_n_s_init_subclass __pyx_mstate_global->__pyx_n_s_init_subclass
#define __pyx_n_s_initializing __pyx_mstate_global->__pyx_n_s_initializing
#define __pyx_kp_u_invalid_file_opening_mode_s __pyx_mstate_global->__pyx_kp_u_invalid_file_opening_mode_s
#define __pyx_n_s_is_coroutine __pyx_mstate_global->__pyx_n_s_is_coroutine
#define __pyx_n_s_is_empty __pyx_mstate_global->__pyx_n_s_is_empty
#define __pyx_n_s_is_open __pyx_mstate_global->__pyx_n_s_is_open
#define __pyx_kp_u_isenabled __pyx_mstate_global->__pyx_kp_u_isenabled
#define __pyx_n_s_iter __pyx_mstate_global->__pyx_n_s_iter
#define __pyx_kp_s_iterate_over_infile_Permits_the __pyx_mstate_global->__pyx_kp_s_iterate_over_infile_Permits_the
#define __pyx_kp_u_iteration_on_closed_file __pyx_mstate_global->__pyx_kp_u_iteration_on_closed_file
#define __pyx_n_s_itr __pyx_mstate_global->__pyx_n_s_itr
#define __pyx_n_s_keep_original __pyx_mstate_global->__pyx_n_s_keep_original
#define __pyx_n_s_keys __pyx_mstate_global->__pyx_n_s_keys
#define __pyx_n_s_length __pyx_mstate_global->__pyx_n_s_length
#define __pyx_n_s_line __pyx_mstate_global->__pyx_n_s_line
#define __pyx_n_s_line_skip __pyx_mstate_global->__pyx_n_s_line_skip
#define __pyx_n_s_main __pyx_mstate_global->__pyx_n_s_main
#define __pyx_n_s_meta_char __pyx_mstate_global->__pyx_n_s_meta_char
#define __pyx_n_s_metaclass __pyx_mstate_global->__pyx_n_s_metaclass
#define __pyx_n_s_min_shift __pyx_mstate_global->__pyx_n_s_min_shift
#define __pyx_n_s_mode __pyx_mstate_global->__pyx_n_s_mode
#define __pyx_n_s_module __pyx_mstate_global->__pyx_n_s_module
#define __pyx_n_s_multiple_iterators __pyx_mstate_global->__pyx_n_s_multiple_iterators
#define __pyx_n_s_name __pyx_mstate_global->__pyx_n_s_name
#define __pyx_n_s_nbytes __pyx_mstate_global->__pyx_n_s_nbytes
#define __pyx_kp_u_neither_preset_nor_seq_col_start __pyx_mstate_global->__pyx_kp_u_neither_preset_nor_seq_col_start
#define __pyx_n_s_new __pyx_mstate_global->__pyx_n_s_new
#define __pyx_n_s_next __pyx_mstate_global->__pyx_n_s_next
#define __pyx_kp_s_no_default___reduce___due_to_non __pyx_mstate_global->__pyx_kp_s_no_default___reduce___due_to_non
#define __pyx_n_s_open __pyx_mstate_global->__pyx_n_s_open
#define __pyx_n_s_os __pyx_mstate_global->__pyx_n_s_os
#define __pyx_kp_u_parse_method_of_s_not_implemente __pyx_mstate_global->__pyx_kp_u_parse_method_of_s_not_implemente
#define __pyx_n_s_parser __pyx_mstate_global->__pyx_n_s_parser
#define __pyx_n_s_path __pyx_mstate_global->__pyx_n_s_path
#define __pyx_n_s_pickle __pyx_mstate_global->__pyx_n_s_pickle
#define __pyx_n_s_prepare __pyx_mstate_global->__pyx_n_s_prepare
#define __pyx_n_s_preset __pyx_mstate_global->__pyx_n_s_preset
#define __pyx_n_s_preset2conf __pyx_mstate_global->__pyx_n_s_preset2conf
#define __pyx_n_u_psltbl __pyx_mstate_global->__pyx_n_u_psltbl
#define __pyx_n_s_pysam_libctabix __pyx_mstate_global->__pyx_n_s_pysam_libctabix
#define __pyx_kp_s_pysam_libctabix_pyx __pyx_mstate_global->__pyx_kp_s_pysam_libctabix_pyx
#define __pyx_n_s_pyx_PickleError __pyx_mstate_global->__pyx_n_s_pyx_PickleError
#define __pyx_n_s_pyx_checksum __pyx_mstate_global->__pyx_n_s_pyx_checksum
#define __pyx_n_s_pyx_result __pyx_mstate_global->__pyx_n_s_pyx_result
#define __pyx_n_s_pyx_state __pyx_mstate_global->__pyx_n_s_pyx_state
#define __pyx_n_s_pyx_type __pyx_mstate_global->__pyx_n_s_pyx_type
#define __pyx_n_s_pyx_unpickle_Parser __pyx_mstate_global->__pyx_n_s_pyx_unpickle_Parser
#define __pyx_n_s_pyx_unpickle_asBed __pyx_mstate_global->__pyx_n_s_pyx_unpickle_asBed
#define __pyx_n_s_pyx_unpickle_asGFF3 __pyx_mstate_global->__pyx_n_s_pyx_unpickle_asGFF3
#define __pyx_n_s_pyx_unpickle_asGTF __pyx_mstate_global->__pyx_n_s_pyx_unpickle_asGTF
#define __pyx_n_s_pyx_unpickle_asTuple __pyx_mstate_global->__pyx_n_s_pyx_unpickle_asTuple
#define __pyx_n_s_pyx_unpickle_asVCF __pyx_mstate_global->__pyx_n_s_pyx_unpickle_asVCF
#define __pyx_n_s_pyx_vtable __pyx_mstate_global->__pyx_n_s_pyx_vtable
#define __pyx_n_s_qualname __pyx_mstate_global->__pyx_n_s_qualname
#define __pyx_n_s_r __pyx_mstate_global->__pyx_n_s_r
#define __pyx_n_u_r __pyx_mstate_global->__pyx_n_u_r
#define __pyx_n_s_readline __pyx_mstate_global->__pyx_n_s_readline
#define __pyx_n_s_reduce __pyx_mstate_global->__pyx_n_s_reduce
#define __pyx_n_s_reduce_cython __pyx_mstate_global->__pyx_n_s_reduce_cython
#define __pyx_n_s_reduce_ex __pyx_mstate_global->__pyx_n_s_reduce_ex
#define __pyx_n_s_reference __pyx_mstate_global->__pyx_n_s_reference
#define __pyx_n_s_region __pyx_mstate_global->__pyx_n_s_region
#define __pyx_n_s_retval __pyx_mstate_global->__pyx_n_s_retval
#define __pyx_kp_u_s __pyx_mstate_global->__pyx_kp_u_s
#define __pyx_n_s_s_2 __pyx_mstate_global->__pyx_n_s_s_2
#define __pyx_kp_u_s_i __pyx_mstate_global->__pyx_kp_u_s_i
#define __pyx_kp_u_s_i_i __pyx_mstate_global->__pyx_kp_u_s_i_i
#define __pyx_n_u_sam __pyx_mstate_global->__pyx_n_u_sam
#define __pyx_n_s_self __pyx_mstate_global->__pyx_n_s_self
#define __pyx_kp_s_self_gzipfile_self_kstream_canno __pyx_mstate_global->__pyx_kp_s_self_gzipfile_self_kstream_canno
#define __pyx_kp_s_self_iterator_cannot_be_converte __pyx_mstate_global->__pyx_kp_s_self_iterator_cannot_be_converte
#define __pyx_n_s_seq_col __pyx_mstate_global->__pyx_n_s_seq_col
#define __pyx_n_s_set_encoding __pyx_mstate_global->__pyx_n_s_set_encoding
#define __pyx_n_s_set_name __pyx_mstate_global->__pyx_n_s_set_name
#define __pyx_n_s_setstate __pyx_mstate_global->__pyx_n_s_setstate
#define __pyx_n_s_setstate_cython __pyx_mstate_global->__pyx_n_s_setstate_cython
#define __pyx_n_s_spec __pyx_mstate_global->__pyx_n_s_spec
#define __pyx_n_s_start __pyx_mstate_global->__pyx_n_s_start
#define __pyx_n_s_start_col __pyx_mstate_global->__pyx_n_s_start_col
#define __pyx_kp_u_start_i_end_i __pyx_mstate_global->__pyx_kp_u_start_i_end_i
#define __pyx_kp_u_start_out_of_range_i __pyx_mstate_global->__pyx_kp_u_start_out_of_range_i
#define __pyx_n_s_state __pyx_mstate_global->__pyx_n_s_state
#define __pyx_kp_s_stringsource __pyx_mstate_global->__pyx_kp_s_stringsource
#define __pyx_n_s_suffix __pyx_mstate_global->__pyx_n_s_suffix
#define __pyx_n_s_super __pyx_mstate_global->__pyx_n_s_super
#define __pyx_n_s_sys __pyx_mstate_global->__pyx_n_s_sys
#define __pyx_n_s_tabix_compress __pyx_mstate_global->__pyx_n_s_tabix_compress
#define __pyx_n_u_tabix_compress __pyx_mstate_global->__pyx_n_u_tabix_compress
#define __pyx_n_s_tabix_file_iterator __pyx_mstate_global->__pyx_n_s_tabix_file_iterator
#define __pyx_n_u_tabix_file_iterator __pyx_mstate_global->__pyx_n_u_tabix_file_iterator
#define __pyx_n_s_tabix_file_iterator___reduce_cyt __pyx_mstate_global->__pyx_n_s_tabix_file_iterator___reduce_cyt
#define __pyx_n_s_tabix_file_iterator___setstate_c __pyx_mstate_global->__pyx_n_s_tabix_file_iterator___setstate_c
#define __pyx_n_s_tabix_generic_iterator __pyx_mstate_global->__pyx_n_s_tabix_generic_iterator
#define __pyx_n_u_tabix_generic_iterator __pyx_mstate_global->__pyx_n_u_tabix_generic_iterator
#define __pyx_n_s_tabix_generic_iterator___init __pyx_mstate_global->__pyx_n_s_tabix_generic_iterator___init
#define __pyx_n_s_tabix_generic_iterator___iter __pyx_mstate_global->__pyx_n_s_tabix_generic_iterator___iter
#define __pyx_n_s_tabix_generic_iterator___next __pyx_mstate_global->__pyx_n_s_tabix_generic_iterator___next
#define __pyx_n_s_tabix_index __pyx_mstate_global->__pyx_n_s_tabix_index
#define __pyx_n_u_tabix_index __pyx_mstate_global->__pyx_n_u_tabix_index
#define __pyx_n_s_tabix_iterator __pyx_mstate_global->__pyx_n_s_tabix_iterator
#define __pyx_n_u_tabix_iterator __pyx_mstate_global->__pyx_n_u_tabix_iterator
#define __pyx_kp_u_tbi __pyx_mstate_global->__pyx_kp_u_tbi
#define __pyx_n_s_tell __pyx_mstate_global->__pyx_n_s_tell
#define __pyx_n_s_test __pyx_mstate_global->__pyx_n_s_test
#define __pyx_n_s_threads __pyx_mstate_global->__pyx_n_s_threads
#define __pyx_kp_u_unknown_preset __pyx_mstate_global->__pyx_kp_u_unknown_preset
#define __pyx_n_s_unlink __pyx_mstate_global->__pyx_n_s_unlink
#define __pyx_n_s_update __pyx_mstate_global->__pyx_n_s_update
#define __pyx_n_s_use_setstate __pyx_mstate_global->__pyx_n_s_use_setstate
#define __pyx_kp_u_valid_presets_are __pyx_mstate_global->__pyx_kp_u_valid_presets_are
#define __pyx_n_u_vcf __pyx_mstate_global->__pyx_n_u_vcf
#define __pyx_kp_u_writing_failed __pyx_mstate_global->__pyx_kp_u_writing_failed
#define __pyx_n_s_zerobased __pyx_mstate_global->__pyx_n_s_zerobased
#define __pyx_int_0 __pyx_mstate_global->__pyx_int_0
#define __pyx_int_1 __pyx_mstate_global->__pyx_int_1
#define __pyx_int_2 __pyx_mstate_global->__pyx_int_2
#define __pyx_int_3 __pyx_mstate_global->__pyx_int_3
#define __pyx_int_4 __pyx_mstate_global->__pyx_int_4
#define __pyx_int_5 __pyx_mstate_global->__pyx_int_5
#define __pyx_int_15 __pyx_mstate_global->__pyx_int_15
#define __pyx_int_17 __pyx_mstate_global->__pyx_int_17
#define __pyx_int_18 __pyx_mstate_global->__pyx_int_18
#define __pyx_int_35 __pyx_mstate_global->__pyx_int_35
#define __pyx_int_64 __pyx_mstate_global->__pyx_int_64
#define __pyx_int_21667264 __pyx_mstate_global->__pyx_int_21667264
#define __pyx_int_139192863 __pyx_mstate_global->__pyx_int_139192863
#define __pyx_int_243541226 __pyx_mstate_global->__pyx_int_243541226
#define __pyx_int_neg_1 __pyx_mstate_global->__pyx_int_neg_1
#define __pyx_codeobj_ __pyx_mstate_global->__pyx_codeobj_
#define __pyx_tuple__19 __pyx_mstate_global->__pyx_tuple__19
#define __pyx_tuple__20 __pyx_mstate_global->__pyx_tuple__20
#define __pyx_tuple__24 __pyx_mstate_global->__pyx_tuple__24
#define __pyx_tuple__38 __pyx_mstate_global->__pyx_tuple__38
#define __pyx_tuple__41 __pyx_mstate_global->__pyx_tuple__41
#define __pyx_tuple__45 __pyx_mstate_global->__pyx_tuple__45
#define __pyx_tuple__55 __pyx_mstate_global->__pyx_tuple__55
#define __pyx_tuple__63 __pyx_mstate_global->__pyx_tuple__63
#define __pyx_tuple__64 __pyx_mstate_global->__pyx_tuple__64
#define __pyx_tuple__65 __pyx_mstate_global->__pyx_tuple__65
#define __pyx_tuple__66 __pyx_mstate_global->__pyx_tuple__66
#define __pyx_tuple__67 __pyx_mstate_global->__pyx_tuple__67
#define __pyx_tuple__68 __pyx_mstate_global->__pyx_tuple__68
#define __pyx_tuple__69 __pyx_mstate_global->__pyx_tuple__69
#define __pyx_tuple__70 __pyx_mstate_global->__pyx_tuple__70
#define __pyx_tuple__71 __pyx_mstate_global->__pyx_tuple__71
#define __pyx_tuple__72 __pyx_mstate_global->__pyx_tuple__72
#define __pyx_tuple__73 __pyx_mstate_global->__pyx_tuple__73
#define __pyx_tuple__74 __pyx_mstate_global->__pyx_tuple__74
#define __pyx_tuple__75 __pyx_mstate_global->__pyx_tuple__75
#define __pyx_tuple__76 __pyx_mstate_global->__pyx_tuple__76
#define __pyx_tuple__77 __pyx_mstate_global->__pyx_tuple__77
#define __pyx_codeobj__2 __pyx_mstate_global->__pyx_codeobj__2
#define __pyx_codeobj__3 __pyx_mstate_global->__pyx_codeobj__3
#define __pyx_codeobj__4 __pyx_mstate_global->__pyx_codeobj__4
#define __pyx_codeobj__5 __pyx_mstate_global->__pyx_codeobj__5
#define __pyx_codeobj__6 __pyx_mstate_global->__pyx_codeobj__6
#define __pyx_codeobj__7 __pyx_mstate_global->__pyx_codeobj__7
#define __pyx_codeobj__8 __pyx_mstate_global->__pyx_codeobj__8
#define __pyx_codeobj__9 __pyx_mstate_global->__pyx_codeobj__9
#define __pyx_codeobj__10 __pyx_mstate_global->__pyx_codeobj__10
#define __pyx_codeobj__11 __pyx_mstate_global->__pyx_codeobj__11
#define __pyx_codeobj__12 __pyx_mstate_global->__pyx_codeobj__12
#define __pyx_codeobj__13 __pyx_mstate_global->__pyx_codeobj__13
#define __pyx_codeobj__14 __pyx_mstate_global->__pyx_codeobj__14
#define __pyx_codeobj__15 __pyx_mstate_global->__pyx_codeobj__15
#define __pyx_codeobj__17 __pyx_mstate_global->__pyx_codeobj__17
#define __pyx_codeobj__18 __pyx_mstate_global->__pyx_codeobj__18
#define __pyx_codeobj__21 __pyx_mstate_global->__pyx_codeobj__21
#define __pyx_codeobj__22 __pyx_mstate_global->__pyx_codeobj__22
#define __pyx_codeobj__23 __pyx_mstate_global->__pyx_codeobj__23
#define __pyx_codeobj__25 __pyx_mstate_global->__pyx_codeobj__25
#define __pyx_codeobj__26 __pyx_mstate_global->__pyx_codeobj__26
#define __pyx_codeobj__27 __pyx_mstate_global->__pyx_codeobj__27
#define __pyx_codeobj__28 __pyx_mstate_global->__pyx_codeobj__28
#define __pyx_codeobj__29 __pyx_mstate_global->__pyx_codeobj__29
#define __pyx_codeobj__30 __pyx_mstate_global->__pyx_codeobj__30
#define __pyx_codeobj__31 __pyx_mstate_global->__pyx_codeobj__31
#define __pyx_codeobj__32 __pyx_mstate_global->__pyx_codeobj__32
#define __pyx_codeobj__33 __pyx_mstate_global->__pyx_codeobj__33
#define __pyx_codeobj__34 __pyx_mstate_global->__pyx_codeobj__34
#define __pyx_codeobj__35 __pyx_mstate_global->__pyx_codeobj__35
#define __pyx_codeobj__36 __pyx_mstate_global->__pyx_codeobj__36
#define __pyx_codeobj__37 __pyx_mstate_global->__pyx_codeobj__37
#define __pyx_codeobj__40 __pyx_mstate_global->__pyx_codeobj__40
#define __pyx_codeobj__46 __pyx_mstate_global->__pyx_codeobj__46
#define __pyx_codeobj__47 __pyx_mstate_global->__pyx_codeobj__47
#define __pyx_codeobj__48 __pyx_mstate_global->__pyx_codeobj__48
#define __pyx_codeobj__49 __pyx_mstate_global->__pyx_codeobj__49
#define __pyx_codeobj__50 __pyx_mstate_global->__pyx_codeobj__50
#define __pyx_codeobj__51 __pyx_mstate_global->__pyx_codeobj__51
#define __pyx_codeobj__52 __pyx_mstate_global->__pyx_codeobj__52
#define __pyx_codeobj__53 __pyx_mstate_global->__pyx_codeobj__53
#define __pyx_codeobj__54 __pyx_mstate_global->__pyx_codeobj__54
#define __pyx_codeobj__57 __pyx_mstate_global->__pyx_codeobj__57
#define __pyx_codeobj__58 __pyx_mstate_global->__pyx_codeobj__58
#define __pyx_codeobj__59 __pyx_mstate_global->__pyx_codeobj__59
#define __pyx_codeobj__60 __pyx_mstate_global->__pyx_codeobj__60
#define __pyx_codeobj__61 __pyx_mstate_global->__pyx_codeobj__61
/* #### Code section: module_code ### */

/* "cpython/complex.pxd":19
 * 
 *         @property
 *         cdef inline double real(self):             # <<<<<<<<<<<<<<
 *             return self.cval.real
 * 
 */

static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4real_real(PyComplexObject *__pyx_v_self) {
  double __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("real", 0);

  /* "cpython/complex.pxd":20
 *         @property
 *         cdef inline double real(self):
 *             return self.cval.real             # <<<<<<<<<<<<<<
 * 
 *         @property
 */
  __pyx_r = __pyx_v_self->cval.real;
  goto __pyx_L0;

  /* "cpython/complex.pxd":19
 * 
 *         @property
 *         cdef inline double real(self):             # <<<<<<<<<<<<<<
 *             return self.cval.real
 * 
 */

  /* function exit code */
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "cpython/complex.pxd":23
 * 
 *         @property
 *         cdef inline double imag(self):             # <<<<<<<<<<<<<<
 *             return self.cval.imag
 * 
 */

static CYTHON_INLINE double __pyx_f_7cpython_7complex_7complex_4imag_imag(PyComplexObject *__pyx_v_self) {
  double __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("imag", 0);

  /* "cpython/complex.pxd":24
 *         @property
 *         cdef inline double imag(self):
 *             return self.cval.imag             # <<<<<<<<<<<<<<
 * 
 *     # PyTypeObject PyComplex_Type
 */
  __pyx_r = __pyx_v_self->cval.imag;
  goto __pyx_L0;

  /* "cpython/complex.pxd":23
 * 
 *         @property
 *         cdef inline double imag(self):             # <<<<<<<<<<<<<<
 *             return self.cval.imag
 * 
 */

  /* function exit code */
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "cpython/contextvars.pxd":112
 * 
 * 
 * cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the default value of the context variable,
 */

static CYTHON_INLINE PyObject *__pyx_f_7cpython_11contextvars_get_value(PyObject *__pyx_v_var, struct __pyx_opt_args_7cpython_11contextvars_get_value *__pyx_optional_args) {
  PyObject *__pyx_v_default_value = ((PyObject *)Py_None);
  PyObject *__pyx_v_value;
  PyObject *__pyx_v_pyvalue = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("get_value", 0);
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_default_value = __pyx_optional_args->default_value;
    }
  }

  /* "cpython/contextvars.pxd":117
 *     or None if no such value or default was found.
 *     """
 *     cdef PyObject *value = NULL             # <<<<<<<<<<<<<<
 *     PyContextVar_Get(var, NULL, &value)
 *     if value is NULL:
 */
  __pyx_v_value = NULL;

  /* "cpython/contextvars.pxd":118
 *     """
 *     cdef PyObject *value = NULL
 *     PyContextVar_Get(var, NULL, &value)             # <<<<<<<<<<<<<<
 *     if value is NULL:
 *         # context variable does not have a default
 */
  __pyx_t_1 = PyContextVar_Get(__pyx_v_var, NULL, (&__pyx_v_value)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(2, 118, __pyx_L1_error)

  /* "cpython/contextvars.pxd":119
 *     cdef PyObject *value = NULL
 *     PyContextVar_Get(var, NULL, &value)
 *     if value is NULL:             # <<<<<<<<<<<<<<
 *         # context variable does not have a default
 *         pyvalue = default_value
 */
  __pyx_t_2 = (__pyx_v_value == NULL);
  if (__pyx_t_2) {

    /* "cpython/contextvars.pxd":121
 *     if value is NULL:
 *         # context variable does not have a default
 *         pyvalue = default_value             # <<<<<<<<<<<<<<
 *     else:
 *         # value or default value of context variable
 */
    __Pyx_INCREF(__pyx_v_default_value);
    __pyx_v_pyvalue = __pyx_v_default_value;

    /* "cpython/contextvars.pxd":119
 *     cdef PyObject *value = NULL
 *     PyContextVar_Get(var, NULL, &value)
 *     if value is NULL:             # <<<<<<<<<<<<<<
 *         # context variable does not have a default
 *         pyvalue = default_value
 */
    goto __pyx_L3;
  }

  /* "cpython/contextvars.pxd":124
 *     else:
 *         # value or default value of context variable
 *         pyvalue = <object>value             # <<<<<<<<<<<<<<
 *         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
 *     return pyvalue
 */
  /*else*/ {
    __pyx_t_3 = ((PyObject *)__pyx_v_value);
    __Pyx_INCREF(__pyx_t_3);
    __pyx_v_pyvalue = __pyx_t_3;
    __pyx_t_3 = 0;

    /* "cpython/contextvars.pxd":125
 *         # value or default value of context variable
 *         pyvalue = <object>value
 *         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'             # <<<<<<<<<<<<<<
 *     return pyvalue
 * 
 */
    Py_XDECREF(__pyx_v_value);
  }
  __pyx_L3:;

  /* "cpython/contextvars.pxd":126
 *         pyvalue = <object>value
 *         Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
 *     return pyvalue             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_pyvalue);
  __pyx_r = __pyx_v_pyvalue;
  goto __pyx_L0;

  /* "cpython/contextvars.pxd":112
 * 
 * 
 * cdef inline object get_value(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the default value of the context variable,
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("cpython.contextvars.get_value", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_pyvalue);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "cpython/contextvars.pxd":129
 * 
 * 
 * cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the provided default value if no such value was found.
 */

static CYTHON_INLINE PyObject *__pyx_f_7cpython_11contextvars_get_value_no_default(PyObject *__pyx_v_var, struct __pyx_opt_args_7cpython_11contextvars_get_value_no_default *__pyx_optional_args) {
  PyObject *__pyx_v_default_value = ((PyObject *)Py_None);
  PyObject *__pyx_v_value;
  PyObject *__pyx_v_pyvalue = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("get_value_no_default", 0);
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_default_value = __pyx_optional_args->default_value;
    }
  }

  /* "cpython/contextvars.pxd":135
 *     Ignores the default value of the context variable, if any.
 *     """
 *     cdef PyObject *value = NULL             # <<<<<<<<<<<<<<
 *     PyContextVar_Get(var, <PyObject*>default_value, &value)
 *     # value of context variable or 'default_value'
 */
  __pyx_v_value = NULL;

  /* "cpython/contextvars.pxd":136
 *     """
 *     cdef PyObject *value = NULL
 *     PyContextVar_Get(var, <PyObject*>default_value, &value)             # <<<<<<<<<<<<<<
 *     # value of context variable or 'default_value'
 *     pyvalue = <object>value
 */
  __pyx_t_1 = PyContextVar_Get(__pyx_v_var, ((PyObject *)__pyx_v_default_value), (&__pyx_v_value)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(2, 136, __pyx_L1_error)

  /* "cpython/contextvars.pxd":138
 *     PyContextVar_Get(var, <PyObject*>default_value, &value)
 *     # value of context variable or 'default_value'
 *     pyvalue = <object>value             # <<<<<<<<<<<<<<
 *     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
 *     return pyvalue
 */
  __pyx_t_2 = ((PyObject *)__pyx_v_value);
  __Pyx_INCREF(__pyx_t_2);
  __pyx_v_pyvalue = __pyx_t_2;
  __pyx_t_2 = 0;

  /* "cpython/contextvars.pxd":139
 *     # value of context variable or 'default_value'
 *     pyvalue = <object>value
 *     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'             # <<<<<<<<<<<<<<
 *     return pyvalue
 */
  Py_XDECREF(__pyx_v_value);

  /* "cpython/contextvars.pxd":140
 *     pyvalue = <object>value
 *     Py_XDECREF(value)  # PyContextVar_Get() returned an owned reference as 'PyObject*'
 *     return pyvalue             # <<<<<<<<<<<<<<
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_pyvalue);
  __pyx_r = __pyx_v_pyvalue;
  goto __pyx_L0;

  /* "cpython/contextvars.pxd":129
 * 
 * 
 * cdef inline object get_value_no_default(var, default_value=None):             # <<<<<<<<<<<<<<
 *     """Return a new reference to the value of the context variable,
 *     or the provided default value if no such value was found.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_AddTraceback("cpython.contextvars.get_value_no_default", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_pyvalue);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":104
 *             __data_union data
 * 
 *         def __getbuffer__(self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
 *             # This implementation of getbuffer is geared towards Cython
 *             # requirements, and does not yet fulfill the PEP.
 */

/* Python wrapper */
CYTHON_UNUSED static int __pyx_pw_7cpython_5array_5array_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags); /*proto*/
CYTHON_UNUSED static int __pyx_pw_7cpython_5array_5array_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__getbuffer__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_7cpython_5array_5array___getbuffer__(((arrayobject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info), ((int)__pyx_v_flags));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_7cpython_5array_5array___getbuffer__(arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info, CYTHON_UNUSED int __pyx_v_flags) {
  PyObject *__pyx_v_item_count = NULL;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  char *__pyx_t_2;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  Py_ssize_t __pyx_t_5;
  int __pyx_t_6;
  char __pyx_t_7;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  if (unlikely(__pyx_v_info == NULL)) {
    PyErr_SetString(PyExc_BufferError, "PyObject_GetBuffer: view==NULL argument is obsolete");
    return -1;
  }
  __Pyx_RefNannySetupContext("__getbuffer__", 0);
  __pyx_v_info->obj = Py_None; __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(__pyx_v_info->obj);

  /* "array.pxd":109
 *             # In particular strided access is always provided regardless
 *             # of flags
 *             item_count = Py_SIZE(self)             # <<<<<<<<<<<<<<
 * 
 *             info.suboffsets = NULL
 */
  __pyx_t_1 = PyInt_FromSsize_t(Py_SIZE(((PyObject *)__pyx_v_self))); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 109, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_item_count = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "array.pxd":111
 *             item_count = Py_SIZE(self)
 * 
 *             info.suboffsets = NULL             # <<<<<<<<<<<<<<
 *             info.buf = self.data.as_chars
 *             info.readonly = 0
 */
  __pyx_v_info->suboffsets = NULL;

  /* "array.pxd":112
 * 
 *             info.suboffsets = NULL
 *             info.buf = self.data.as_chars             # <<<<<<<<<<<<<<
 *             info.readonly = 0
 *             info.ndim = 1
 */
  __pyx_t_2 = __pyx_v_self->data.as_chars;
  __pyx_v_info->buf = __pyx_t_2;

  /* "array.pxd":113
 *             info.suboffsets = NULL
 *             info.buf = self.data.as_chars
 *             info.readonly = 0             # <<<<<<<<<<<<<<
 *             info.ndim = 1
 *             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
 */
  __pyx_v_info->readonly = 0;

  /* "array.pxd":114
 *             info.buf = self.data.as_chars
 *             info.readonly = 0
 *             info.ndim = 1             # <<<<<<<<<<<<<<
 *             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
 *             info.len = info.itemsize * item_count
 */
  __pyx_v_info->ndim = 1;

  /* "array.pxd":115
 *             info.readonly = 0
 *             info.ndim = 1
 *             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)             # <<<<<<<<<<<<<<
 *             info.len = info.itemsize * item_count
 * 
 */
  __pyx_t_3 = __pyx_v_self->ob_descr->itemsize;
  __pyx_v_info->itemsize = __pyx_t_3;

  /* "array.pxd":116
 *             info.ndim = 1
 *             info.itemsize = self.ob_descr.itemsize   # e.g. sizeof(float)
 *             info.len = info.itemsize * item_count             # <<<<<<<<<<<<<<
 * 
 *             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
 */
  __pyx_t_1 = PyInt_FromSsize_t(__pyx_v_info->itemsize); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 116, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_4 = PyNumber_Multiply(__pyx_t_1, __pyx_v_item_count); if (unlikely(!__pyx_t_4)) __PYX_ERR(3, 116, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __Pyx_PyIndex_AsSsize_t(__pyx_t_4); if (unlikely((__pyx_t_5 == (Py_ssize_t)-1) && PyErr_Occurred())) __PYX_ERR(3, 116, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_v_info->len = __pyx_t_5;

  /* "array.pxd":118
 *             info.len = info.itemsize * item_count
 * 
 *             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)             # <<<<<<<<<<<<<<
 *             if not info.shape:
 *                 raise MemoryError()
 */
  __pyx_v_info->shape = ((Py_ssize_t *)PyObject_Malloc(((sizeof(Py_ssize_t)) + 2)));

  /* "array.pxd":119
 * 
 *             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
 *             if not info.shape:             # <<<<<<<<<<<<<<
 *                 raise MemoryError()
 *             info.shape[0] = item_count      # constant regardless of resizing
 */
  __pyx_t_6 = (!(__pyx_v_info->shape != 0));
  if (unlikely(__pyx_t_6)) {

    /* "array.pxd":120
 *             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
 *             if not info.shape:
 *                 raise MemoryError()             # <<<<<<<<<<<<<<
 *             info.shape[0] = item_count      # constant regardless of resizing
 *             info.strides = &info.itemsize
 */
    PyErr_NoMemory(); __PYX_ERR(3, 120, __pyx_L1_error)

    /* "array.pxd":119
 * 
 *             info.shape = <Py_ssize_t*> PyObject_Malloc(sizeof(Py_ssize_t) + 2)
 *             if not info.shape:             # <<<<<<<<<<<<<<
 *                 raise MemoryError()
 *             info.shape[0] = item_count      # constant regardless of resizing
 */
  }

  /* "array.pxd":121
 *             if not info.shape:
 *                 raise MemoryError()
 *             info.shape[0] = item_count      # constant regardless of resizing             # <<<<<<<<<<<<<<
 *             info.strides = &info.itemsize
 * 
 */
  __pyx_t_5 = __Pyx_PyIndex_AsSsize_t(__pyx_v_item_count); if (unlikely((__pyx_t_5 == (Py_ssize_t)-1) && PyErr_Occurred())) __PYX_ERR(3, 121, __pyx_L1_error)
  (__pyx_v_info->shape[0]) = __pyx_t_5;

  /* "array.pxd":122
 *                 raise MemoryError()
 *             info.shape[0] = item_count      # constant regardless of resizing
 *             info.strides = &info.itemsize             # <<<<<<<<<<<<<<
 * 
 *             info.format = <char*> (info.shape + 1)
 */
  __pyx_v_info->strides = (&__pyx_v_info->itemsize);

  /* "array.pxd":124
 *             info.strides = &info.itemsize
 * 
 *             info.format = <char*> (info.shape + 1)             # <<<<<<<<<<<<<<
 *             info.format[0] = self.ob_descr.typecode
 *             info.format[1] = 0
 */
  __pyx_v_info->format = ((char *)(__pyx_v_info->shape + 1));

  /* "array.pxd":125
 * 
 *             info.format = <char*> (info.shape + 1)
 *             info.format[0] = self.ob_descr.typecode             # <<<<<<<<<<<<<<
 *             info.format[1] = 0
 *             info.obj = self
 */
  __pyx_t_7 = __pyx_v_self->ob_descr->typecode;
  (__pyx_v_info->format[0]) = __pyx_t_7;

  /* "array.pxd":126
 *             info.format = <char*> (info.shape + 1)
 *             info.format[0] = self.ob_descr.typecode
 *             info.format[1] = 0             # <<<<<<<<<<<<<<
 *             info.obj = self
 * 
 */
  (__pyx_v_info->format[1]) = 0;

  /* "array.pxd":127
 *             info.format[0] = self.ob_descr.typecode
 *             info.format[1] = 0
 *             info.obj = self             # <<<<<<<<<<<<<<
 * 
 *         def __releasebuffer__(self, Py_buffer* info):
 */
  __Pyx_INCREF((PyObject *)__pyx_v_self);
  __Pyx_GIVEREF((PyObject *)__pyx_v_self);
  __Pyx_GOTREF(__pyx_v_info->obj);
  __Pyx_DECREF(__pyx_v_info->obj);
  __pyx_v_info->obj = ((PyObject *)__pyx_v_self);

  /* "array.pxd":104
 *             __data_union data
 * 
 *         def __getbuffer__(self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
 *             # This implementation of getbuffer is geared towards Cython
 *             # requirements, and does not yet fulfill the PEP.
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("cpython.array.array.__getbuffer__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  if (__pyx_v_info->obj != NULL) {
    __Pyx_GOTREF(__pyx_v_info->obj);
    __Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
  }
  goto __pyx_L2;
  __pyx_L0:;
  if (__pyx_v_info->obj == Py_None) {
    __Pyx_GOTREF(__pyx_v_info->obj);
    __Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
  }
  __pyx_L2:;
  __Pyx_XDECREF(__pyx_v_item_count);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":129
 *             info.obj = self
 * 
 *         def __releasebuffer__(self, Py_buffer* info):             # <<<<<<<<<<<<<<
 *             PyObject_Free(info.shape)
 * 
 */

/* Python wrapper */
CYTHON_UNUSED static void __pyx_pw_7cpython_5array_5array_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info); /*proto*/
CYTHON_UNUSED static void __pyx_pw_7cpython_5array_5array_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__releasebuffer__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_pf_7cpython_5array_5array_2__releasebuffer__(((arrayobject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_7cpython_5array_5array_2__releasebuffer__(CYTHON_UNUSED arrayobject *__pyx_v_self, Py_buffer *__pyx_v_info) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__releasebuffer__", 0);

  /* "array.pxd":130
 * 
 *         def __releasebuffer__(self, Py_buffer* info):
 *             PyObject_Free(info.shape)             # <<<<<<<<<<<<<<
 * 
 *     array newarrayobject(PyTypeObject* type, Py_ssize_t size, arraydescr *descr)
 */
  PyObject_Free(__pyx_v_info->shape);

  /* "array.pxd":129
 *             info.obj = self
 * 
 *         def __releasebuffer__(self, Py_buffer* info):             # <<<<<<<<<<<<<<
 *             PyObject_Free(info.shape)
 * 
 */

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

/* "array.pxd":141
 * 
 * 
 * cdef inline array clone(array template, Py_ssize_t length, bint zero):             # <<<<<<<<<<<<<<
 *     """ fast creation of a new array, given a template array.
 *     type will be same as template.
 */

static CYTHON_INLINE arrayobject *__pyx_f_7cpython_5array_clone(arrayobject *__pyx_v_template, Py_ssize_t __pyx_v_length, int __pyx_v_zero) {
  arrayobject *__pyx_v_op = 0;
  arrayobject *__pyx_r = NULL;
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  int __pyx_t_3;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("clone", 0);

  /* "array.pxd":145
 *     type will be same as template.
 *     if zero is true, new array will be initialized with zeroes."""
 *     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)             # <<<<<<<<<<<<<<
 *     if zero and op is not None:
 *         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
 */
  __pyx_t_1 = ((PyObject *)newarrayobject(Py_TYPE(((PyObject *)__pyx_v_template)), __pyx_v_length, __pyx_v_template->ob_descr)); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 145, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_op = ((arrayobject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "array.pxd":146
 *     if zero is true, new array will be initialized with zeroes."""
 *     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
 *     if zero and op is not None:             # <<<<<<<<<<<<<<
 *         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
 *     return op
 */
  if (__pyx_v_zero) {
  } else {
    __pyx_t_2 = __pyx_v_zero;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_3 = (((PyObject *)__pyx_v_op) != Py_None);
  __pyx_t_2 = __pyx_t_3;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "array.pxd":147
 *     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
 *     if zero and op is not None:
 *         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)             # <<<<<<<<<<<<<<
 *     return op
 * 
 */
    (void)(memset(__pyx_v_op->data.as_chars, 0, (__pyx_v_length * __pyx_v_op->ob_descr->itemsize)));

    /* "array.pxd":146
 *     if zero is true, new array will be initialized with zeroes."""
 *     cdef array op = newarrayobject(Py_TYPE(template), length, template.ob_descr)
 *     if zero and op is not None:             # <<<<<<<<<<<<<<
 *         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
 *     return op
 */
  }

  /* "array.pxd":148
 *     if zero and op is not None:
 *         memset(op.data.as_chars, 0, length * op.ob_descr.itemsize)
 *     return op             # <<<<<<<<<<<<<<
 * 
 * cdef inline array copy(array self):
 */
  __Pyx_XDECREF((PyObject *)__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_op);
  __pyx_r = __pyx_v_op;
  goto __pyx_L0;

  /* "array.pxd":141
 * 
 * 
 * cdef inline array clone(array template, Py_ssize_t length, bint zero):             # <<<<<<<<<<<<<<
 *     """ fast creation of a new array, given a template array.
 *     type will be same as template.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("cpython.array.clone", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_op);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":150
 *     return op
 * 
 * cdef inline array copy(array self):             # <<<<<<<<<<<<<<
 *     """ make a copy of an array. """
 *     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
 */

static CYTHON_INLINE arrayobject *__pyx_f_7cpython_5array_copy(arrayobject *__pyx_v_self) {
  arrayobject *__pyx_v_op = 0;
  arrayobject *__pyx_r = NULL;
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("copy", 0);

  /* "array.pxd":152
 * cdef inline array copy(array self):
 *     """ make a copy of an array. """
 *     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)             # <<<<<<<<<<<<<<
 *     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)
 *     return op
 */
  __pyx_t_1 = ((PyObject *)newarrayobject(Py_TYPE(((PyObject *)__pyx_v_self)), Py_SIZE(((PyObject *)__pyx_v_self)), __pyx_v_self->ob_descr)); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 152, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_op = ((arrayobject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "array.pxd":153
 *     """ make a copy of an array. """
 *     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
 *     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)             # <<<<<<<<<<<<<<
 *     return op
 * 
 */
  (void)(memcpy(__pyx_v_op->data.as_chars, __pyx_v_self->data.as_chars, (Py_SIZE(((PyObject *)__pyx_v_op)) * __pyx_v_op->ob_descr->itemsize)));

  /* "array.pxd":154
 *     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
 *     memcpy(op.data.as_chars, self.data.as_chars, Py_SIZE(op) * op.ob_descr.itemsize)
 *     return op             # <<<<<<<<<<<<<<
 * 
 * cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:
 */
  __Pyx_XDECREF((PyObject *)__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_op);
  __pyx_r = __pyx_v_op;
  goto __pyx_L0;

  /* "array.pxd":150
 *     return op
 * 
 * cdef inline array copy(array self):             # <<<<<<<<<<<<<<
 *     """ make a copy of an array. """
 *     cdef array op = newarrayobject(Py_TYPE(self), Py_SIZE(self), self.ob_descr)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("cpython.array.copy", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_op);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":156
 *     return op
 * 
 * cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:             # <<<<<<<<<<<<<<
 *     """ efficient appending of new stuff of same type
 *     (e.g. of same array type)
 */

static CYTHON_INLINE int __pyx_f_7cpython_5array_extend_buffer(arrayobject *__pyx_v_self, char *__pyx_v_stuff, Py_ssize_t __pyx_v_n) {
  Py_ssize_t __pyx_v_itemsize;
  Py_ssize_t __pyx_v_origsize;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("extend_buffer", 0);

  /* "array.pxd":160
 *     (e.g. of same array type)
 *     n: number of elements (not number of bytes!) """
 *     cdef Py_ssize_t itemsize = self.ob_descr.itemsize             # <<<<<<<<<<<<<<
 *     cdef Py_ssize_t origsize = Py_SIZE(self)
 *     resize_smart(self, origsize + n)
 */
  __pyx_t_1 = __pyx_v_self->ob_descr->itemsize;
  __pyx_v_itemsize = __pyx_t_1;

  /* "array.pxd":161
 *     n: number of elements (not number of bytes!) """
 *     cdef Py_ssize_t itemsize = self.ob_descr.itemsize
 *     cdef Py_ssize_t origsize = Py_SIZE(self)             # <<<<<<<<<<<<<<
 *     resize_smart(self, origsize + n)
 *     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
 */
  __pyx_v_origsize = Py_SIZE(((PyObject *)__pyx_v_self));

  /* "array.pxd":162
 *     cdef Py_ssize_t itemsize = self.ob_descr.itemsize
 *     cdef Py_ssize_t origsize = Py_SIZE(self)
 *     resize_smart(self, origsize + n)             # <<<<<<<<<<<<<<
 *     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
 *     return 0
 */
  __pyx_t_1 = resize_smart(__pyx_v_self, (__pyx_v_origsize + __pyx_v_n)); if (unlikely(__pyx_t_1 == ((int)-1))) __PYX_ERR(3, 162, __pyx_L1_error)

  /* "array.pxd":163
 *     cdef Py_ssize_t origsize = Py_SIZE(self)
 *     resize_smart(self, origsize + n)
 *     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)             # <<<<<<<<<<<<<<
 *     return 0
 * 
 */
  (void)(memcpy((__pyx_v_self->data.as_chars + (__pyx_v_origsize * __pyx_v_itemsize)), __pyx_v_stuff, (__pyx_v_n * __pyx_v_itemsize)));

  /* "array.pxd":164
 *     resize_smart(self, origsize + n)
 *     memcpy(self.data.as_chars + origsize * itemsize, stuff, n * itemsize)
 *     return 0             # <<<<<<<<<<<<<<
 * 
 * cdef inline int extend(array self, array other) except -1:
 */
  __pyx_r = 0;
  goto __pyx_L0;

  /* "array.pxd":156
 *     return op
 * 
 * cdef inline int extend_buffer(array self, char* stuff, Py_ssize_t n) except -1:             # <<<<<<<<<<<<<<
 *     """ efficient appending of new stuff of same type
 *     (e.g. of same array type)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("cpython.array.extend_buffer", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":166
 *     return 0
 * 
 * cdef inline int extend(array self, array other) except -1:             # <<<<<<<<<<<<<<
 *     """ extend array with data from another array; types must match. """
 *     if self.ob_descr.typecode != other.ob_descr.typecode:
 */

static CYTHON_INLINE int __pyx_f_7cpython_5array_extend(arrayobject *__pyx_v_self, arrayobject *__pyx_v_other) {
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_t_2;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("extend", 0);

  /* "array.pxd":168
 * cdef inline int extend(array self, array other) except -1:
 *     """ extend array with data from another array; types must match. """
 *     if self.ob_descr.typecode != other.ob_descr.typecode:             # <<<<<<<<<<<<<<
 *         PyErr_BadArgument()
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
 */
  __pyx_t_1 = (__pyx_v_self->ob_descr->typecode != __pyx_v_other->ob_descr->typecode);
  if (__pyx_t_1) {

    /* "array.pxd":169
 *     """ extend array with data from another array; types must match. """
 *     if self.ob_descr.typecode != other.ob_descr.typecode:
 *         PyErr_BadArgument()             # <<<<<<<<<<<<<<
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
 * 
 */
    __pyx_t_2 = PyErr_BadArgument(); if (unlikely(__pyx_t_2 == ((int)0))) __PYX_ERR(3, 169, __pyx_L1_error)

    /* "array.pxd":168
 * cdef inline int extend(array self, array other) except -1:
 *     """ extend array with data from another array; types must match. """
 *     if self.ob_descr.typecode != other.ob_descr.typecode:             # <<<<<<<<<<<<<<
 *         PyErr_BadArgument()
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
 */
  }

  /* "array.pxd":170
 *     if self.ob_descr.typecode != other.ob_descr.typecode:
 *         PyErr_BadArgument()
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))             # <<<<<<<<<<<<<<
 * 
 * cdef inline void zero(array self):
 */
  __pyx_t_2 = __pyx_f_7cpython_5array_extend_buffer(__pyx_v_self, __pyx_v_other->data.as_chars, Py_SIZE(((PyObject *)__pyx_v_other))); if (unlikely(__pyx_t_2 == ((int)-1))) __PYX_ERR(3, 170, __pyx_L1_error)
  __pyx_r = __pyx_t_2;
  goto __pyx_L0;

  /* "array.pxd":166
 *     return 0
 * 
 * cdef inline int extend(array self, array other) except -1:             # <<<<<<<<<<<<<<
 *     """ extend array with data from another array; types must match. """
 *     if self.ob_descr.typecode != other.ob_descr.typecode:
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("cpython.array.extend", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "array.pxd":172
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
 * 
 * cdef inline void zero(array self):             # <<<<<<<<<<<<<<
 *     """ set all elements of array to zero. """
 *     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)
 */

static CYTHON_INLINE void __pyx_f_7cpython_5array_zero(arrayobject *__pyx_v_self) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("zero", 0);

  /* "array.pxd":174
 * cdef inline void zero(array self):
 *     """ set all elements of array to zero. """
 *     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)             # <<<<<<<<<<<<<<
 */
  (void)(memset(__pyx_v_self->data.as_chars, 0, (Py_SIZE(((PyObject *)__pyx_v_self)) * __pyx_v_self->ob_descr->itemsize)));

  /* "array.pxd":172
 *     return extend_buffer(self, other.data.as_chars, Py_SIZE(other))
 * 
 * cdef inline void zero(array self):             # <<<<<<<<<<<<<<
 *     """ set all elements of array to zero. """
 *     memset(self.data.as_chars, 0, Py_SIZE(self) * self.ob_descr.itemsize)
 */

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

/* "pysam/libctabix.pyx":84
 * cdef class Parser:
 * 
 *     def __init__(self, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_6Parser_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_6Parser_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_encoding = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 84, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_encoding,0};
    values[0] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_n_u_ascii));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_encoding);
          if (value) { values[0] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 84, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 84, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_encoding = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 0, 0, 1, __pyx_nargs); __PYX_ERR(0, 84, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.Parser.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser___init__(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self), __pyx_v_encoding);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_6Parser___init__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v_encoding) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 84, 0, __PYX_ERR(0, 84, __pyx_L1_error));

  /* "pysam/libctabix.pyx":85
 * 
 *     def __init__(self, encoding="ascii"):
 *         self.encoding = encoding             # <<<<<<<<<<<<<<
 * 
 *     def set_encoding(self, encoding):
 */
  __Pyx_INCREF(__pyx_v_encoding);
  __Pyx_GIVEREF(__pyx_v_encoding);
  __Pyx_GOTREF(__pyx_v_self->encoding);
  __Pyx_DECREF(__pyx_v_self->encoding);
  __pyx_v_self->encoding = __pyx_v_encoding;

  /* "pysam/libctabix.pyx":84
 * cdef class Parser:
 * 
 *     def __init__(self, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.Parser.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":87
 *         self.encoding = encoding
 * 
 *     def set_encoding(self, encoding):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_3set_encoding(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6Parser_2set_encoding, "Parser.set_encoding(self, encoding)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6Parser_3set_encoding = {"set_encoding", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_3set_encoding, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_2set_encoding};
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_3set_encoding(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_encoding = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("set_encoding (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 87, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_encoding,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_encoding)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 87, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "set_encoding") < 0)) __PYX_ERR(0, 87, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v_encoding = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("set_encoding", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 87, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.Parser.set_encoding", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser_2set_encoding(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self), __pyx_v_encoding);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_2set_encoding(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v_encoding) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj_)
  __Pyx_RefNannySetupContext("set_encoding", 0);
  __Pyx_TraceCall("set_encoding", __pyx_f[0], 87, 0, __PYX_ERR(0, 87, __pyx_L1_error));

  /* "pysam/libctabix.pyx":88
 * 
 *     def set_encoding(self, encoding):
 *         self.encoding = encoding             # <<<<<<<<<<<<<<
 * 
 *     def get_encoding(self):
 */
  __Pyx_INCREF(__pyx_v_encoding);
  __Pyx_GIVEREF(__pyx_v_encoding);
  __Pyx_GOTREF(__pyx_v_self->encoding);
  __Pyx_DECREF(__pyx_v_self->encoding);
  __pyx_v_self->encoding = __pyx_v_encoding;

  /* "pysam/libctabix.pyx":87
 *         self.encoding = encoding
 * 
 *     def set_encoding(self, encoding):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.Parser.set_encoding", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":90
 *         self.encoding = encoding
 * 
 *     def get_encoding(self):             # <<<<<<<<<<<<<<
 *         return self.encoding
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_5get_encoding(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6Parser_4get_encoding, "Parser.get_encoding(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6Parser_5get_encoding = {"get_encoding", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_5get_encoding, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_4get_encoding};
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_5get_encoding(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("get_encoding (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 90, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("get_encoding", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "get_encoding", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.Parser.get_encoding", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser_4get_encoding(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_4get_encoding(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__2)
  __Pyx_RefNannySetupContext("get_encoding", 0);
  __Pyx_TraceCall("get_encoding", __pyx_f[0], 90, 0, __PYX_ERR(0, 90, __pyx_L1_error));

  /* "pysam/libctabix.pyx":91
 * 
 *     def get_encoding(self):
 *         return self.encoding             # <<<<<<<<<<<<<<
 * 
 *     cdef parse(self, char * buffer, int length):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_self->encoding);
  __pyx_r = __pyx_v_self->encoding;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":90
 *         self.encoding = encoding
 * 
 *     def get_encoding(self):             # <<<<<<<<<<<<<<
 *         return self.encoding
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.Parser.get_encoding", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":93
 *         return self.encoding
 * 
 *     cdef parse(self, char * buffer, int length):             # <<<<<<<<<<<<<<
 *         raise NotImplementedError(
 *             'parse method of %s not implemented' % str(self))
 */

static PyObject *__pyx_f_5pysam_9libctabix_6Parser_parse(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, CYTHON_UNUSED char *__pyx_v_buffer, CYTHON_UNUSED int __pyx_v_length) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 93, 0, __PYX_ERR(0, 93, __pyx_L1_error));

  /* "pysam/libctabix.pyx":95
 *     cdef parse(self, char * buffer, int length):
 *         raise NotImplementedError(
 *             'parse method of %s not implemented' % str(self))             # <<<<<<<<<<<<<<
 * 
 *     def __call__(self, char * buffer, int length):
 */
  __pyx_t_1 = __Pyx_PyObject_Str(((PyObject *)__pyx_v_self)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 95, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_parse_method_of_s_not_implemente, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 95, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":94
 * 
 *     cdef parse(self, char * buffer, int length):
 *         raise NotImplementedError(             # <<<<<<<<<<<<<<
 *             'parse method of %s not implemented' % str(self))
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(__pyx_builtin_NotImplementedError, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 94, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_Raise(__pyx_t_1, 0, 0, 0);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __PYX_ERR(0, 94, __pyx_L1_error)

  /* "pysam/libctabix.pyx":93
 *         return self.encoding
 * 
 *     cdef parse(self, char * buffer, int length):             # <<<<<<<<<<<<<<
 *         raise NotImplementedError(
 *             'parse method of %s not implemented' % str(self))
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_AddTraceback("pysam.libctabix.Parser.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":97
 *             'parse method of %s not implemented' % str(self))
 * 
 *     def __call__(self, char * buffer, int length):             # <<<<<<<<<<<<<<
 *         return self.parse(buffer, length)
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_7__call__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_7__call__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  char *__pyx_v_buffer;
  int __pyx_v_length;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[2] = {0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__call__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 97, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_buffer,&__pyx_n_s_length,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_buffer)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 97, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_length)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 97, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__call__", 1, 2, 2, 1); __PYX_ERR(0, 97, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__call__") < 0)) __PYX_ERR(0, 97, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 2)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
      values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
    }
    __pyx_v_buffer = __Pyx_PyObject_AsWritableString(values[0]); if (unlikely((!__pyx_v_buffer) && PyErr_Occurred())) __PYX_ERR(0, 97, __pyx_L3_error)
    __pyx_v_length = __Pyx_PyInt_As_int(values[1]); if (unlikely((__pyx_v_length == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 97, __pyx_L3_error)
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__call__", 1, 2, 2, __pyx_nargs); __PYX_ERR(0, 97, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.Parser.__call__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser_6__call__(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self), __pyx_v_buffer, __pyx_v_length);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_6__call__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_length) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__call__", 0);
  __Pyx_TraceCall("__call__", __pyx_f[0], 97, 0, __PYX_ERR(0, 97, __pyx_L1_error));

  /* "pysam/libctabix.pyx":98
 * 
 *     def __call__(self, char * buffer, int length):
 *         return self.parse(buffer, length)             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_Parser *)__pyx_v_self->__pyx_vtab)->parse(__pyx_v_self, __pyx_v_buffer, __pyx_v_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 98, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":97
 *             'parse method of %s not implemented' % str(self))
 * 
 *     def __call__(self, char * buffer, int length):             # <<<<<<<<<<<<<<
 *         return self.parse(buffer, length)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.Parser.__call__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6Parser_8__reduce_cython__, "Parser.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6Parser_9__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_8__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.Parser.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser_8__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_8__reduce_cython__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__3)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->encoding);
  __Pyx_GIVEREF(__pyx_v_self->encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_Parser); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_Parser); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.Parser.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6Parser_10__setstate_cython__, "Parser.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6Parser_11__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_10__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_6Parser_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.Parser.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6Parser_10__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6Parser_10__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__4)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_Parser__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.Parser.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":106
 *     A field in a row is accessed by numeric index.
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.TupleProxy r
 *         r = ctabixproxies.TupleProxy(self.encoding)
 */

static PyObject *__pyx_f_5pysam_9libctabix_7asTuple_parse(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len) {
  struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *__pyx_v_r = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 106, 0, __PYX_ERR(0, 106, __pyx_L1_error));

  /* "pysam/libctabix.pyx":108
 *     cdef parse(self, char * buffer, int len):
 *         cdef ctabixproxies.TupleProxy r
 *         r = ctabixproxies.TupleProxy(self.encoding)             # <<<<<<<<<<<<<<
 *         # need to copy - there were some
 *         # persistence issues with "present"
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_16libctabixproxies_TupleProxy), __pyx_v_self->__pyx_base.encoding); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 108, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_r = ((struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":111
 *         # need to copy - there were some
 *         # persistence issues with "present"
 *         r.copy(buffer, len)             # <<<<<<<<<<<<<<
 *         return r
 * 
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy *)__pyx_v_r->__pyx_vtab)->copy(__pyx_v_r, __pyx_v_buffer, __pyx_v_len, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 111, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":112
 *         # persistence issues with "present"
 *         r.copy(buffer, len)
 *         return r             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_r);
  __pyx_r = ((PyObject *)__pyx_v_r);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":106
 *     A field in a row is accessed by numeric index.
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.TupleProxy r
 *         r = ctabixproxies.TupleProxy(self.encoding)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asTuple.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_r);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_7asTuple_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_7asTuple___reduce_cython__, "asTuple.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_7asTuple_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_7asTuple_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_7asTuple___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_7asTuple_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.asTuple.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_7asTuple___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_asTuple *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_7asTuple___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__5)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.encoding);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->__pyx_base.encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_asTuple); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_asTuple); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.asTuple.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_7asTuple_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_7asTuple_2__setstate_cython__, "asTuple.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_7asTuple_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_7asTuple_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_7asTuple_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_7asTuple_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.asTuple.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_7asTuple_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_asTuple *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_7asTuple_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__6)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asTuple__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asTuple.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":144
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.GFF3Proxy r
 *         r = ctabixproxies.GFF3Proxy(self.encoding)
 */

static PyObject *__pyx_f_5pysam_9libctabix_6asGFF3_parse(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len) {
  struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy *__pyx_v_r = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 144, 0, __PYX_ERR(0, 144, __pyx_L1_error));

  /* "pysam/libctabix.pyx":146
 *     cdef parse(self, char * buffer, int len):
 *         cdef ctabixproxies.GFF3Proxy r
 *         r = ctabixproxies.GFF3Proxy(self.encoding)             # <<<<<<<<<<<<<<
 *         r.copy(buffer, len)
 *         return r
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy), __pyx_v_self->__pyx_base.encoding); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 146, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_r = ((struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":147
 *         cdef ctabixproxies.GFF3Proxy r
 *         r = ctabixproxies.GFF3Proxy(self.encoding)
 *         r.copy(buffer, len)             # <<<<<<<<<<<<<<
 *         return r
 * 
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_16libctabixproxies_GFF3Proxy *)__pyx_v_r->__pyx_base.__pyx_base.__pyx_base.__pyx_vtab)->__pyx_base.__pyx_base.__pyx_base.copy(((struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *)__pyx_v_r), __pyx_v_buffer, __pyx_v_len, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 147, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":148
 *         r = ctabixproxies.GFF3Proxy(self.encoding)
 *         r.copy(buffer, len)
 *         return r             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_r);
  __pyx_r = ((PyObject *)__pyx_v_r);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":144
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.GFF3Proxy r
 *         r = ctabixproxies.GFF3Proxy(self.encoding)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asGFF3.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_r);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6asGFF3_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6asGFF3___reduce_cython__, "asGFF3.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6asGFF3_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6asGFF3_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6asGFF3___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_6asGFF3_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.asGFF3.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6asGFF3___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_asGFF3 *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6asGFF3___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__7)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.encoding);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->__pyx_base.encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_asGFF3); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_asGFF3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.asGFF3.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_6asGFF3_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6asGFF3_2__setstate_cython__, "asGFF3.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_6asGFF3_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6asGFF3_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6asGFF3_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_6asGFF3_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.asGFF3.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6asGFF3_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_asGFF3 *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6asGFF3_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__8)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asGFF3__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asGFF3.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":191
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.GTFProxy r
 *         r = ctabixproxies.GTFProxy(self.encoding)
 */

static PyObject *__pyx_f_5pysam_9libctabix_5asGTF_parse(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len) {
  struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy *__pyx_v_r = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 191, 0, __PYX_ERR(0, 191, __pyx_L1_error));

  /* "pysam/libctabix.pyx":193
 *     cdef parse(self, char * buffer, int len):
 *         cdef ctabixproxies.GTFProxy r
 *         r = ctabixproxies.GTFProxy(self.encoding)             # <<<<<<<<<<<<<<
 *         r.copy(buffer, len)
 *         return r
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_16libctabixproxies_GTFProxy), __pyx_v_self->__pyx_base.encoding); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 193, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_r = ((struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":194
 *         cdef ctabixproxies.GTFProxy r
 *         r = ctabixproxies.GTFProxy(self.encoding)
 *         r.copy(buffer, len)             # <<<<<<<<<<<<<<
 *         return r
 * 
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_16libctabixproxies_GTFProxy *)__pyx_v_r->__pyx_base.__pyx_base.__pyx_vtab)->__pyx_base.__pyx_base.copy(((struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *)__pyx_v_r), __pyx_v_buffer, __pyx_v_len, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 194, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":195
 *         r = ctabixproxies.GTFProxy(self.encoding)
 *         r.copy(buffer, len)
 *         return r             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_r);
  __pyx_r = ((PyObject *)__pyx_v_r);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":191
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.GTFProxy r
 *         r = ctabixproxies.GTFProxy(self.encoding)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asGTF.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_r);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asGTF_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asGTF___reduce_cython__, "asGTF.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asGTF_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asGTF_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asGTF___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asGTF_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.asGTF.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asGTF___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_asGTF *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asGTF___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__9)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.encoding);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->__pyx_base.encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_asGTF); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_asGTF); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.asGTF.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asGTF_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asGTF_2__setstate_cython__, "asGTF.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asGTF_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asGTF_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asGTF_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asGTF_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.asGTF.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asGTF_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_asGTF *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asGTF_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__10)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asGTF__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asGTF.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":239
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.BedProxy r
 *         r = ctabixproxies.BedProxy(self.encoding)
 */

static PyObject *__pyx_f_5pysam_9libctabix_5asBed_parse(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len) {
  struct __pyx_obj_5pysam_16libctabixproxies_BedProxy *__pyx_v_r = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 239, 0, __PYX_ERR(0, 239, __pyx_L1_error));

  /* "pysam/libctabix.pyx":241
 *     cdef parse(self, char * buffer, int len):
 *         cdef ctabixproxies.BedProxy r
 *         r = ctabixproxies.BedProxy(self.encoding)             # <<<<<<<<<<<<<<
 *         r.copy(buffer, len)
 *         return r
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_16libctabixproxies_BedProxy), __pyx_v_self->__pyx_base.encoding); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 241, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_r = ((struct __pyx_obj_5pysam_16libctabixproxies_BedProxy *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":242
 *         cdef ctabixproxies.BedProxy r
 *         r = ctabixproxies.BedProxy(self.encoding)
 *         r.copy(buffer, len)             # <<<<<<<<<<<<<<
 *         return r
 * 
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_16libctabixproxies_BedProxy *)__pyx_v_r->__pyx_base.__pyx_base.__pyx_vtab)->__pyx_base.__pyx_base.copy(((struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *)__pyx_v_r), __pyx_v_buffer, __pyx_v_len, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 242, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":243
 *         r = ctabixproxies.BedProxy(self.encoding)
 *         r.copy(buffer, len)
 *         return r             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_r);
  __pyx_r = ((PyObject *)__pyx_v_r);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":239
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.BedProxy r
 *         r = ctabixproxies.BedProxy(self.encoding)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asBed.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_r);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asBed_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asBed___reduce_cython__, "asBed.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asBed_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asBed_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asBed___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asBed_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.asBed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asBed___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_asBed *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asBed___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__11)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.encoding);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->__pyx_base.encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_asBed); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_asBed); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.asBed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asBed_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asBed_2__setstate_cython__, "asBed.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asBed_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asBed_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asBed_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asBed_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.asBed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asBed_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_asBed *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asBed_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__12)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asBed__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asBed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":280
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.VCFProxy r
 *         r = ctabixproxies.VCFProxy(self.encoding)
 */

static PyObject *__pyx_f_5pysam_9libctabix_5asVCF_parse(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self, char *__pyx_v_buffer, int __pyx_v_len) {
  struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy *__pyx_v_r = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("parse", 0);
  __Pyx_TraceCall("parse", __pyx_f[0], 280, 0, __PYX_ERR(0, 280, __pyx_L1_error));

  /* "pysam/libctabix.pyx":282
 *     cdef parse(self, char * buffer, int len):
 *         cdef ctabixproxies.VCFProxy r
 *         r = ctabixproxies.VCFProxy(self.encoding)             # <<<<<<<<<<<<<<
 *         r.copy(buffer, len)
 *         return r
 */
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_16libctabixproxies_VCFProxy), __pyx_v_self->__pyx_base.encoding); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_r = ((struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":283
 *         cdef ctabixproxies.VCFProxy r
 *         r = ctabixproxies.VCFProxy(self.encoding)
 *         r.copy(buffer, len)             # <<<<<<<<<<<<<<
 *         return r
 * 
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_16libctabixproxies_VCFProxy *)__pyx_v_r->__pyx_base.__pyx_base.__pyx_vtab)->__pyx_base.__pyx_base.copy(((struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy *)__pyx_v_r), __pyx_v_buffer, __pyx_v_len, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 283, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":284
 *         r = ctabixproxies.VCFProxy(self.encoding)
 *         r.copy(buffer, len)
 *         return r             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_r);
  __pyx_r = ((PyObject *)__pyx_v_r);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":280
 * 
 *     '''
 *     cdef parse(self, char * buffer, int len):             # <<<<<<<<<<<<<<
 *         cdef ctabixproxies.VCFProxy r
 *         r = ctabixproxies.VCFProxy(self.encoding)
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asVCF.parse", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_r);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asVCF_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asVCF___reduce_cython__, "asVCF.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asVCF_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asVCF_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asVCF___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asVCF_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.asVCF.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asVCF___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_asVCF *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asVCF___reduce_cython__(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self) {
  PyObject *__pyx_v_state = 0;
  PyObject *__pyx_v__dict = 0;
  int __pyx_v_use_setstate;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__13)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":5
 *     cdef object _dict
 *     cdef bint use_setstate
 *     state = (self.encoding,)             # <<<<<<<<<<<<<<
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 */
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.encoding);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.encoding);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.encoding)) __PYX_ERR(1, 5, __pyx_L1_error);
  __pyx_v_state = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "(tree fragment)":6
 *     cdef bint use_setstate
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)             # <<<<<<<<<<<<<<
 *     if _dict is not None:
 *         state += (_dict,)
 */
  __pyx_t_1 = __Pyx_GetAttr3(((PyObject *)__pyx_v_self), __pyx_n_s_dict, Py_None); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v__dict = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
  __pyx_t_2 = (__pyx_v__dict != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":8
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:
 *         state += (_dict,)             # <<<<<<<<<<<<<<
 *         use_setstate = True
 *     else:
 */
    __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_v__dict);
    __Pyx_GIVEREF(__pyx_v__dict);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v__dict)) __PYX_ERR(1, 8, __pyx_L1_error);
    __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_v_state, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 8, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF_SET(__pyx_v_state, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "(tree fragment)":9
 *     if _dict is not None:
 *         state += (_dict,)
 *         use_setstate = True             # <<<<<<<<<<<<<<
 *     else:
 *         use_setstate = self.encoding is not None
 */
    __pyx_v_use_setstate = 1;

    /* "(tree fragment)":7
 *     state = (self.encoding,)
 *     _dict = getattr(self, '__dict__', None)
 *     if _dict is not None:             # <<<<<<<<<<<<<<
 *         state += (_dict,)
 *         use_setstate = True
 */
    goto __pyx_L3;
  }

  /* "(tree fragment)":11
 *         use_setstate = True
 *     else:
 *         use_setstate = self.encoding is not None             # <<<<<<<<<<<<<<
 *     if use_setstate:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, None), state
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_self->__pyx_base.encoding != Py_None);
    __pyx_v_use_setstate = __pyx_t_2;
  }
  __pyx_L3:;

  /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, None), state
 *     else:
 */
  if (__pyx_v_use_setstate) {

    /* "(tree fragment)":13
 *         use_setstate = self.encoding is not None
 *     if use_setstate:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, None), state             # <<<<<<<<<<<<<<
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 */
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_pyx_unpickle_asVCF); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(Py_None);
    __Pyx_GIVEREF(Py_None);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, Py_None)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_4 = PyTuple_New(3); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 13, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_1)) __PYX_ERR(1, 13, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_state)) __PYX_ERR(1, 13, __pyx_L1_error);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;

    /* "(tree fragment)":12
 *     else:
 *         use_setstate = self.encoding is not None
 *     if use_setstate:             # <<<<<<<<<<<<<<
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, None), state
 *     else:
 */
  }

  /* "(tree fragment)":15
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, None), state
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)
 */
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pyx_unpickle_asVCF); if (unlikely(!__pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    __Pyx_GIVEREF(((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))));
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, ((PyObject *)Py_TYPE(((PyObject *)__pyx_v_self))))) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_int_243541226);
    __Pyx_GIVEREF(__pyx_int_243541226);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_int_243541226)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_state);
    __Pyx_GIVEREF(__pyx_v_state);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_v_state)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 15, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4)) __PYX_ERR(1, 15, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_1);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1)) __PYX_ERR(1, 15, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
  }

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.asVCF.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_state);
  __Pyx_XDECREF(__pyx_v__dict);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5asVCF_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_5asVCF_2__setstate_cython__, "asVCF.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5asVCF_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asVCF_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asVCF_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_5asVCF_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 16, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 16, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 16, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 16, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.asVCF.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_5asVCF_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_asVCF *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_5asVCF_2__setstate_cython__(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__14)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 16, 0, __PYX_ERR(1, 16, __pyx_L1_error));

  /* "(tree fragment)":17
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)             # <<<<<<<<<<<<<<
 */
  if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 17, __pyx_L1_error)
  __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asVCF__set_state(__pyx_v_self, ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.asVCF.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":334
 *         if file could not be opened
 *     """
 *     def __cinit__(self,             # <<<<<<<<<<<<<<
 *                   filename,
 *                   mode='r',
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_9TabixFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_9TabixFile_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_filename = 0;
  PyObject *__pyx_v_mode = 0;
  PyObject *__pyx_v_parser = 0;
  PyObject *__pyx_v_index = 0;
  PyObject *__pyx_v_encoding = 0;
  PyObject *__pyx_v_threads = 0;
  PyObject *__pyx_v_args = 0;
  PyObject *__pyx_v_kwargs = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[6] = {0,0,0,0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__cinit__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 334, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_v_kwargs = PyDict_New(); if (unlikely(!__pyx_v_kwargs)) return -1;
  __Pyx_GOTREF(__pyx_v_kwargs);
  __pyx_v_args = __Pyx_ArgsSlice_VARARGS(__pyx_args, 6, __pyx_nargs);
  if (unlikely(!__pyx_v_args)) {
    __Pyx_DECREF(__pyx_v_kwargs); __pyx_v_kwargs = 0;
    __Pyx_RefNannyFinishContext();
    return -1;
  }
  __Pyx_GOTREF(__pyx_v_args);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_mode,&__pyx_n_s_parser,&__pyx_n_s_index,&__pyx_n_s_encoding,&__pyx_n_s_threads,0};
    values[1] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_n_u_r));

    /* "pysam/libctabix.pyx":337
 *                   filename,
 *                   mode='r',
 *                   parser=None,             # <<<<<<<<<<<<<<
 *                   index=None,
 *                   encoding="ascii",
 */
    values[2] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":338
 *                   mode='r',
 *                   parser=None,
 *                   index=None,             # <<<<<<<<<<<<<<
 *                   encoding="ascii",
 *                   threads=1,
 */
    values[3] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)Py_None));
    values[4] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_n_u_ascii));
    values[5] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_int_1));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        default:
        case  6: values[5] = __Pyx_Arg_VARARGS(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_VARARGS(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_VARARGS(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_mode);
          if (value) { values[1] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser);
          if (value) { values[2] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_index);
          if (value) { values[3] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_encoding);
          if (value) { values[4] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_threads);
          if (value) { values[5] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 334, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        const Py_ssize_t used_pos_args = (kwd_pos_args < 6) ? kwd_pos_args : 6;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, __pyx_v_kwargs, values + 0, used_pos_args, "__cinit__") < 0)) __PYX_ERR(0, 334, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        default:
        case  6: values[5] = __Pyx_Arg_VARARGS(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_VARARGS(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_VARARGS(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        break;
        case  0:
        goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_filename = values[0];
    __pyx_v_mode = values[1];
    __pyx_v_parser = values[2];
    __pyx_v_index = values[3];
    __pyx_v_encoding = values[4];
    __pyx_v_threads = values[5];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 1, 6, __pyx_nargs); __PYX_ERR(0, 334, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_DECREF(__pyx_v_args); __pyx_v_args = 0;
  __Pyx_DECREF(__pyx_v_kwargs); __pyx_v_kwargs = 0;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile___cinit__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self), __pyx_v_filename, __pyx_v_mode, __pyx_v_parser, __pyx_v_index, __pyx_v_encoding, __pyx_v_threads, __pyx_v_args, __pyx_v_kwargs);

  /* "pysam/libctabix.pyx":334
 *         if file could not be opened
 *     """
 *     def __cinit__(self,             # <<<<<<<<<<<<<<
 *                   filename,
 *                   mode='r',
 */

  /* function exit code */
  __Pyx_DECREF(__pyx_v_args);
  __Pyx_DECREF(__pyx_v_kwargs);
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_9TabixFile___cinit__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_mode, PyObject *__pyx_v_parser, PyObject *__pyx_v_index, PyObject *__pyx_v_encoding, PyObject *__pyx_v_threads, PyObject *__pyx_v_args, PyObject *__pyx_v_kwargs) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__cinit__", 0);
  __Pyx_TraceCall("__cinit__", __pyx_f[0], 334, 0, __PYX_ERR(0, 334, __pyx_L1_error));

  /* "pysam/libctabix.pyx":344
 *                   **kwargs ):
 * 
 *         self.htsfile = NULL             # <<<<<<<<<<<<<<
 *         self.is_remote = False
 *         self.is_stream = False
 */
  __pyx_v_self->__pyx_base.htsfile = NULL;

  /* "pysam/libctabix.pyx":345
 * 
 *         self.htsfile = NULL
 *         self.is_remote = False             # <<<<<<<<<<<<<<
 *         self.is_stream = False
 *         self.parser = parser
 */
  __pyx_v_self->__pyx_base.is_remote = 0;

  /* "pysam/libctabix.pyx":346
 *         self.htsfile = NULL
 *         self.is_remote = False
 *         self.is_stream = False             # <<<<<<<<<<<<<<
 *         self.parser = parser
 *         self.threads = threads
 */
  __pyx_v_self->__pyx_base.is_stream = 0;

  /* "pysam/libctabix.pyx":347
 *         self.is_remote = False
 *         self.is_stream = False
 *         self.parser = parser             # <<<<<<<<<<<<<<
 *         self.threads = threads
 *         self._open(filename, mode, index, *args, **kwargs)
 */
  if (!(likely(((__pyx_v_parser) == Py_None) || likely(__Pyx_TypeTest(__pyx_v_parser, __pyx_ptype_5pysam_9libctabix_Parser))))) __PYX_ERR(0, 347, __pyx_L1_error)
  __pyx_t_1 = __pyx_v_parser;
  __Pyx_INCREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF((PyObject *)__pyx_v_self->parser);
  __Pyx_DECREF((PyObject *)__pyx_v_self->parser);
  __pyx_v_self->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":348
 *         self.is_stream = False
 *         self.parser = parser
 *         self.threads = threads             # <<<<<<<<<<<<<<
 *         self._open(filename, mode, index, *args, **kwargs)
 *         self.encoding = encoding
 */
  __Pyx_INCREF(__pyx_v_threads);
  __Pyx_GIVEREF(__pyx_v_threads);
  __Pyx_GOTREF(__pyx_v_self->__pyx_base.threads);
  __Pyx_DECREF(__pyx_v_self->__pyx_base.threads);
  __pyx_v_self->__pyx_base.threads = __pyx_v_threads;

  /* "pysam/libctabix.pyx":349
 *         self.parser = parser
 *         self.threads = threads
 *         self._open(filename, mode, index, *args, **kwargs)             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_open); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = PyTuple_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_v_filename);
  __Pyx_GIVEREF(__pyx_v_filename);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_v_filename)) __PYX_ERR(0, 349, __pyx_L1_error);
  __Pyx_INCREF(__pyx_v_mode);
  __Pyx_GIVEREF(__pyx_v_mode);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_v_mode)) __PYX_ERR(0, 349, __pyx_L1_error);
  __Pyx_INCREF(__pyx_v_index);
  __Pyx_GIVEREF(__pyx_v_index);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 2, __pyx_v_index)) __PYX_ERR(0, 349, __pyx_L1_error);
  __pyx_t_3 = PyNumber_Add(__pyx_t_2, __pyx_v_args); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = PyDict_Copy(__pyx_v_kwargs); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "pysam/libctabix.pyx":350
 *         self.threads = threads
 *         self._open(filename, mode, index, *args, **kwargs)
 *         self.encoding = encoding             # <<<<<<<<<<<<<<
 * 
 *     def _open( self,
 */
  __Pyx_INCREF(__pyx_v_encoding);
  __Pyx_GIVEREF(__pyx_v_encoding);
  __Pyx_GOTREF(__pyx_v_self->encoding);
  __Pyx_DECREF(__pyx_v_self->encoding);
  __pyx_v_self->encoding = __pyx_v_encoding;

  /* "pysam/libctabix.pyx":334
 *         if file could not be opened
 *     """
 *     def __cinit__(self,             # <<<<<<<<<<<<<<
 *                   filename,
 *                   mode='r',
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":352
 *         self.encoding = encoding
 * 
 *     def _open( self,             # <<<<<<<<<<<<<<
 *                filename,
 *                mode='r',
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_3_open(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_2_open, "TabixFile._open(self, filename, mode=u'r', index=None, threads=1)\nopen a :term:`tabix file` for reading.");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_3_open = {"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_3_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_2_open};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_3_open(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_filename = 0;
  PyObject *__pyx_v_mode = 0;
  PyObject *__pyx_v_index = 0;
  PyObject *__pyx_v_threads = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[4] = {0,0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("_open (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 352, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_mode,&__pyx_n_s_index,&__pyx_n_s_threads,0};
    values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)__pyx_n_u_r));

    /* "pysam/libctabix.pyx":355
 *                filename,
 *                mode='r',
 *                index=None,             # <<<<<<<<<<<<<<
 *                threads=1,
 *               ):
 */
    values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
    values[3] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)__pyx_int_1));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 352, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_mode);
          if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 352, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_index);
          if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 352, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_threads);
          if (value) { values[3] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 352, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "_open") < 0)) __PYX_ERR(0, 352, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_filename = values[0];
    __pyx_v_mode = values[1];
    __pyx_v_index = values[2];
    __pyx_v_threads = values[3];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("_open", 0, 1, 4, __pyx_nargs); __PYX_ERR(0, 352, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_2_open(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self), __pyx_v_filename, __pyx_v_mode, __pyx_v_index, __pyx_v_threads);

  /* "pysam/libctabix.pyx":352
 *         self.encoding = encoding
 * 
 *     def _open( self,             # <<<<<<<<<<<<<<
 *                filename,
 *                mode='r',
 */

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_2_open(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_mode, PyObject *__pyx_v_index, PyObject *__pyx_v_threads) {
  PyObject *__pyx_v_filename_index = NULL;
  char *__pyx_v_cfilename;
  char *__pyx_v_cfilename_index;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  char const *__pyx_t_6;
  int __pyx_t_7;
  char *__pyx_t_8;
  int64_t __pyx_t_9;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__15)
  __Pyx_RefNannySetupContext("_open", 0);
  __Pyx_TraceCall("_open", __pyx_f[0], 352, 0, __PYX_ERR(0, 352, __pyx_L1_error));

  /* "pysam/libctabix.pyx":360
 *         '''open a :term:`tabix file` for reading.'''
 * 
 *         if mode != 'r':             # <<<<<<<<<<<<<<
 *             raise ValueError("invalid file opening mode `%s`" % mode)
 * 
 */
  __pyx_t_1 = (__Pyx_PyUnicode_Equals(__pyx_v_mode, __pyx_n_u_r, Py_NE)); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 360, __pyx_L1_error)
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":361
 * 
 *         if mode != 'r':
 *             raise ValueError("invalid file opening mode `%s`" % mode)             # <<<<<<<<<<<<<<
 * 
 *         if self.htsfile != NULL:
 */
    __pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_invalid_file_opening_mode_s, __pyx_v_mode); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 361, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 361, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 361, __pyx_L1_error)

    /* "pysam/libctabix.pyx":360
 *         '''open a :term:`tabix file` for reading.'''
 * 
 *         if mode != 'r':             # <<<<<<<<<<<<<<
 *             raise ValueError("invalid file opening mode `%s`" % mode)
 * 
 */
  }

  /* "pysam/libctabix.pyx":363
 *             raise ValueError("invalid file opening mode `%s`" % mode)
 * 
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             self.close()
 *         self.htsfile = NULL
 */
  __pyx_t_1 = (__pyx_v_self->__pyx_base.htsfile != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":364
 * 
 *         if self.htsfile != NULL:
 *             self.close()             # <<<<<<<<<<<<<<
 *         self.htsfile = NULL
 *         self.threads=threads
 */
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_close); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 364, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = NULL;
    __pyx_t_5 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_4)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_4);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_5 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[1] = {__pyx_t_4, };
      __pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 0+__pyx_t_5);
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 364, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "pysam/libctabix.pyx":363
 *             raise ValueError("invalid file opening mode `%s`" % mode)
 * 
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             self.close()
 *         self.htsfile = NULL
 */
  }

  /* "pysam/libctabix.pyx":365
 *         if self.htsfile != NULL:
 *             self.close()
 *         self.htsfile = NULL             # <<<<<<<<<<<<<<
 *         self.threads=threads
 * 
 */
  __pyx_v_self->__pyx_base.htsfile = NULL;

  /* "pysam/libctabix.pyx":366
 *             self.close()
 *         self.htsfile = NULL
 *         self.threads=threads             # <<<<<<<<<<<<<<
 * 
 *         filename_index = index or (filename + ".tbi")
 */
  __Pyx_INCREF(__pyx_v_threads);
  __Pyx_GIVEREF(__pyx_v_threads);
  __Pyx_GOTREF(__pyx_v_self->__pyx_base.threads);
  __Pyx_DECREF(__pyx_v_self->__pyx_base.threads);
  __pyx_v_self->__pyx_base.threads = __pyx_v_threads;

  /* "pysam/libctabix.pyx":368
 *         self.threads=threads
 * 
 *         filename_index = index or (filename + ".tbi")             # <<<<<<<<<<<<<<
 *         # encode all the strings to pass to tabix
 *         self.filename = encode_filename(filename)
 */
  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_index); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 368, __pyx_L1_error)
  if (!__pyx_t_1) {
  } else {
    __Pyx_INCREF(__pyx_v_index);
    __pyx_t_3 = __pyx_v_index;
    goto __pyx_L5_bool_binop_done;
  }
  __pyx_t_2 = PyNumber_Add(__pyx_v_filename, __pyx_kp_u_tbi); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 368, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_t_2);
  __pyx_t_3 = __pyx_t_2;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_L5_bool_binop_done:;
  __pyx_v_filename_index = __pyx_t_3;
  __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":370
 *         filename_index = index or (filename + ".tbi")
 *         # encode all the strings to pass to tabix
 *         self.filename = encode_filename(filename)             # <<<<<<<<<<<<<<
 *         self.filename_index = encode_filename(filename_index)
 * 
 */
  __pyx_t_3 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 370, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_3);
  __Pyx_GOTREF(__pyx_v_self->__pyx_base.filename);
  __Pyx_DECREF(__pyx_v_self->__pyx_base.filename);
  __pyx_v_self->__pyx_base.filename = __pyx_t_3;
  __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":371
 *         # encode all the strings to pass to tabix
 *         self.filename = encode_filename(filename)
 *         self.filename_index = encode_filename(filename_index)             # <<<<<<<<<<<<<<
 * 
 *         self.is_stream = self.filename == b'-'
 */
  __pyx_t_3 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename_index); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_3);
  __Pyx_GOTREF(__pyx_v_self->filename_index);
  __Pyx_DECREF(__pyx_v_self->filename_index);
  __pyx_v_self->filename_index = __pyx_t_3;
  __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":373
 *         self.filename_index = encode_filename(filename_index)
 * 
 *         self.is_stream = self.filename == b'-'             # <<<<<<<<<<<<<<
 *         self.is_remote = hisremote(self.filename)
 * 
 */
  __pyx_t_3 = PyObject_RichCompare(__pyx_v_self->__pyx_base.filename, __pyx_kp_b__16, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 373, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely((__pyx_t_1 == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 373, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_self->__pyx_base.is_stream = __pyx_t_1;

  /* "pysam/libctabix.pyx":374
 * 
 *         self.is_stream = self.filename == b'-'
 *         self.is_remote = hisremote(self.filename)             # <<<<<<<<<<<<<<
 * 
 *         if not self.is_remote:
 */
  __pyx_t_6 = __Pyx_PyObject_AsString(__pyx_v_self->__pyx_base.filename); if (unlikely((!__pyx_t_6) && PyErr_Occurred())) __PYX_ERR(0, 374, __pyx_L1_error)
  __pyx_v_self->__pyx_base.is_remote = hisremote(__pyx_t_6);

  /* "pysam/libctabix.pyx":376
 *         self.is_remote = hisremote(self.filename)
 * 
 *         if not self.is_remote:             # <<<<<<<<<<<<<<
 *             if not os.path.exists(filename):
 *                 raise IOError("file `%s` not found" % filename)
 */
  __pyx_t_1 = (!__pyx_v_self->__pyx_base.is_remote);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":377
 * 
 *         if not self.is_remote:
 *             if not os.path.exists(filename):             # <<<<<<<<<<<<<<
 *                 raise IOError("file `%s` not found" % filename)
 * 
 */
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_os); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 377, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 377, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 377, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = NULL;
    __pyx_t_5 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_4)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_4);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_5 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filename};
      __pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 377, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 377, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_7 = (!__pyx_t_1);
    if (unlikely(__pyx_t_7)) {

      /* "pysam/libctabix.pyx":378
 *         if not self.is_remote:
 *             if not os.path.exists(filename):
 *                 raise IOError("file `%s` not found" % filename)             # <<<<<<<<<<<<<<
 * 
 *             if not os.path.exists(filename_index):
 */
      __pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_file_s_not_found, __pyx_v_filename); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 378, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 378, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_Raise(__pyx_t_2, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __PYX_ERR(0, 378, __pyx_L1_error)

      /* "pysam/libctabix.pyx":377
 * 
 *         if not self.is_remote:
 *             if not os.path.exists(filename):             # <<<<<<<<<<<<<<
 *                 raise IOError("file `%s` not found" % filename)
 * 
 */
    }

    /* "pysam/libctabix.pyx":380
 *                 raise IOError("file `%s` not found" % filename)
 * 
 *             if not os.path.exists(filename_index):             # <<<<<<<<<<<<<<
 *                 raise IOError("index `%s` not found" % filename_index)
 * 
 */
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 380, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 380, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_exists); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 380, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = NULL;
    __pyx_t_5 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_3))) {
      __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
      if (likely(__pyx_t_4)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
        __Pyx_INCREF(__pyx_t_4);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_3, function);
        __pyx_t_5 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v_filename_index};
      __pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 380, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    }
    __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_7 < 0))) __PYX_ERR(0, 380, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_1 = (!__pyx_t_7);
    if (unlikely(__pyx_t_1)) {

      /* "pysam/libctabix.pyx":381
 * 
 *             if not os.path.exists(filename_index):
 *                 raise IOError("index `%s` not found" % filename_index)             # <<<<<<<<<<<<<<
 * 
 *         # open file
 */
      __pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_index_s_not_found, __pyx_v_filename_index); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 381, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 381, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_Raise(__pyx_t_3, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __PYX_ERR(0, 381, __pyx_L1_error)

      /* "pysam/libctabix.pyx":380
 *                 raise IOError("file `%s` not found" % filename)
 * 
 *             if not os.path.exists(filename_index):             # <<<<<<<<<<<<<<
 *                 raise IOError("index `%s` not found" % filename_index)
 * 
 */
    }

    /* "pysam/libctabix.pyx":376
 *         self.is_remote = hisremote(self.filename)
 * 
 *         if not self.is_remote:             # <<<<<<<<<<<<<<
 *             if not os.path.exists(filename):
 *                 raise IOError("file `%s` not found" % filename)
 */
  }

  /* "pysam/libctabix.pyx":384
 * 
 *         # open file
 *         cdef char *cfilename = self.filename             # <<<<<<<<<<<<<<
 *         cdef char *cfilename_index = self.filename_index
 *         with nogil:
 */
  __pyx_t_8 = __Pyx_PyObject_AsWritableString(__pyx_v_self->__pyx_base.filename); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 384, __pyx_L1_error)
  __pyx_v_cfilename = __pyx_t_8;

  /* "pysam/libctabix.pyx":385
 *         # open file
 *         cdef char *cfilename = self.filename
 *         cdef char *cfilename_index = self.filename_index             # <<<<<<<<<<<<<<
 *         with nogil:
 *             self.htsfile = hts_open(cfilename, 'r')
 */
  __pyx_t_8 = __Pyx_PyObject_AsWritableString(__pyx_v_self->filename_index); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 385, __pyx_L1_error)
  __pyx_v_cfilename_index = __pyx_t_8;

  /* "pysam/libctabix.pyx":386
 *         cdef char *cfilename = self.filename
 *         cdef char *cfilename_index = self.filename_index
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.htsfile = hts_open(cfilename, 'r')
 * 
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":387
 *         cdef char *cfilename_index = self.filename_index
 *         with nogil:
 *             self.htsfile = hts_open(cfilename, 'r')             # <<<<<<<<<<<<<<
 * 
 *         if self.htsfile == NULL:
 */
        __pyx_v_self->__pyx_base.htsfile = hts_open(__pyx_v_cfilename, ((char const *)"r"));
      }

      /* "pysam/libctabix.pyx":386
 *         cdef char *cfilename = self.filename
 *         cdef char *cfilename_index = self.filename_index
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.htsfile = hts_open(cfilename, 'r')
 * 
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L12;
        }
        __pyx_L12:;
      }
  }

  /* "pysam/libctabix.pyx":389
 *             self.htsfile = hts_open(cfilename, 'r')
 * 
 *         if self.htsfile == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError("could not open file `%s`" % filename)
 * 
 */
  __pyx_t_1 = (__pyx_v_self->__pyx_base.htsfile == NULL);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":390
 * 
 *         if self.htsfile == NULL:
 *             raise IOError("could not open file `%s`" % filename)             # <<<<<<<<<<<<<<
 * 
 *         #if self.htsfile.format.category != region_list:
 */
    __pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_could_not_open_file_s, __pyx_v_filename); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 390, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 390, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_t_2, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __PYX_ERR(0, 390, __pyx_L1_error)

    /* "pysam/libctabix.pyx":389
 *             self.htsfile = hts_open(cfilename, 'r')
 * 
 *         if self.htsfile == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError("could not open file `%s`" % filename)
 * 
 */
  }

  /* "pysam/libctabix.pyx":395
 *         #    raise ValueError("file does not contain region data")
 * 
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.index = tbx_index_load2(cfilename, cfilename_index)
 * 
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":396
 * 
 *         with nogil:
 *             self.index = tbx_index_load2(cfilename, cfilename_index)             # <<<<<<<<<<<<<<
 * 
 *         if self.index == NULL:
 */
        __pyx_v_self->index = tbx_index_load2(__pyx_v_cfilename, __pyx_v_cfilename_index);
      }

      /* "pysam/libctabix.pyx":395
 *         #    raise ValueError("file does not contain region data")
 * 
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.index = tbx_index_load2(cfilename, cfilename_index)
 * 
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L16;
        }
        __pyx_L16:;
      }
  }

  /* "pysam/libctabix.pyx":398
 *             self.index = tbx_index_load2(cfilename, cfilename_index)
 * 
 *         if self.index == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError("could not open index for `%s`" % filename)
 * 
 */
  __pyx_t_1 = (__pyx_v_self->index == NULL);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":399
 * 
 *         if self.index == NULL:
 *             raise IOError("could not open index for `%s`" % filename)             # <<<<<<<<<<<<<<
 * 
 *         if not self.is_stream:
 */
    __pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_could_not_open_index_for_s, __pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 399, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 399, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 399, __pyx_L1_error)

    /* "pysam/libctabix.pyx":398
 *             self.index = tbx_index_load2(cfilename, cfilename_index)
 * 
 *         if self.index == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError("could not open index for `%s`" % filename)
 * 
 */
  }

  /* "pysam/libctabix.pyx":401
 *             raise IOError("could not open index for `%s`" % filename)
 * 
 *         if not self.is_stream:             # <<<<<<<<<<<<<<
 *             self.start_offset = self.tell()
 * 
 */
  __pyx_t_1 = (!__pyx_v_self->__pyx_base.is_stream);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":402
 * 
 *         if not self.is_stream:
 *             self.start_offset = self.tell()             # <<<<<<<<<<<<<<
 * 
 *     def _dup(self):
 */
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_tell); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 402, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = NULL;
    __pyx_t_5 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_4)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_4);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_5 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[1] = {__pyx_t_4, };
      __pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_5, 0+__pyx_t_5);
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 402, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __pyx_t_9 = __Pyx_PyInt_As_int64_t(__pyx_t_3); if (unlikely((__pyx_t_9 == ((int64_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 402, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_self->__pyx_base.start_offset = __pyx_t_9;

    /* "pysam/libctabix.pyx":401
 *             raise IOError("could not open index for `%s`" % filename)
 * 
 *         if not self.is_stream:             # <<<<<<<<<<<<<<
 *             self.start_offset = self.tell()
 * 
 */
  }

  /* "pysam/libctabix.pyx":352
 *         self.encoding = encoding
 * 
 *     def _open( self,             # <<<<<<<<<<<<<<
 *                filename,
 *                mode='r',
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile._open", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_filename_index);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":404
 *             self.start_offset = self.tell()
 * 
 *     def _dup(self):             # <<<<<<<<<<<<<<
 *         '''return a copy of this tabix file.
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_5_dup(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_4_dup, "TabixFile._dup(self)\nreturn a copy of this tabix file.\n        \n        The file is being re-opened.\n        ");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_5_dup = {"_dup", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_5_dup, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_4_dup};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_5_dup(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("_dup (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 404, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("_dup", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "_dup", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile._dup", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_4_dup(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_4_dup(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__17)
  __Pyx_RefNannySetupContext("_dup", 0);
  __Pyx_TraceCall("_dup", __pyx_f[0], 404, 0, __PYX_ERR(0, 404, __pyx_L1_error));

  /* "pysam/libctabix.pyx":409
 *         The file is being re-opened.
 *         '''
 *         return TabixFile(self.filename,             # <<<<<<<<<<<<<<
 *                          mode="r",
 *                          threads=self.threads,
 */
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyTuple_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 409, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_self->__pyx_base.filename);
  __Pyx_GIVEREF(__pyx_v_self->__pyx_base.filename);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_self->__pyx_base.filename)) __PYX_ERR(0, 409, __pyx_L1_error);

  /* "pysam/libctabix.pyx":410
 *         '''
 *         return TabixFile(self.filename,
 *                          mode="r",             # <<<<<<<<<<<<<<
 *                          threads=self.threads,
 *                          parser=self.parser,
 */
  __pyx_t_2 = __Pyx_PyDict_NewPresized(5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 410, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_mode, __pyx_n_u_r) < 0) __PYX_ERR(0, 410, __pyx_L1_error)

  /* "pysam/libctabix.pyx":411
 *         return TabixFile(self.filename,
 *                          mode="r",
 *                          threads=self.threads,             # <<<<<<<<<<<<<<
 *                          parser=self.parser,
 *                          index=self.filename_index,
 */
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_threads, __pyx_v_self->__pyx_base.threads) < 0) __PYX_ERR(0, 410, __pyx_L1_error)

  /* "pysam/libctabix.pyx":412
 *                          mode="r",
 *                          threads=self.threads,
 *                          parser=self.parser,             # <<<<<<<<<<<<<<
 *                          index=self.filename_index,
 *                          encoding=self.encoding)
 */
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_parser, ((PyObject *)__pyx_v_self->parser)) < 0) __PYX_ERR(0, 410, __pyx_L1_error)

  /* "pysam/libctabix.pyx":413
 *                          threads=self.threads,
 *                          parser=self.parser,
 *                          index=self.filename_index,             # <<<<<<<<<<<<<<
 *                          encoding=self.encoding)
 * 
 */
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_index, __pyx_v_self->filename_index) < 0) __PYX_ERR(0, 410, __pyx_L1_error)

  /* "pysam/libctabix.pyx":414
 *                          parser=self.parser,
 *                          index=self.filename_index,
 *                          encoding=self.encoding)             # <<<<<<<<<<<<<<
 * 
 *     def fetch(self,
 */
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_encoding, __pyx_v_self->encoding) < 0) __PYX_ERR(0, 410, __pyx_L1_error)

  /* "pysam/libctabix.pyx":409
 *         The file is being re-opened.
 *         '''
 *         return TabixFile(self.filename,             # <<<<<<<<<<<<<<
 *                          mode="r",
 *                          threads=self.threads,
 */
  __pyx_t_3 = __Pyx_PyObject_Call(((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile), __pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 409, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_r = __pyx_t_3;
  __pyx_t_3 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":404
 *             self.start_offset = self.tell()
 * 
 *     def _dup(self):             # <<<<<<<<<<<<<<
 *         '''return a copy of this tabix file.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile._dup", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":416
 *                          encoding=self.encoding)
 * 
 *     def fetch(self,             # <<<<<<<<<<<<<<
 *               reference=None,
 *               start=None,
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_7fetch(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_6fetch, "TabixFile.fetch(self, reference=None, start=None, end=None, region=None, parser=None, multiple_iterators=False)\nfetch one or more rows in a :term:`region` using 0-based\n        indexing. The region is specified by :term:`reference`,\n        *start* and *end*. Alternatively, a samtools :term:`region`\n        string can be supplied.\n\n        Without *reference* or *region* all entries will be fetched. \n        \n        If only *reference* is set, all reads matching on *reference*\n        will be fetched.\n\n        If *parser* is None, the default parser will be used for\n        parsing.\n        \n        Set *multiple_iterators* to true if you will be using multiple\n        iterators on the same file at the same time. The iterator\n        returned will receive its own copy of a filehandle to the file\n        effectively re-opening the file. Re-opening a file creates\n        some overhead, so beware.\n\n        ");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_7fetch = {"fetch", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_7fetch, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_6fetch};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_7fetch(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_reference = 0;
  PyObject *__pyx_v_start = 0;
  PyObject *__pyx_v_end = 0;
  PyObject *__pyx_v_region = 0;
  PyObject *__pyx_v_parser = 0;
  PyObject *__pyx_v_multiple_iterators = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[6] = {0,0,0,0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("fetch (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 416, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_reference,&__pyx_n_s_start,&__pyx_n_s_end,&__pyx_n_s_region,&__pyx_n_s_parser,&__pyx_n_s_multiple_iterators,0};

    /* "pysam/libctabix.pyx":417
 * 
 *     def fetch(self,
 *               reference=None,             # <<<<<<<<<<<<<<
 *               start=None,
 *               end=None,
 */
    values[0] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":418
 *     def fetch(self,
 *               reference=None,
 *               start=None,             # <<<<<<<<<<<<<<
 *               end=None,
 *               region=None,
 */
    values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":419
 *               reference=None,
 *               start=None,
 *               end=None,             # <<<<<<<<<<<<<<
 *               region=None,
 *               parser=None,
 */
    values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":420
 *               start=None,
 *               end=None,
 *               region=None,             # <<<<<<<<<<<<<<
 *               parser=None,
 *               multiple_iterators=False):
 */
    values[3] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":421
 *               end=None,
 *               region=None,
 *               parser=None,             # <<<<<<<<<<<<<<
 *               multiple_iterators=False):
 *         '''fetch one or more rows in a :term:`region` using 0-based
 */
    values[4] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":422
 *               region=None,
 *               parser=None,
 *               multiple_iterators=False):             # <<<<<<<<<<<<<<
 *         '''fetch one or more rows in a :term:`region` using 0-based
 *         indexing. The region is specified by :term:`reference`,
 */
    values[5] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_False));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  6: values[5] = __Pyx_Arg_FASTCALL(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_FASTCALL(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_reference);
          if (value) { values[0] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_start);
          if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_end);
          if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_region);
          if (value) { values[3] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser);
          if (value) { values[4] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_multiple_iterators);
          if (value) { values[5] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 416, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "fetch") < 0)) __PYX_ERR(0, 416, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  6: values[5] = __Pyx_Arg_FASTCALL(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_FASTCALL(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_reference = values[0];
    __pyx_v_start = values[1];
    __pyx_v_end = values[2];
    __pyx_v_region = values[3];
    __pyx_v_parser = values[4];
    __pyx_v_multiple_iterators = values[5];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("fetch", 0, 0, 6, __pyx_nargs); __PYX_ERR(0, 416, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.fetch", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_6fetch(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self), __pyx_v_reference, __pyx_v_start, __pyx_v_end, __pyx_v_region, __pyx_v_parser, __pyx_v_multiple_iterators);

  /* "pysam/libctabix.pyx":416
 *                          encoding=self.encoding)
 * 
 *     def fetch(self,             # <<<<<<<<<<<<<<
 *               reference=None,
 *               start=None,
 */

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_6fetch(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, PyObject *__pyx_v_reference, PyObject *__pyx_v_start, PyObject *__pyx_v_end, PyObject *__pyx_v_region, PyObject *__pyx_v_parser, PyObject *__pyx_v_multiple_iterators) {
  hts_itr_t *__pyx_v_itr;
  char *__pyx_v_cstr;
  struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_fileobj = 0;
  PyObject *__pyx_v_s = NULL;
  struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_a = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_t_5;
  int __pyx_t_6;
  struct __pyx_opt_args_5pysam_9libcutils_force_bytes __pyx_t_7;
  char *__pyx_t_8;
  Py_ssize_t __pyx_t_9;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__18)
  __Pyx_RefNannySetupContext("fetch", 0);
  __Pyx_TraceCall("fetch", __pyx_f[0], 416, 0, __PYX_ERR(0, 416, __pyx_L1_error));
  __Pyx_INCREF(__pyx_v_start);
  __Pyx_INCREF(__pyx_v_region);
  __Pyx_INCREF(__pyx_v_parser);

  /* "pysam/libctabix.pyx":443
 * 
 *         '''
 *         if not self.is_open():             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file")
 * 
 */
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_is_open); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 443, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = NULL;
  __pyx_t_4 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_4 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[1] = {__pyx_t_3, };
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 443, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  }
  __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 443, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_6 = (!__pyx_t_5);
  if (unlikely(__pyx_t_6)) {

    /* "pysam/libctabix.pyx":444
 *         '''
 *         if not self.is_open():
 *             raise ValueError("I/O operation on closed file")             # <<<<<<<<<<<<<<
 * 
 *         # convert coordinates to region string, which is one-based
 */
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__19, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 444, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_Raise(__pyx_t_1, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(0, 444, __pyx_L1_error)

    /* "pysam/libctabix.pyx":443
 * 
 *         '''
 *         if not self.is_open():             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file")
 * 
 */
  }

  /* "pysam/libctabix.pyx":447
 * 
 *         # convert coordinates to region string, which is one-based
 *         if reference:             # <<<<<<<<<<<<<<
 *             if end is not None:
 *                 if end < 0:
 */
  __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_v_reference); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 447, __pyx_L1_error)
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":448
 *         # convert coordinates to region string, which is one-based
 *         if reference:
 *             if end is not None:             # <<<<<<<<<<<<<<
 *                 if end < 0:
 *                     raise ValueError("end out of range (%i)" % end)
 */
    __pyx_t_6 = (__pyx_v_end != Py_None);
    if (__pyx_t_6) {

      /* "pysam/libctabix.pyx":449
 *         if reference:
 *             if end is not None:
 *                 if end < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("end out of range (%i)" % end)
 *                 if start is None:
 */
      __pyx_t_1 = PyObject_RichCompare(__pyx_v_end, __pyx_int_0, Py_LT); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 449, __pyx_L1_error)
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 449, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (unlikely(__pyx_t_6)) {

        /* "pysam/libctabix.pyx":450
 *             if end is not None:
 *                 if end < 0:
 *                     raise ValueError("end out of range (%i)" % end)             # <<<<<<<<<<<<<<
 *                 if start is None:
 *                     start = 0
 */
        __pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_end_out_of_range_i, __pyx_v_end); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 450, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 450, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __Pyx_Raise(__pyx_t_2, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __PYX_ERR(0, 450, __pyx_L1_error)

        /* "pysam/libctabix.pyx":449
 *         if reference:
 *             if end is not None:
 *                 if end < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("end out of range (%i)" % end)
 *                 if start is None:
 */
      }

      /* "pysam/libctabix.pyx":451
 *                 if end < 0:
 *                     raise ValueError("end out of range (%i)" % end)
 *                 if start is None:             # <<<<<<<<<<<<<<
 *                     start = 0
 * 
 */
      __pyx_t_6 = (__pyx_v_start == Py_None);
      if (__pyx_t_6) {

        /* "pysam/libctabix.pyx":452
 *                     raise ValueError("end out of range (%i)" % end)
 *                 if start is None:
 *                     start = 0             # <<<<<<<<<<<<<<
 * 
 *                 if start < 0:
 */
        __Pyx_INCREF(__pyx_int_0);
        __Pyx_DECREF_SET(__pyx_v_start, __pyx_int_0);

        /* "pysam/libctabix.pyx":451
 *                 if end < 0:
 *                     raise ValueError("end out of range (%i)" % end)
 *                 if start is None:             # <<<<<<<<<<<<<<
 *                     start = 0
 * 
 */
      }

      /* "pysam/libctabix.pyx":454
 *                     start = 0
 * 
 *                 if start < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("start out of range (%i)" % end)
 *                 elif start > end:
 */
      __pyx_t_2 = PyObject_RichCompare(__pyx_v_start, __pyx_int_0, Py_LT); __Pyx_XGOTREF(__pyx_t_2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 454, __pyx_L1_error)
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 454, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (unlikely(__pyx_t_6)) {

        /* "pysam/libctabix.pyx":455
 * 
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)             # <<<<<<<<<<<<<<
 *                 elif start > end:
 *                     raise ValueError(
 */
        __pyx_t_2 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_start_out_of_range_i, __pyx_v_end); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 455, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_1 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 455, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_Raise(__pyx_t_1, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __PYX_ERR(0, 455, __pyx_L1_error)

        /* "pysam/libctabix.pyx":454
 *                     start = 0
 * 
 *                 if start < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("start out of range (%i)" % end)
 *                 elif start > end:
 */
      }

      /* "pysam/libctabix.pyx":456
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)
 *                 elif start > end:             # <<<<<<<<<<<<<<
 *                     raise ValueError(
 *                         'start (%i) >= end (%i)' % (start, end))
 */
      __pyx_t_1 = PyObject_RichCompare(__pyx_v_start, __pyx_v_end, Py_GT); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 456, __pyx_L1_error)
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 456, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (unlikely(__pyx_t_6)) {

        /* "pysam/libctabix.pyx":458
 *                 elif start > end:
 *                     raise ValueError(
 *                         'start (%i) >= end (%i)' % (start, end))             # <<<<<<<<<<<<<<
 *                 elif start == end:
 *                     return EmptyIterator()
 */
        __pyx_t_1 = PyTuple_New(2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 458, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_INCREF(__pyx_v_start);
        __Pyx_GIVEREF(__pyx_v_start);
        if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_start)) __PYX_ERR(0, 458, __pyx_L1_error);
        __Pyx_INCREF(__pyx_v_end);
        __Pyx_GIVEREF(__pyx_v_end);
        if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_v_end)) __PYX_ERR(0, 458, __pyx_L1_error);
        __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_start_i_end_i, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 458, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

        /* "pysam/libctabix.pyx":457
 *                     raise ValueError("start out of range (%i)" % end)
 *                 elif start > end:
 *                     raise ValueError(             # <<<<<<<<<<<<<<
 *                         'start (%i) >= end (%i)' % (start, end))
 *                 elif start == end:
 */
        __pyx_t_1 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 457, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_Raise(__pyx_t_1, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __PYX_ERR(0, 457, __pyx_L1_error)

        /* "pysam/libctabix.pyx":456
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)
 *                 elif start > end:             # <<<<<<<<<<<<<<
 *                     raise ValueError(
 *                         'start (%i) >= end (%i)' % (start, end))
 */
      }

      /* "pysam/libctabix.pyx":459
 *                     raise ValueError(
 *                         'start (%i) >= end (%i)' % (start, end))
 *                 elif start == end:             # <<<<<<<<<<<<<<
 *                     return EmptyIterator()
 *                 else:
 */
      __pyx_t_1 = PyObject_RichCompare(__pyx_v_start, __pyx_v_end, Py_EQ); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 459, __pyx_L1_error)
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 459, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (__pyx_t_6) {

        /* "pysam/libctabix.pyx":460
 *                         'start (%i) >= end (%i)' % (start, end))
 *                 elif start == end:
 *                     return EmptyIterator()             # <<<<<<<<<<<<<<
 *                 else:
 *                     region = '%s:%i-%i' % (reference, start + 1, end)
 */
        __Pyx_XDECREF(__pyx_r);
        __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_EmptyIterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 460, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_3 = NULL;
        __pyx_t_4 = 0;
        #if CYTHON_UNPACK_METHODS
        if (unlikely(PyMethod_Check(__pyx_t_2))) {
          __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
          if (likely(__pyx_t_3)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
            __Pyx_INCREF(__pyx_t_3);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_2, function);
            __pyx_t_4 = 1;
          }
        }
        #endif
        {
          PyObject *__pyx_callargs[1] = {__pyx_t_3, };
          __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
          __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
          if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 460, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        }
        __pyx_r = __pyx_t_1;
        __pyx_t_1 = 0;
        goto __pyx_L0;

        /* "pysam/libctabix.pyx":459
 *                     raise ValueError(
 *                         'start (%i) >= end (%i)' % (start, end))
 *                 elif start == end:             # <<<<<<<<<<<<<<
 *                     return EmptyIterator()
 *                 else:
 */
      }

      /* "pysam/libctabix.pyx":462
 *                     return EmptyIterator()
 *                 else:
 *                     region = '%s:%i-%i' % (reference, start + 1, end)             # <<<<<<<<<<<<<<
 *             elif start is not None:
 *                 if start < 0:
 */
      /*else*/ {
        __pyx_t_1 = __Pyx_PyInt_AddObjC(__pyx_v_start, __pyx_int_1, 1, 0, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 462, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_2 = PyTuple_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 462, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_INCREF(__pyx_v_reference);
        __Pyx_GIVEREF(__pyx_v_reference);
        if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_v_reference)) __PYX_ERR(0, 462, __pyx_L1_error);
        __Pyx_GIVEREF(__pyx_t_1);
        if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_1)) __PYX_ERR(0, 462, __pyx_L1_error);
        __Pyx_INCREF(__pyx_v_end);
        __Pyx_GIVEREF(__pyx_v_end);
        if (__Pyx_PyTuple_SET_ITEM(__pyx_t_2, 2, __pyx_v_end)) __PYX_ERR(0, 462, __pyx_L1_error);
        __pyx_t_1 = 0;
        __pyx_t_1 = PyUnicode_Format(__pyx_kp_u_s_i_i, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 462, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_DECREF_SET(__pyx_v_region, __pyx_t_1);
        __pyx_t_1 = 0;
      }

      /* "pysam/libctabix.pyx":448
 *         # convert coordinates to region string, which is one-based
 *         if reference:
 *             if end is not None:             # <<<<<<<<<<<<<<
 *                 if end < 0:
 *                     raise ValueError("end out of range (%i)" % end)
 */
      goto __pyx_L5;
    }

    /* "pysam/libctabix.pyx":463
 *                 else:
 *                     region = '%s:%i-%i' % (reference, start + 1, end)
 *             elif start is not None:             # <<<<<<<<<<<<<<
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)
 */
    __pyx_t_6 = (__pyx_v_start != Py_None);
    if (__pyx_t_6) {

      /* "pysam/libctabix.pyx":464
 *                     region = '%s:%i-%i' % (reference, start + 1, end)
 *             elif start is not None:
 *                 if start < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("start out of range (%i)" % end)
 *                 region = '%s:%i' % (reference, start + 1)
 */
      __pyx_t_1 = PyObject_RichCompare(__pyx_v_start, __pyx_int_0, Py_LT); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 464, __pyx_L1_error)
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 464, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (unlikely(__pyx_t_6)) {

        /* "pysam/libctabix.pyx":465
 *             elif start is not None:
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)             # <<<<<<<<<<<<<<
 *                 region = '%s:%i' % (reference, start + 1)
 *             else:
 */
        __pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_start_out_of_range_i, __pyx_v_end); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 465, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 465, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __Pyx_Raise(__pyx_t_2, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __PYX_ERR(0, 465, __pyx_L1_error)

        /* "pysam/libctabix.pyx":464
 *                     region = '%s:%i-%i' % (reference, start + 1, end)
 *             elif start is not None:
 *                 if start < 0:             # <<<<<<<<<<<<<<
 *                     raise ValueError("start out of range (%i)" % end)
 *                 region = '%s:%i' % (reference, start + 1)
 */
      }

      /* "pysam/libctabix.pyx":466
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)
 *                 region = '%s:%i' % (reference, start + 1)             # <<<<<<<<<<<<<<
 *             else:
 *                 region = reference
 */
      __pyx_t_2 = __Pyx_PyInt_AddObjC(__pyx_v_start, __pyx_int_1, 1, 0, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 466, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_1 = PyTuple_New(2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 466, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_INCREF(__pyx_v_reference);
      __Pyx_GIVEREF(__pyx_v_reference);
      if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_reference)) __PYX_ERR(0, 466, __pyx_L1_error);
      __Pyx_GIVEREF(__pyx_t_2);
      if (__Pyx_PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_t_2)) __PYX_ERR(0, 466, __pyx_L1_error);
      __pyx_t_2 = 0;
      __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_s_i, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 466, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF_SET(__pyx_v_region, __pyx_t_2);
      __pyx_t_2 = 0;

      /* "pysam/libctabix.pyx":463
 *                 else:
 *                     region = '%s:%i-%i' % (reference, start + 1, end)
 *             elif start is not None:             # <<<<<<<<<<<<<<
 *                 if start < 0:
 *                     raise ValueError("start out of range (%i)" % end)
 */
      goto __pyx_L5;
    }

    /* "pysam/libctabix.pyx":468
 *                 region = '%s:%i' % (reference, start + 1)
 *             else:
 *                 region = reference             # <<<<<<<<<<<<<<
 * 
 *         # get iterator
 */
    /*else*/ {
      __Pyx_INCREF(__pyx_v_reference);
      __Pyx_DECREF_SET(__pyx_v_region, __pyx_v_reference);
    }
    __pyx_L5:;

    /* "pysam/libctabix.pyx":447
 * 
 *         # convert coordinates to region string, which is one-based
 *         if reference:             # <<<<<<<<<<<<<<
 *             if end is not None:
 *                 if end < 0:
 */
  }

  /* "pysam/libctabix.pyx":476
 * 
 *         # reopen the same file if necessary
 *         if multiple_iterators:             # <<<<<<<<<<<<<<
 *             fileobj = self._dup()
 *         else:
 */
  __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_v_multiple_iterators); if (unlikely((__pyx_t_6 < 0))) __PYX_ERR(0, 476, __pyx_L1_error)
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":477
 *         # reopen the same file if necessary
 *         if multiple_iterators:
 *             fileobj = self._dup()             # <<<<<<<<<<<<<<
 *         else:
 *             fileobj = self
 */
    __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_dup); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 477, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = NULL;
    __pyx_t_4 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_1))) {
      __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_1);
      if (likely(__pyx_t_3)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_1);
        __Pyx_INCREF(__pyx_t_3);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_1, function);
        __pyx_t_4 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[1] = {__pyx_t_3, };
      __pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_1, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
      __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 477, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    }
    if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5pysam_9libctabix_TabixFile))))) __PYX_ERR(0, 477, __pyx_L1_error)
    __pyx_v_fileobj = ((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_t_2);
    __pyx_t_2 = 0;

    /* "pysam/libctabix.pyx":476
 * 
 *         # reopen the same file if necessary
 *         if multiple_iterators:             # <<<<<<<<<<<<<<
 *             fileobj = self._dup()
 *         else:
 */
    goto __pyx_L10;
  }

  /* "pysam/libctabix.pyx":479
 *             fileobj = self._dup()
 *         else:
 *             fileobj = self             # <<<<<<<<<<<<<<
 * 
 *         if region is None:
 */
  /*else*/ {
    __Pyx_INCREF((PyObject *)__pyx_v_self);
    __pyx_v_fileobj = __pyx_v_self;
  }
  __pyx_L10:;

  /* "pysam/libctabix.pyx":481
 *             fileobj = self
 * 
 *         if region is None:             # <<<<<<<<<<<<<<
 *             # without region or reference - iterate from start
 *             with nogil:
 */
  __pyx_t_6 = (__pyx_v_region == Py_None);
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":483
 *         if region is None:
 *             # without region or reference - iterate from start
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 itr = tbx_itr_queryi(fileobj.index,
 *                                      HTS_IDX_START,
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":484
 *             # without region or reference - iterate from start
 *             with nogil:
 *                 itr = tbx_itr_queryi(fileobj.index,             # <<<<<<<<<<<<<<
 *                                      HTS_IDX_START,
 *                                      0,
 */
          __pyx_v_itr = tbx_itr_queryi(__pyx_v_fileobj->index, HTS_IDX_START, 0, 0);
        }

        /* "pysam/libctabix.pyx":483
 *         if region is None:
 *             # without region or reference - iterate from start
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 itr = tbx_itr_queryi(fileobj.index,
 *                                      HTS_IDX_START,
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L14;
          }
          __pyx_L14:;
        }
    }

    /* "pysam/libctabix.pyx":481
 *             fileobj = self
 * 
 *         if region is None:             # <<<<<<<<<<<<<<
 *             # without region or reference - iterate from start
 *             with nogil:
 */
    goto __pyx_L11;
  }

  /* "pysam/libctabix.pyx":489
 *                                      0)
 *         else:
 *             s = force_bytes(region, encoding=fileobj.encoding)             # <<<<<<<<<<<<<<
 *             cstr = s
 *             with nogil:
 */
  /*else*/ {
    __pyx_t_2 = __pyx_v_fileobj->encoding;
    __Pyx_INCREF(__pyx_t_2);
    __pyx_t_7.__pyx_n = 1;
    __pyx_t_7.encoding = __pyx_t_2;
    __pyx_t_1 = __pyx_f_5pysam_9libcutils_force_bytes(__pyx_v_region, &__pyx_t_7); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 489, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_v_s = ((PyObject*)__pyx_t_1);
    __pyx_t_1 = 0;

    /* "pysam/libctabix.pyx":490
 *         else:
 *             s = force_bytes(region, encoding=fileobj.encoding)
 *             cstr = s             # <<<<<<<<<<<<<<
 *             with nogil:
 *                 itr = tbx_itr_querys(fileobj.index, cstr)
 */
    if (unlikely(__pyx_v_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 490, __pyx_L1_error)
    }
    __pyx_t_8 = __Pyx_PyBytes_AsWritableString(__pyx_v_s); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 490, __pyx_L1_error)
    __pyx_v_cstr = __pyx_t_8;

    /* "pysam/libctabix.pyx":491
 *             s = force_bytes(region, encoding=fileobj.encoding)
 *             cstr = s
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 itr = tbx_itr_querys(fileobj.index, cstr)
 * 
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":492
 *             cstr = s
 *             with nogil:
 *                 itr = tbx_itr_querys(fileobj.index, cstr)             # <<<<<<<<<<<<<<
 * 
 *         if itr == NULL:
 */
          __pyx_v_itr = tbx_itr_querys(__pyx_v_fileobj->index, __pyx_v_cstr);
        }

        /* "pysam/libctabix.pyx":491
 *             s = force_bytes(region, encoding=fileobj.encoding)
 *             cstr = s
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 itr = tbx_itr_querys(fileobj.index, cstr)
 * 
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L17;
          }
          __pyx_L17:;
        }
    }
  }
  __pyx_L11:;

  /* "pysam/libctabix.pyx":494
 *                 itr = tbx_itr_querys(fileobj.index, cstr)
 * 
 *         if itr == NULL:             # <<<<<<<<<<<<<<
 *             if region is None:
 *                 if len(self.contigs) > 0:
 */
  __pyx_t_6 = (__pyx_v_itr == NULL);
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":495
 * 
 *         if itr == NULL:
 *             if region is None:             # <<<<<<<<<<<<<<
 *                 if len(self.contigs) > 0:
 *                     # when accessing a tabix file created prior tabix 1.0
 */
    __pyx_t_6 = (__pyx_v_region == Py_None);
    if (likely(__pyx_t_6)) {

      /* "pysam/libctabix.pyx":496
 *         if itr == NULL:
 *             if region is None:
 *                 if len(self.contigs) > 0:             # <<<<<<<<<<<<<<
 *                     # when accessing a tabix file created prior tabix 1.0
 *                     # the full-file iterator is empty.
 */
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_contigs); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 496, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_9 = PyObject_Length(__pyx_t_1); if (unlikely(__pyx_t_9 == ((Py_ssize_t)-1))) __PYX_ERR(0, 496, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_6 = (__pyx_t_9 > 0);
      if (unlikely(__pyx_t_6)) {

        /* "pysam/libctabix.pyx":499
 *                     # when accessing a tabix file created prior tabix 1.0
 *                     # the full-file iterator is empty.
 *                     raise ValueError(             # <<<<<<<<<<<<<<
 *                         "could not create iterator, possible "
 *                         "tabix version mismatch")
 */
        __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__20, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 499, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_Raise(__pyx_t_1, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __PYX_ERR(0, 499, __pyx_L1_error)

        /* "pysam/libctabix.pyx":496
 *         if itr == NULL:
 *             if region is None:
 *                 if len(self.contigs) > 0:             # <<<<<<<<<<<<<<
 *                     # when accessing a tabix file created prior tabix 1.0
 *                     # the full-file iterator is empty.
 */
      }

      /* "pysam/libctabix.pyx":505
 *                     # possible reason is that the file is empty -
 *                     # return an empty iterator
 *                     return EmptyIterator()             # <<<<<<<<<<<<<<
 *             else:
 *                 raise ValueError(
 */
      /*else*/ {
        __Pyx_XDECREF(__pyx_r);
        __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_EmptyIterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 505, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_3 = NULL;
        __pyx_t_4 = 0;
        #if CYTHON_UNPACK_METHODS
        if (unlikely(PyMethod_Check(__pyx_t_2))) {
          __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
          if (likely(__pyx_t_3)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
            __Pyx_INCREF(__pyx_t_3);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_2, function);
            __pyx_t_4 = 1;
          }
        }
        #endif
        {
          PyObject *__pyx_callargs[1] = {__pyx_t_3, };
          __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
          __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
          if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 505, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        }
        __pyx_r = __pyx_t_1;
        __pyx_t_1 = 0;
        goto __pyx_L0;
      }

      /* "pysam/libctabix.pyx":495
 * 
 *         if itr == NULL:
 *             if region is None:             # <<<<<<<<<<<<<<
 *                 if len(self.contigs) > 0:
 *                     # when accessing a tabix file created prior tabix 1.0
 */
    }

    /* "pysam/libctabix.pyx":507
 *                     return EmptyIterator()
 *             else:
 *                 raise ValueError(             # <<<<<<<<<<<<<<
 *                     "could not create iterator for region '%s'" %
 *                     region)
 */
    /*else*/ {

      /* "pysam/libctabix.pyx":508
 *             else:
 *                 raise ValueError(
 *                     "could not create iterator for region '%s'" %             # <<<<<<<<<<<<<<
 *                     region)
 * 
 */
      __pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_could_not_create_iterator_for_re, __pyx_v_region); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 508, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);

      /* "pysam/libctabix.pyx":507
 *                     return EmptyIterator()
 *             else:
 *                 raise ValueError(             # <<<<<<<<<<<<<<
 *                     "could not create iterator for region '%s'" %
 *                     region)
 */
      __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 507, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_Raise(__pyx_t_2, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __PYX_ERR(0, 507, __pyx_L1_error)
    }

    /* "pysam/libctabix.pyx":494
 *                 itr = tbx_itr_querys(fileobj.index, cstr)
 * 
 *         if itr == NULL:             # <<<<<<<<<<<<<<
 *             if region is None:
 *                 if len(self.contigs) > 0:
 */
  }

  /* "pysam/libctabix.pyx":512
 * 
 *         # use default parser if no parser is specified
 *         if parser is None:             # <<<<<<<<<<<<<<
 *             parser = fileobj.parser
 * 
 */
  __pyx_t_6 = (__pyx_v_parser == Py_None);
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":513
 *         # use default parser if no parser is specified
 *         if parser is None:
 *             parser = fileobj.parser             # <<<<<<<<<<<<<<
 * 
 *         cdef TabixIterator a
 */
    __pyx_t_2 = ((PyObject *)__pyx_v_fileobj->parser);
    __Pyx_INCREF(__pyx_t_2);
    __Pyx_DECREF_SET(__pyx_v_parser, __pyx_t_2);
    __pyx_t_2 = 0;

    /* "pysam/libctabix.pyx":512
 * 
 *         # use default parser if no parser is specified
 *         if parser is None:             # <<<<<<<<<<<<<<
 *             parser = fileobj.parser
 * 
 */
  }

  /* "pysam/libctabix.pyx":516
 * 
 *         cdef TabixIterator a
 *         if parser is None:             # <<<<<<<<<<<<<<
 *             a = TabixIterator(encoding=fileobj.encoding)
 *         else:
 */
  __pyx_t_6 = (__pyx_v_parser == Py_None);
  if (__pyx_t_6) {

    /* "pysam/libctabix.pyx":517
 *         cdef TabixIterator a
 *         if parser is None:
 *             a = TabixIterator(encoding=fileobj.encoding)             # <<<<<<<<<<<<<<
 *         else:
 *             parser.set_encoding(fileobj.encoding)
 */
    __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 517, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_encoding, __pyx_v_fileobj->encoding) < 0) __PYX_ERR(0, 517, __pyx_L1_error)
    __pyx_t_1 = __Pyx_PyObject_Call(((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIterator), __pyx_empty_tuple, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 517, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_v_a = ((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_t_1);
    __pyx_t_1 = 0;

    /* "pysam/libctabix.pyx":516
 * 
 *         cdef TabixIterator a
 *         if parser is None:             # <<<<<<<<<<<<<<
 *             a = TabixIterator(encoding=fileobj.encoding)
 *         else:
 */
    goto __pyx_L22;
  }

  /* "pysam/libctabix.pyx":519
 *             a = TabixIterator(encoding=fileobj.encoding)
 *         else:
 *             parser.set_encoding(fileobj.encoding)             # <<<<<<<<<<<<<<
 *             a = TabixIteratorParsed(parser)
 * 
 */
  /*else*/ {
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_parser, __pyx_n_s_set_encoding); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 519, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = NULL;
    __pyx_t_4 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_3)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_3);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_4 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_3, __pyx_v_fileobj->encoding};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 1+__pyx_t_4);
      __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 519, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "pysam/libctabix.pyx":520
 *         else:
 *             parser.set_encoding(fileobj.encoding)
 *             a = TabixIteratorParsed(parser)             # <<<<<<<<<<<<<<
 * 
 *         a.tabixfile = fileobj
 */
    __pyx_t_1 = __Pyx_PyObject_CallOneArg(((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed), __pyx_v_parser); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 520, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_v_a = ((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_t_1);
    __pyx_t_1 = 0;
  }
  __pyx_L22:;

  /* "pysam/libctabix.pyx":522
 *             a = TabixIteratorParsed(parser)
 * 
 *         a.tabixfile = fileobj             # <<<<<<<<<<<<<<
 *         a.iterator = itr
 * 
 */
  __Pyx_INCREF((PyObject *)__pyx_v_fileobj);
  __Pyx_GIVEREF((PyObject *)__pyx_v_fileobj);
  __Pyx_GOTREF((PyObject *)__pyx_v_a->tabixfile);
  __Pyx_DECREF((PyObject *)__pyx_v_a->tabixfile);
  __pyx_v_a->tabixfile = __pyx_v_fileobj;

  /* "pysam/libctabix.pyx":523
 * 
 *         a.tabixfile = fileobj
 *         a.iterator = itr             # <<<<<<<<<<<<<<
 * 
 *         return a
 */
  __pyx_v_a->iterator = __pyx_v_itr;

  /* "pysam/libctabix.pyx":525
 *         a.iterator = itr
 * 
 *         return a             # <<<<<<<<<<<<<<
 * 
 *     ###############################################################
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_a);
  __pyx_r = ((PyObject *)__pyx_v_a);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":416
 *                          encoding=self.encoding)
 * 
 *     def fetch(self,             # <<<<<<<<<<<<<<
 *               reference=None,
 *               start=None,
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.fetch", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_fileobj);
  __Pyx_XDECREF(__pyx_v_s);
  __Pyx_XDECREF((PyObject *)__pyx_v_a);
  __Pyx_XDECREF(__pyx_v_start);
  __Pyx_XDECREF(__pyx_v_region);
  __Pyx_XDECREF(__pyx_v_parser);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":543
 *         '''
 * 
 *         def __get__(self):             # <<<<<<<<<<<<<<
 * 
 *             cdef char *cfilename = self.filename
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_6header_1__get__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_6header_1__get__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_6header___get__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_6header___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  char *__pyx_v_cfilename;
  char *__pyx_v_cfilename_index;
  kstring_t __pyx_v_buffer;
  htsFile *__pyx_v_fp;
  int __pyx_v_KS_SEP_LINE;
  tbx_t *__pyx_v_tbx;
  PyObject *__pyx_v_lines = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  char *__pyx_t_1;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  int __pyx_t_7;
  struct __pyx_opt_args_5pysam_9libcutils_force_str __pyx_t_8;
  int __pyx_t_9;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__get__", 0);
  __Pyx_TraceCall("__get__", __pyx_f[0], 543, 0, __PYX_ERR(0, 543, __pyx_L1_error));

  /* "pysam/libctabix.pyx":545
 *         def __get__(self):
 * 
 *             cdef char *cfilename = self.filename             # <<<<<<<<<<<<<<
 *             cdef char *cfilename_index = self.filename_index
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_AsWritableString(__pyx_v_self->__pyx_base.filename); if (unlikely((!__pyx_t_1) && PyErr_Occurred())) __PYX_ERR(0, 545, __pyx_L1_error)
  __pyx_v_cfilename = __pyx_t_1;

  /* "pysam/libctabix.pyx":546
 * 
 *             cdef char *cfilename = self.filename
 *             cdef char *cfilename_index = self.filename_index             # <<<<<<<<<<<<<<
 * 
 *             cdef kstring_t buffer
 */
  __pyx_t_1 = __Pyx_PyObject_AsWritableString(__pyx_v_self->filename_index); if (unlikely((!__pyx_t_1) && PyErr_Occurred())) __PYX_ERR(0, 546, __pyx_L1_error)
  __pyx_v_cfilename_index = __pyx_t_1;

  /* "pysam/libctabix.pyx":549
 * 
 *             cdef kstring_t buffer
 *             buffer.l = buffer.m = 0             # <<<<<<<<<<<<<<
 *             buffer.s = NULL
 * 
 */
  __pyx_v_buffer.l = 0;
  __pyx_v_buffer.m = 0;

  /* "pysam/libctabix.pyx":550
 *             cdef kstring_t buffer
 *             buffer.l = buffer.m = 0
 *             buffer.s = NULL             # <<<<<<<<<<<<<<
 * 
 *             cdef htsFile * fp = NULL
 */
  __pyx_v_buffer.s = NULL;

  /* "pysam/libctabix.pyx":552
 *             buffer.s = NULL
 * 
 *             cdef htsFile * fp = NULL             # <<<<<<<<<<<<<<
 *             cdef int KS_SEP_LINE = 2
 *             cdef tbx_t * tbx = NULL
 */
  __pyx_v_fp = NULL;

  /* "pysam/libctabix.pyx":553
 * 
 *             cdef htsFile * fp = NULL
 *             cdef int KS_SEP_LINE = 2             # <<<<<<<<<<<<<<
 *             cdef tbx_t * tbx = NULL
 *             lines = []
 */
  __pyx_v_KS_SEP_LINE = 2;

  /* "pysam/libctabix.pyx":554
 *             cdef htsFile * fp = NULL
 *             cdef int KS_SEP_LINE = 2
 *             cdef tbx_t * tbx = NULL             # <<<<<<<<<<<<<<
 *             lines = []
 *             with nogil:
 */
  __pyx_v_tbx = NULL;

  /* "pysam/libctabix.pyx":555
 *             cdef int KS_SEP_LINE = 2
 *             cdef tbx_t * tbx = NULL
 *             lines = []             # <<<<<<<<<<<<<<
 *             with nogil:
 *                 fp = hts_open(cfilename, 'r')
 */
  __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 555, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_v_lines = ((PyObject*)__pyx_t_2);
  __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":556
 *             cdef tbx_t * tbx = NULL
 *             lines = []
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 fp = hts_open(cfilename, 'r')
 * 
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":557
 *             lines = []
 *             with nogil:
 *                 fp = hts_open(cfilename, 'r')             # <<<<<<<<<<<<<<
 * 
 *             if fp == NULL:
 */
        __pyx_v_fp = hts_open(__pyx_v_cfilename, ((char const *)"r"));
      }

      /* "pysam/libctabix.pyx":556
 *             cdef tbx_t * tbx = NULL
 *             lines = []
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 fp = hts_open(cfilename, 'r')
 * 
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L5;
        }
        __pyx_L5:;
      }
  }

  /* "pysam/libctabix.pyx":559
 *                 fp = hts_open(cfilename, 'r')
 * 
 *             if fp == NULL:             # <<<<<<<<<<<<<<
 *                 raise OSError("could not open {} for reading header".format(self.filename))
 * 
 */
  __pyx_t_3 = (__pyx_v_fp == NULL);
  if (unlikely(__pyx_t_3)) {

    /* "pysam/libctabix.pyx":560
 * 
 *             if fp == NULL:
 *                 raise OSError("could not open {} for reading header".format(self.filename))             # <<<<<<<<<<<<<<
 * 
 *             with nogil:
 */
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_could_not_open_for_reading_heade, __pyx_n_s_format); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 560, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = NULL;
    __pyx_t_6 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_4))) {
      __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_4);
      if (likely(__pyx_t_5)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
        __Pyx_INCREF(__pyx_t_5);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_4, function);
        __pyx_t_6 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_5, __pyx_v_self->__pyx_base.filename};
      __pyx_t_2 = __Pyx_PyObject_FastCall(__pyx_t_4, __pyx_callargs+1-__pyx_t_6, 1+__pyx_t_6);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 560, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    }
    __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_OSError, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 560, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_Raise(__pyx_t_4, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __PYX_ERR(0, 560, __pyx_L1_error)

    /* "pysam/libctabix.pyx":559
 *                 fp = hts_open(cfilename, 'r')
 * 
 *             if fp == NULL:             # <<<<<<<<<<<<<<
 *                 raise OSError("could not open {} for reading header".format(self.filename))
 * 
 */
  }

  /* "pysam/libctabix.pyx":562
 *                 raise OSError("could not open {} for reading header".format(self.filename))
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 tbx = tbx_index_load2(cfilename, cfilename_index)
 * 
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":563
 * 
 *             with nogil:
 *                 tbx = tbx_index_load2(cfilename, cfilename_index)             # <<<<<<<<<<<<<<
 * 
 *             if tbx == NULL:
 */
        __pyx_v_tbx = tbx_index_load2(__pyx_v_cfilename, __pyx_v_cfilename_index);
      }

      /* "pysam/libctabix.pyx":562
 *                 raise OSError("could not open {} for reading header".format(self.filename))
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 tbx = tbx_index_load2(cfilename, cfilename_index)
 * 
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L9;
        }
        __pyx_L9:;
      }
  }

  /* "pysam/libctabix.pyx":565
 *                 tbx = tbx_index_load2(cfilename, cfilename_index)
 * 
 *             if tbx == NULL:             # <<<<<<<<<<<<<<
 *                 raise OSError("could not load .tbi/.csi index of {}".format(self.filename))
 * 
 */
  __pyx_t_3 = (__pyx_v_tbx == NULL);
  if (unlikely(__pyx_t_3)) {

    /* "pysam/libctabix.pyx":566
 * 
 *             if tbx == NULL:
 *                 raise OSError("could not load .tbi/.csi index of {}".format(self.filename))             # <<<<<<<<<<<<<<
 * 
 *             while hts_getline(fp, KS_SEP_LINE, &buffer) >= 0:
 */
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_could_not_load_tbi_csi_index_of, __pyx_n_s_format); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 566, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = NULL;
    __pyx_t_6 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_5)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_5);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_6 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_5, __pyx_v_self->__pyx_base.filename};
      __pyx_t_4 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_6, 1+__pyx_t_6);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 566, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_OSError, __pyx_t_4); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 566, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_Raise(__pyx_t_2, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __PYX_ERR(0, 566, __pyx_L1_error)

    /* "pysam/libctabix.pyx":565
 *                 tbx = tbx_index_load2(cfilename, cfilename_index)
 * 
 *             if tbx == NULL:             # <<<<<<<<<<<<<<
 *                 raise OSError("could not load .tbi/.csi index of {}".format(self.filename))
 * 
 */
  }

  /* "pysam/libctabix.pyx":568
 *                 raise OSError("could not load .tbi/.csi index of {}".format(self.filename))
 * 
 *             while hts_getline(fp, KS_SEP_LINE, &buffer) >= 0:             # <<<<<<<<<<<<<<
 *                 if not buffer.l or buffer.s[0] != tbx.conf.meta_char:
 *                     break
 */
  while (1) {
    __pyx_t_3 = (hts_getline(__pyx_v_fp, __pyx_v_KS_SEP_LINE, (&__pyx_v_buffer)) >= 0);
    if (!__pyx_t_3) break;

    /* "pysam/libctabix.pyx":569
 * 
 *             while hts_getline(fp, KS_SEP_LINE, &buffer) >= 0:
 *                 if not buffer.l or buffer.s[0] != tbx.conf.meta_char:             # <<<<<<<<<<<<<<
 *                     break
 *                 lines.append(force_str(buffer.s, self.encoding))
 */
    __pyx_t_7 = (!(__pyx_v_buffer.l != 0));
    if (!__pyx_t_7) {
    } else {
      __pyx_t_3 = __pyx_t_7;
      goto __pyx_L14_bool_binop_done;
    }
    __pyx_t_7 = ((__pyx_v_buffer.s[0]) != __pyx_v_tbx->conf.meta_char);
    __pyx_t_3 = __pyx_t_7;
    __pyx_L14_bool_binop_done:;
    if (__pyx_t_3) {

      /* "pysam/libctabix.pyx":570
 *             while hts_getline(fp, KS_SEP_LINE, &buffer) >= 0:
 *                 if not buffer.l or buffer.s[0] != tbx.conf.meta_char:
 *                     break             # <<<<<<<<<<<<<<
 *                 lines.append(force_str(buffer.s, self.encoding))
 * 
 */
      goto __pyx_L12_break;

      /* "pysam/libctabix.pyx":569
 * 
 *             while hts_getline(fp, KS_SEP_LINE, &buffer) >= 0:
 *                 if not buffer.l or buffer.s[0] != tbx.conf.meta_char:             # <<<<<<<<<<<<<<
 *                     break
 *                 lines.append(force_str(buffer.s, self.encoding))
 */
    }

    /* "pysam/libctabix.pyx":571
 *                 if not buffer.l or buffer.s[0] != tbx.conf.meta_char:
 *                     break
 *                 lines.append(force_str(buffer.s, self.encoding))             # <<<<<<<<<<<<<<
 * 
 *             with nogil:
 */
    __pyx_t_2 = __Pyx_PyBytes_FromString(__pyx_v_buffer.s); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 571, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = __pyx_v_self->encoding;
    __Pyx_INCREF(__pyx_t_4);
    __pyx_t_8.__pyx_n = 1;
    __pyx_t_8.encoding = __pyx_t_4;
    __pyx_t_5 = __pyx_f_5pysam_9libcutils_force_str(__pyx_t_2, &__pyx_t_8); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 571, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_9 = __Pyx_PyList_Append(__pyx_v_lines, __pyx_t_5); if (unlikely(__pyx_t_9 == ((int)-1))) __PYX_ERR(0, 571, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  }
  __pyx_L12_break:;

  /* "pysam/libctabix.pyx":573
 *                 lines.append(force_str(buffer.s, self.encoding))
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 hts_close(fp)
 *                 free(buffer.s)
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":574
 * 
 *             with nogil:
 *                 hts_close(fp)             # <<<<<<<<<<<<<<
 *                 free(buffer.s)
 * 
 */
        (void)(hts_close(__pyx_v_fp));

        /* "pysam/libctabix.pyx":575
 *             with nogil:
 *                 hts_close(fp)
 *                 free(buffer.s)             # <<<<<<<<<<<<<<
 * 
 *             return lines
 */
        free(__pyx_v_buffer.s);
      }

      /* "pysam/libctabix.pyx":573
 *                 lines.append(force_str(buffer.s, self.encoding))
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 hts_close(fp)
 *                 free(buffer.s)
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L18;
        }
        __pyx_L18:;
      }
  }

  /* "pysam/libctabix.pyx":577
 *                 free(buffer.s)
 * 
 *             return lines             # <<<<<<<<<<<<<<
 * 
 *     property contigs:
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_lines);
  __pyx_r = __pyx_v_lines;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":543
 *         '''
 * 
 *         def __get__(self):             # <<<<<<<<<<<<<<
 * 
 *             cdef char *cfilename = self.filename
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.header.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_lines);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":581
 *     property contigs:
 *         '''list of chromosome names'''
 *         def __get__(self):             # <<<<<<<<<<<<<<
 *             cdef const char ** sequences
 *             cdef int nsequences
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_7contigs_1__get__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_7contigs_1__get__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_7contigs___get__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_7contigs___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  char const **__pyx_v_sequences;
  int __pyx_v_nsequences;
  int __pyx_v_x;
  PyObject *__pyx_v_result = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__get__", 0);
  __Pyx_TraceCall("__get__", __pyx_f[0], 581, 0, __PYX_ERR(0, 581, __pyx_L1_error));

  /* "pysam/libctabix.pyx":585
 *             cdef int nsequences
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 sequences = tbx_seqnames(self.index, &nsequences)
 *             cdef int x
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":586
 * 
 *             with nogil:
 *                 sequences = tbx_seqnames(self.index, &nsequences)             # <<<<<<<<<<<<<<
 *             cdef int x
 *             result = []
 */
        __pyx_v_sequences = tbx_seqnames(__pyx_v_self->index, (&__pyx_v_nsequences));
      }

      /* "pysam/libctabix.pyx":585
 *             cdef int nsequences
 * 
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 sequences = tbx_seqnames(self.index, &nsequences)
 *             cdef int x
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L5;
        }
        __pyx_L5:;
      }
  }

  /* "pysam/libctabix.pyx":588
 *                 sequences = tbx_seqnames(self.index, &nsequences)
 *             cdef int x
 *             result = []             # <<<<<<<<<<<<<<
 *             for x from 0 <= x < nsequences:
 *                 result.append(force_str(sequences[x]))
 */
  __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 588, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_result = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":589
 *             cdef int x
 *             result = []
 *             for x from 0 <= x < nsequences:             # <<<<<<<<<<<<<<
 *                 result.append(force_str(sequences[x]))
 * 
 */
  __pyx_t_2 = __pyx_v_nsequences;
  for (__pyx_v_x = 0; __pyx_v_x < __pyx_t_2; __pyx_v_x++) {

    /* "pysam/libctabix.pyx":590
 *             result = []
 *             for x from 0 <= x < nsequences:
 *                 result.append(force_str(sequences[x]))             # <<<<<<<<<<<<<<
 * 
 *             # htslib instructions:
 */
    __pyx_t_1 = __Pyx_PyBytes_FromString((__pyx_v_sequences[__pyx_v_x])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 590, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = __pyx_f_5pysam_9libcutils_force_str(__pyx_t_1, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 590, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_4 = __Pyx_PyList_Append(__pyx_v_result, __pyx_t_3); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(0, 590, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }

  /* "pysam/libctabix.pyx":594
 *             # htslib instructions:
 *             # only free container, not the sequences themselves
 *             free(sequences)             # <<<<<<<<<<<<<<
 * 
 *             return result
 */
  free(__pyx_v_sequences);

  /* "pysam/libctabix.pyx":596
 *             free(sequences)
 * 
 *             return result             # <<<<<<<<<<<<<<
 * 
 *     def close(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_result);
  __pyx_r = __pyx_v_result;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":581
 *     property contigs:
 *         '''list of chromosome names'''
 *         def __get__(self):             # <<<<<<<<<<<<<<
 *             cdef const char ** sequences
 *             cdef int nsequences
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.contigs.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":598
 *             return result
 * 
 *     def close(self):             # <<<<<<<<<<<<<<
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_9close(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_8close, "TabixFile.close(self)\n\n        closes the :class:`pysam.TabixFile`.");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_9close = {"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_9close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_8close};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_9close(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("close (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 598, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("close", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "close", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.close", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_8close(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_8close(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__21)
  __Pyx_RefNannySetupContext("close", 0);
  __Pyx_TraceCall("close", __pyx_f[0], 598, 0, __PYX_ERR(0, 598, __pyx_L1_error));

  /* "pysam/libctabix.pyx":601
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 */
  __pyx_t_1 = (__pyx_v_self->__pyx_base.htsfile != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":602
 *         closes the :class:`pysam.TabixFile`.'''
 *         if self.htsfile != NULL:
 *             hts_close(self.htsfile)             # <<<<<<<<<<<<<<
 *             self.htsfile = NULL
 *         if self.index != NULL:
 */
    (void)(hts_close(__pyx_v_self->__pyx_base.htsfile));

    /* "pysam/libctabix.pyx":603
 *         if self.htsfile != NULL:
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL             # <<<<<<<<<<<<<<
 *         if self.index != NULL:
 *             tbx_destroy(self.index)
 */
    __pyx_v_self->__pyx_base.htsfile = NULL;

    /* "pysam/libctabix.pyx":601
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 */
  }

  /* "pysam/libctabix.pyx":604
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 *         if self.index != NULL:             # <<<<<<<<<<<<<<
 *             tbx_destroy(self.index)
 *             self.index = NULL
 */
  __pyx_t_1 = (__pyx_v_self->index != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":605
 *             self.htsfile = NULL
 *         if self.index != NULL:
 *             tbx_destroy(self.index)             # <<<<<<<<<<<<<<
 *             self.index = NULL
 * 
 */
    tbx_destroy(__pyx_v_self->index);

    /* "pysam/libctabix.pyx":606
 *         if self.index != NULL:
 *             tbx_destroy(self.index)
 *             self.index = NULL             # <<<<<<<<<<<<<<
 * 
 *     def __dealloc__( self ):
 */
    __pyx_v_self->index = NULL;

    /* "pysam/libctabix.pyx":604
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 *         if self.index != NULL:             # <<<<<<<<<<<<<<
 *             tbx_destroy(self.index)
 *             self.index = NULL
 */
  }

  /* "pysam/libctabix.pyx":598
 *             return result
 * 
 *     def close(self):             # <<<<<<<<<<<<<<
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.close", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":608
 *             self.index = NULL
 * 
 *     def __dealloc__( self ):             # <<<<<<<<<<<<<<
 *         # remember: dealloc cannot call other python methods
 *         # note: no doc string
 */

/* Python wrapper */
static void __pyx_pw_5pysam_9libctabix_9TabixFile_11__dealloc__(PyObject *__pyx_v_self); /*proto*/
static void __pyx_pw_5pysam_9libctabix_9TabixFile_11__dealloc__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_pf_5pysam_9libctabix_9TabixFile_10__dealloc__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_5pysam_9libctabix_9TabixFile_10__dealloc__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__dealloc__", 0);
  __Pyx_TraceCall("__dealloc__", __pyx_f[0], 608, 0, __PYX_ERR(0, 608, __pyx_L1_error));

  /* "pysam/libctabix.pyx":612
 *         # note: no doc string
 *         # note: __del__ is not called.
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 */
  __pyx_t_1 = (__pyx_v_self->__pyx_base.htsfile != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":613
 *         # note: __del__ is not called.
 *         if self.htsfile != NULL:
 *             hts_close(self.htsfile)             # <<<<<<<<<<<<<<
 *             self.htsfile = NULL
 *         if self.index != NULL:
 */
    (void)(hts_close(__pyx_v_self->__pyx_base.htsfile));

    /* "pysam/libctabix.pyx":614
 *         if self.htsfile != NULL:
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL             # <<<<<<<<<<<<<<
 *         if self.index != NULL:
 *             tbx_destroy(self.index)
 */
    __pyx_v_self->__pyx_base.htsfile = NULL;

    /* "pysam/libctabix.pyx":612
 *         # note: no doc string
 *         # note: __del__ is not called.
 *         if self.htsfile != NULL:             # <<<<<<<<<<<<<<
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 */
  }

  /* "pysam/libctabix.pyx":615
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 *         if self.index != NULL:             # <<<<<<<<<<<<<<
 *             tbx_destroy(self.index)
 * 
 */
  __pyx_t_1 = (__pyx_v_self->index != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":616
 *             self.htsfile = NULL
 *         if self.index != NULL:
 *             tbx_destroy(self.index)             # <<<<<<<<<<<<<<
 * 
 * 
 */
    tbx_destroy(__pyx_v_self->index);

    /* "pysam/libctabix.pyx":615
 *             hts_close(self.htsfile)
 *             self.htsfile = NULL
 *         if self.index != NULL:             # <<<<<<<<<<<<<<
 *             tbx_destroy(self.index)
 * 
 */
  }

  /* "pysam/libctabix.pyx":608
 *             self.index = NULL
 * 
 *     def __dealloc__( self ):             # <<<<<<<<<<<<<<
 *         # remember: dealloc cannot call other python methods
 *         # note: no doc string
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("pysam.libctabix.TabixFile.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "pysam/libctabix.pxd":65
 *     cdef tbx_t * index
 * 
 *     cdef readonly object filename_index             # <<<<<<<<<<<<<<
 * 
 *     cdef Parser parser
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_14filename_index_1__get__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_14filename_index_1__get__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__get__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_14filename_index___get__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_14filename_index___get__(struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__get__", 0);
  __Pyx_TraceCall("__get__", __pyx_f[4], 65, 0, __PYX_ERR(4, 65, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_self->filename_index);
  __pyx_r = __pyx_v_self->filename_index;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.filename_index.__get__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_13__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_12__reduce_cython__, "TabixFile.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_13__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_13__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_12__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_13__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_12__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_12__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__22)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_15__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9TabixFile_14__setstate_cython__, "TabixFile.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9TabixFile_15__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_15__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_14__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_9TabixFile_15__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9TabixFile_14__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixFile *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9TabixFile_14__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixFile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__23)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixFile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":624
 *     """
 * 
 *     def __init__(self, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_13TabixIterator_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_13TabixIterator_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_encoding = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 624, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_encoding,0};
    values[0] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_n_u_ascii));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_encoding);
          if (value) { values[0] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 624, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 624, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_encoding = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 0, 0, 1, __pyx_nargs); __PYX_ERR(0, 624, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_13TabixIterator___init__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self), __pyx_v_encoding);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_13TabixIterator___init__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self, PyObject *__pyx_v_encoding) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 624, 0, __PYX_ERR(0, 624, __pyx_L1_error));

  /* "pysam/libctabix.pyx":625
 * 
 *     def __init__(self, encoding="ascii"):
 *         self.encoding = encoding             # <<<<<<<<<<<<<<
 * 
 *     def __iter__(self):
 */
  __Pyx_INCREF(__pyx_v_encoding);
  __Pyx_GIVEREF(__pyx_v_encoding);
  __Pyx_GOTREF(__pyx_v_self->encoding);
  __Pyx_DECREF(__pyx_v_self->encoding);
  __pyx_v_self->encoding = __pyx_v_encoding;

  /* "pysam/libctabix.pyx":624
 *     """
 * 
 *     def __init__(self, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":627
 *         self.encoding = encoding
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         self.buffer.s = NULL
 *         self.buffer.l = 0
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_3__iter__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_3__iter__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_13TabixIterator_2__iter__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_2__iter__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__iter__", 0);
  __Pyx_TraceCall("__iter__", __pyx_f[0], 627, 0, __PYX_ERR(0, 627, __pyx_L1_error));

  /* "pysam/libctabix.pyx":628
 * 
 *     def __iter__(self):
 *         self.buffer.s = NULL             # <<<<<<<<<<<<<<
 *         self.buffer.l = 0
 *         self.buffer.m = 0
 */
  __pyx_v_self->buffer.s = NULL;

  /* "pysam/libctabix.pyx":629
 *     def __iter__(self):
 *         self.buffer.s = NULL
 *         self.buffer.l = 0             # <<<<<<<<<<<<<<
 *         self.buffer.m = 0
 * 
 */
  __pyx_v_self->buffer.l = 0;

  /* "pysam/libctabix.pyx":630
 *         self.buffer.s = NULL
 *         self.buffer.l = 0
 *         self.buffer.m = 0             # <<<<<<<<<<<<<<
 * 
 *         return self
 */
  __pyx_v_self->buffer.m = 0;

  /* "pysam/libctabix.pyx":632
 *         self.buffer.m = 0
 * 
 *         return self             # <<<<<<<<<<<<<<
 * 
 *     cdef int __cnext__(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_self);
  __pyx_r = ((PyObject *)__pyx_v_self);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":627
 *         self.encoding = encoding
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         self.buffer.s = NULL
 *         self.buffer.l = 0
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":634
 *         return self
 * 
 *     cdef int __cnext__(self):             # <<<<<<<<<<<<<<
 *         '''iterate to next element.
 * 
 */

static int __pyx_f_5pysam_9libctabix_13TabixIterator___cnext__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self) {
  int __pyx_v_retval;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__cnext__", 0);
  __Pyx_TraceCall("__cnext__", __pyx_f[0], 634, 0, __PYX_ERR(0, 634, __pyx_L1_error));

  /* "pysam/libctabix.pyx":640
 *         was called.
 *         '''
 *         if self.tabixfile.htsfile == NULL:             # <<<<<<<<<<<<<<
 *             return -5
 * 
 */
  __pyx_t_1 = (__pyx_v_self->tabixfile->__pyx_base.htsfile == NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":641
 *         '''
 *         if self.tabixfile.htsfile == NULL:
 *             return -5             # <<<<<<<<<<<<<<
 * 
 *         cdef int retval
 */
    __pyx_r = -5;
    goto __pyx_L0;

    /* "pysam/libctabix.pyx":640
 *         was called.
 *         '''
 *         if self.tabixfile.htsfile == NULL:             # <<<<<<<<<<<<<<
 *             return -5
 * 
 */
  }

  /* "pysam/libctabix.pyx":645
 *         cdef int retval
 * 
 *         while 1:             # <<<<<<<<<<<<<<
 *             with nogil:
 *                 retval = tbx_itr_next(
 */
  while (1) {

    /* "pysam/libctabix.pyx":646
 * 
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = tbx_itr_next(
 *                     self.tabixfile.htsfile,
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":647
 *         while 1:
 *             with nogil:
 *                 retval = tbx_itr_next(             # <<<<<<<<<<<<<<
 *                     self.tabixfile.htsfile,
 *                     self.tabixfile.index,
 */
          __pyx_v_retval = tbx_itr_next(__pyx_v_self->tabixfile->__pyx_base.htsfile, __pyx_v_self->tabixfile->index, __pyx_v_self->iterator, (&__pyx_v_self->buffer));
        }

        /* "pysam/libctabix.pyx":646
 * 
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = tbx_itr_next(
 *                     self.tabixfile.htsfile,
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L10;
          }
          __pyx_L10:;
        }
    }

    /* "pysam/libctabix.pyx":653
 *                     &self.buffer)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    __pyx_t_1 = (__pyx_v_retval < 0);
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":654
 * 
 *             if retval < 0:
 *                 break             # <<<<<<<<<<<<<<
 * 
 *             if self.buffer.s[0] != b'#':
 */
      goto __pyx_L5_break;

      /* "pysam/libctabix.pyx":653
 *                     &self.buffer)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    }

    /* "pysam/libctabix.pyx":656
 *                 break
 * 
 *             if self.buffer.s[0] != b'#':             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    __pyx_t_1 = ((__pyx_v_self->buffer.s[0]) != '#');
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":657
 * 
 *             if self.buffer.s[0] != b'#':
 *                 break             # <<<<<<<<<<<<<<
 * 
 *         return retval
 */
      goto __pyx_L5_break;

      /* "pysam/libctabix.pyx":656
 *                 break
 * 
 *             if self.buffer.s[0] != b'#':             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    }
  }
  __pyx_L5_break:;

  /* "pysam/libctabix.pyx":659
 *                 break
 * 
 *         return retval             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  __pyx_r = __pyx_v_retval;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":634
 *         return self
 * 
 *     cdef int __cnext__(self):             # <<<<<<<<<<<<<<
 *         '''iterate to next element.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__cnext__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":661
 *         return retval
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__(PyObject *__pyx_v_self); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_13TabixIterator_4__next__, "python version of next().\n\n        pyrex uses this non-standard name instead of next()\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_13TabixIterator_4__next__;
#endif
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_13TabixIterator_4__next__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_4__next__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self) {
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_error_without_exception = 0; /* StopIteration */
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 661, 0, __PYX_ERR(0, 661, __pyx_L1_error));

  /* "pysam/libctabix.pyx":667
 *         """
 * 
 *         cdef int retval = self.__cnext__()             # <<<<<<<<<<<<<<
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator *)__pyx_v_self->__pyx_vtab)->__pyx___cnext__(__pyx_v_self); if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 667, __pyx_L1_error)
  __pyx_v_retval = __pyx_t_1;

  /* "pysam/libctabix.pyx":668
 * 
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:             # <<<<<<<<<<<<<<
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 */
  __pyx_t_2 = (__pyx_v_retval == -5L);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":669
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:
 *             raise IOError("iteration on closed file")             # <<<<<<<<<<<<<<
 *         elif retval < 0:
 *             raise StopIteration
 */
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_IOError, __pyx_tuple__24, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 669, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 669, __pyx_L1_error)

    /* "pysam/libctabix.pyx":668
 * 
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:             # <<<<<<<<<<<<<<
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 */
  }

  /* "pysam/libctabix.pyx":670
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  __pyx_t_2 = (__pyx_v_retval < 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":671
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 * 
 *         return charptr_to_str(self.buffer.s, self.encoding)
 */
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;

    /* "pysam/libctabix.pyx":670
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  }

  /* "pysam/libctabix.pyx":673
 *             raise StopIteration
 * 
 *         return charptr_to_str(self.buffer.s, self.encoding)             # <<<<<<<<<<<<<<
 * 
 *     def __dealloc__(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_3 = __pyx_v_self->encoding;
  __Pyx_INCREF(__pyx_t_3);
  __pyx_t_5.__pyx_n = 1;
  __pyx_t_5.encoding = __pyx_t_3;
  __pyx_t_4 = __pyx_f_5pysam_9libcutils_charptr_to_str(__pyx_v_self->buffer.s, &__pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 673, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_r = __pyx_t_4;
  __pyx_t_4 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":661
 *         return retval
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  if (!__pyx_error_without_exception) {
    __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  }
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":675
 *         return charptr_to_str(self.buffer.s, self.encoding)
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         if <void*>self.iterator != NULL:
 *             tbx_itr_destroy(self.iterator)
 */

/* Python wrapper */
static void __pyx_pw_5pysam_9libctabix_13TabixIterator_7__dealloc__(PyObject *__pyx_v_self); /*proto*/
static void __pyx_pw_5pysam_9libctabix_13TabixIterator_7__dealloc__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_pf_5pysam_9libctabix_13TabixIterator_6__dealloc__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_5pysam_9libctabix_13TabixIterator_6__dealloc__(struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__dealloc__", 0);
  __Pyx_TraceCall("__dealloc__", __pyx_f[0], 675, 0, __PYX_ERR(0, 675, __pyx_L1_error));

  /* "pysam/libctabix.pyx":676
 * 
 *     def __dealloc__(self):
 *         if <void*>self.iterator != NULL:             # <<<<<<<<<<<<<<
 *             tbx_itr_destroy(self.iterator)
 *         if self.buffer.s != NULL:
 */
  __pyx_t_1 = (((void *)__pyx_v_self->iterator) != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":677
 *     def __dealloc__(self):
 *         if <void*>self.iterator != NULL:
 *             tbx_itr_destroy(self.iterator)             # <<<<<<<<<<<<<<
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)
 */
    tbx_itr_destroy(__pyx_v_self->iterator);

    /* "pysam/libctabix.pyx":676
 * 
 *     def __dealloc__(self):
 *         if <void*>self.iterator != NULL:             # <<<<<<<<<<<<<<
 *             tbx_itr_destroy(self.iterator)
 *         if self.buffer.s != NULL:
 */
  }

  /* "pysam/libctabix.pyx":678
 *         if <void*>self.iterator != NULL:
 *             tbx_itr_destroy(self.iterator)
 *         if self.buffer.s != NULL:             # <<<<<<<<<<<<<<
 *             free(self.buffer.s)
 * 
 */
  __pyx_t_1 = (__pyx_v_self->buffer.s != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":679
 *             tbx_itr_destroy(self.iterator)
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)             # <<<<<<<<<<<<<<
 * 
 * 
 */
    free(__pyx_v_self->buffer.s);

    /* "pysam/libctabix.pyx":678
 *         if <void*>self.iterator != NULL:
 *             tbx_itr_destroy(self.iterator)
 *         if self.buffer.s != NULL:             # <<<<<<<<<<<<<<
 *             free(self.buffer.s)
 * 
 */
  }

  /* "pysam/libctabix.pyx":675
 *         return charptr_to_str(self.buffer.s, self.encoding)
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         if <void*>self.iterator != NULL:
 *             tbx_itr_destroy(self.iterator)
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("pysam.libctabix.TabixIterator.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_13TabixIterator_8__reduce_cython__, "TabixIterator.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_13TabixIterator_9__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13TabixIterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13TabixIterator_8__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_13TabixIterator_8__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__25)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_iterator_cannot_be_converte, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_13TabixIterator_10__setstate_cython__, "TabixIterator.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_13TabixIterator_11__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13TabixIterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13TabixIterator_10__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_13TabixIterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_13TabixIterator_10__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13TabixIterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__26)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_iterator_cannot_be_converte, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":685
 *     '''empty iterator'''
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13EmptyIterator_1__iter__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_13EmptyIterator___iter__, "EmptyIterator.__iter__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_13EmptyIterator_1__iter__ = {"__iter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13EmptyIterator_1__iter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13EmptyIterator___iter__};
static PyObject *__pyx_pw_5pysam_9libctabix_13EmptyIterator_1__iter__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_self = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 685, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_self,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_self)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 685, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__iter__") < 0)) __PYX_ERR(0, 685, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v_self = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__iter__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 685, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.EmptyIterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_13EmptyIterator___iter__(__pyx_self, __pyx_v_self);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13EmptyIterator___iter__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__27)
  __Pyx_RefNannySetupContext("__iter__", 0);
  __Pyx_TraceCall("__iter__", __pyx_f[0], 685, 0, __PYX_ERR(0, 685, __pyx_L1_error));

  /* "pysam/libctabix.pyx":686
 * 
 *     def __iter__(self):
 *         return self             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_self);
  __pyx_r = __pyx_v_self;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":685
 *     '''empty iterator'''
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.EmptyIterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":688
 *         return self
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         raise StopIteration()
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13EmptyIterator_3__next__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_13EmptyIterator_2__next__, "EmptyIterator.__next__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_13EmptyIterator_3__next__ = {"__next__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13EmptyIterator_3__next__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13EmptyIterator_2__next__};
static PyObject *__pyx_pw_5pysam_9libctabix_13EmptyIterator_3__next__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v_self = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 688, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_self,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_self)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 688, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__next__") < 0)) __PYX_ERR(0, 688, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v_self = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__next__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 688, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.EmptyIterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_13EmptyIterator_2__next__(__pyx_self, __pyx_v_self);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_13EmptyIterator_2__next__(CYTHON_UNUSED PyObject *__pyx_self, CYTHON_UNUSED PyObject *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__28)
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 688, 0, __PYX_ERR(0, 688, __pyx_L1_error));

  /* "pysam/libctabix.pyx":689
 * 
 *     def __next__(self):
 *         raise StopIteration()             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_CallNoArg(__pyx_builtin_StopIteration); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 689, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_Raise(__pyx_t_1, 0, 0, 0);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __PYX_ERR(0, 689, __pyx_L1_error)

  /* "pysam/libctabix.pyx":688
 *         return self
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         raise StopIteration()
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.EmptyIterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":700
 *     """
 * 
 *     def __init__(self,             # <<<<<<<<<<<<<<
 *                  Parser parser):
 * 
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 700, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_parser,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 700, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 700, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
    }
    __pyx_v_parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)values[0]);
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 700, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_parser), __pyx_ptype_5pysam_9libctabix_Parser, 1, "parser", 0))) __PYX_ERR(0, 701, __pyx_L1_error)
  __pyx_r = __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed___init__(((struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)__pyx_v_self), __pyx_v_parser);

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __pyx_r = -1;
  __pyx_L0:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed___init__(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self, struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 700, 0, __PYX_ERR(0, 700, __pyx_L1_error));

  /* "pysam/libctabix.pyx":703
 *                  Parser parser):
 * 
 *         TabixIterator.__init__(self)             # <<<<<<<<<<<<<<
 *         self.parser = parser
 * 
 */
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIterator), __pyx_n_s_init); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 703, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = NULL;
  __pyx_t_4 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_4 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_3, ((PyObject *)__pyx_v_self)};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 1+__pyx_t_4);
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 703, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":704
 * 
 *         TabixIterator.__init__(self)
 *         self.parser = parser             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  __Pyx_INCREF((PyObject *)__pyx_v_parser);
  __Pyx_GIVEREF((PyObject *)__pyx_v_parser);
  __Pyx_GOTREF((PyObject *)__pyx_v_self->parser);
  __Pyx_DECREF((PyObject *)__pyx_v_self->parser);
  __pyx_v_self->parser = __pyx_v_parser;

  /* "pysam/libctabix.pyx":700
 *     """
 * 
 *     def __init__(self,             # <<<<<<<<<<<<<<
 *                  Parser parser):
 * 
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":706
 *         self.parser = parser
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__(PyObject *__pyx_v_self); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_2__next__, "python version of next().\n\n        pyrex uses this non-standard name instead of next()\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_19TabixIteratorParsed_2__next__;
#endif
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_2__next__(((struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_2__next__(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self) {
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_error_without_exception = 0; /* StopIteration */
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 706, 0, __PYX_ERR(0, 706, __pyx_L1_error));

  /* "pysam/libctabix.pyx":712
 *         """
 * 
 *         cdef int retval = self.__cnext__()             # <<<<<<<<<<<<<<
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_TabixIteratorParsed *)__pyx_v_self->__pyx_base.__pyx_vtab)->__pyx_base.__pyx___cnext__(((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)__pyx_v_self)); if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 712, __pyx_L1_error)
  __pyx_v_retval = __pyx_t_1;

  /* "pysam/libctabix.pyx":713
 * 
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:             # <<<<<<<<<<<<<<
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 */
  __pyx_t_2 = (__pyx_v_retval == -5L);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":714
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:
 *             raise IOError("iteration on closed file")             # <<<<<<<<<<<<<<
 *         elif retval < 0:
 *             raise StopIteration
 */
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_IOError, __pyx_tuple__24, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 714, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 714, __pyx_L1_error)

    /* "pysam/libctabix.pyx":713
 * 
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:             # <<<<<<<<<<<<<<
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 */
  }

  /* "pysam/libctabix.pyx":715
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  __pyx_t_2 = (__pyx_v_retval < 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":716
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 * 
 *         return self.parser.parse(self.buffer.s,
 */
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;

    /* "pysam/libctabix.pyx":715
 *         if retval == -5:
 *             raise IOError("iteration on closed file")
 *         elif retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  }

  /* "pysam/libctabix.pyx":718
 *             raise StopIteration
 * 
 *         return self.parser.parse(self.buffer.s,             # <<<<<<<<<<<<<<
 *                                  self.buffer.l)
 * 
 */
  __Pyx_XDECREF(__pyx_r);

  /* "pysam/libctabix.pyx":719
 * 
 *         return self.parser.parse(self.buffer.s,
 *                                  self.buffer.l)             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __pyx_t_3 = ((struct __pyx_vtabstruct_5pysam_9libctabix_Parser *)__pyx_v_self->parser->__pyx_vtab)->parse(__pyx_v_self->parser, __pyx_v_self->__pyx_base.buffer.s, __pyx_v_self->__pyx_base.buffer.l); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 718, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_r = __pyx_t_3;
  __pyx_t_3 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":706
 *         self.parser = parser
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  if (!__pyx_error_without_exception) {
    __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  }
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__, "TabixIteratorParsed.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__29)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_iterator_cannot_be_converte, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__, "TabixIteratorParsed.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__30)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_iterator_cannot_be_converte, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.TabixIteratorParsed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":723
 * 
 * cdef class GZIterator:
 *     def __init__(self, filename, int buffer_size=65536, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         '''iterate line-by-line through gzip (or bgzip)
 *         compressed file.
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_10GZIterator_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_10GZIterator___init__, "iterate line-by-line through gzip (or bgzip)\n        compressed file.\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_10GZIterator___init__;
#endif
static int __pyx_pw_5pysam_9libctabix_10GZIterator_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_filename = 0;
  int __pyx_v_buffer_size;
  PyObject *__pyx_v_encoding = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 723, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_buffer_size,&__pyx_n_s_encoding,0};
    values[2] = __Pyx_Arg_NewRef_VARARGS(((PyObject *)__pyx_n_u_ascii));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 723, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_buffer_size);
          if (value) { values[1] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 723, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_encoding);
          if (value) { values[2] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 723, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 723, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_filename = values[0];
    if (values[1]) {
      __pyx_v_buffer_size = __Pyx_PyInt_As_int(values[1]); if (unlikely((__pyx_v_buffer_size == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 723, __pyx_L3_error)
    } else {
      __pyx_v_buffer_size = ((int)0x10000);
    }
    __pyx_v_encoding = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 0, 1, 3, __pyx_nargs); __PYX_ERR(0, 723, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_10GZIterator___init__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self), __pyx_v_filename, __pyx_v_buffer_size, __pyx_v_encoding);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_10GZIterator___init__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self, PyObject *__pyx_v_filename, int __pyx_v_buffer_size, PyObject *__pyx_v_encoding) {
  char *__pyx_v_cfilename;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_t_5;
  int __pyx_t_6;
  char *__pyx_t_7;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 723, 0, __PYX_ERR(0, 723, __pyx_L1_error));
  __Pyx_INCREF(__pyx_v_filename);

  /* "pysam/libctabix.pyx":727
 *         compressed file.
 *         '''
 *         if not os.path.exists(filename):             # <<<<<<<<<<<<<<
 *             raise IOError("No such file or directory: %s" % filename)
 * 
 */
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_os); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 727, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_path); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 727, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_exists); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 727, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = NULL;
  __pyx_t_4 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_4 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_3, __pyx_v_filename};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 1+__pyx_t_4);
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 727, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  }
  __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 727, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_6 = (!__pyx_t_5);
  if (unlikely(__pyx_t_6)) {

    /* "pysam/libctabix.pyx":728
 *         '''
 *         if not os.path.exists(filename):
 *             raise IOError("No such file or directory: %s" % filename)             # <<<<<<<<<<<<<<
 * 
 *         filename = encode_filename(filename)
 */
    __pyx_t_1 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_No_such_file_or_directory_s, __pyx_v_filename); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 728, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 728, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_Raise(__pyx_t_2, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __PYX_ERR(0, 728, __pyx_L1_error)

    /* "pysam/libctabix.pyx":727
 *         compressed file.
 *         '''
 *         if not os.path.exists(filename):             # <<<<<<<<<<<<<<
 *             raise IOError("No such file or directory: %s" % filename)
 * 
 */
  }

  /* "pysam/libctabix.pyx":730
 *             raise IOError("No such file or directory: %s" % filename)
 * 
 *         filename = encode_filename(filename)             # <<<<<<<<<<<<<<
 *         cdef char *cfilename = filename
 *         with nogil:
 */
  __pyx_t_2 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 730, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF_SET(__pyx_v_filename, __pyx_t_2);
  __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":731
 * 
 *         filename = encode_filename(filename)
 *         cdef char *cfilename = filename             # <<<<<<<<<<<<<<
 *         with nogil:
 *             self.gzipfile = bgzf_open(cfilename, "r")
 */
  __pyx_t_7 = __Pyx_PyObject_AsWritableString(__pyx_v_filename); if (unlikely((!__pyx_t_7) && PyErr_Occurred())) __PYX_ERR(0, 731, __pyx_L1_error)
  __pyx_v_cfilename = __pyx_t_7;

  /* "pysam/libctabix.pyx":732
 *         filename = encode_filename(filename)
 *         cdef char *cfilename = filename
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.gzipfile = bgzf_open(cfilename, "r")
 *         self._filename = filename
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":733
 *         cdef char *cfilename = filename
 *         with nogil:
 *             self.gzipfile = bgzf_open(cfilename, "r")             # <<<<<<<<<<<<<<
 *         self._filename = filename
 *         self.kstream = ks_init(self.gzipfile)
 */
        __pyx_v_self->gzipfile = bgzf_open(__pyx_v_cfilename, ((char const *)"r"));
      }

      /* "pysam/libctabix.pyx":732
 *         filename = encode_filename(filename)
 *         cdef char *cfilename = filename
 *         with nogil:             # <<<<<<<<<<<<<<
 *             self.gzipfile = bgzf_open(cfilename, "r")
 *         self._filename = filename
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L6;
        }
        __pyx_L6:;
      }
  }

  /* "pysam/libctabix.pyx":734
 *         with nogil:
 *             self.gzipfile = bgzf_open(cfilename, "r")
 *         self._filename = filename             # <<<<<<<<<<<<<<
 *         self.kstream = ks_init(self.gzipfile)
 *         self.encoding = encoding
 */
  __Pyx_INCREF(__pyx_v_filename);
  __Pyx_GIVEREF(__pyx_v_filename);
  __Pyx_GOTREF(__pyx_v_self->_filename);
  __Pyx_DECREF(__pyx_v_self->_filename);
  __pyx_v_self->_filename = __pyx_v_filename;

  /* "pysam/libctabix.pyx":735
 *             self.gzipfile = bgzf_open(cfilename, "r")
 *         self._filename = filename
 *         self.kstream = ks_init(self.gzipfile)             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */
  __pyx_v_self->kstream = ks_init(__pyx_v_self->gzipfile);

  /* "pysam/libctabix.pyx":736
 *         self._filename = filename
 *         self.kstream = ks_init(self.gzipfile)
 *         self.encoding = encoding             # <<<<<<<<<<<<<<
 * 
 *         self.buffer.l = 0
 */
  __Pyx_INCREF(__pyx_v_encoding);
  __Pyx_GIVEREF(__pyx_v_encoding);
  __Pyx_GOTREF(__pyx_v_self->encoding);
  __Pyx_DECREF(__pyx_v_self->encoding);
  __pyx_v_self->encoding = __pyx_v_encoding;

  /* "pysam/libctabix.pyx":738
 *         self.encoding = encoding
 * 
 *         self.buffer.l = 0             # <<<<<<<<<<<<<<
 *         self.buffer.m = 0
 *         self.buffer.s = <char*>malloc(buffer_size)
 */
  __pyx_v_self->buffer.l = 0;

  /* "pysam/libctabix.pyx":739
 * 
 *         self.buffer.l = 0
 *         self.buffer.m = 0             # <<<<<<<<<<<<<<
 *         self.buffer.s = <char*>malloc(buffer_size)
 * 
 */
  __pyx_v_self->buffer.m = 0;

  /* "pysam/libctabix.pyx":740
 *         self.buffer.l = 0
 *         self.buffer.m = 0
 *         self.buffer.s = <char*>malloc(buffer_size)             # <<<<<<<<<<<<<<
 * 
 *     def __dealloc__(self):
 */
  __pyx_v_self->buffer.s = ((char *)malloc(__pyx_v_buffer_size));

  /* "pysam/libctabix.pyx":723
 * 
 * cdef class GZIterator:
 *     def __init__(self, filename, int buffer_size=65536, encoding="ascii"):             # <<<<<<<<<<<<<<
 *         '''iterate line-by-line through gzip (or bgzip)
 *         compressed file.
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_filename);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":742
 *         self.buffer.s = <char*>malloc(buffer_size)
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         '''close file.'''
 *         if self.gzipfile != NULL:
 */

/* Python wrapper */
static void __pyx_pw_5pysam_9libctabix_10GZIterator_3__dealloc__(PyObject *__pyx_v_self); /*proto*/
static void __pyx_pw_5pysam_9libctabix_10GZIterator_3__dealloc__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_pf_5pysam_9libctabix_10GZIterator_2__dealloc__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_5pysam_9libctabix_10GZIterator_2__dealloc__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__dealloc__", 0);
  __Pyx_TraceCall("__dealloc__", __pyx_f[0], 742, 0, __PYX_ERR(0, 742, __pyx_L1_error));

  /* "pysam/libctabix.pyx":744
 *     def __dealloc__(self):
 *         '''close file.'''
 *         if self.gzipfile != NULL:             # <<<<<<<<<<<<<<
 *             bgzf_close(self.gzipfile)
 *             self.gzipfile = NULL
 */
  __pyx_t_1 = (__pyx_v_self->gzipfile != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":745
 *         '''close file.'''
 *         if self.gzipfile != NULL:
 *             bgzf_close(self.gzipfile)             # <<<<<<<<<<<<<<
 *             self.gzipfile = NULL
 *         if self.buffer.s != NULL:
 */
    (void)(bgzf_close(__pyx_v_self->gzipfile));

    /* "pysam/libctabix.pyx":746
 *         if self.gzipfile != NULL:
 *             bgzf_close(self.gzipfile)
 *             self.gzipfile = NULL             # <<<<<<<<<<<<<<
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)
 */
    __pyx_v_self->gzipfile = NULL;

    /* "pysam/libctabix.pyx":744
 *     def __dealloc__(self):
 *         '''close file.'''
 *         if self.gzipfile != NULL:             # <<<<<<<<<<<<<<
 *             bgzf_close(self.gzipfile)
 *             self.gzipfile = NULL
 */
  }

  /* "pysam/libctabix.pyx":747
 *             bgzf_close(self.gzipfile)
 *             self.gzipfile = NULL
 *         if self.buffer.s != NULL:             # <<<<<<<<<<<<<<
 *             free(self.buffer.s)
 *         if self.kstream != NULL:
 */
  __pyx_t_1 = (__pyx_v_self->buffer.s != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":748
 *             self.gzipfile = NULL
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)             # <<<<<<<<<<<<<<
 *         if self.kstream != NULL:
 *             ks_destroy(self.kstream)
 */
    free(__pyx_v_self->buffer.s);

    /* "pysam/libctabix.pyx":747
 *             bgzf_close(self.gzipfile)
 *             self.gzipfile = NULL
 *         if self.buffer.s != NULL:             # <<<<<<<<<<<<<<
 *             free(self.buffer.s)
 *         if self.kstream != NULL:
 */
  }

  /* "pysam/libctabix.pyx":749
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)
 *         if self.kstream != NULL:             # <<<<<<<<<<<<<<
 *             ks_destroy(self.kstream)
 * 
 */
  __pyx_t_1 = (__pyx_v_self->kstream != NULL);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":750
 *             free(self.buffer.s)
 *         if self.kstream != NULL:
 *             ks_destroy(self.kstream)             # <<<<<<<<<<<<<<
 * 
 *     def __iter__(self):
 */
    ks_destroy(__pyx_v_self->kstream);

    /* "pysam/libctabix.pyx":749
 *         if self.buffer.s != NULL:
 *             free(self.buffer.s)
 *         if self.kstream != NULL:             # <<<<<<<<<<<<<<
 *             ks_destroy(self.kstream)
 * 
 */
  }

  /* "pysam/libctabix.pyx":742
 *         self.buffer.s = <char*>malloc(buffer_size)
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         '''close file.'''
 *         if self.gzipfile != NULL:
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("pysam.libctabix.GZIterator.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "pysam/libctabix.pyx":752
 *             ks_destroy(self.kstream)
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_10GZIterator_4__iter__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_4__iter__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__iter__", 0);
  __Pyx_TraceCall("__iter__", __pyx_f[0], 752, 0, __PYX_ERR(0, 752, __pyx_L1_error));

  /* "pysam/libctabix.pyx":753
 * 
 *     def __iter__(self):
 *         return self             # <<<<<<<<<<<<<<
 * 
 *     cdef int __cnext__(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_self);
  __pyx_r = ((PyObject *)__pyx_v_self);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":752
 *             ks_destroy(self.kstream)
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":755
 *         return self
 * 
 *     cdef int __cnext__(self):             # <<<<<<<<<<<<<<
 *         cdef int dret = 0
 *         cdef int retval = 0
 */

static int __pyx_f_5pysam_9libctabix_10GZIterator___cnext__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self) {
  int __pyx_v_dret;
  int __pyx_v_retval;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__cnext__", 0);
  __Pyx_TraceCall("__cnext__", __pyx_f[0], 755, 0, __PYX_ERR(0, 755, __pyx_L1_error));

  /* "pysam/libctabix.pyx":756
 * 
 *     cdef int __cnext__(self):
 *         cdef int dret = 0             # <<<<<<<<<<<<<<
 *         cdef int retval = 0
 *         while 1:
 */
  __pyx_v_dret = 0;

  /* "pysam/libctabix.pyx":757
 *     cdef int __cnext__(self):
 *         cdef int dret = 0
 *         cdef int retval = 0             # <<<<<<<<<<<<<<
 *         while 1:
 *             with nogil:
 */
  __pyx_v_retval = 0;

  /* "pysam/libctabix.pyx":758
 *         cdef int dret = 0
 *         cdef int retval = 0
 *         while 1:             # <<<<<<<<<<<<<<
 *             with nogil:
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 */
  while (1) {

    /* "pysam/libctabix.pyx":759
 *         cdef int retval = 0
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":760
 *         while 1:
 *             with nogil:
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)             # <<<<<<<<<<<<<<
 * 
 *             if retval < 0:
 */
          __pyx_v_retval = ks_getuntil(__pyx_v_self->kstream, '\n', (&__pyx_v_self->buffer), (&__pyx_v_dret));
        }

        /* "pysam/libctabix.pyx":759
 *         cdef int retval = 0
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L9;
          }
          __pyx_L9:;
        }
    }

    /* "pysam/libctabix.pyx":762
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    __pyx_t_1 = (__pyx_v_retval < 0);
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":763
 * 
 *             if retval < 0:
 *                 break             # <<<<<<<<<<<<<<
 * 
 *             return dret
 */
      goto __pyx_L4_break;

      /* "pysam/libctabix.pyx":762
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    }

    /* "pysam/libctabix.pyx":765
 *                 break
 * 
 *             return dret             # <<<<<<<<<<<<<<
 *         return -1
 * 
 */
    __pyx_r = __pyx_v_dret;
    goto __pyx_L0;
  }
  __pyx_L4_break:;

  /* "pysam/libctabix.pyx":766
 * 
 *             return dret
 *         return -1             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  __pyx_r = -1;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":755
 *         return self
 * 
 *     cdef int __cnext__(self):             # <<<<<<<<<<<<<<
 *         cdef int dret = 0
 *         cdef int retval = 0
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__cnext__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":768
 *         return -1
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_7__next__(PyObject *__pyx_v_self); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_10GZIterator_6__next__, "python version of next().\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_10GZIterator_6__next__;
#endif
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_7__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_10GZIterator_6__next__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_6__next__(struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self) {
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_error_without_exception = 0; /* StopIteration */
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  struct __pyx_opt_args_5pysam_9libcutils_force_str __pyx_t_6;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 768, 0, __PYX_ERR(0, 768, __pyx_L1_error));

  /* "pysam/libctabix.pyx":771
 *         """python version of next().
 *         """
 *         cdef int retval = self.__cnext__()             # <<<<<<<<<<<<<<
 *         if retval < 0:
 *             raise StopIteration
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator *)__pyx_v_self->__pyx_vtab)->__pyx___cnext__(__pyx_v_self); if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 771, __pyx_L1_error)
  __pyx_v_retval = __pyx_t_1;

  /* "pysam/libctabix.pyx":772
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 *         return force_str(self.buffer.s, self.encoding)
 */
  __pyx_t_2 = (__pyx_v_retval < 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":773
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 *         return force_str(self.buffer.s, self.encoding)
 * 
 */
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;

    /* "pysam/libctabix.pyx":772
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 *         return force_str(self.buffer.s, self.encoding)
 */
  }

  /* "pysam/libctabix.pyx":774
 *         if retval < 0:
 *             raise StopIteration
 *         return force_str(self.buffer.s, self.encoding)             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_3 = __Pyx_PyBytes_FromString(__pyx_v_self->buffer.s); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 774, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __pyx_v_self->encoding;
  __Pyx_INCREF(__pyx_t_4);
  __pyx_t_6.__pyx_n = 1;
  __pyx_t_6.encoding = __pyx_t_4;
  __pyx_t_5 = __pyx_f_5pysam_9libcutils_force_str(__pyx_t_3, &__pyx_t_6); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 774, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_r = __pyx_t_5;
  __pyx_t_5 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":768
 *         return -1
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  if (!__pyx_error_without_exception) {
    __Pyx_AddTraceback("pysam.libctabix.GZIterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  }
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_10GZIterator_8__reduce_cython__, "GZIterator.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_10GZIterator_9__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_10GZIterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_10GZIterator_8__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_10GZIterator_8__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__31)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_10GZIterator_10__setstate_cython__, "GZIterator.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_10GZIterator_11__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_10GZIterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_10GZIterator_10__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_10GZIterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_10GZIterator_10__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_10GZIterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__32)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":782
 *     '''
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__(PyObject *__pyx_v_self); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_14GZIteratorHead___next__, "python version of next().\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_14GZIteratorHead___next__;
#endif
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_14GZIteratorHead___next__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead___next__(struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self) {
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_error_without_exception = 0; /* StopIteration */
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 782, 0, __PYX_ERR(0, 782, __pyx_L1_error));

  /* "pysam/libctabix.pyx":785
 *         """python version of next().
 *         """
 *         cdef int retval = self.__cnext__()             # <<<<<<<<<<<<<<
 *         if retval < 0:
 *             raise StopIteration
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorHead *)__pyx_v_self->__pyx_base.__pyx_vtab)->__pyx_base.__pyx___cnext__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self)); if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 785, __pyx_L1_error)
  __pyx_v_retval = __pyx_t_1;

  /* "pysam/libctabix.pyx":786
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 *         if self.buffer.s[0] == b'#':
 */
  __pyx_t_2 = (__pyx_v_retval < 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":787
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 *         if self.buffer.s[0] == b'#':
 *             return self.buffer.s
 */
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;

    /* "pysam/libctabix.pyx":786
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 *         if self.buffer.s[0] == b'#':
 */
  }

  /* "pysam/libctabix.pyx":788
 *         if retval < 0:
 *             raise StopIteration
 *         if self.buffer.s[0] == b'#':             # <<<<<<<<<<<<<<
 *             return self.buffer.s
 *         else:
 */
  __pyx_t_2 = ((__pyx_v_self->__pyx_base.buffer.s[0]) == '#');
  if (likely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":789
 *             raise StopIteration
 *         if self.buffer.s[0] == b'#':
 *             return self.buffer.s             # <<<<<<<<<<<<<<
 *         else:
 *             raise StopIteration
 */
    __Pyx_XDECREF(__pyx_r);
    __pyx_t_3 = __Pyx_PyBytes_FromString(__pyx_v_self->__pyx_base.buffer.s); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 789, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;

    /* "pysam/libctabix.pyx":788
 *         if retval < 0:
 *             raise StopIteration
 *         if self.buffer.s[0] == b'#':             # <<<<<<<<<<<<<<
 *             return self.buffer.s
 *         else:
 */
  }

  /* "pysam/libctabix.pyx":791
 *             return self.buffer.s
 *         else:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 * 
 * 
 */
  /*else*/ {
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;
  }

  /* "pysam/libctabix.pyx":782
 *     '''
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  if (!__pyx_error_without_exception) {
    __Pyx_AddTraceback("pysam.libctabix.GZIteratorHead.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  }
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__, "GZIteratorHead.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorHead.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__33)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorHead.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__, "GZIteratorHead.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorHead.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__34)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorHead.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":799
 *     '''
 * 
 *     def __init__(self, parser):             # <<<<<<<<<<<<<<
 *         self.parser = parser
 * 
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_16GZIteratorParsed_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_16GZIteratorParsed_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_parser = 0;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 799, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_parser,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 799, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 799, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
    }
    __pyx_v_parser = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 799, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_16GZIteratorParsed___init__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)__pyx_v_self), __pyx_v_parser);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_16GZIteratorParsed___init__(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self, PyObject *__pyx_v_parser) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 799, 0, __PYX_ERR(0, 799, __pyx_L1_error));

  /* "pysam/libctabix.pyx":800
 * 
 *     def __init__(self, parser):
 *         self.parser = parser             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  if (!(likely(((__pyx_v_parser) == Py_None) || likely(__Pyx_TypeTest(__pyx_v_parser, __pyx_ptype_5pysam_9libctabix_Parser))))) __PYX_ERR(0, 800, __pyx_L1_error)
  __pyx_t_1 = __pyx_v_parser;
  __Pyx_INCREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF((PyObject *)__pyx_v_self->parser);
  __Pyx_DECREF((PyObject *)__pyx_v_self->parser);
  __pyx_v_self->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":799
 *     '''
 * 
 *     def __init__(self, parser):             # <<<<<<<<<<<<<<
 *         self.parser = parser
 * 
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":802
 *         self.parser = parser
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__(PyObject *__pyx_v_self); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_16GZIteratorParsed_2__next__, "python version of next().\n        ");
#if CYTHON_UPDATE_DESCRIPTOR_DOC
struct wrapperbase __pyx_wrapperbase_5pysam_9libctabix_16GZIteratorParsed_2__next__;
#endif
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_16GZIteratorParsed_2__next__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_2__next__(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self) {
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_error_without_exception = 0; /* StopIteration */
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 802, 0, __PYX_ERR(0, 802, __pyx_L1_error));

  /* "pysam/libctabix.pyx":805
 *         """python version of next().
 *         """
 *         cdef int retval = self.__cnext__()             # <<<<<<<<<<<<<<
 *         if retval < 0:
 *             raise StopIteration
 */
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorParsed *)__pyx_v_self->__pyx_base.__pyx_vtab)->__pyx_base.__pyx___cnext__(((struct __pyx_obj_5pysam_9libctabix_GZIterator *)__pyx_v_self)); if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 805, __pyx_L1_error)
  __pyx_v_retval = __pyx_t_1;

  /* "pysam/libctabix.pyx":806
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  __pyx_t_2 = (__pyx_v_retval < 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":807
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:
 *             raise StopIteration             # <<<<<<<<<<<<<<
 * 
 *         return self.parser.parse(self.buffer.s,
 */
    __pyx_error_without_exception = 1;
    goto __pyx_L1_error;;

    /* "pysam/libctabix.pyx":806
 *         """
 *         cdef int retval = self.__cnext__()
 *         if retval < 0:             # <<<<<<<<<<<<<<
 *             raise StopIteration
 * 
 */
  }

  /* "pysam/libctabix.pyx":809
 *             raise StopIteration
 * 
 *         return self.parser.parse(self.buffer.s,             # <<<<<<<<<<<<<<
 *                                  self.buffer.l)
 * 
 */
  __Pyx_XDECREF(__pyx_r);

  /* "pysam/libctabix.pyx":810
 * 
 *         return self.parser.parse(self.buffer.s,
 *                                  self.buffer.l)             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __pyx_t_3 = ((struct __pyx_vtabstruct_5pysam_9libctabix_Parser *)__pyx_v_self->parser->__pyx_vtab)->parse(__pyx_v_self->parser, __pyx_v_self->__pyx_base.buffer.s, __pyx_v_self->__pyx_base.buffer.l); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 809, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_r = __pyx_t_3;
  __pyx_t_3 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":802
 *         self.parser = parser
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         """python version of next().
 *         """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  if (!__pyx_error_without_exception) {
    __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  }
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__, "GZIteratorParsed.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__35)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__, "GZIteratorParsed.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__36)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_self_gzipfile_self_kstream_canno, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.GZIteratorParsed.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":813
 * 
 * 
 * def tabix_compress(filename_in,             # <<<<<<<<<<<<<<
 *                    filename_out,
 *                    force=False):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_1tabix_compress(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_tabix_compress, "tabix_compress(filename_in, filename_out, force=False)\ncompress *filename_in* writing the output to *filename_out*.\n    \n    Raise an IOError if *filename_out* already exists, unless *force*\n    is set.\n    ");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_1tabix_compress = {"tabix_compress", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_1tabix_compress, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_tabix_compress};
static PyObject *__pyx_pw_5pysam_9libctabix_1tabix_compress(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_filename_in = 0;
  PyObject *__pyx_v_filename_out = 0;
  PyObject *__pyx_v_force = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("tabix_compress (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 813, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename_in,&__pyx_n_s_filename_out,&__pyx_n_s_force,0};

    /* "pysam/libctabix.pyx":815
 * def tabix_compress(filename_in,
 *                    filename_out,
 *                    force=False):             # <<<<<<<<<<<<<<
 *     '''compress *filename_in* writing the output to *filename_out*.
 * 
 */
    values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject *)Py_False)));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename_in)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 813, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename_out)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 813, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("tabix_compress", 0, 2, 3, 1); __PYX_ERR(0, 813, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_force);
          if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 813, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "tabix_compress") < 0)) __PYX_ERR(0, 813, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_filename_in = values[0];
    __pyx_v_filename_out = values[1];
    __pyx_v_force = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("tabix_compress", 0, 2, 3, __pyx_nargs); __PYX_ERR(0, 813, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_compress", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_tabix_compress(__pyx_self, __pyx_v_filename_in, __pyx_v_filename_out, __pyx_v_force);

  /* "pysam/libctabix.pyx":813
 * 
 * 
 * def tabix_compress(filename_in,             # <<<<<<<<<<<<<<
 *                    filename_out,
 *                    force=False):
 */

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_tabix_compress(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_filename_in, PyObject *__pyx_v_filename_out, PyObject *__pyx_v_force) {
  int __pyx_v_WINDOW_SIZE;
  int __pyx_v_c;
  int __pyx_v_r;
  void *__pyx_v_buffer;
  BGZF *__pyx_v_fp;
  int __pyx_v_fd_src;
  int __pyx_v_is_empty;
  int __pyx_v_O_RDONLY;
  PyObject *__pyx_v_fn = NULL;
  char *__pyx_v_cfn;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_t_2;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  int __pyx_t_7;
  char *__pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__37)
  __Pyx_RefNannySetupContext("tabix_compress", 0);
  __Pyx_TraceCall("tabix_compress", __pyx_f[0], 813, 0, __PYX_ERR(0, 813, __pyx_L1_error));

  /* "pysam/libctabix.pyx":822
 *     '''
 * 
 *     if not force and os.path.exists(filename_out):             # <<<<<<<<<<<<<<
 *         raise IOError(
 *             "Filename '%s' already exists, use *force* to "
 */
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_force); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 822, __pyx_L1_error)
  __pyx_t_3 = (!__pyx_t_2);
  if (__pyx_t_3) {
  } else {
    __pyx_t_1 = __pyx_t_3;
    goto __pyx_L4_bool_binop_done;
  }
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_os); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 822, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_path); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 822, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_exists); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 822, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = NULL;
  __pyx_t_7 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
      __pyx_t_7 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_6, __pyx_v_filename_out};
    __pyx_t_4 = __Pyx_PyObject_FastCall(__pyx_t_5, __pyx_callargs+1-__pyx_t_7, 1+__pyx_t_7);
    __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
    if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 822, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  }
  __pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely((__pyx_t_3 < 0))) __PYX_ERR(0, 822, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_1 = __pyx_t_3;
  __pyx_L4_bool_binop_done:;
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":825
 *         raise IOError(
 *             "Filename '%s' already exists, use *force* to "
 *             "overwrite" % filename_out)             # <<<<<<<<<<<<<<
 * 
 *     cdef int WINDOW_SIZE
 */
    __pyx_t_4 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_Filename_s_already_exists_use_fo, __pyx_v_filename_out); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 825, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);

    /* "pysam/libctabix.pyx":823
 * 
 *     if not force and os.path.exists(filename_out):
 *         raise IOError(             # <<<<<<<<<<<<<<
 *             "Filename '%s' already exists, use *force* to "
 *             "overwrite" % filename_out)
 */
    __pyx_t_5 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_4); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 823, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_Raise(__pyx_t_5, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __PYX_ERR(0, 823, __pyx_L1_error)

    /* "pysam/libctabix.pyx":822
 *     '''
 * 
 *     if not force and os.path.exists(filename_out):             # <<<<<<<<<<<<<<
 *         raise IOError(
 *             "Filename '%s' already exists, use *force* to "
 */
  }

  /* "pysam/libctabix.pyx":832
 *     cdef BGZF * fp
 *     cdef int fd_src
 *     cdef bint is_empty = True             # <<<<<<<<<<<<<<
 *     cdef int O_RDONLY
 *     O_RDONLY = os.O_RDONLY
 */
  __pyx_v_is_empty = 1;

  /* "pysam/libctabix.pyx":834
 *     cdef bint is_empty = True
 *     cdef int O_RDONLY
 *     O_RDONLY = os.O_RDONLY             # <<<<<<<<<<<<<<
 * 
 *     WINDOW_SIZE = 64 * 1024
 */
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_os); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 834, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_O_RDONLY); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 834, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_7 = __Pyx_PyInt_As_int(__pyx_t_4); if (unlikely((__pyx_t_7 == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 834, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_v_O_RDONLY = __pyx_t_7;

  /* "pysam/libctabix.pyx":836
 *     O_RDONLY = os.O_RDONLY
 * 
 *     WINDOW_SIZE = 64 * 1024             # <<<<<<<<<<<<<<
 * 
 *     fn = encode_filename(filename_out)
 */
  __pyx_v_WINDOW_SIZE = 0x10000;

  /* "pysam/libctabix.pyx":838
 *     WINDOW_SIZE = 64 * 1024
 * 
 *     fn = encode_filename(filename_out)             # <<<<<<<<<<<<<<
 *     cdef char *cfn = fn
 *     with nogil:
 */
  __pyx_t_4 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename_out); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 838, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_fn = ((PyObject*)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "pysam/libctabix.pyx":839
 * 
 *     fn = encode_filename(filename_out)
 *     cdef char *cfn = fn             # <<<<<<<<<<<<<<
 *     with nogil:
 *         fp = bgzf_open(cfn, "w")
 */
  if (unlikely(__pyx_v_fn == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 839, __pyx_L1_error)
  }
  __pyx_t_8 = __Pyx_PyBytes_AsWritableString(__pyx_v_fn); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 839, __pyx_L1_error)
  __pyx_v_cfn = __pyx_t_8;

  /* "pysam/libctabix.pyx":840
 *     fn = encode_filename(filename_out)
 *     cdef char *cfn = fn
 *     with nogil:             # <<<<<<<<<<<<<<
 *         fp = bgzf_open(cfn, "w")
 *     if fp == NULL:
 */
  {
      #ifdef WITH_THREAD
      PyThreadState *_save;
      _save = NULL;
      Py_UNBLOCK_THREADS
      __Pyx_FastGIL_Remember();
      #endif
      /*try:*/ {

        /* "pysam/libctabix.pyx":841
 *     cdef char *cfn = fn
 *     with nogil:
 *         fp = bgzf_open(cfn, "w")             # <<<<<<<<<<<<<<
 *     if fp == NULL:
 *         raise IOError("could not open '%s' for writing" % filename_out)
 */
        __pyx_v_fp = bgzf_open(__pyx_v_cfn, ((char const *)"w"));
      }

      /* "pysam/libctabix.pyx":840
 *     fn = encode_filename(filename_out)
 *     cdef char *cfn = fn
 *     with nogil:             # <<<<<<<<<<<<<<
 *         fp = bgzf_open(cfn, "w")
 *     if fp == NULL:
 */
      /*finally:*/ {
        /*normal exit:*/{
          #ifdef WITH_THREAD
          __Pyx_FastGIL_Forget();
          Py_BLOCK_THREADS
          #endif
          goto __pyx_L8;
        }
        __pyx_L8:;
      }
  }

  /* "pysam/libctabix.pyx":842
 *     with nogil:
 *         fp = bgzf_open(cfn, "w")
 *     if fp == NULL:             # <<<<<<<<<<<<<<
 *         raise IOError("could not open '%s' for writing" % filename_out)
 * 
 */
  __pyx_t_1 = (__pyx_v_fp == NULL);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":843
 *         fp = bgzf_open(cfn, "w")
 *     if fp == NULL:
 *         raise IOError("could not open '%s' for writing" % filename_out)             # <<<<<<<<<<<<<<
 * 
 *     fn = encode_filename(filename_in)
 */
    __pyx_t_4 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_could_not_open_s_for_writing, __pyx_v_filename_out); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 843, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_4); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 843, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_Raise(__pyx_t_5, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __PYX_ERR(0, 843, __pyx_L1_error)

    /* "pysam/libctabix.pyx":842
 *     with nogil:
 *         fp = bgzf_open(cfn, "w")
 *     if fp == NULL:             # <<<<<<<<<<<<<<
 *         raise IOError("could not open '%s' for writing" % filename_out)
 * 
 */
  }

  /* "pysam/libctabix.pyx":845
 *         raise IOError("could not open '%s' for writing" % filename_out)
 * 
 *     fn = encode_filename(filename_in)             # <<<<<<<<<<<<<<
 *     fd_src = open(fn, O_RDONLY)
 *     if fd_src == 0:
 */
  __pyx_t_5 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename_in); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 845, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF_SET(__pyx_v_fn, ((PyObject*)__pyx_t_5));
  __pyx_t_5 = 0;

  /* "pysam/libctabix.pyx":846
 * 
 *     fn = encode_filename(filename_in)
 *     fd_src = open(fn, O_RDONLY)             # <<<<<<<<<<<<<<
 *     if fd_src == 0:
 *         raise IOError("could not open '%s' for reading" % filename_in)
 */
  if (unlikely(__pyx_v_fn == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 846, __pyx_L1_error)
  }
  __pyx_t_8 = __Pyx_PyBytes_AsWritableString(__pyx_v_fn); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 846, __pyx_L1_error)
  __pyx_v_fd_src = open(__pyx_t_8, __pyx_v_O_RDONLY);

  /* "pysam/libctabix.pyx":847
 *     fn = encode_filename(filename_in)
 *     fd_src = open(fn, O_RDONLY)
 *     if fd_src == 0:             # <<<<<<<<<<<<<<
 *         raise IOError("could not open '%s' for reading" % filename_in)
 * 
 */
  __pyx_t_1 = (__pyx_v_fd_src == 0);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":848
 *     fd_src = open(fn, O_RDONLY)
 *     if fd_src == 0:
 *         raise IOError("could not open '%s' for reading" % filename_in)             # <<<<<<<<<<<<<<
 * 
 *     buffer = malloc(WINDOW_SIZE)
 */
    __pyx_t_5 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_could_not_open_s_for_reading, __pyx_v_filename_in); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 848, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 848, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_Raise(__pyx_t_4, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __PYX_ERR(0, 848, __pyx_L1_error)

    /* "pysam/libctabix.pyx":847
 *     fn = encode_filename(filename_in)
 *     fd_src = open(fn, O_RDONLY)
 *     if fd_src == 0:             # <<<<<<<<<<<<<<
 *         raise IOError("could not open '%s' for reading" % filename_in)
 * 
 */
  }

  /* "pysam/libctabix.pyx":850
 *         raise IOError("could not open '%s' for reading" % filename_in)
 * 
 *     buffer = malloc(WINDOW_SIZE)             # <<<<<<<<<<<<<<
 *     c = 1
 * 
 */
  __pyx_v_buffer = malloc(__pyx_v_WINDOW_SIZE);

  /* "pysam/libctabix.pyx":851
 * 
 *     buffer = malloc(WINDOW_SIZE)
 *     c = 1             # <<<<<<<<<<<<<<
 * 
 *     while c > 0:
 */
  __pyx_v_c = 1;

  /* "pysam/libctabix.pyx":853
 *     c = 1
 * 
 *     while c > 0:             # <<<<<<<<<<<<<<
 *         with nogil:
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 */
  while (1) {
    __pyx_t_1 = (__pyx_v_c > 0);
    if (!__pyx_t_1) break;

    /* "pysam/libctabix.pyx":854
 * 
 *     while c > 0:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 *             if c > 0:
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":855
 *     while c > 0:
 *         with nogil:
 *             c = read(fd_src, buffer, WINDOW_SIZE)             # <<<<<<<<<<<<<<
 *             if c > 0:
 *                 is_empty = False
 */
          __pyx_v_c = read(__pyx_v_fd_src, __pyx_v_buffer, __pyx_v_WINDOW_SIZE);

          /* "pysam/libctabix.pyx":856
 *         with nogil:
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 *             if c > 0:             # <<<<<<<<<<<<<<
 *                 is_empty = False
 *             r = bgzf_write(fp, buffer, c)
 */
          __pyx_t_1 = (__pyx_v_c > 0);
          if (__pyx_t_1) {

            /* "pysam/libctabix.pyx":857
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 *             if c > 0:
 *                 is_empty = False             # <<<<<<<<<<<<<<
 *             r = bgzf_write(fp, buffer, c)
 *         if r < 0:
 */
            __pyx_v_is_empty = 0;

            /* "pysam/libctabix.pyx":856
 *         with nogil:
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 *             if c > 0:             # <<<<<<<<<<<<<<
 *                 is_empty = False
 *             r = bgzf_write(fp, buffer, c)
 */
          }

          /* "pysam/libctabix.pyx":858
 *             if c > 0:
 *                 is_empty = False
 *             r = bgzf_write(fp, buffer, c)             # <<<<<<<<<<<<<<
 *         if r < 0:
 *             free(buffer)
 */
          __pyx_v_r = bgzf_write(__pyx_v_fp, __pyx_v_buffer, __pyx_v_c);
        }

        /* "pysam/libctabix.pyx":854
 * 
 *     while c > 0:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             c = read(fd_src, buffer, WINDOW_SIZE)
 *             if c > 0:
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L17;
          }
          __pyx_L17:;
        }
    }

    /* "pysam/libctabix.pyx":859
 *                 is_empty = False
 *             r = bgzf_write(fp, buffer, c)
 *         if r < 0:             # <<<<<<<<<<<<<<
 *             free(buffer)
 *             raise IOError("writing failed")
 */
    __pyx_t_1 = (__pyx_v_r < 0);
    if (unlikely(__pyx_t_1)) {

      /* "pysam/libctabix.pyx":860
 *             r = bgzf_write(fp, buffer, c)
 *         if r < 0:
 *             free(buffer)             # <<<<<<<<<<<<<<
 *             raise IOError("writing failed")
 * 
 */
      free(__pyx_v_buffer);

      /* "pysam/libctabix.pyx":861
 *         if r < 0:
 *             free(buffer)
 *             raise IOError("writing failed")             # <<<<<<<<<<<<<<
 * 
 *     free(buffer)
 */
      __pyx_t_4 = __Pyx_PyObject_Call(__pyx_builtin_IOError, __pyx_tuple__38, NULL); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 861, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_Raise(__pyx_t_4, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __PYX_ERR(0, 861, __pyx_L1_error)

      /* "pysam/libctabix.pyx":859
 *                 is_empty = False
 *             r = bgzf_write(fp, buffer, c)
 *         if r < 0:             # <<<<<<<<<<<<<<
 *             free(buffer)
 *             raise IOError("writing failed")
 */
    }
  }

  /* "pysam/libctabix.pyx":863
 *             raise IOError("writing failed")
 * 
 *     free(buffer)             # <<<<<<<<<<<<<<
 *     r = bgzf_close(fp)
 *     if r < 0:
 */
  free(__pyx_v_buffer);

  /* "pysam/libctabix.pyx":864
 * 
 *     free(buffer)
 *     r = bgzf_close(fp)             # <<<<<<<<<<<<<<
 *     if r < 0:
 *         raise IOError("error %i when writing to file %s" % (r, filename_out))
 */
  __pyx_v_r = bgzf_close(__pyx_v_fp);

  /* "pysam/libctabix.pyx":865
 *     free(buffer)
 *     r = bgzf_close(fp)
 *     if r < 0:             # <<<<<<<<<<<<<<
 *         raise IOError("error %i when writing to file %s" % (r, filename_out))
 * 
 */
  __pyx_t_1 = (__pyx_v_r < 0);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":866
 *     r = bgzf_close(fp)
 *     if r < 0:
 *         raise IOError("error %i when writing to file %s" % (r, filename_out))             # <<<<<<<<<<<<<<
 * 
 *     r = close(fd_src)
 */
    __pyx_t_4 = __Pyx_PyInt_From_int(__pyx_v_r); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = PyTuple_New(2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_GIVEREF(__pyx_t_4);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_t_4)) __PYX_ERR(0, 866, __pyx_L1_error);
    __Pyx_INCREF(__pyx_v_filename_out);
    __Pyx_GIVEREF(__pyx_v_filename_out);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_v_filename_out)) __PYX_ERR(0, 866, __pyx_L1_error);
    __pyx_t_4 = 0;
    __pyx_t_4 = PyUnicode_Format(__pyx_kp_u_error_i_when_writing_to_file_s, __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_5 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_4); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_Raise(__pyx_t_5, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __PYX_ERR(0, 866, __pyx_L1_error)

    /* "pysam/libctabix.pyx":865
 *     free(buffer)
 *     r = bgzf_close(fp)
 *     if r < 0:             # <<<<<<<<<<<<<<
 *         raise IOError("error %i when writing to file %s" % (r, filename_out))
 * 
 */
  }

  /* "pysam/libctabix.pyx":868
 *         raise IOError("error %i when writing to file %s" % (r, filename_out))
 * 
 *     r = close(fd_src)             # <<<<<<<<<<<<<<
 *     # an empty file will return with -1, thus ignore this.
 *     if r < 0:
 */
  __pyx_v_r = close(__pyx_v_fd_src);

  /* "pysam/libctabix.pyx":870
 *     r = close(fd_src)
 *     # an empty file will return with -1, thus ignore this.
 *     if r < 0:             # <<<<<<<<<<<<<<
 *         if not (r == -1 and is_empty):
 *             raise IOError("error %i when closing file %s" % (r, filename_in))
 */
  __pyx_t_1 = (__pyx_v_r < 0);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":871
 *     # an empty file will return with -1, thus ignore this.
 *     if r < 0:
 *         if not (r == -1 and is_empty):             # <<<<<<<<<<<<<<
 *             raise IOError("error %i when closing file %s" % (r, filename_in))
 * 
 */
    __pyx_t_3 = (__pyx_v_r == -1L);
    if (__pyx_t_3) {
    } else {
      __pyx_t_1 = __pyx_t_3;
      goto __pyx_L23_bool_binop_done;
    }
    __pyx_t_1 = __pyx_v_is_empty;
    __pyx_L23_bool_binop_done:;
    __pyx_t_3 = (!__pyx_t_1);
    if (unlikely(__pyx_t_3)) {

      /* "pysam/libctabix.pyx":872
 *     if r < 0:
 *         if not (r == -1 and is_empty):
 *             raise IOError("error %i when closing file %s" % (r, filename_in))             # <<<<<<<<<<<<<<
 * 
 * 
 */
      __pyx_t_5 = __Pyx_PyInt_From_int(__pyx_v_r); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 872, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_4 = PyTuple_New(2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 872, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_GIVEREF(__pyx_t_5);
      if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_5)) __PYX_ERR(0, 872, __pyx_L1_error);
      __Pyx_INCREF(__pyx_v_filename_in);
      __Pyx_GIVEREF(__pyx_v_filename_in);
      if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_v_filename_in)) __PYX_ERR(0, 872, __pyx_L1_error);
      __pyx_t_5 = 0;
      __pyx_t_5 = PyUnicode_Format(__pyx_kp_u_error_i_when_closing_file_s, __pyx_t_4); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 872, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 872, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __Pyx_Raise(__pyx_t_4, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __PYX_ERR(0, 872, __pyx_L1_error)

      /* "pysam/libctabix.pyx":871
 *     # an empty file will return with -1, thus ignore this.
 *     if r < 0:
 *         if not (r == -1 and is_empty):             # <<<<<<<<<<<<<<
 *             raise IOError("error %i when closing file %s" % (r, filename_in))
 * 
 */
    }

    /* "pysam/libctabix.pyx":870
 *     r = close(fd_src)
 *     # an empty file will return with -1, thus ignore this.
 *     if r < 0:             # <<<<<<<<<<<<<<
 *         if not (r == -1 and is_empty):
 *             raise IOError("error %i when closing file %s" % (r, filename_in))
 */
  }

  /* "pysam/libctabix.pyx":813
 * 
 * 
 * def tabix_compress(filename_in,             # <<<<<<<<<<<<<<
 *                    filename_out,
 *                    force=False):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_AddTraceback("pysam.libctabix.tabix_compress", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_fn);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":875
 * 
 * 
 * def tabix_index(filename,             # <<<<<<<<<<<<<<
 *                 force=False,
 *                 seq_col=None,
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_3tabix_index(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_2tabix_index, "tabix_index(filename, force=False, seq_col=None, start_col=None, end_col=None, preset=None, meta_char=u'#', int line_skip=0, zerobased=False, int min_shift=-1, index=None, keep_original=False, csi=False)\nindex tab-separated *filename* using tabix.\n\n    An existing index will not be overwritten unless *force* is set.\n\n    The index will be built from coordinates in columns *seq_col*,\n    *start_col* and *end_col*.\n\n    The contents of *filename* have to be sorted by contig and\n    position - the method does not check if the file is sorted.\n\n    Column indices are 0-based. Note that this is different from the\n    tabix command line utility where column indices start at 1.\n    \n    Coordinates in the file are assumed to be 1-based unless\n    *zerobased* is set.\n\n    If *preset* is provided, the column coordinates are taken from a\n    preset. Valid values for preset are \"gff\", \"bed\", \"sam\", \"vcf\",\n    psltbl\", \"pileup\".\n    \n    Lines beginning with *meta_char* and the first *line_skip* lines\n    will be skipped.\n\n    If *filename* is not detected as a gzip file it will be automatically\n    compressed. The original file will be removed and only the compressed\n    file will be retained.\n\n    By default or when *min_shift* is 0, creates a TBI index. If *min_shift*\n    is greater than zero and/or *csi* is True, creates a CSI index with a\n    minimal interval size of 1<<*min_shift* (1<<14 if only *csi* is set).\n\n    *index* controls the filename which should be used for creating the index.\n    If not set, the default is to append ``.tbi`` to *filename*.\n\n    When automatically compressing files, if *keep_original* is set the\n    uncompressed file will not be deleted.\n\n    returns the filename of the compressed data\n\n    ");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_3tabix_index = {"tabix_index", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_3tabix_index, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_2tabix_index};
static PyObject *__pyx_pw_5pysam_9libctabix_3tabix_index(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_filename = 0;
  PyObject *__pyx_v_force = 0;
  PyObject *__pyx_v_seq_col = 0;
  PyObject *__pyx_v_start_col = 0;
  PyObject *__pyx_v_end_col = 0;
  PyObject *__pyx_v_preset = 0;
  PyObject *__pyx_v_meta_char = 0;
  int __pyx_v_line_skip;
  PyObject *__pyx_v_zerobased = 0;
  int __pyx_v_min_shift;
  PyObject *__pyx_v_index = 0;
  PyObject *__pyx_v_keep_original = 0;
  PyObject *__pyx_v_csi = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[13] = {0,0,0,0,0,0,0,0,0,0,0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("tabix_index (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 875, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_filename,&__pyx_n_s_force,&__pyx_n_s_seq_col,&__pyx_n_s_start_col,&__pyx_n_s_end_col,&__pyx_n_s_preset,&__pyx_n_s_meta_char,&__pyx_n_s_line_skip,&__pyx_n_s_zerobased,&__pyx_n_s_min_shift,&__pyx_n_s_index,&__pyx_n_s_keep_original,&__pyx_n_s_csi,0};

    /* "pysam/libctabix.pyx":876
 * 
 * def tabix_index(filename,
 *                 force=False,             # <<<<<<<<<<<<<<
 *                 seq_col=None,
 *                 start_col=None,
 */
    values[1] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject *)Py_False)));

    /* "pysam/libctabix.pyx":877
 * def tabix_index(filename,
 *                 force=False,
 *                 seq_col=None,             # <<<<<<<<<<<<<<
 *                 start_col=None,
 *                 end_col=None,
 */
    values[2] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":878
 *                 force=False,
 *                 seq_col=None,
 *                 start_col=None,             # <<<<<<<<<<<<<<
 *                 end_col=None,
 *                 preset=None,
 */
    values[3] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":879
 *                 seq_col=None,
 *                 start_col=None,
 *                 end_col=None,             # <<<<<<<<<<<<<<
 *                 preset=None,
 *                 meta_char="#",
 */
    values[4] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":880
 *                 start_col=None,
 *                 end_col=None,
 *                 preset=None,             # <<<<<<<<<<<<<<
 *                 meta_char="#",
 *                 int line_skip=0,
 */
    values[5] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));
    values[6] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject*)__pyx_kp_u__39)));

    /* "pysam/libctabix.pyx":883
 *                 meta_char="#",
 *                 int line_skip=0,
 *                 zerobased=False,             # <<<<<<<<<<<<<<
 *                 int min_shift=-1,
 *                 index=None,
 */
    values[8] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject *)Py_False)));

    /* "pysam/libctabix.pyx":885
 *                 zerobased=False,
 *                 int min_shift=-1,
 *                 index=None,             # <<<<<<<<<<<<<<
 *                 keep_original=False,
 *                 csi=False,
 */
    values[10] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)Py_None));

    /* "pysam/libctabix.pyx":886
 *                 int min_shift=-1,
 *                 index=None,
 *                 keep_original=False,             # <<<<<<<<<<<<<<
 *                 csi=False,
 *                 ):
 */
    values[11] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject *)Py_False)));

    /* "pysam/libctabix.pyx":887
 *                 index=None,
 *                 keep_original=False,
 *                 csi=False,             # <<<<<<<<<<<<<<
 *                 ):
 *     '''index tab-separated *filename* using tabix.
 */
    values[12] = __Pyx_Arg_NewRef_FASTCALL(((PyObject *)((PyObject *)Py_False)));
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case 13: values[12] = __Pyx_Arg_FASTCALL(__pyx_args, 12);
        CYTHON_FALLTHROUGH;
        case 12: values[11] = __Pyx_Arg_FASTCALL(__pyx_args, 11);
        CYTHON_FALLTHROUGH;
        case 11: values[10] = __Pyx_Arg_FASTCALL(__pyx_args, 10);
        CYTHON_FALLTHROUGH;
        case 10: values[9] = __Pyx_Arg_FASTCALL(__pyx_args, 9);
        CYTHON_FALLTHROUGH;
        case  9: values[8] = __Pyx_Arg_FASTCALL(__pyx_args, 8);
        CYTHON_FALLTHROUGH;
        case  8: values[7] = __Pyx_Arg_FASTCALL(__pyx_args, 7);
        CYTHON_FALLTHROUGH;
        case  7: values[6] = __Pyx_Arg_FASTCALL(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = __Pyx_Arg_FASTCALL(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_FASTCALL(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_filename)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_force);
          if (value) { values[1] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_seq_col);
          if (value) { values[2] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_start_col);
          if (value) { values[3] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_end_col);
          if (value) { values[4] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_preset);
          if (value) { values[5] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  6:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_meta_char);
          if (value) { values[6] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  7:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_line_skip);
          if (value) { values[7] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  8:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_zerobased);
          if (value) { values[8] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  9:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_min_shift);
          if (value) { values[9] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case 10:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_index);
          if (value) { values[10] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case 11:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_keep_original);
          if (value) { values[11] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case 12:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_csi);
          if (value) { values[12] = __Pyx_Arg_NewRef_FASTCALL(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 875, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "tabix_index") < 0)) __PYX_ERR(0, 875, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case 13: values[12] = __Pyx_Arg_FASTCALL(__pyx_args, 12);
        CYTHON_FALLTHROUGH;
        case 12: values[11] = __Pyx_Arg_FASTCALL(__pyx_args, 11);
        CYTHON_FALLTHROUGH;
        case 11: values[10] = __Pyx_Arg_FASTCALL(__pyx_args, 10);
        CYTHON_FALLTHROUGH;
        case 10: values[9] = __Pyx_Arg_FASTCALL(__pyx_args, 9);
        CYTHON_FALLTHROUGH;
        case  9: values[8] = __Pyx_Arg_FASTCALL(__pyx_args, 8);
        CYTHON_FALLTHROUGH;
        case  8: values[7] = __Pyx_Arg_FASTCALL(__pyx_args, 7);
        CYTHON_FALLTHROUGH;
        case  7: values[6] = __Pyx_Arg_FASTCALL(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = __Pyx_Arg_FASTCALL(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = __Pyx_Arg_FASTCALL(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = __Pyx_Arg_FASTCALL(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_filename = values[0];
    __pyx_v_force = values[1];
    __pyx_v_seq_col = values[2];
    __pyx_v_start_col = values[3];
    __pyx_v_end_col = values[4];
    __pyx_v_preset = values[5];
    __pyx_v_meta_char = values[6];
    if (values[7]) {
      __pyx_v_line_skip = __Pyx_PyInt_As_int(values[7]); if (unlikely((__pyx_v_line_skip == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 882, __pyx_L3_error)
    } else {
      __pyx_v_line_skip = ((int)((int)0));
    }
    __pyx_v_zerobased = values[8];
    if (values[9]) {
      __pyx_v_min_shift = __Pyx_PyInt_As_int(values[9]); if (unlikely((__pyx_v_min_shift == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 884, __pyx_L3_error)
    } else {
      __pyx_v_min_shift = ((int)((int)-1));
    }
    __pyx_v_index = values[10];
    __pyx_v_keep_original = values[11];
    __pyx_v_csi = values[12];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("tabix_index", 0, 1, 13, __pyx_nargs); __PYX_ERR(0, 875, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_index", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_2tabix_index(__pyx_self, __pyx_v_filename, __pyx_v_force, __pyx_v_seq_col, __pyx_v_start_col, __pyx_v_end_col, __pyx_v_preset, __pyx_v_meta_char, __pyx_v_line_skip, __pyx_v_zerobased, __pyx_v_min_shift, __pyx_v_index, __pyx_v_keep_original, __pyx_v_csi);

  /* "pysam/libctabix.pyx":875
 * 
 * 
 * def tabix_index(filename,             # <<<<<<<<<<<<<<
 *                 force=False,
 *                 seq_col=None,
 */

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_2tabix_index(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_filename, PyObject *__pyx_v_force, PyObject *__pyx_v_seq_col, PyObject *__pyx_v_start_col, PyObject *__pyx_v_end_col, PyObject *__pyx_v_preset, PyObject *__pyx_v_meta_char, int __pyx_v_line_skip, PyObject *__pyx_v_zerobased, int __pyx_v_min_shift, PyObject *__pyx_v_index, PyObject *__pyx_v_keep_original, PyObject *__pyx_v_csi) {
  PyObject *__pyx_v_fn = NULL;
  char *__pyx_v_cfn;
  htsFile *__pyx_v_fp;
  htsFormat __pyx_v_fmt;
  PyObject *__pyx_v_preset2conf = NULL;
  PyObject *__pyx_v_conf_data = NULL;
  tbx_conf_t __pyx_v_conf;
  PyObject *__pyx_v_suffix = NULL;
  PyObject *__pyx_v_fn_index = NULL;
  char *__pyx_v_fnidx;
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  char *__pyx_t_4;
  Py_ssize_t __pyx_t_5;
  Py_UCS4 __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  int __pyx_t_10;
  PyObject *__pyx_t_11 = NULL;
  PyObject *__pyx_t_12 = NULL;
  PyObject *__pyx_t_13 = NULL;
  PyObject *__pyx_t_14 = NULL;
  PyObject *__pyx_t_15 = NULL;
  long __pyx_t_16;
  PyObject *__pyx_t_17 = NULL;
  PyObject *(*__pyx_t_18)(PyObject *);
  int32_t __pyx_t_19;
  int32_t __pyx_t_20;
  int32_t __pyx_t_21;
  int32_t __pyx_t_22;
  int32_t __pyx_t_23;
  int32_t __pyx_t_24;
  int __pyx_t_25;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__40)
  __Pyx_RefNannySetupContext("tabix_index", 0);
  __Pyx_TraceCall("tabix_index", __pyx_f[0], 875, 0, __PYX_ERR(0, 875, __pyx_L1_error));
  __Pyx_INCREF(__pyx_v_filename);
  __Pyx_INCREF(__pyx_v_end_col);
  __Pyx_INCREF(__pyx_v_preset);
  __Pyx_INCREF(__pyx_v_index);
  __Pyx_INCREF(__pyx_v_csi);

  /* "pysam/libctabix.pyx":930
 *     '''
 * 
 *     if preset is None and \             # <<<<<<<<<<<<<<
 *        (seq_col is None or start_col is None or end_col is None):
 *         raise ValueError(
 */
  __pyx_t_2 = (__pyx_v_preset == Py_None);
  if (__pyx_t_2) {
  } else {
    __pyx_t_1 = __pyx_t_2;
    goto __pyx_L4_bool_binop_done;
  }

  /* "pysam/libctabix.pyx":931
 * 
 *     if preset is None and \
 *        (seq_col is None or start_col is None or end_col is None):             # <<<<<<<<<<<<<<
 *         raise ValueError(
 *             "neither preset nor seq_col,start_col and end_col given")
 */
  __pyx_t_2 = (__pyx_v_seq_col == Py_None);
  if (!__pyx_t_2) {
  } else {
    __pyx_t_1 = __pyx_t_2;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_2 = (__pyx_v_start_col == Py_None);
  if (!__pyx_t_2) {
  } else {
    __pyx_t_1 = __pyx_t_2;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_2 = (__pyx_v_end_col == Py_None);
  __pyx_t_1 = __pyx_t_2;
  __pyx_L4_bool_binop_done:;

  /* "pysam/libctabix.pyx":930
 *     '''
 * 
 *     if preset is None and \             # <<<<<<<<<<<<<<
 *        (seq_col is None or start_col is None or end_col is None):
 *         raise ValueError(
 */
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":932
 *     if preset is None and \
 *        (seq_col is None or start_col is None or end_col is None):
 *         raise ValueError(             # <<<<<<<<<<<<<<
 *             "neither preset nor seq_col,start_col and end_col given")
 * 
 */
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__41, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 932, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 932, __pyx_L1_error)

    /* "pysam/libctabix.pyx":930
 *     '''
 * 
 *     if preset is None and \             # <<<<<<<<<<<<<<
 *        (seq_col is None or start_col is None or end_col is None):
 *         raise ValueError(
 */
  }

  /* "pysam/libctabix.pyx":935
 *             "neither preset nor seq_col,start_col and end_col given")
 * 
 *     fn = encode_filename(filename)             # <<<<<<<<<<<<<<
 *     cdef char *cfn = fn
 * 
 */
  __pyx_t_3 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 935, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_fn = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":936
 * 
 *     fn = encode_filename(filename)
 *     cdef char *cfn = fn             # <<<<<<<<<<<<<<
 * 
 *     cdef htsFile *fp = hts_open(cfn, "r")
 */
  if (unlikely(__pyx_v_fn == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 936, __pyx_L1_error)
  }
  __pyx_t_4 = __Pyx_PyBytes_AsWritableString(__pyx_v_fn); if (unlikely((!__pyx_t_4) && PyErr_Occurred())) __PYX_ERR(0, 936, __pyx_L1_error)
  __pyx_v_cfn = __pyx_t_4;

  /* "pysam/libctabix.pyx":938
 *     cdef char *cfn = fn
 * 
 *     cdef htsFile *fp = hts_open(cfn, "r")             # <<<<<<<<<<<<<<
 *     if fp == NULL:
 *         raise IOError("Could not open file '%s': %s" % (filename, force_str(strerror(errno))))
 */
  __pyx_v_fp = hts_open(__pyx_v_cfn, ((char const *)"r"));

  /* "pysam/libctabix.pyx":939
 * 
 *     cdef htsFile *fp = hts_open(cfn, "r")
 *     if fp == NULL:             # <<<<<<<<<<<<<<
 *         raise IOError("Could not open file '%s': %s" % (filename, force_str(strerror(errno))))
 * 
 */
  __pyx_t_1 = (__pyx_v_fp == NULL);
  if (unlikely(__pyx_t_1)) {

    /* "pysam/libctabix.pyx":940
 *     cdef htsFile *fp = hts_open(cfn, "r")
 *     if fp == NULL:
 *         raise IOError("Could not open file '%s': %s" % (filename, force_str(strerror(errno))))             # <<<<<<<<<<<<<<
 * 
 *     cdef htsFormat fmt = hts_get_format(fp)[0]
 */
    __pyx_t_3 = PyTuple_New(4); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_5 = 0;
    __pyx_t_6 = 127;
    __Pyx_INCREF(__pyx_kp_u_Could_not_open_file);
    __pyx_t_5 += 21;
    __Pyx_GIVEREF(__pyx_kp_u_Could_not_open_file);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_kp_u_Could_not_open_file);
    __pyx_t_7 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_v_filename), __pyx_empty_unicode); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_6 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_7) > __pyx_t_6) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_7) : __pyx_t_6;
    __pyx_t_5 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_7);
    __Pyx_GIVEREF(__pyx_t_7);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_7);
    __pyx_t_7 = 0;
    __Pyx_INCREF(__pyx_kp_u__42);
    __pyx_t_5 += 3;
    __Pyx_GIVEREF(__pyx_kp_u__42);
    PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_kp_u__42);
    __pyx_t_7 = __Pyx_PyBytes_FromString(strerror(errno)); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = __pyx_f_5pysam_9libcutils_force_str(__pyx_t_7, NULL); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __pyx_t_7 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_t_8), __pyx_empty_unicode); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_6 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_7) > __pyx_t_6) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_7) : __pyx_t_6;
    __pyx_t_5 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_7);
    __Pyx_GIVEREF(__pyx_t_7);
    PyTuple_SET_ITEM(__pyx_t_3, 3, __pyx_t_7);
    __pyx_t_7 = 0;
    __pyx_t_7 = __Pyx_PyUnicode_Join(__pyx_t_3, 4, __pyx_t_5, __pyx_t_6); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_7); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 940, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 940, __pyx_L1_error)

    /* "pysam/libctabix.pyx":939
 * 
 *     cdef htsFile *fp = hts_open(cfn, "r")
 *     if fp == NULL:             # <<<<<<<<<<<<<<
 *         raise IOError("Could not open file '%s': %s" % (filename, force_str(strerror(errno))))
 * 
 */
  }

  /* "pysam/libctabix.pyx":942
 *         raise IOError("Could not open file '%s': %s" % (filename, force_str(strerror(errno))))
 * 
 *     cdef htsFormat fmt = hts_get_format(fp)[0]             # <<<<<<<<<<<<<<
 *     hts_close(fp)
 * 
 */
  __pyx_v_fmt = (hts_get_format(__pyx_v_fp)[0]);

  /* "pysam/libctabix.pyx":943
 * 
 *     cdef htsFormat fmt = hts_get_format(fp)[0]
 *     hts_close(fp)             # <<<<<<<<<<<<<<
 * 
 *     if fmt.compression == no_compression:
 */
  (void)(hts_close(__pyx_v_fp));

  /* "pysam/libctabix.pyx":945
 *     hts_close(fp)
 * 
 *     if fmt.compression == no_compression:             # <<<<<<<<<<<<<<
 *         tabix_compress(filename, filename + ".gz", force=force)
 *         if not keep_original:
 */
  __pyx_t_1 = (__pyx_v_fmt.compression == no_compression);
  if (__pyx_t_1) {

    /* "pysam/libctabix.pyx":946
 * 
 *     if fmt.compression == no_compression:
 *         tabix_compress(filename, filename + ".gz", force=force)             # <<<<<<<<<<<<<<
 *         if not keep_original:
 *             os.unlink(filename)
 */
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_tabix_compress); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 946, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_7 = PyNumber_Add(__pyx_v_filename, __pyx_kp_u_gz); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 946, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = PyTuple_New(2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 946, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_INCREF(__pyx_v_filename);
    __Pyx_GIVEREF(__pyx_v_filename);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_v_filename)) __PYX_ERR(0, 946, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_7);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 1, __pyx_t_7)) __PYX_ERR(0, 946, __pyx_L1_error);
    __pyx_t_7 = 0;
    __pyx_t_7 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 946, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_force, __pyx_v_force) < 0) __PYX_ERR(0, 946, __pyx_L1_error)
    __pyx_t_9 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_8, __pyx_t_7); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 946, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;

    /* "pysam/libctabix.pyx":947
 *     if fmt.compression == no_compression:
 *         tabix_compress(filename, filename + ".gz", force=force)
 *         if not keep_original:             # <<<<<<<<<<<<<<
 *             os.unlink(filename)
 *         filename += ".gz"
 */
    __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_keep_original); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 947, __pyx_L1_error)
    __pyx_t_2 = (!__pyx_t_1);
    if (__pyx_t_2) {

      /* "pysam/libctabix.pyx":948
 *         tabix_compress(filename, filename + ".gz", force=force)
 *         if not keep_original:
 *             os.unlink(filename)             # <<<<<<<<<<<<<<
 *         filename += ".gz"
 *         fn = encode_filename(filename)
 */
      __Pyx_GetModuleGlobalName(__pyx_t_7, __pyx_n_s_os); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 948, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_t_7, __pyx_n_s_unlink); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 948, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __pyx_t_7 = NULL;
      __pyx_t_10 = 0;
      #if CYTHON_UNPACK_METHODS
      if (unlikely(PyMethod_Check(__pyx_t_8))) {
        __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_8);
        if (likely(__pyx_t_7)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
          __Pyx_INCREF(__pyx_t_7);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_8, function);
          __pyx_t_10 = 1;
        }
      }
      #endif
      {
        PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_v_filename};
        __pyx_t_9 = __Pyx_PyObject_FastCall(__pyx_t_8, __pyx_callargs+1-__pyx_t_10, 1+__pyx_t_10);
        __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
        if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 948, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_9);
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      }
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;

      /* "pysam/libctabix.pyx":947
 *     if fmt.compression == no_compression:
 *         tabix_compress(filename, filename + ".gz", force=force)
 *         if not keep_original:             # <<<<<<<<<<<<<<
 *             os.unlink(filename)
 *         filename += ".gz"
 */
    }

    /* "pysam/libctabix.pyx":949
 *         if not keep_original:
 *             os.unlink(filename)
 *         filename += ".gz"             # <<<<<<<<<<<<<<
 *         fn = encode_filename(filename)
 *         cfn = fn
 */
    __pyx_t_9 = PyNumber_InPlaceAdd(__pyx_v_filename, __pyx_kp_u_gz); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 949, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF_SET(__pyx_v_filename, __pyx_t_9);
    __pyx_t_9 = 0;

    /* "pysam/libctabix.pyx":950
 *             os.unlink(filename)
 *         filename += ".gz"
 *         fn = encode_filename(filename)             # <<<<<<<<<<<<<<
 *         cfn = fn
 * 
 */
    __pyx_t_9 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_filename); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 950, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF_SET(__pyx_v_fn, ((PyObject*)__pyx_t_9));
    __pyx_t_9 = 0;

    /* "pysam/libctabix.pyx":951
 *         filename += ".gz"
 *         fn = encode_filename(filename)
 *         cfn = fn             # <<<<<<<<<<<<<<
 * 
 *     # columns (1-based):
 */
    if (unlikely(__pyx_v_fn == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 951, __pyx_L1_error)
    }
    __pyx_t_4 = __Pyx_PyBytes_AsWritableString(__pyx_v_fn); if (unlikely((!__pyx_t_4) && PyErr_Occurred())) __PYX_ERR(0, 951, __pyx_L1_error)
    __pyx_v_cfn = __pyx_t_4;

    /* "pysam/libctabix.pyx":945
 *     hts_close(fp)
 * 
 *     if fmt.compression == no_compression:             # <<<<<<<<<<<<<<
 *         tabix_compress(filename, filename + ".gz", force=force)
 *         if not keep_original:
 */
  }

  /* "pysam/libctabix.pyx":958
 *     # 0 is a missing column
 *     preset2conf = {
 *         'gff' : (TBX_GENERIC, 1, 4, 5, ord('#'), 0),             # <<<<<<<<<<<<<<
 *         'bed' : (TBX_UCSC, 1, 2, 3, ord('#'), 0),
 *         'psltbl' : (TBX_UCSC, 15, 17, 18, ord('#'), 0),
 */
  __pyx_t_9 = __Pyx_PyDict_NewPresized(5); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_9);
  __pyx_t_8 = __Pyx_PyInt_From_int32_t(TBX_GENERIC); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_7 = PyTuple_New(6); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_GIVEREF(__pyx_t_8);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_8)) __PYX_ERR(0, 958, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_1);
  __Pyx_GIVEREF(__pyx_int_1);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_int_1)) __PYX_ERR(0, 958, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_4);
  __Pyx_GIVEREF(__pyx_int_4);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 2, __pyx_int_4)) __PYX_ERR(0, 958, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_5);
  __Pyx_GIVEREF(__pyx_int_5);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 3, __pyx_int_5)) __PYX_ERR(0, 958, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_35);
  __Pyx_GIVEREF(__pyx_int_35);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 4, __pyx_int_35)) __PYX_ERR(0, 958, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 5, __pyx_int_0)) __PYX_ERR(0, 958, __pyx_L1_error);
  __pyx_t_8 = 0;
  if (PyDict_SetItem(__pyx_t_9, __pyx_n_u_gff, __pyx_t_7) < 0) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "pysam/libctabix.pyx":959
 *     preset2conf = {
 *         'gff' : (TBX_GENERIC, 1, 4, 5, ord('#'), 0),
 *         'bed' : (TBX_UCSC, 1, 2, 3, ord('#'), 0),             # <<<<<<<<<<<<<<
 *         'psltbl' : (TBX_UCSC, 15, 17, 18, ord('#'), 0),
 *         'sam' : (TBX_SAM, 3, 4, 0, ord('@'), 0),
 */
  __pyx_t_7 = __Pyx_PyInt_From_int32_t(TBX_UCSC); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 959, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_t_8 = PyTuple_New(6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 959, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_GIVEREF(__pyx_t_7);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_7)) __PYX_ERR(0, 959, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_1);
  __Pyx_GIVEREF(__pyx_int_1);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 1, __pyx_int_1)) __PYX_ERR(0, 959, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_2);
  __Pyx_GIVEREF(__pyx_int_2);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 2, __pyx_int_2)) __PYX_ERR(0, 959, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_3);
  __Pyx_GIVEREF(__pyx_int_3);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 3, __pyx_int_3)) __PYX_ERR(0, 959, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_35);
  __Pyx_GIVEREF(__pyx_int_35);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 4, __pyx_int_35)) __PYX_ERR(0, 959, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 5, __pyx_int_0)) __PYX_ERR(0, 959, __pyx_L1_error);
  __pyx_t_7 = 0;
  if (PyDict_SetItem(__pyx_t_9, __pyx_n_u_bed, __pyx_t_8) < 0) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

  /* "pysam/libctabix.pyx":960
 *         'gff' : (TBX_GENERIC, 1, 4, 5, ord('#'), 0),
 *         'bed' : (TBX_UCSC, 1, 2, 3, ord('#'), 0),
 *         'psltbl' : (TBX_UCSC, 15, 17, 18, ord('#'), 0),             # <<<<<<<<<<<<<<
 *         'sam' : (TBX_SAM, 3, 4, 0, ord('@'), 0),
 *         'vcf' : (TBX_VCF, 1, 2, 0, ord('#'), 0),
 */
  __pyx_t_8 = __Pyx_PyInt_From_int32_t(TBX_UCSC); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 960, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_7 = PyTuple_New(6); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 960, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_GIVEREF(__pyx_t_8);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_8)) __PYX_ERR(0, 960, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_15);
  __Pyx_GIVEREF(__pyx_int_15);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_int_15)) __PYX_ERR(0, 960, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_17);
  __Pyx_GIVEREF(__pyx_int_17);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 2, __pyx_int_17)) __PYX_ERR(0, 960, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_18);
  __Pyx_GIVEREF(__pyx_int_18);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 3, __pyx_int_18)) __PYX_ERR(0, 960, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_35);
  __Pyx_GIVEREF(__pyx_int_35);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 4, __pyx_int_35)) __PYX_ERR(0, 960, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 5, __pyx_int_0)) __PYX_ERR(0, 960, __pyx_L1_error);
  __pyx_t_8 = 0;
  if (PyDict_SetItem(__pyx_t_9, __pyx_n_u_psltbl, __pyx_t_7) < 0) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "pysam/libctabix.pyx":961
 *         'bed' : (TBX_UCSC, 1, 2, 3, ord('#'), 0),
 *         'psltbl' : (TBX_UCSC, 15, 17, 18, ord('#'), 0),
 *         'sam' : (TBX_SAM, 3, 4, 0, ord('@'), 0),             # <<<<<<<<<<<<<<
 *         'vcf' : (TBX_VCF, 1, 2, 0, ord('#'), 0),
 *         }
 */
  __pyx_t_7 = __Pyx_PyInt_From_int32_t(TBX_SAM); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 961, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_t_8 = PyTuple_New(6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 961, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_GIVEREF(__pyx_t_7);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_7)) __PYX_ERR(0, 961, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_3);
  __Pyx_GIVEREF(__pyx_int_3);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 1, __pyx_int_3)) __PYX_ERR(0, 961, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_4);
  __Pyx_GIVEREF(__pyx_int_4);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 2, __pyx_int_4)) __PYX_ERR(0, 961, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 3, __pyx_int_0)) __PYX_ERR(0, 961, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_64);
  __Pyx_GIVEREF(__pyx_int_64);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 4, __pyx_int_64)) __PYX_ERR(0, 961, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_8, 5, __pyx_int_0)) __PYX_ERR(0, 961, __pyx_L1_error);
  __pyx_t_7 = 0;
  if (PyDict_SetItem(__pyx_t_9, __pyx_n_u_sam, __pyx_t_8) < 0) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

  /* "pysam/libctabix.pyx":962
 *         'psltbl' : (TBX_UCSC, 15, 17, 18, ord('#'), 0),
 *         'sam' : (TBX_SAM, 3, 4, 0, ord('@'), 0),
 *         'vcf' : (TBX_VCF, 1, 2, 0, ord('#'), 0),             # <<<<<<<<<<<<<<
 *         }
 * 
 */
  __pyx_t_8 = __Pyx_PyInt_From_int32_t(TBX_VCF); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 962, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_7 = PyTuple_New(6); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 962, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_GIVEREF(__pyx_t_8);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_8)) __PYX_ERR(0, 962, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_1);
  __Pyx_GIVEREF(__pyx_int_1);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_int_1)) __PYX_ERR(0, 962, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_2);
  __Pyx_GIVEREF(__pyx_int_2);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 2, __pyx_int_2)) __PYX_ERR(0, 962, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 3, __pyx_int_0)) __PYX_ERR(0, 962, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_35);
  __Pyx_GIVEREF(__pyx_int_35);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 4, __pyx_int_35)) __PYX_ERR(0, 962, __pyx_L1_error);
  __Pyx_INCREF(__pyx_int_0);
  __Pyx_GIVEREF(__pyx_int_0);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_7, 5, __pyx_int_0)) __PYX_ERR(0, 962, __pyx_L1_error);
  __pyx_t_8 = 0;
  if (PyDict_SetItem(__pyx_t_9, __pyx_n_u_vcf, __pyx_t_7) < 0) __PYX_ERR(0, 958, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  __pyx_v_preset2conf = ((PyObject*)__pyx_t_9);
  __pyx_t_9 = 0;

  /* "pysam/libctabix.pyx":965
 *         }
 * 
 *     conf_data = None             # <<<<<<<<<<<<<<
 *     if preset == "bcf" or fmt.format == bcf:
 *         csi = True
 */
  __Pyx_INCREF(Py_None);
  __pyx_v_conf_data = Py_None;

  /* "pysam/libctabix.pyx":966
 * 
 *     conf_data = None
 *     if preset == "bcf" or fmt.format == bcf:             # <<<<<<<<<<<<<<
 *         csi = True
 *     elif preset:
 */
  __pyx_t_1 = (__Pyx_PyUnicode_Equals(__pyx_v_preset, __pyx_n_u_bcf, Py_EQ)); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 966, __pyx_L1_error)
  if (!__pyx_t_1) {
  } else {
    __pyx_t_2 = __pyx_t_1;
    goto __pyx_L12_bool_binop_done;
  }
  __pyx_t_1 = (__pyx_v_fmt.format == bcf);
  __pyx_t_2 = __pyx_t_1;
  __pyx_L12_bool_binop_done:;
  if (__pyx_t_2) {

    /* "pysam/libctabix.pyx":967
 *     conf_data = None
 *     if preset == "bcf" or fmt.format == bcf:
 *         csi = True             # <<<<<<<<<<<<<<
 *     elif preset:
 *         try:
 */
    __Pyx_INCREF(Py_True);
    __Pyx_DECREF_SET(__pyx_v_csi, Py_True);

    /* "pysam/libctabix.pyx":966
 * 
 *     conf_data = None
 *     if preset == "bcf" or fmt.format == bcf:             # <<<<<<<<<<<<<<
 *         csi = True
 *     elif preset:
 */
    goto __pyx_L11;
  }

  /* "pysam/libctabix.pyx":968
 *     if preset == "bcf" or fmt.format == bcf:
 *         csi = True
 *     elif preset:             # <<<<<<<<<<<<<<
 *         try:
 *             conf_data = preset2conf[preset]
 */
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_preset); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 968, __pyx_L1_error)
  if (__pyx_t_2) {

    /* "pysam/libctabix.pyx":969
 *         csi = True
 *     elif preset:
 *         try:             # <<<<<<<<<<<<<<
 *             conf_data = preset2conf[preset]
 *         except KeyError:
 */
    {
      __Pyx_PyThreadState_declare
      __Pyx_PyThreadState_assign
      __Pyx_ExceptionSave(&__pyx_t_11, &__pyx_t_12, &__pyx_t_13);
      __Pyx_XGOTREF(__pyx_t_11);
      __Pyx_XGOTREF(__pyx_t_12);
      __Pyx_XGOTREF(__pyx_t_13);
      /*try:*/ {

        /* "pysam/libctabix.pyx":970
 *     elif preset:
 *         try:
 *             conf_data = preset2conf[preset]             # <<<<<<<<<<<<<<
 *         except KeyError:
 *             raise KeyError(
 */
        __pyx_t_9 = __Pyx_PyDict_GetItem(__pyx_v_preset2conf, __pyx_v_preset); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 970, __pyx_L14_error)
        __Pyx_GOTREF(__pyx_t_9);
        __Pyx_DECREF_SET(__pyx_v_conf_data, __pyx_t_9);
        __pyx_t_9 = 0;

        /* "pysam/libctabix.pyx":969
 *         csi = True
 *     elif preset:
 *         try:             # <<<<<<<<<<<<<<
 *             conf_data = preset2conf[preset]
 *         except KeyError:
 */
      }
      __Pyx_XDECREF(__pyx_t_11); __pyx_t_11 = 0;
      __Pyx_XDECREF(__pyx_t_12); __pyx_t_12 = 0;
      __Pyx_XDECREF(__pyx_t_13); __pyx_t_13 = 0;
      goto __pyx_L19_try_end;
      __pyx_L14_error:;
      __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;

      /* "pysam/libctabix.pyx":971
 *         try:
 *             conf_data = preset2conf[preset]
 *         except KeyError:             # <<<<<<<<<<<<<<
 *             raise KeyError(
 *                 "unknown preset '%s', valid presets are '%s'" %
 */
      __pyx_t_10 = __Pyx_PyErr_ExceptionMatches(__pyx_builtin_KeyError);
      if (__pyx_t_10) {
        __Pyx_AddTraceback("pysam.libctabix.tabix_index", __pyx_clineno, __pyx_lineno, __pyx_filename);
        if (__Pyx_GetException(&__pyx_t_9, &__pyx_t_7, &__pyx_t_8) < 0) __PYX_ERR(0, 971, __pyx_L16_except_error)
        __Pyx_XGOTREF(__pyx_t_9);
        __Pyx_XGOTREF(__pyx_t_7);
        __Pyx_XGOTREF(__pyx_t_8);

        /* "pysam/libctabix.pyx":973
 *         except KeyError:
 *             raise KeyError(
 *                 "unknown preset '%s', valid presets are '%s'" %             # <<<<<<<<<<<<<<
 *                 (preset, ",".join(preset2conf.keys())))
 *     else:
 */
        __pyx_t_3 = PyTuple_New(5); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 973, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_5 = 0;
        __pyx_t_6 = 127;
        __Pyx_INCREF(__pyx_kp_u_unknown_preset);
        __pyx_t_5 += 16;
        __Pyx_GIVEREF(__pyx_kp_u_unknown_preset);
        PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_kp_u_unknown_preset);

        /* "pysam/libctabix.pyx":974
 *             raise KeyError(
 *                 "unknown preset '%s', valid presets are '%s'" %
 *                 (preset, ",".join(preset2conf.keys())))             # <<<<<<<<<<<<<<
 *     else:
 *         if end_col is None:
 */
        __pyx_t_14 = __Pyx_PyObject_FormatSimpleAndDecref(PyObject_Unicode(__pyx_v_preset), __pyx_empty_unicode); if (unlikely(!__pyx_t_14)) __PYX_ERR(0, 974, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_14);
        __pyx_t_6 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_14) > __pyx_t_6) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_14) : __pyx_t_6;
        __pyx_t_5 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_14);
        __Pyx_GIVEREF(__pyx_t_14);
        PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_14);
        __pyx_t_14 = 0;
        __Pyx_INCREF(__pyx_kp_u_valid_presets_are);
        __pyx_t_5 += 22;
        __Pyx_GIVEREF(__pyx_kp_u_valid_presets_are);
        PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_kp_u_valid_presets_are);
        __pyx_t_14 = __Pyx_PyDict_Keys(__pyx_v_preset2conf); if (unlikely(!__pyx_t_14)) __PYX_ERR(0, 974, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_14);
        __pyx_t_15 = PyUnicode_Join(__pyx_kp_u__43, __pyx_t_14); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 974, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_15);
        __Pyx_DECREF(__pyx_t_14); __pyx_t_14 = 0;
        __pyx_t_6 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_15) > __pyx_t_6) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_15) : __pyx_t_6;
        __pyx_t_5 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_15);
        __Pyx_GIVEREF(__pyx_t_15);
        PyTuple_SET_ITEM(__pyx_t_3, 3, __pyx_t_15);
        __pyx_t_15 = 0;
        __Pyx_INCREF(__pyx_kp_u__44);
        __pyx_t_5 += 1;
        __Pyx_GIVEREF(__pyx_kp_u__44);
        PyTuple_SET_ITEM(__pyx_t_3, 4, __pyx_kp_u__44);

        /* "pysam/libctabix.pyx":973
 *         except KeyError:
 *             raise KeyError(
 *                 "unknown preset '%s', valid presets are '%s'" %             # <<<<<<<<<<<<<<
 *                 (preset, ",".join(preset2conf.keys())))
 *     else:
 */
        __pyx_t_15 = __Pyx_PyUnicode_Join(__pyx_t_3, 5, __pyx_t_5, __pyx_t_6); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 973, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_15);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

        /* "pysam/libctabix.pyx":972
 *             conf_data = preset2conf[preset]
 *         except KeyError:
 *             raise KeyError(             # <<<<<<<<<<<<<<
 *                 "unknown preset '%s', valid presets are '%s'" %
 *                 (preset, ",".join(preset2conf.keys())))
 */
        __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_KeyError, __pyx_t_15); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 972, __pyx_L16_except_error)
        __Pyx_GOTREF(__pyx_t_3);
        __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
        __Pyx_Raise(__pyx_t_3, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __PYX_ERR(0, 972, __pyx_L16_except_error)
      }
      goto __pyx_L16_except_error;

      /* "pysam/libctabix.pyx":969
 *         csi = True
 *     elif preset:
 *         try:             # <<<<<<<<<<<<<<
 *             conf_data = preset2conf[preset]
 *         except KeyError:
 */
      __pyx_L16_except_error:;
      __Pyx_XGIVEREF(__pyx_t_11);
      __Pyx_XGIVEREF(__pyx_t_12);
      __Pyx_XGIVEREF(__pyx_t_13);
      __Pyx_ExceptionReset(__pyx_t_11, __pyx_t_12, __pyx_t_13);
      goto __pyx_L1_error;
      __pyx_L19_try_end:;
    }

    /* "pysam/libctabix.pyx":968
 *     if preset == "bcf" or fmt.format == bcf:
 *         csi = True
 *     elif preset:             # <<<<<<<<<<<<<<
 *         try:
 *             conf_data = preset2conf[preset]
 */
    goto __pyx_L11;
  }

  /* "pysam/libctabix.pyx":976
 *                 (preset, ",".join(preset2conf.keys())))
 *     else:
 *         if end_col is None:             # <<<<<<<<<<<<<<
 *             end_col = -1
 * 
 */
  /*else*/ {
    __pyx_t_2 = (__pyx_v_end_col == Py_None);
    if (__pyx_t_2) {

      /* "pysam/libctabix.pyx":977
 *     else:
 *         if end_col is None:
 *             end_col = -1             # <<<<<<<<<<<<<<
 * 
 *         preset = 0
 */
      __Pyx_INCREF(__pyx_int_neg_1);
      __Pyx_DECREF_SET(__pyx_v_end_col, __pyx_int_neg_1);

      /* "pysam/libctabix.pyx":976
 *                 (preset, ",".join(preset2conf.keys())))
 *     else:
 *         if end_col is None:             # <<<<<<<<<<<<<<
 *             end_col = -1
 * 
 */
    }

    /* "pysam/libctabix.pyx":979
 *             end_col = -1
 * 
 *         preset = 0             # <<<<<<<<<<<<<<
 *         # tabix internally works with 0-based coordinates and
 *         # open/closed intervals.  When using a preset, conversion is
 */
    __Pyx_INCREF(__pyx_int_0);
    __Pyx_DECREF_SET(__pyx_v_preset, __pyx_int_0);

    /* "pysam/libctabix.pyx":986
 *         # from the start coordinate. To avoid doing this, set the
 *         # TI_FLAG_UCSC=0x10000 flag:
 *         if zerobased:             # <<<<<<<<<<<<<<
 *             preset = preset | TBX_UCSC
 * 
 */
    __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_zerobased); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 986, __pyx_L1_error)
    if (__pyx_t_2) {

      /* "pysam/libctabix.pyx":987
 *         # TI_FLAG_UCSC=0x10000 flag:
 *         if zerobased:
 *             preset = preset | TBX_UCSC             # <<<<<<<<<<<<<<
 * 
 *         conf_data = (preset, seq_col + 1, start_col + 1, end_col + 1, ord(meta_char), line_skip)
 */
      __pyx_t_8 = __Pyx_PyInt_From_int32_t(TBX_UCSC); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 987, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __pyx_t_7 = PyNumber_Or(__pyx_v_preset, __pyx_t_8); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 987, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_DECREF_SET(__pyx_v_preset, __pyx_t_7);
      __pyx_t_7 = 0;

      /* "pysam/libctabix.pyx":986
 *         # from the start coordinate. To avoid doing this, set the
 *         # TI_FLAG_UCSC=0x10000 flag:
 *         if zerobased:             # <<<<<<<<<<<<<<
 *             preset = preset | TBX_UCSC
 * 
 */
    }

    /* "pysam/libctabix.pyx":989
 *             preset = preset | TBX_UCSC
 * 
 *         conf_data = (preset, seq_col + 1, start_col + 1, end_col + 1, ord(meta_char), line_skip)             # <<<<<<<<<<<<<<
 * 
 *     cdef tbx_conf_t conf
 */
    __pyx_t_7 = __Pyx_PyInt_AddObjC(__pyx_v_seq_col, __pyx_int_1, 1, 0, 0); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = __Pyx_PyInt_AddObjC(__pyx_v_start_col, __pyx_int_1, 1, 0, 0); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_9 = __Pyx_PyInt_AddObjC(__pyx_v_end_col, __pyx_int_1, 1, 0, 0); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __pyx_t_16 = __Pyx_PyObject_Ord(__pyx_v_meta_char); if (unlikely(__pyx_t_16 == ((long)(long)(Py_UCS4)-1))) __PYX_ERR(0, 989, __pyx_L1_error)
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_t_16); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_15 = __Pyx_PyInt_From_int(__pyx_v_line_skip); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_14 = PyTuple_New(6); if (unlikely(!__pyx_t_14)) __PYX_ERR(0, 989, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_14);
    __Pyx_INCREF(__pyx_v_preset);
    __Pyx_GIVEREF(__pyx_v_preset);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 0, __pyx_v_preset)) __PYX_ERR(0, 989, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_7);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 1, __pyx_t_7)) __PYX_ERR(0, 989, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_8);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 2, __pyx_t_8)) __PYX_ERR(0, 989, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_9);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 3, __pyx_t_9)) __PYX_ERR(0, 989, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_3);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 4, __pyx_t_3)) __PYX_ERR(0, 989, __pyx_L1_error);
    __Pyx_GIVEREF(__pyx_t_15);
    if (__Pyx_PyTuple_SET_ITEM(__pyx_t_14, 5, __pyx_t_15)) __PYX_ERR(0, 989, __pyx_L1_error);
    __pyx_t_7 = 0;
    __pyx_t_8 = 0;
    __pyx_t_9 = 0;
    __pyx_t_3 = 0;
    __pyx_t_15 = 0;
    __Pyx_DECREF_SET(__pyx_v_conf_data, __pyx_t_14);
    __pyx_t_14 = 0;
  }
  __pyx_L11:;

  /* "pysam/libctabix.pyx":992
 * 
 *     cdef tbx_conf_t conf
 *     if conf_data:             # <<<<<<<<<<<<<<
 *         conf.preset, conf.sc, conf.bc, conf.ec, conf.meta_char, conf.line_skip = conf_data
 * 
 */
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_conf_data); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 992, __pyx_L1_error)
  if (__pyx_t_2) {

    /* "pysam/libctabix.pyx":993
 *     cdef tbx_conf_t conf
 *     if conf_data:
 *         conf.preset, conf.sc, conf.bc, conf.ec, conf.meta_char, conf.line_skip = conf_data             # <<<<<<<<<<<<<<
 * 
 *     if csi or min_shift > 0:
 */
    if ((likely(PyTuple_CheckExact(__pyx_v_conf_data))) || (PyList_CheckExact(__pyx_v_conf_data))) {
      PyObject* sequence = __pyx_v_conf_data;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 6)) {
        if (size > 6) __Pyx_RaiseTooManyValuesError(6);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 993, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_14 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_15 = PyTuple_GET_ITEM(sequence, 1); 
        __pyx_t_3 = PyTuple_GET_ITEM(sequence, 2); 
        __pyx_t_9 = PyTuple_GET_ITEM(sequence, 3); 
        __pyx_t_8 = PyTuple_GET_ITEM(sequence, 4); 
        __pyx_t_7 = PyTuple_GET_ITEM(sequence, 5); 
      } else {
        __pyx_t_14 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_15 = PyList_GET_ITEM(sequence, 1); 
        __pyx_t_3 = PyList_GET_ITEM(sequence, 2); 
        __pyx_t_9 = PyList_GET_ITEM(sequence, 3); 
        __pyx_t_8 = PyList_GET_ITEM(sequence, 4); 
        __pyx_t_7 = PyList_GET_ITEM(sequence, 5); 
      }
      __Pyx_INCREF(__pyx_t_14);
      __Pyx_INCREF(__pyx_t_15);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_9);
      __Pyx_INCREF(__pyx_t_8);
      __Pyx_INCREF(__pyx_t_7);
      #else
      {
        Py_ssize_t i;
        PyObject** temps[6] = {&__pyx_t_14,&__pyx_t_15,&__pyx_t_3,&__pyx_t_9,&__pyx_t_8,&__pyx_t_7};
        for (i=0; i < 6; i++) {
          PyObject* item = PySequence_ITEM(sequence, i); if (unlikely(!item)) __PYX_ERR(0, 993, __pyx_L1_error)
          __Pyx_GOTREF(item);
          *(temps[i]) = item;
        }
      }
      #endif
    } else {
      Py_ssize_t index = -1;
      PyObject** temps[6] = {&__pyx_t_14,&__pyx_t_15,&__pyx_t_3,&__pyx_t_9,&__pyx_t_8,&__pyx_t_7};
      __pyx_t_17 = PyObject_GetIter(__pyx_v_conf_data); if (unlikely(!__pyx_t_17)) __PYX_ERR(0, 993, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_17);
      __pyx_t_18 = __Pyx_PyObject_GetIterNextFunc(__pyx_t_17);
      for (index=0; index < 6; index++) {
        PyObject* item = __pyx_t_18(__pyx_t_17); if (unlikely(!item)) goto __pyx_L25_unpacking_failed;
        __Pyx_GOTREF(item);
        *(temps[index]) = item;
      }
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_18(__pyx_t_17), 6) < 0) __PYX_ERR(0, 993, __pyx_L1_error)
      __pyx_t_18 = NULL;
      __Pyx_DECREF(__pyx_t_17); __pyx_t_17 = 0;
      goto __pyx_L26_unpacking_done;
      __pyx_L25_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_17); __pyx_t_17 = 0;
      __pyx_t_18 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 993, __pyx_L1_error)
      __pyx_L26_unpacking_done:;
    }
    __pyx_t_19 = __Pyx_PyInt_As_int32_t(__pyx_t_14); if (unlikely((__pyx_t_19 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_14); __pyx_t_14 = 0;
    __pyx_t_20 = __Pyx_PyInt_As_int32_t(__pyx_t_15); if (unlikely((__pyx_t_20 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    __pyx_t_21 = __Pyx_PyInt_As_int32_t(__pyx_t_3); if (unlikely((__pyx_t_21 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_22 = __Pyx_PyInt_As_int32_t(__pyx_t_9); if (unlikely((__pyx_t_22 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __pyx_t_23 = __Pyx_PyInt_As_int32_t(__pyx_t_8); if (unlikely((__pyx_t_23 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_24 = __Pyx_PyInt_As_int32_t(__pyx_t_7); if (unlikely((__pyx_t_24 == ((int32_t)-1)) && PyErr_Occurred())) __PYX_ERR(0, 993, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __pyx_v_conf.preset = __pyx_t_19;
    __pyx_v_conf.sc = __pyx_t_20;
    __pyx_v_conf.bc = __pyx_t_21;
    __pyx_v_conf.ec = __pyx_t_22;
    __pyx_v_conf.meta_char = __pyx_t_23;
    __pyx_v_conf.line_skip = __pyx_t_24;

    /* "pysam/libctabix.pyx":992
 * 
 *     cdef tbx_conf_t conf
 *     if conf_data:             # <<<<<<<<<<<<<<
 *         conf.preset, conf.sc, conf.bc, conf.ec, conf.meta_char, conf.line_skip = conf_data
 * 
 */
  }

  /* "pysam/libctabix.pyx":995
 *         conf.preset, conf.sc, conf.bc, conf.ec, conf.meta_char, conf.line_skip = conf_data
 * 
 *     if csi or min_shift > 0:             # <<<<<<<<<<<<<<
 *         suffix = ".csi"
 *         if min_shift <= 0: min_shift = 14
 */
  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_csi); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 995, __pyx_L1_error)
  if (!__pyx_t_1) {
  } else {
    __pyx_t_2 = __pyx_t_1;
    goto __pyx_L28_bool_binop_done;
  }
  __pyx_t_1 = (__pyx_v_min_shift > 0);
  __pyx_t_2 = __pyx_t_1;
  __pyx_L28_bool_binop_done:;
  if (__pyx_t_2) {

    /* "pysam/libctabix.pyx":996
 * 
 *     if csi or min_shift > 0:
 *         suffix = ".csi"             # <<<<<<<<<<<<<<
 *         if min_shift <= 0: min_shift = 14
 *     else:
 */
    __Pyx_INCREF(__pyx_kp_u_csi_2);
    __pyx_v_suffix = __pyx_kp_u_csi_2;

    /* "pysam/libctabix.pyx":997
 *     if csi or min_shift > 0:
 *         suffix = ".csi"
 *         if min_shift <= 0: min_shift = 14             # <<<<<<<<<<<<<<
 *     else:
 *         suffix = ".tbi"
 */
    __pyx_t_2 = (__pyx_v_min_shift <= 0);
    if (__pyx_t_2) {
      __pyx_v_min_shift = 14;
    }

    /* "pysam/libctabix.pyx":995
 *         conf.preset, conf.sc, conf.bc, conf.ec, conf.meta_char, conf.line_skip = conf_data
 * 
 *     if csi or min_shift > 0:             # <<<<<<<<<<<<<<
 *         suffix = ".csi"
 *         if min_shift <= 0: min_shift = 14
 */
    goto __pyx_L27;
  }

  /* "pysam/libctabix.pyx":999
 *         if min_shift <= 0: min_shift = 14
 *     else:
 *         suffix = ".tbi"             # <<<<<<<<<<<<<<
 *         min_shift = 0
 * 
 */
  /*else*/ {
    __Pyx_INCREF(__pyx_kp_u_tbi);
    __pyx_v_suffix = __pyx_kp_u_tbi;

    /* "pysam/libctabix.pyx":1000
 *     else:
 *         suffix = ".tbi"
 *         min_shift = 0             # <<<<<<<<<<<<<<
 * 
 *     index = index or filename + suffix
 */
    __pyx_v_min_shift = 0;
  }
  __pyx_L27:;

  /* "pysam/libctabix.pyx":1002
 *         min_shift = 0
 * 
 *     index = index or filename + suffix             # <<<<<<<<<<<<<<
 *     fn_index = encode_filename(index)
 * 
 */
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_index); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 1002, __pyx_L1_error)
  if (!__pyx_t_2) {
  } else {
    __Pyx_INCREF(__pyx_v_index);
    __pyx_t_7 = __pyx_v_index;
    goto __pyx_L31_bool_binop_done;
  }
  __pyx_t_8 = PyNumber_Add(__pyx_v_filename, __pyx_v_suffix); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1002, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_INCREF(__pyx_t_8);
  __pyx_t_7 = __pyx_t_8;
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __pyx_L31_bool_binop_done:;
  __Pyx_DECREF_SET(__pyx_v_index, __pyx_t_7);
  __pyx_t_7 = 0;

  /* "pysam/libctabix.pyx":1003
 * 
 *     index = index or filename + suffix
 *     fn_index = encode_filename(index)             # <<<<<<<<<<<<<<
 * 
 *     if not force and os.path.exists(index):
 */
  __pyx_t_7 = __pyx_f_5pysam_9libcutils_encode_filename(__pyx_v_index); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1003, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_v_fn_index = ((PyObject*)__pyx_t_7);
  __pyx_t_7 = 0;

  /* "pysam/libctabix.pyx":1005
 *     fn_index = encode_filename(index)
 * 
 *     if not force and os.path.exists(index):             # <<<<<<<<<<<<<<
 *         raise IOError(
 *             "filename '%s' already exists, use *force* to overwrite" % index)
 */
  __pyx_t_1 = __Pyx_PyObject_IsTrue(__pyx_v_force); if (unlikely((__pyx_t_1 < 0))) __PYX_ERR(0, 1005, __pyx_L1_error)
  __pyx_t_25 = (!__pyx_t_1);
  if (__pyx_t_25) {
  } else {
    __pyx_t_2 = __pyx_t_25;
    goto __pyx_L34_bool_binop_done;
  }
  __Pyx_GetModuleGlobalName(__pyx_t_8, __pyx_n_s_os); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1005, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_9 = __Pyx_PyObject_GetAttrStr(__pyx_t_8, __pyx_n_s_path); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1005, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_9);
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_t_9, __pyx_n_s_exists); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1005, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
  __pyx_t_9 = NULL;
  __pyx_t_10 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_8))) {
    __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_8);
    if (likely(__pyx_t_9)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
      __Pyx_INCREF(__pyx_t_9);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_8, function);
      __pyx_t_10 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_9, __pyx_v_index};
    __pyx_t_7 = __Pyx_PyObject_FastCall(__pyx_t_8, __pyx_callargs+1-__pyx_t_10, 1+__pyx_t_10);
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
    if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1005, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  }
  __pyx_t_25 = __Pyx_PyObject_IsTrue(__pyx_t_7); if (unlikely((__pyx_t_25 < 0))) __PYX_ERR(0, 1005, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  __pyx_t_2 = __pyx_t_25;
  __pyx_L34_bool_binop_done:;
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":1007
 *     if not force and os.path.exists(index):
 *         raise IOError(
 *             "filename '%s' already exists, use *force* to overwrite" % index)             # <<<<<<<<<<<<<<
 * 
 *     cdef char *fnidx = fn_index
 */
    __pyx_t_7 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_filename_s_already_exists_use_fo, __pyx_v_index); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1007, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);

    /* "pysam/libctabix.pyx":1006
 * 
 *     if not force and os.path.exists(index):
 *         raise IOError(             # <<<<<<<<<<<<<<
 *             "filename '%s' already exists, use *force* to overwrite" % index)
 * 
 */
    __pyx_t_8 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1006, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_Raise(__pyx_t_8, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __PYX_ERR(0, 1006, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1005
 *     fn_index = encode_filename(index)
 * 
 *     if not force and os.path.exists(index):             # <<<<<<<<<<<<<<
 *         raise IOError(
 *             "filename '%s' already exists, use *force* to overwrite" % index)
 */
  }

  /* "pysam/libctabix.pyx":1009
 *             "filename '%s' already exists, use *force* to overwrite" % index)
 * 
 *     cdef char *fnidx = fn_index             # <<<<<<<<<<<<<<
 *     cdef int retval = 0
 * 
 */
  if (unlikely(__pyx_v_fn_index == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 1009, __pyx_L1_error)
  }
  __pyx_t_4 = __Pyx_PyBytes_AsWritableString(__pyx_v_fn_index); if (unlikely((!__pyx_t_4) && PyErr_Occurred())) __PYX_ERR(0, 1009, __pyx_L1_error)
  __pyx_v_fnidx = __pyx_t_4;

  /* "pysam/libctabix.pyx":1010
 * 
 *     cdef char *fnidx = fn_index
 *     cdef int retval = 0             # <<<<<<<<<<<<<<
 * 
 *     if csi and fmt.format == bcf:
 */
  __pyx_v_retval = 0;

  /* "pysam/libctabix.pyx":1012
 *     cdef int retval = 0
 * 
 *     if csi and fmt.format == bcf:             # <<<<<<<<<<<<<<
 *         with nogil:
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 */
  __pyx_t_25 = __Pyx_PyObject_IsTrue(__pyx_v_csi); if (unlikely((__pyx_t_25 < 0))) __PYX_ERR(0, 1012, __pyx_L1_error)
  if (__pyx_t_25) {
  } else {
    __pyx_t_2 = __pyx_t_25;
    goto __pyx_L37_bool_binop_done;
  }
  __pyx_t_25 = (__pyx_v_fmt.format == bcf);
  __pyx_t_2 = __pyx_t_25;
  __pyx_L37_bool_binop_done:;
  if (__pyx_t_2) {

    /* "pysam/libctabix.pyx":1013
 * 
 *     if csi and fmt.format == bcf:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 *     else:
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":1014
 *     if csi and fmt.format == bcf:
 *         with nogil:
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)             # <<<<<<<<<<<<<<
 *     else:
 *         with nogil:
 */
          __pyx_v_retval = bcf_index_build2(__pyx_v_cfn, __pyx_v_fnidx, __pyx_v_min_shift);
        }

        /* "pysam/libctabix.pyx":1013
 * 
 *     if csi and fmt.format == bcf:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 *     else:
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L41;
          }
          __pyx_L41:;
        }
    }

    /* "pysam/libctabix.pyx":1012
 *     cdef int retval = 0
 * 
 *     if csi and fmt.format == bcf:             # <<<<<<<<<<<<<<
 *         with nogil:
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 */
    goto __pyx_L36;
  }

  /* "pysam/libctabix.pyx":1016
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 *     else:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             retval = tbx_index_build2(cfn, fnidx, min_shift, &conf)
 * 
 */
  /*else*/ {
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":1017
 *     else:
 *         with nogil:
 *             retval = tbx_index_build2(cfn, fnidx, min_shift, &conf)             # <<<<<<<<<<<<<<
 * 
 *     if retval != 0:
 */
          __pyx_v_retval = tbx_index_build2(__pyx_v_cfn, __pyx_v_fnidx, __pyx_v_min_shift, (&__pyx_v_conf));
        }

        /* "pysam/libctabix.pyx":1016
 *             retval = bcf_index_build2(cfn, fnidx, min_shift)
 *     else:
 *         with nogil:             # <<<<<<<<<<<<<<
 *             retval = tbx_index_build2(cfn, fnidx, min_shift, &conf)
 * 
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L44;
          }
          __pyx_L44:;
        }
    }
  }
  __pyx_L36:;

  /* "pysam/libctabix.pyx":1019
 *             retval = tbx_index_build2(cfn, fnidx, min_shift, &conf)
 * 
 *     if retval != 0:             # <<<<<<<<<<<<<<
 *         raise OSError("building of index for {} failed".format(filename))
 * 
 */
  __pyx_t_2 = (__pyx_v_retval != 0);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":1020
 * 
 *     if retval != 0:
 *         raise OSError("building of index for {} failed".format(filename))             # <<<<<<<<<<<<<<
 * 
 *     return filename
 */
    __pyx_t_7 = __Pyx_PyObject_GetAttrStr(__pyx_kp_u_building_of_index_for_failed, __pyx_n_s_format); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1020, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_9 = NULL;
    __pyx_t_10 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_7))) {
      __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_7);
      if (likely(__pyx_t_9)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_7);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_7, function);
        __pyx_t_10 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_9, __pyx_v_filename};
      __pyx_t_8 = __Pyx_PyObject_FastCall(__pyx_t_7, __pyx_callargs+1-__pyx_t_10, 1+__pyx_t_10);
      __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
      if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1020, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    }
    __pyx_t_7 = __Pyx_PyObject_CallOneArg(__pyx_builtin_OSError, __pyx_t_8); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1020, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_Raise(__pyx_t_7, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __PYX_ERR(0, 1020, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1019
 *             retval = tbx_index_build2(cfn, fnidx, min_shift, &conf)
 * 
 *     if retval != 0:             # <<<<<<<<<<<<<<
 *         raise OSError("building of index for {} failed".format(filename))
 * 
 */
  }

  /* "pysam/libctabix.pyx":1022
 *         raise OSError("building of index for {} failed".format(filename))
 * 
 *     return filename             # <<<<<<<<<<<<<<
 * 
 * # #########################################################
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_filename);
  __pyx_r = __pyx_v_filename;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":875
 * 
 * 
 * def tabix_index(filename,             # <<<<<<<<<<<<<<
 *                 force=False,
 *                 seq_col=None,
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_XDECREF(__pyx_t_9);
  __Pyx_XDECREF(__pyx_t_14);
  __Pyx_XDECREF(__pyx_t_15);
  __Pyx_XDECREF(__pyx_t_17);
  __Pyx_AddTraceback("pysam.libctabix.tabix_index", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_fn);
  __Pyx_XDECREF(__pyx_v_preset2conf);
  __Pyx_XDECREF(__pyx_v_conf_data);
  __Pyx_XDECREF(__pyx_v_suffix);
  __Pyx_XDECREF(__pyx_v_fn_index);
  __Pyx_XDECREF(__pyx_v_filename);
  __Pyx_XDECREF(__pyx_v_end_col);
  __Pyx_XDECREF(__pyx_v_preset);
  __Pyx_XDECREF(__pyx_v_index);
  __Pyx_XDECREF(__pyx_v_csi);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1104
 *     '''
 * 
 *     def __cinit__(self,             # <<<<<<<<<<<<<<
 *                   infile,
 *                   Parser parser,
 */

/* Python wrapper */
static int __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static int __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_1__cinit__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_infile = 0;
  struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser = 0;
  int __pyx_v_buffer_size;
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__cinit__ (wrapper)", 0);
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 1104, __pyx_L3_error)
  #endif
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_infile,&__pyx_n_s_parser,&__pyx_n_s_buffer_size,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_VARARGS(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_infile)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1104, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser)) != 0)) {
          (void)__Pyx_Arg_NewRef_VARARGS(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1104, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 2, 3, 1); __PYX_ERR(0, 1104, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_GetKwValue_VARARGS(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_buffer_size);
          if (value) { values[2] = __Pyx_Arg_NewRef_VARARGS(value); kw_args--; }
          else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1104, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__cinit__") < 0)) __PYX_ERR(0, 1104, __pyx_L3_error)
      }
    } else {
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_VARARGS(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_VARARGS(__pyx_args, 1);
        values[0] = __Pyx_Arg_VARARGS(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_infile = values[0];
    __pyx_v_parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)values[1]);
    if (values[2]) {
      __pyx_v_buffer_size = __Pyx_PyInt_As_int(values[2]); if (unlikely((__pyx_v_buffer_size == (int)-1) && PyErr_Occurred())) __PYX_ERR(0, 1107, __pyx_L3_error)
    } else {
      __pyx_v_buffer_size = ((int)0x10000);
    }
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__cinit__", 0, 2, 3, __pyx_nargs); __PYX_ERR(0, 1104, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_parser), __pyx_ptype_5pysam_9libctabix_Parser, 1, "parser", 0))) __PYX_ERR(0, 1106, __pyx_L1_error)
  __pyx_r = __pyx_pf_5pysam_9libctabix_19tabix_file_iterator___cinit__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self), __pyx_v_infile, __pyx_v_parser, __pyx_v_buffer_size);

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __pyx_r = -1;
  __pyx_L0:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_VARARGS(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5pysam_9libctabix_19tabix_file_iterator___cinit__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self, PyObject *__pyx_v_infile, struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v_parser, int __pyx_v_buffer_size) {
  int __pyx_v_fd;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__cinit__", 0);
  __Pyx_TraceCall("__cinit__", __pyx_f[0], 1104, 0, __PYX_ERR(0, 1104, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1109
 *                   int buffer_size=65536):
 * 
 *         if infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_infile, __pyx_n_s_closed); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1109, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(0, 1109, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":1110
 * 
 *         if infile.closed:
 *             raise ValueError("I/O operation on closed file.")             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__45, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1110, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_Raise(__pyx_t_1, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(0, 1110, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1109
 *                   int buffer_size=65536):
 * 
 *         if infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  }

  /* "pysam/libctabix.pyx":1112
 *             raise ValueError("I/O operation on closed file.")
 * 
 *         self.infile = infile             # <<<<<<<<<<<<<<
 * 
 *         cdef int fd = PyObject_AsFileDescriptor(infile)
 */
  __Pyx_INCREF(__pyx_v_infile);
  __Pyx_GIVEREF(__pyx_v_infile);
  __Pyx_GOTREF(__pyx_v_self->infile);
  __Pyx_DECREF(__pyx_v_self->infile);
  __pyx_v_self->infile = __pyx_v_infile;

  /* "pysam/libctabix.pyx":1114
 *         self.infile = infile
 * 
 *         cdef int fd = PyObject_AsFileDescriptor(infile)             # <<<<<<<<<<<<<<
 *         if fd == -1:
 *             raise ValueError("I/O operation on closed file.")
 */
  __pyx_t_3 = PyObject_AsFileDescriptor(__pyx_v_infile); if (unlikely(__pyx_t_3 == ((int)-1))) __PYX_ERR(0, 1114, __pyx_L1_error)
  __pyx_v_fd = __pyx_t_3;

  /* "pysam/libctabix.pyx":1115
 * 
 *         cdef int fd = PyObject_AsFileDescriptor(infile)
 *         if fd == -1:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  __pyx_t_2 = (__pyx_v_fd == -1L);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":1116
 *         cdef int fd = PyObject_AsFileDescriptor(infile)
 *         if fd == -1:
 *             raise ValueError("I/O operation on closed file.")             # <<<<<<<<<<<<<<
 * 
 *         self.duplicated_fd = dup(fd)
 */
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__45, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1116, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_Raise(__pyx_t_1, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(0, 1116, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1115
 * 
 *         cdef int fd = PyObject_AsFileDescriptor(infile)
 *         if fd == -1:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  }

  /* "pysam/libctabix.pyx":1118
 *             raise ValueError("I/O operation on closed file.")
 * 
 *         self.duplicated_fd = dup(fd)             # <<<<<<<<<<<<<<
 * 
 *         # From the manual:
 */
  __pyx_v_self->duplicated_fd = dup(__pyx_v_fd);

  /* "pysam/libctabix.pyx":1125
 *         # When reading, this will be detected automatically by looking
 *         # for the magic two-byte gzip header.
 *         self.fh = bgzf_dopen(self.duplicated_fd, 'r')             # <<<<<<<<<<<<<<
 * 
 *         if self.fh == NULL:
 */
  __pyx_v_self->fh = bgzf_dopen(__pyx_v_self->duplicated_fd, ((char const *)"r"));

  /* "pysam/libctabix.pyx":1127
 *         self.fh = bgzf_dopen(self.duplicated_fd, 'r')
 * 
 *         if self.fh == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError('%s' % strerror(errno))
 * 
 */
  __pyx_t_2 = (__pyx_v_self->fh == NULL);
  if (unlikely(__pyx_t_2)) {

    /* "pysam/libctabix.pyx":1128
 * 
 *         if self.fh == NULL:
 *             raise IOError('%s' % strerror(errno))             # <<<<<<<<<<<<<<
 * 
 *         self.kstream = ks_init(self.fh)
 */
    __pyx_t_1 = __Pyx_PyBytes_FromString(strerror(errno)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1128, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_4 = PyUnicode_Format(__pyx_kp_u_s, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1128, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_PyObject_CallOneArg(__pyx_builtin_IOError, __pyx_t_4); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1128, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_Raise(__pyx_t_1, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(0, 1128, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1127
 *         self.fh = bgzf_dopen(self.duplicated_fd, 'r')
 * 
 *         if self.fh == NULL:             # <<<<<<<<<<<<<<
 *             raise IOError('%s' % strerror(errno))
 * 
 */
  }

  /* "pysam/libctabix.pyx":1130
 *             raise IOError('%s' % strerror(errno))
 * 
 *         self.kstream = ks_init(self.fh)             # <<<<<<<<<<<<<<
 * 
 *         self.buffer.s = <char*>malloc(buffer_size)
 */
  __pyx_v_self->kstream = ks_init(__pyx_v_self->fh);

  /* "pysam/libctabix.pyx":1132
 *         self.kstream = ks_init(self.fh)
 * 
 *         self.buffer.s = <char*>malloc(buffer_size)             # <<<<<<<<<<<<<<
 *         #if self.buffer == NULL:
 *         #    raise MemoryError( "tabix_file_iterator: could not allocate %i bytes" % buffer_size)
 */
  __pyx_v_self->buffer.s = ((char *)malloc(__pyx_v_buffer_size));

  /* "pysam/libctabix.pyx":1136
 *         #    raise MemoryError( "tabix_file_iterator: could not allocate %i bytes" % buffer_size)
 *         #self.size = buffer_size
 *         self.parser = parser             # <<<<<<<<<<<<<<
 * 
 *     def __iter__(self):
 */
  __Pyx_INCREF((PyObject *)__pyx_v_parser);
  __Pyx_GIVEREF((PyObject *)__pyx_v_parser);
  __Pyx_GOTREF((PyObject *)__pyx_v_self->parser);
  __Pyx_DECREF((PyObject *)__pyx_v_self->parser);
  __pyx_v_self->parser = __pyx_v_parser;

  /* "pysam/libctabix.pyx":1104
 *     '''
 * 
 *     def __cinit__(self,             # <<<<<<<<<<<<<<
 *                   infile,
 *                   Parser parser,
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__cinit__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1138
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_3__iter__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_3__iter__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_2__iter__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_2__iter__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__iter__", 0);
  __Pyx_TraceCall("__iter__", __pyx_f[0], 1138, 0, __PYX_ERR(0, 1138, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1139
 * 
 *     def __iter__(self):
 *         return self             # <<<<<<<<<<<<<<
 * 
 *     cdef __cnext__(self):
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF((PyObject *)__pyx_v_self);
  __pyx_r = ((PyObject *)__pyx_v_self);
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":1138
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1141
 *         return self
 * 
 *     cdef __cnext__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */

static PyObject *__pyx_f_5pysam_9libctabix_19tabix_file_iterator___cnext__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self) {
  char *__pyx_v_b;
  int __pyx_v_dret;
  int __pyx_v_retval;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  char *__pyx_t_2;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__cnext__", 0);
  __Pyx_TraceCall("__cnext__", __pyx_f[0], 1141, 0, __PYX_ERR(0, 1141, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1144
 * 
 *         cdef char * b
 *         cdef int dret = 0             # <<<<<<<<<<<<<<
 *         cdef int retval = 0
 *         while 1:
 */
  __pyx_v_dret = 0;

  /* "pysam/libctabix.pyx":1145
 *         cdef char * b
 *         cdef int dret = 0
 *         cdef int retval = 0             # <<<<<<<<<<<<<<
 *         while 1:
 *             with nogil:
 */
  __pyx_v_retval = 0;

  /* "pysam/libctabix.pyx":1146
 *         cdef int dret = 0
 *         cdef int retval = 0
 *         while 1:             # <<<<<<<<<<<<<<
 *             with nogil:
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 */
  while (1) {

    /* "pysam/libctabix.pyx":1147
 *         cdef int retval = 0
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 */
    {
        #ifdef WITH_THREAD
        PyThreadState *_save;
        _save = NULL;
        Py_UNBLOCK_THREADS
        __Pyx_FastGIL_Remember();
        #endif
        /*try:*/ {

          /* "pysam/libctabix.pyx":1148
 *         while 1:
 *             with nogil:
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)             # <<<<<<<<<<<<<<
 * 
 *             if retval < 0:
 */
          __pyx_v_retval = ks_getuntil(__pyx_v_self->kstream, '\n', (&__pyx_v_self->buffer), (&__pyx_v_dret));
        }

        /* "pysam/libctabix.pyx":1147
 *         cdef int retval = 0
 *         while 1:
 *             with nogil:             # <<<<<<<<<<<<<<
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 */
        /*finally:*/ {
          /*normal exit:*/{
            #ifdef WITH_THREAD
            __Pyx_FastGIL_Forget();
            Py_BLOCK_THREADS
            #endif
            goto __pyx_L9;
          }
          __pyx_L9:;
        }
    }

    /* "pysam/libctabix.pyx":1150
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 *                 #raise IOError('gzip error: %s' % buildGzipError( self.fh ))
 */
    __pyx_t_1 = (__pyx_v_retval < 0);
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":1151
 * 
 *             if retval < 0:
 *                 break             # <<<<<<<<<<<<<<
 *                 #raise IOError('gzip error: %s' % buildGzipError( self.fh ))
 * 
 */
      goto __pyx_L4_break;

      /* "pysam/libctabix.pyx":1150
 *                 retval = ks_getuntil(self.kstream, b'\n', &self.buffer, &dret)
 * 
 *             if retval < 0:             # <<<<<<<<<<<<<<
 *                 break
 *                 #raise IOError('gzip error: %s' % buildGzipError( self.fh ))
 */
    }

    /* "pysam/libctabix.pyx":1154
 *                 #raise IOError('gzip error: %s' % buildGzipError( self.fh ))
 * 
 *             b = self.buffer.s             # <<<<<<<<<<<<<<
 * 
 *             # skip comments
 */
    __pyx_t_2 = __pyx_v_self->buffer.s;
    __pyx_v_b = __pyx_t_2;

    /* "pysam/libctabix.pyx":1157
 * 
 *             # skip comments
 *             if (b[0] == b'#'):             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    __pyx_t_1 = ((__pyx_v_b[0]) == '#');
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":1158
 *             # skip comments
 *             if (b[0] == b'#'):
 *                 continue             # <<<<<<<<<<<<<<
 * 
 *             # skip empty lines
 */
      goto __pyx_L3_continue;

      /* "pysam/libctabix.pyx":1157
 * 
 *             # skip comments
 *             if (b[0] == b'#'):             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    }

    /* "pysam/libctabix.pyx":1161
 * 
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    __pyx_t_3 = ((__pyx_v_b[0]) == '\x00');
    if (!__pyx_t_3) {
    } else {
      __pyx_t_1 = __pyx_t_3;
      goto __pyx_L13_bool_binop_done;
    }
    __pyx_t_3 = ((__pyx_v_b[0]) == '\n');
    if (!__pyx_t_3) {
    } else {
      __pyx_t_1 = __pyx_t_3;
      goto __pyx_L13_bool_binop_done;
    }
    __pyx_t_3 = ((__pyx_v_b[0]) == '\r');
    __pyx_t_1 = __pyx_t_3;
    __pyx_L13_bool_binop_done:;
    if (__pyx_t_1) {

      /* "pysam/libctabix.pyx":1162
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':
 *                 continue             # <<<<<<<<<<<<<<
 * 
 *             # gzgets terminates at \n, no need to test
 */
      goto __pyx_L3_continue;

      /* "pysam/libctabix.pyx":1161
 * 
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    }

    /* "pysam/libctabix.pyx":1167
 * 
 *             # parser creates a copy
 *             return self.parser.parse(b, self.buffer.l)             # <<<<<<<<<<<<<<
 * 
 *         raise StopIteration
 */
    __Pyx_XDECREF(__pyx_r);
    __pyx_t_4 = ((struct __pyx_vtabstruct_5pysam_9libctabix_Parser *)__pyx_v_self->parser->__pyx_vtab)->parse(__pyx_v_self->parser, __pyx_v_b, __pyx_v_self->buffer.l); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1167, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_r = __pyx_t_4;
    __pyx_t_4 = 0;
    goto __pyx_L0;
    __pyx_L3_continue:;
  }
  __pyx_L4_break:;

  /* "pysam/libctabix.pyx":1169
 *             return self.parser.parse(b, self.buffer.l)
 * 
 *         raise StopIteration             # <<<<<<<<<<<<<<
 * 
 *     def __dealloc__(self):
 */
  __Pyx_Raise(__pyx_builtin_StopIteration, 0, 0, 0);
  __PYX_ERR(0, 1169, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1141
 *         return self
 * 
 *     cdef __cnext__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__cnext__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1171
 *         raise StopIteration
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         free(self.buffer.s)
 *         ks_destroy(self.kstream)
 */

/* Python wrapper */
static void __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_5__dealloc__(PyObject *__pyx_v_self); /*proto*/
static void __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_5__dealloc__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__dealloc__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_4__dealloc__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_4__dealloc__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__dealloc__", 0);
  __Pyx_TraceCall("__dealloc__", __pyx_f[0], 1171, 0, __PYX_ERR(0, 1171, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1172
 * 
 *     def __dealloc__(self):
 *         free(self.buffer.s)             # <<<<<<<<<<<<<<
 *         ks_destroy(self.kstream)
 *         bgzf_close(self.fh)
 */
  free(__pyx_v_self->buffer.s);

  /* "pysam/libctabix.pyx":1173
 *     def __dealloc__(self):
 *         free(self.buffer.s)
 *         ks_destroy(self.kstream)             # <<<<<<<<<<<<<<
 *         bgzf_close(self.fh)
 * 
 */
  ks_destroy(__pyx_v_self->kstream);

  /* "pysam/libctabix.pyx":1174
 *         free(self.buffer.s)
 *         ks_destroy(self.kstream)
 *         bgzf_close(self.fh)             # <<<<<<<<<<<<<<
 * 
 *     def __next__(self):
 */
  (void)(bgzf_close(__pyx_v_self->fh));

  /* "pysam/libctabix.pyx":1171
 *         raise StopIteration
 * 
 *     def __dealloc__(self):             # <<<<<<<<<<<<<<
 *         free(self.buffer.s)
 *         ks_destroy(self.kstream)
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("pysam.libctabix.tabix_file_iterator.__dealloc__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "pysam/libctabix.pyx":1176
 *         bgzf_close(self.fh)
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         return self.__cnext__()
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__(PyObject *__pyx_v_self); /*proto*/
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__(PyObject *__pyx_v_self) {
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  __pyx_kwvalues = __Pyx_KwValues_VARARGS(__pyx_args, __pyx_nargs);
  __pyx_r = __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_6__next__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_6__next__(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 1176, 0, __PYX_ERR(0, 1176, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1177
 * 
 *     def __next__(self):
 *         return self.__cnext__()             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = ((struct __pyx_vtabstruct_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self->__pyx_vtab)->__pyx___cnext__(__pyx_v_self); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":1176
 *         bgzf_close(self.fh)
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         return self.__cnext__()
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__, "tabix_file_iterator.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__46)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__, "tabix_file_iterator.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__47)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.tabix_file_iterator.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1185
 *     Permits the use of file-like objects for example from the gzip module.
 *     '''
 *     def __init__(self, infile, parser):             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_1__init__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_22tabix_generic_iterator___init__, "tabix_generic_iterator.__init__(self, infile, parser)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_1__init__ = {"__init__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_1__init__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_22tabix_generic_iterator___init__};
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_1__init__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_self = 0;
  PyObject *__pyx_v_infile = 0;
  PyObject *__pyx_v_parser = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 1185, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_self,&__pyx_n_s_infile,&__pyx_n_s_parser,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_self)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1185, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_infile)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1185, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__init__", 1, 3, 3, 1); __PYX_ERR(0, 1185, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1185, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__init__", 1, 3, 3, 2); __PYX_ERR(0, 1185, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__init__") < 0)) __PYX_ERR(0, 1185, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v_self = values[0];
    __pyx_v_infile = values[1];
    __pyx_v_parser = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 1, 3, 3, __pyx_nargs); __PYX_ERR(0, 1185, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_22tabix_generic_iterator___init__(__pyx_self, __pyx_v_self, __pyx_v_infile, __pyx_v_parser);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator___init__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self, PyObject *__pyx_v_infile, PyObject *__pyx_v_parser) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_t_3;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__48)
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 1185, 0, __PYX_ERR(0, 1185, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1187
 *     def __init__(self, infile, parser):
 * 
 *         self.infile = infile             # <<<<<<<<<<<<<<
 *         if self.infile.closed:
 *             raise ValueError("I/O operation on closed file.")
 */
  if (__Pyx_PyObject_SetAttrStr(__pyx_v_self, __pyx_n_s_infile, __pyx_v_infile) < 0) __PYX_ERR(0, 1187, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1188
 * 
 *         self.infile = infile
 *         if self.infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 *         self.parser = parser
 */
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self, __pyx_n_s_infile); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1188, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_closed); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1188, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_3 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely((__pyx_t_3 < 0))) __PYX_ERR(0, 1188, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(__pyx_t_3)) {

    /* "pysam/libctabix.pyx":1189
 *         self.infile = infile
 *         if self.infile.closed:
 *             raise ValueError("I/O operation on closed file.")             # <<<<<<<<<<<<<<
 *         self.parser = parser
 * 
 */
    __pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__45, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1189, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_Raise(__pyx_t_2, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __PYX_ERR(0, 1189, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1188
 * 
 *         self.infile = infile
 *         if self.infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 *         self.parser = parser
 */
  }

  /* "pysam/libctabix.pyx":1190
 *         if self.infile.closed:
 *             raise ValueError("I/O operation on closed file.")
 *         self.parser = parser             # <<<<<<<<<<<<<<
 * 
 *     def __iter__(self):
 */
  if (__Pyx_PyObject_SetAttrStr(__pyx_v_self, __pyx_n_s_parser, __pyx_v_parser) < 0) __PYX_ERR(0, 1190, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1185
 *     Permits the use of file-like objects for example from the gzip module.
 *     '''
 *     def __init__(self, infile, parser):             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1192
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_3__iter__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_22tabix_generic_iterator_2__iter__, "tabix_generic_iterator.__iter__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_3__iter__ = {"__iter__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_3__iter__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_22tabix_generic_iterator_2__iter__};
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_3__iter__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_self = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__iter__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 1192, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_self,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_self)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1192, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__iter__") < 0)) __PYX_ERR(0, 1192, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v_self = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__iter__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 1192, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_2__iter__(__pyx_self, __pyx_v_self);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_2__iter__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__49)
  __Pyx_RefNannySetupContext("__iter__", 0);
  __Pyx_TraceCall("__iter__", __pyx_f[0], 1192, 0, __PYX_ERR(0, 1192, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1193
 * 
 *     def __iter__(self):
 *         return self             # <<<<<<<<<<<<<<
 * 
 *     # cython version - required for python 3
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_self);
  __pyx_r = __pyx_v_self;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":1192
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__iter__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1196
 * 
 *     # cython version - required for python 3
 *     def __next__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_5__next__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_22tabix_generic_iterator_4__next__, "tabix_generic_iterator.__next__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_5__next__ = {"__next__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_5__next__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_22tabix_generic_iterator_4__next__};
static PyObject *__pyx_pw_5pysam_9libctabix_22tabix_generic_iterator_5__next__(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_self = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__next__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 1196, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_self,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_self)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1196, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__next__") < 0)) __PYX_ERR(0, 1196, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v_self = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__next__", 1, 1, 1, __pyx_nargs); __PYX_ERR(0, 1196, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_4__next__(__pyx_self, __pyx_v_self);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_22tabix_generic_iterator_4__next__(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_self) {
  char *__pyx_v_b;
  char *__pyx_v_cpy;
  size_t __pyx_v_nbytes;
  PyObject *__pyx_v_encoding = NULL;
  PyObject *__pyx_v_line = NULL;
  PyObject *__pyx_v_s = NULL;
  PyObject *__pyx_v_bytes_cpy = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_t_5;
  int __pyx_t_6;
  struct __pyx_opt_args_5pysam_9libcutils_force_bytes __pyx_t_7;
  char *__pyx_t_8;
  Py_ssize_t __pyx_t_9;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__50)
  __Pyx_RefNannySetupContext("__next__", 0);
  __Pyx_TraceCall("__next__", __pyx_f[0], 1196, 0, __PYX_ERR(0, 1196, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1202
 *         cdef size_t nbytes
 * 
 *         encoding = self.parser.get_encoding()             # <<<<<<<<<<<<<<
 * 
 *         # note that GzipFile.close() does not close the file
 */
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_self, __pyx_n_s_parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1202, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_get_encoding); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1202, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = NULL;
  __pyx_t_4 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_4 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[1] = {__pyx_t_2, };
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1202, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v_encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "pysam/libctabix.pyx":1206
 *         # note that GzipFile.close() does not close the file
 *         # reading is still possible.
 *         if self.infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self, __pyx_n_s_infile); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1206, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_closed); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1206, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 1206, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (unlikely(__pyx_t_5)) {

    /* "pysam/libctabix.pyx":1207
 *         # reading is still possible.
 *         if self.infile.closed:
 *             raise ValueError("I/O operation on closed file.")             # <<<<<<<<<<<<<<
 * 
 *         while 1:
 */
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__45, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1207, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(0, 1207, __pyx_L1_error)

    /* "pysam/libctabix.pyx":1206
 *         # note that GzipFile.close() does not close the file
 *         # reading is still possible.
 *         if self.infile.closed:             # <<<<<<<<<<<<<<
 *             raise ValueError("I/O operation on closed file.")
 * 
 */
  }

  /* "pysam/libctabix.pyx":1209
 *             raise ValueError("I/O operation on closed file.")
 * 
 *         while 1:             # <<<<<<<<<<<<<<
 * 
 *             line = self.infile.readline()
 */
  while (1) {

    /* "pysam/libctabix.pyx":1211
 *         while 1:
 * 
 *             line = self.infile.readline()             # <<<<<<<<<<<<<<
 *             if not line:
 *                 break
 */
    __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self, __pyx_n_s_infile); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1211, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_readline); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1211, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = NULL;
    __pyx_t_4 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_1 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_1)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_1);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_4 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[1] = {__pyx_t_1, };
      __pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 0+__pyx_t_4);
      __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1211, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __Pyx_XDECREF_SET(__pyx_v_line, __pyx_t_3);
    __pyx_t_3 = 0;

    /* "pysam/libctabix.pyx":1212
 * 
 *             line = self.infile.readline()
 *             if not line:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    __pyx_t_5 = __Pyx_PyObject_IsTrue(__pyx_v_line); if (unlikely((__pyx_t_5 < 0))) __PYX_ERR(0, 1212, __pyx_L1_error)
    __pyx_t_6 = (!__pyx_t_5);
    if (__pyx_t_6) {

      /* "pysam/libctabix.pyx":1213
 *             line = self.infile.readline()
 *             if not line:
 *                 break             # <<<<<<<<<<<<<<
 * 
 *             s = force_bytes(line, encoding)
 */
      goto __pyx_L5_break;

      /* "pysam/libctabix.pyx":1212
 * 
 *             line = self.infile.readline()
 *             if not line:             # <<<<<<<<<<<<<<
 *                 break
 * 
 */
    }

    /* "pysam/libctabix.pyx":1215
 *                 break
 * 
 *             s = force_bytes(line, encoding)             # <<<<<<<<<<<<<<
 *             b = s
 *             nbytes = len(line)
 */
    __pyx_t_7.__pyx_n = 1;
    __pyx_t_7.encoding = __pyx_v_encoding;
    __pyx_t_3 = __pyx_f_5pysam_9libcutils_force_bytes(__pyx_v_line, &__pyx_t_7); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1215, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_XDECREF_SET(__pyx_v_s, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "pysam/libctabix.pyx":1216
 * 
 *             s = force_bytes(line, encoding)
 *             b = s             # <<<<<<<<<<<<<<
 *             nbytes = len(line)
 *             assert b[nbytes] == b'\0'
 */
    if (unlikely(__pyx_v_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 1216, __pyx_L1_error)
    }
    __pyx_t_8 = __Pyx_PyBytes_AsWritableString(__pyx_v_s); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 1216, __pyx_L1_error)
    __pyx_v_b = __pyx_t_8;

    /* "pysam/libctabix.pyx":1217
 *             s = force_bytes(line, encoding)
 *             b = s
 *             nbytes = len(line)             # <<<<<<<<<<<<<<
 *             assert b[nbytes] == b'\0'
 * 
 */
    __pyx_t_9 = PyObject_Length(__pyx_v_line); if (unlikely(__pyx_t_9 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1217, __pyx_L1_error)
    __pyx_v_nbytes = __pyx_t_9;

    /* "pysam/libctabix.pyx":1218
 *             b = s
 *             nbytes = len(line)
 *             assert b[nbytes] == b'\0'             # <<<<<<<<<<<<<<
 * 
 *             # skip comments
 */
    #ifndef CYTHON_WITHOUT_ASSERTIONS
    if (unlikely(__pyx_assertions_enabled())) {
      __pyx_t_6 = ((__pyx_v_b[__pyx_v_nbytes]) == '\x00');
      if (unlikely(!__pyx_t_6)) {
        __Pyx_Raise(__pyx_builtin_AssertionError, 0, 0, 0);
        __PYX_ERR(0, 1218, __pyx_L1_error)
      }
    }
    #else
    if ((1)); else __PYX_ERR(0, 1218, __pyx_L1_error)
    #endif

    /* "pysam/libctabix.pyx":1221
 * 
 *             # skip comments
 *             if b[0] == b'#':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    __pyx_t_6 = ((__pyx_v_b[0]) == '#');
    if (__pyx_t_6) {

      /* "pysam/libctabix.pyx":1222
 *             # skip comments
 *             if b[0] == b'#':
 *                 continue             # <<<<<<<<<<<<<<
 * 
 *             # skip empty lines
 */
      goto __pyx_L4_continue;

      /* "pysam/libctabix.pyx":1221
 * 
 *             # skip comments
 *             if b[0] == b'#':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    }

    /* "pysam/libctabix.pyx":1225
 * 
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    __pyx_t_5 = ((__pyx_v_b[0]) == '\x00');
    if (!__pyx_t_5) {
    } else {
      __pyx_t_6 = __pyx_t_5;
      goto __pyx_L9_bool_binop_done;
    }
    __pyx_t_5 = ((__pyx_v_b[0]) == '\n');
    if (!__pyx_t_5) {
    } else {
      __pyx_t_6 = __pyx_t_5;
      goto __pyx_L9_bool_binop_done;
    }
    __pyx_t_5 = ((__pyx_v_b[0]) == '\r');
    __pyx_t_6 = __pyx_t_5;
    __pyx_L9_bool_binop_done:;
    if (__pyx_t_6) {

      /* "pysam/libctabix.pyx":1226
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':
 *                 continue             # <<<<<<<<<<<<<<
 * 
 *             # make sure that entry is complete
 */
      goto __pyx_L4_continue;

      /* "pysam/libctabix.pyx":1225
 * 
 *             # skip empty lines
 *             if b[0] == b'\0' or b[0] == b'\n' or b[0] == b'\r':             # <<<<<<<<<<<<<<
 *                 continue
 * 
 */
    }

    /* "pysam/libctabix.pyx":1229
 * 
 *             # make sure that entry is complete
 *             if b[nbytes-1] != b'\n' and b[nbytes-1] != b'\r':             # <<<<<<<<<<<<<<
 *                 raise ValueError("incomplete line at %s" % line)
 * 
 */
    __pyx_t_5 = ((__pyx_v_b[(__pyx_v_nbytes - 1)]) != '\n');
    if (__pyx_t_5) {
    } else {
      __pyx_t_6 = __pyx_t_5;
      goto __pyx_L13_bool_binop_done;
    }
    __pyx_t_5 = ((__pyx_v_b[(__pyx_v_nbytes - 1)]) != '\r');
    __pyx_t_6 = __pyx_t_5;
    __pyx_L13_bool_binop_done:;
    if (unlikely(__pyx_t_6)) {

      /* "pysam/libctabix.pyx":1230
 *             # make sure that entry is complete
 *             if b[nbytes-1] != b'\n' and b[nbytes-1] != b'\r':
 *                 raise ValueError("incomplete line at %s" % line)             # <<<<<<<<<<<<<<
 * 
 *             bytes_cpy = <bytes> b
 */
      __pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_incomplete_line_at_s, __pyx_v_line); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1230, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1230, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_Raise(__pyx_t_2, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __PYX_ERR(0, 1230, __pyx_L1_error)

      /* "pysam/libctabix.pyx":1229
 * 
 *             # make sure that entry is complete
 *             if b[nbytes-1] != b'\n' and b[nbytes-1] != b'\r':             # <<<<<<<<<<<<<<
 *                 raise ValueError("incomplete line at %s" % line)
 * 
 */
    }

    /* "pysam/libctabix.pyx":1232
 *                 raise ValueError("incomplete line at %s" % line)
 * 
 *             bytes_cpy = <bytes> b             # <<<<<<<<<<<<<<
 *             cpy = <char *> bytes_cpy
 * 
 */
    __pyx_t_2 = __Pyx_PyBytes_FromString(__pyx_v_b); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1232, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = __pyx_t_2;
    __Pyx_INCREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_v_bytes_cpy = ((PyObject*)__pyx_t_3);
    __pyx_t_3 = 0;

    /* "pysam/libctabix.pyx":1233
 * 
 *             bytes_cpy = <bytes> b
 *             cpy = <char *> bytes_cpy             # <<<<<<<<<<<<<<
 * 
 *             return self.parser(cpy, nbytes)
 */
    if (unlikely(__pyx_v_bytes_cpy == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 1233, __pyx_L1_error)
    }
    __pyx_t_8 = __Pyx_PyBytes_AsWritableString(__pyx_v_bytes_cpy); if (unlikely((!__pyx_t_8) && PyErr_Occurred())) __PYX_ERR(0, 1233, __pyx_L1_error)
    __pyx_v_cpy = ((char *)__pyx_t_8);

    /* "pysam/libctabix.pyx":1235
 *             cpy = <char *> bytes_cpy
 * 
 *             return self.parser(cpy, nbytes)             # <<<<<<<<<<<<<<
 * 
 *         raise StopIteration
 */
    __Pyx_XDECREF(__pyx_r);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_self, __pyx_n_s_parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_1 = __Pyx_PyBytes_FromString(__pyx_v_cpy); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_10 = __Pyx_PyInt_FromSize_t(__pyx_v_nbytes); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_t_11 = NULL;
    __pyx_t_4 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_11 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_11)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_11);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_4 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[3] = {__pyx_t_11, __pyx_t_1, __pyx_t_10};
      __pyx_t_3 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 2+__pyx_t_4);
      __Pyx_XDECREF(__pyx_t_11); __pyx_t_11 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1235, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    }
    __pyx_r = __pyx_t_3;
    __pyx_t_3 = 0;
    goto __pyx_L0;
    __pyx_L4_continue:;
  }
  __pyx_L5_break:;

  /* "pysam/libctabix.pyx":1237
 *             return self.parser(cpy, nbytes)
 * 
 *         raise StopIteration             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_Raise(__pyx_builtin_StopIteration, 0, 0, 0);
  __PYX_ERR(0, 1237, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1196
 * 
 *     # cython version - required for python 3
 *     def __next__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_10);
  __Pyx_XDECREF(__pyx_t_11);
  __Pyx_AddTraceback("pysam.libctabix.tabix_generic_iterator.__next__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_encoding);
  __Pyx_XDECREF(__pyx_v_line);
  __Pyx_XDECREF(__pyx_v_s);
  __Pyx_XDECREF(__pyx_v_bytes_cpy);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "pysam/libctabix.pyx":1240
 * 
 * 
 * def tabix_iterator(infile, parser):             # <<<<<<<<<<<<<<
 *     """return an iterator over all entries in a file.
 * 
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_5tabix_iterator(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_4tabix_iterator, "tabix_iterator(infile, parser)\nreturn an iterator over all entries in a file.\n    \n    Results are returned parsed as specified by the *parser*. If\n    *parser* is None, the results are returned as an unparsed string.\n    Otherwise, *parser* is assumed to be a functor that will return\n    parsed data (see for example :class:`~pysam.asTuple` and\n    :class:`~pysam.asGTF`).\n\n    ");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_5tabix_iterator = {"tabix_iterator", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5tabix_iterator, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_4tabix_iterator};
static PyObject *__pyx_pw_5pysam_9libctabix_5tabix_iterator(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v_infile = 0;
  PyObject *__pyx_v_parser = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[2] = {0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("tabix_iterator (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(0, 1240, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_infile,&__pyx_n_s_parser,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_infile)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1240, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_parser)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1240, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("tabix_iterator", 1, 2, 2, 1); __PYX_ERR(0, 1240, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "tabix_iterator") < 0)) __PYX_ERR(0, 1240, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 2)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
    }
    __pyx_v_infile = values[0];
    __pyx_v_parser = values[1];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("tabix_iterator", 1, 2, 2, __pyx_nargs); __PYX_ERR(0, 1240, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.tabix_iterator", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_4tabix_iterator(__pyx_self, __pyx_v_infile, __pyx_v_parser);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_4tabix_iterator(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v_infile, PyObject *__pyx_v_parser) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__51)
  __Pyx_RefNannySetupContext("tabix_iterator", 0);
  __Pyx_TraceCall("tabix_iterator", __pyx_f[0], 1240, 0, __PYX_ERR(0, 1240, __pyx_L1_error));

  /* "pysam/libctabix.pyx":1250
 * 
 *     """
 *     return tabix_generic_iterator(infile, parser)             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_tabix_generic_iterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1250, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = NULL;
  __pyx_t_4 = 0;
  #if CYTHON_UNPACK_METHODS
  if (unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_4 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[3] = {__pyx_t_3, __pyx_v_infile, __pyx_v_parser};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_2, __pyx_callargs+1-__pyx_t_4, 2+__pyx_t_4);
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1250, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  }
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "pysam/libctabix.pyx":1240
 * 
 * 
 * def tabix_iterator(infile, parser):             # <<<<<<<<<<<<<<
 *     """return an iterator over all entries in a file.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("pysam.libctabix.tabix_iterator", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9Tabixfile_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9Tabixfile___reduce_cython__, "Tabixfile.__reduce_cython__(self)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9Tabixfile_1__reduce_cython__ = {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9Tabixfile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9Tabixfile___reduce_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_9Tabixfile_1__reduce_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  if (unlikely(__pyx_nargs > 0)) {
    __Pyx_RaiseArgtupleInvalid("__reduce_cython__", 1, 0, 0, __pyx_nargs); return NULL;}
  if (unlikely(__pyx_kwds) && __Pyx_NumKwargs_FASTCALL(__pyx_kwds) && unlikely(!__Pyx_CheckKeywordStrings(__pyx_kwds, "__reduce_cython__", 0))) return NULL;
  goto __pyx_L4_argument_unpacking_done;
  goto __pyx_L3_error;
  __pyx_L3_error:;
  __Pyx_AddTraceback("pysam.libctabix.Tabixfile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9Tabixfile___reduce_cython__(((struct __pyx_obj_5pysam_9libctabix_Tabixfile *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9Tabixfile___reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_Tabixfile *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__52)
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.Tabixfile.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9Tabixfile_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_9Tabixfile_2__setstate_cython__, "Tabixfile.__setstate_cython__(self, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9Tabixfile_3__setstate_cython__ = {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9Tabixfile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9Tabixfile_2__setstate_cython__};
static PyObject *__pyx_pw_5pysam_9libctabix_9Tabixfile_3__setstate_cython__(PyObject *__pyx_v_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  CYTHON_UNUSED PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[1] = {0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 3, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 3, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__setstate_cython__") < 0)) __PYX_ERR(1, 3, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 1)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
    }
    __pyx_v___pyx_state = values[0];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__setstate_cython__", 1, 1, 1, __pyx_nargs); __PYX_ERR(1, 3, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.Tabixfile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_9Tabixfile_2__setstate_cython__(((struct __pyx_obj_5pysam_9libctabix_Tabixfile *)__pyx_v_self), __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_9Tabixfile_2__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5pysam_9libctabix_Tabixfile *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__53)
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"             # <<<<<<<<<<<<<<
 */
  __Pyx_Raise(__pyx_builtin_TypeError, __pyx_kp_s_no_default___reduce___due_to_non, 0, 0);
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("pysam.libctabix.Tabixfile.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_Parser(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_7__pyx_unpickle_Parser(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_6__pyx_unpickle_Parser, "__pyx_unpickle_Parser(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_7__pyx_unpickle_Parser = {"__pyx_unpickle_Parser", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_7__pyx_unpickle_Parser, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6__pyx_unpickle_Parser};
static PyObject *__pyx_pw_5pysam_9libctabix_7__pyx_unpickle_Parser(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_Parser (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_Parser", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_Parser", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_Parser") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_Parser", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_Parser", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_6__pyx_unpickle_Parser(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_6__pyx_unpickle_Parser(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__54)
  __Pyx_RefNannySetupContext("__pyx_unpickle_Parser", 0);
  __Pyx_TraceCall("__pyx_unpickle_Parser", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = Parser.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = Parser.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = Parser.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_Parser), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = Parser.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = Parser.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_Parser__set_state(((struct __pyx_obj_5pysam_9libctabix_Parser *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = Parser.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_Parser(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_Parser", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_Parser__set_state(struct __pyx_obj_5pysam_9libctabix_Parser *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_Parser__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_Parser__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->encoding);
  __pyx_v___pyx_result->encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_Parser__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_asTuple(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_9__pyx_unpickle_asTuple(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_8__pyx_unpickle_asTuple, "__pyx_unpickle_asTuple(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_9__pyx_unpickle_asTuple = {"__pyx_unpickle_asTuple", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9__pyx_unpickle_asTuple, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_8__pyx_unpickle_asTuple};
static PyObject *__pyx_pw_5pysam_9libctabix_9__pyx_unpickle_asTuple(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_asTuple (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asTuple", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asTuple", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_asTuple") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asTuple", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asTuple", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_8__pyx_unpickle_asTuple(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_8__pyx_unpickle_asTuple(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__57)
  __Pyx_RefNannySetupContext("__pyx_unpickle_asTuple", 0);
  __Pyx_TraceCall("__pyx_unpickle_asTuple", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asTuple.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = asTuple.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asTuple.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_asTuple), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asTuple.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = asTuple.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asTuple__set_state(((struct __pyx_obj_5pysam_9libctabix_asTuple *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asTuple.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asTuple(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asTuple", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asTuple__set_state(struct __pyx_obj_5pysam_9libctabix_asTuple *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_asTuple__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_asTuple__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __pyx_v___pyx_result->__pyx_base.encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_asTuple__set_state(<asTuple> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asTuple__set_state(asTuple __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asTuple__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_asGFF3(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_11__pyx_unpickle_asGFF3(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_10__pyx_unpickle_asGFF3, "__pyx_unpickle_asGFF3(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_11__pyx_unpickle_asGFF3 = {"__pyx_unpickle_asGFF3", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_11__pyx_unpickle_asGFF3, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_10__pyx_unpickle_asGFF3};
static PyObject *__pyx_pw_5pysam_9libctabix_11__pyx_unpickle_asGFF3(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGFF3 (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGFF3", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGFF3", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_asGFF3") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGFF3", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGFF3", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_10__pyx_unpickle_asGFF3(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_10__pyx_unpickle_asGFF3(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__58)
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGFF3", 0);
  __Pyx_TraceCall("__pyx_unpickle_asGFF3", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGFF3.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = asGFF3.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGFF3.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_asGFF3), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGFF3.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = asGFF3.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asGFF3__set_state(((struct __pyx_obj_5pysam_9libctabix_asGFF3 *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGFF3.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asGFF3(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGFF3", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asGFF3__set_state(struct __pyx_obj_5pysam_9libctabix_asGFF3 *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGFF3__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_asGFF3__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __pyx_v___pyx_result->__pyx_base.encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGFF3__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_asGTF(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_13__pyx_unpickle_asGTF(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_12__pyx_unpickle_asGTF, "__pyx_unpickle_asGTF(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_13__pyx_unpickle_asGTF = {"__pyx_unpickle_asGTF", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13__pyx_unpickle_asGTF, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_12__pyx_unpickle_asGTF};
static PyObject *__pyx_pw_5pysam_9libctabix_13__pyx_unpickle_asGTF(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGTF (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGTF", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGTF", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_asGTF") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asGTF", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGTF", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_12__pyx_unpickle_asGTF(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_12__pyx_unpickle_asGTF(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__59)
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGTF", 0);
  __Pyx_TraceCall("__pyx_unpickle_asGTF", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGTF.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = asGTF.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGTF.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_asGTF), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGTF.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = asGTF.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asGTF__set_state(((struct __pyx_obj_5pysam_9libctabix_asGTF *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asGTF.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asGTF(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGTF", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asGTF__set_state(struct __pyx_obj_5pysam_9libctabix_asGTF *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_asGTF__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_asGTF__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __pyx_v___pyx_result->__pyx_base.encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_asGTF__set_state(<asGTF> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asGTF__set_state(asGTF __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asGTF__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_asBed(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_15__pyx_unpickle_asBed(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_14__pyx_unpickle_asBed, "__pyx_unpickle_asBed(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_15__pyx_unpickle_asBed = {"__pyx_unpickle_asBed", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_15__pyx_unpickle_asBed, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_14__pyx_unpickle_asBed};
static PyObject *__pyx_pw_5pysam_9libctabix_15__pyx_unpickle_asBed(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_asBed (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asBed", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asBed", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_asBed") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asBed", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asBed", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_14__pyx_unpickle_asBed(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_14__pyx_unpickle_asBed(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__60)
  __Pyx_RefNannySetupContext("__pyx_unpickle_asBed", 0);
  __Pyx_TraceCall("__pyx_unpickle_asBed", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asBed.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = asBed.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asBed.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_asBed), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asBed.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = asBed.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asBed__set_state(((struct __pyx_obj_5pysam_9libctabix_asBed *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asBed.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asBed(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asBed", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asBed__set_state(struct __pyx_obj_5pysam_9libctabix_asBed *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_asBed__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_asBed__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __pyx_v___pyx_result->__pyx_base.encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asBed__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __pyx_unpickle_asVCF(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

/* Python wrapper */
static PyObject *__pyx_pw_5pysam_9libctabix_17__pyx_unpickle_asVCF(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
); /*proto*/
PyDoc_STRVAR(__pyx_doc_5pysam_9libctabix_16__pyx_unpickle_asVCF, "__pyx_unpickle_asVCF(__pyx_type, long __pyx_checksum, __pyx_state)");
static PyMethodDef __pyx_mdef_5pysam_9libctabix_17__pyx_unpickle_asVCF = {"__pyx_unpickle_asVCF", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_17__pyx_unpickle_asVCF, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_16__pyx_unpickle_asVCF};
static PyObject *__pyx_pw_5pysam_9libctabix_17__pyx_unpickle_asVCF(PyObject *__pyx_self, 
#if CYTHON_METH_FASTCALL
PyObject *const *__pyx_args, Py_ssize_t __pyx_nargs, PyObject *__pyx_kwds
#else
PyObject *__pyx_args, PyObject *__pyx_kwds
#endif
) {
  PyObject *__pyx_v___pyx_type = 0;
  long __pyx_v___pyx_checksum;
  PyObject *__pyx_v___pyx_state = 0;
  #if !CYTHON_METH_FASTCALL
  CYTHON_UNUSED Py_ssize_t __pyx_nargs;
  #endif
  CYTHON_UNUSED PyObject *const *__pyx_kwvalues;
  PyObject* values[3] = {0,0,0};
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__pyx_unpickle_asVCF (wrapper)", 0);
  #if !CYTHON_METH_FASTCALL
  #if CYTHON_ASSUME_SAFE_MACROS
  __pyx_nargs = PyTuple_GET_SIZE(__pyx_args);
  #else
  __pyx_nargs = PyTuple_Size(__pyx_args);
  if (unlikely((__pyx_nargs < 0))) __PYX_ERR(1, 1, __pyx_L3_error)
  #endif
  #endif
  __pyx_kwvalues = __Pyx_KwValues_FASTCALL(__pyx_args, __pyx_nargs);
  {
    PyObject **__pyx_pyargnames[] = {&__pyx_n_s_pyx_type,&__pyx_n_s_pyx_checksum,&__pyx_n_s_pyx_state,0};
    if (__pyx_kwds) {
      Py_ssize_t kw_args;
      switch (__pyx_nargs) {
        case  3: values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = __Pyx_NumKwargs_FASTCALL(__pyx_kwds);
      switch (__pyx_nargs) {
        case  0:
        if (likely((values[0] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_type)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[0]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_checksum)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[1]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asVCF", 1, 3, 3, 1); __PYX_ERR(1, 1, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_GetKwValue_FASTCALL(__pyx_kwds, __pyx_kwvalues, __pyx_n_s_pyx_state)) != 0)) {
          (void)__Pyx_Arg_NewRef_FASTCALL(values[2]);
          kw_args--;
        }
        else if (unlikely(PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
        else {
          __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asVCF", 1, 3, 3, 2); __PYX_ERR(1, 1, __pyx_L3_error)
        }
      }
      if (unlikely(kw_args > 0)) {
        const Py_ssize_t kwd_pos_args = __pyx_nargs;
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_kwvalues, __pyx_pyargnames, 0, values + 0, kwd_pos_args, "__pyx_unpickle_asVCF") < 0)) __PYX_ERR(1, 1, __pyx_L3_error)
      }
    } else if (unlikely(__pyx_nargs != 3)) {
      goto __pyx_L5_argtuple_error;
    } else {
      values[0] = __Pyx_Arg_FASTCALL(__pyx_args, 0);
      values[1] = __Pyx_Arg_FASTCALL(__pyx_args, 1);
      values[2] = __Pyx_Arg_FASTCALL(__pyx_args, 2);
    }
    __pyx_v___pyx_type = values[0];
    __pyx_v___pyx_checksum = __Pyx_PyInt_As_long(values[1]); if (unlikely((__pyx_v___pyx_checksum == (long)-1) && PyErr_Occurred())) __PYX_ERR(1, 1, __pyx_L3_error)
    __pyx_v___pyx_state = values[2];
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__pyx_unpickle_asVCF", 1, 3, 3, __pyx_nargs); __PYX_ERR(1, 1, __pyx_L3_error)
  goto __pyx_L3_error;
  __pyx_L3_error:;
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asVCF", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5pysam_9libctabix_16__pyx_unpickle_asVCF(__pyx_self, __pyx_v___pyx_type, __pyx_v___pyx_checksum, __pyx_v___pyx_state);

  /* function exit code */
  {
    Py_ssize_t __pyx_temp;
    for (__pyx_temp=0; __pyx_temp < (Py_ssize_t)(sizeof(values)/sizeof(values[0])); ++__pyx_temp) {
      __Pyx_Arg_XDECREF_FASTCALL(values[__pyx_temp]);
    }
  }
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5pysam_9libctabix_16__pyx_unpickle_asVCF(CYTHON_UNUSED PyObject *__pyx_self, PyObject *__pyx_v___pyx_type, long __pyx_v___pyx_checksum, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_v___pyx_PickleError = 0;
  PyObject *__pyx_v___pyx_result = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_TraceFrameInit(__pyx_codeobj__61)
  __Pyx_RefNannySetupContext("__pyx_unpickle_asVCF", 0);
  __Pyx_TraceCall("__pyx_unpickle_asVCF", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_t_1 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_t_1, __pyx_tuple__55, Py_NE)); if (unlikely((__pyx_t_2 < 0))) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (__pyx_t_2) {

    /* "(tree fragment)":5
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError             # <<<<<<<<<<<<<<
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asVCF.__new__(__pyx_type)
 */
    __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_n_s_PickleError);
    __Pyx_GIVEREF(__pyx_n_s_PickleError);
    if (__Pyx_PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_PickleError)) __PYX_ERR(1, 5, __pyx_L1_error);
    __pyx_t_3 = __Pyx_Import(__pyx_n_s_pickle, __pyx_t_1, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_3, __pyx_n_s_PickleError); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 5, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_1);
    __pyx_v___pyx_PickleError = __pyx_t_1;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "(tree fragment)":6
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum             # <<<<<<<<<<<<<<
 *     __pyx_result = asVCF.__new__(__pyx_type)
 *     if __pyx_state is not None:
 */
    __pyx_t_3 = __Pyx_PyInt_From_long(__pyx_v___pyx_checksum); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = __Pyx_PyString_Format(__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 6, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_Raise(__pyx_v___pyx_PickleError, __pyx_t_1, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(1, 6, __pyx_L1_error)

    /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  }

  /* "(tree fragment)":7
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asVCF.__new__(__pyx_type)             # <<<<<<<<<<<<<<
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 */
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_ptype_5pysam_9libctabix_asVCF), __pyx_n_s_new); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 7, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  #if CYTHON_UNPACK_METHODS
  if (likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_5 = 1;
    }
  }
  #endif
  {
    PyObject *__pyx_callargs[2] = {__pyx_t_4, __pyx_v___pyx_type};
    __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_3, __pyx_callargs+1-__pyx_t_5, 1+__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 7, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  }
  __pyx_v___pyx_result = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asVCF.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  __pyx_t_2 = (__pyx_v___pyx_state != Py_None);
  if (__pyx_t_2) {

    /* "(tree fragment)":9
 *     __pyx_result = asVCF.__new__(__pyx_type)
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)             # <<<<<<<<<<<<<<
 *     return __pyx_result
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):
 */
    if (!(likely(PyTuple_CheckExact(__pyx_v___pyx_state))||((__pyx_v___pyx_state) == Py_None) || __Pyx_RaiseUnexpectedTypeError("tuple", __pyx_v___pyx_state))) __PYX_ERR(1, 9, __pyx_L1_error)
    __pyx_t_1 = __pyx_f_5pysam_9libctabix___pyx_unpickle_asVCF__set_state(((struct __pyx_obj_5pysam_9libctabix_asVCF *)__pyx_v___pyx_result), ((PyObject*)__pyx_v___pyx_state)); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 9, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":8
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 *     __pyx_result = asVCF.__new__(__pyx_type)
 *     if __pyx_state is not None:             # <<<<<<<<<<<<<<
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 *     return __pyx_result
 */
  }

  /* "(tree fragment)":10
 *     if __pyx_state is not None:
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 *     return __pyx_result             # <<<<<<<<<<<<<<
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 */
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v___pyx_result);
  __pyx_r = __pyx_v___pyx_result;
  goto __pyx_L0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asVCF(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asVCF", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v___pyx_PickleError);
  __Pyx_XDECREF(__pyx_v___pyx_result);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":11
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

static PyObject *__pyx_f_5pysam_9libctabix___pyx_unpickle_asVCF__set_state(struct __pyx_obj_5pysam_9libctabix_asVCF *__pyx_v___pyx_result, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__pyx_unpickle_asVCF__set_state", 0);
  __Pyx_TraceCall("__pyx_unpickle_asVCF__set_state", __pyx_f[1], 11, 0, __PYX_ERR(1, 11, __pyx_L1_error));

  /* "(tree fragment)":12
 *     return __pyx_result
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]             # <<<<<<<<<<<<<<
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(1, 12, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 12, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __Pyx_DECREF(__pyx_v___pyx_result->__pyx_base.encoding);
  __pyx_v___pyx_result->__pyx_base.encoding = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "(tree fragment)":13
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  if (unlikely(__pyx_v___pyx_state == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(1, 13, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_PyTuple_GET_SIZE(__pyx_v___pyx_state); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_4 = (__pyx_t_3 > 1);
  if (__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L4_bool_binop_done;
  }
  __pyx_t_4 = __Pyx_HasAttr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(1, 13, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_4;
  __pyx_L4_bool_binop_done:;
  if (__pyx_t_2) {

    /* "(tree fragment)":14
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 *         __pyx_result.__dict__.update(__pyx_state[1])             # <<<<<<<<<<<<<<
 */
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v___pyx_result), __pyx_n_s_dict); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_update); if (unlikely(!__pyx_t_6)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v___pyx_state == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(1, 14, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_GetItemInt_Tuple(__pyx_v___pyx_state, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(1, 14, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_7 = NULL;
    __pyx_t_8 = 0;
    #if CYTHON_UNPACK_METHODS
    if (likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_7)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_7);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
        __pyx_t_8 = 1;
      }
    }
    #endif
    {
      PyObject *__pyx_callargs[2] = {__pyx_t_7, __pyx_t_5};
      __pyx_t_1 = __Pyx_PyObject_FastCall(__pyx_t_6, __pyx_callargs+1-__pyx_t_8, 1+__pyx_t_8);
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 14, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "(tree fragment)":13
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):             # <<<<<<<<<<<<<<
 *         __pyx_result.__dict__.update(__pyx_state[1])
 */
  }

  /* "(tree fragment)":11
 *         __pyx_unpickle_asVCF__set_state(<asVCF> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asVCF__set_state(asVCF __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("pysam.libctabix.__pyx_unpickle_asVCF__set_state", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}
static struct __pyx_vtabstruct_5pysam_9libctabix_tabix_file_iterator __pyx_vtable_5pysam_9libctabix_tabix_file_iterator;

static PyObject *__pyx_tp_new_5pysam_9libctabix_tabix_file_iterator(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *p;
  PyObject *o;
  #if CYTHON_COMPILING_IN_LIMITED_API
  allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
  o = alloc_func(t, 0);
  #else
  if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
    o = (*t->tp_alloc)(t, 0);
  } else {
    o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
  }
  if (unlikely(!o)) return 0;
  #endif
  p = ((struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)o);
  p->__pyx_vtab = __pyx_vtabptr_5pysam_9libctabix_tabix_file_iterator;
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  p->infile = Py_None; Py_INCREF(Py_None);
  if (unlikely(__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_1__cinit__(o, a, k) < 0)) goto bad;
  return o;
  bad:
  Py_DECREF(o); o = 0;
  return NULL;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_tabix_file_iterator(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *p = (struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_tabix_file_iterator) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  {
    PyObject *etype, *eval, *etb;
    PyErr_Fetch(&etype, &eval, &etb);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
    __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_5__dealloc__(o);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
    PyErr_Restore(etype, eval, etb);
  }
  Py_CLEAR(p->parser);
  Py_CLEAR(p->infile);
  #if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
  (*Py_TYPE(o)->tp_free)(o);
  #else
  {
    freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
    if (tp_free) tp_free(o);
  }
  #endif
}

static int __pyx_tp_traverse_5pysam_9libctabix_tabix_file_iterator(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *p = (struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)o;
  if (p->parser) {
    e = (*v)(((PyObject *)p->parser), a); if (e) return e;
  }
  if (p->infile) {
    e = (*v)(p->infile, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_tabix_file_iterator(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *p = (struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *)o;
  tmp = ((PyObject*)p->parser);
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->infile);
  p->infile = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_tabix_file_iterator[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__, METH_NOARGS|METH_COEXIST, 0},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19tabix_file_iterator_8__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19tabix_file_iterator_10__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_tabix_file_iterator_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_tabix_file_iterator},
  {Py_tp_doc, (void *)PyDoc_STR("iterate over a compressed or uncompressed ``infile``.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_tabix_file_iterator},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_tabix_file_iterator},
  {Py_tp_iter, (void *)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_3__iter__},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_tabix_file_iterator},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_tabix_file_iterator},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_tabix_file_iterator_spec = {
  "pysam.libctabix.tabix_file_iterator",
  sizeof(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_tabix_file_iterator_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_tabix_file_iterator = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""tabix_file_iterator", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_tabix_file_iterator, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("iterate over a compressed or uncompressed ``infile``.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_tabix_file_iterator, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_tabix_file_iterator, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_3__iter__, /*tp_iter*/
  __pyx_pw_5pysam_9libctabix_19tabix_file_iterator_7__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_tabix_file_iterator, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  0, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_tabix_file_iterator, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixFile __pyx_vtable_5pysam_9libctabix_TabixFile;

static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixFile(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_TabixFile *p;
  PyObject *o = __Pyx_PyType_GetSlot(__pyx_ptype_5pysam_10libchtslib_HTSFile, tp_new, newfunc)(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_TabixFile *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile*)__pyx_vtabptr_5pysam_9libctabix_TabixFile;
  p->filename_index = Py_None; Py_INCREF(Py_None);
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  p->encoding = Py_None; Py_INCREF(Py_None);
  if (unlikely(__pyx_pw_5pysam_9libctabix_9TabixFile_1__cinit__(o, a, k) < 0)) goto bad;
  return o;
  bad:
  Py_DECREF(o); o = 0;
  return NULL;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_TabixFile(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_TabixFile *p = (struct __pyx_obj_5pysam_9libctabix_TabixFile *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_TabixFile) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  {
    PyObject *etype, *eval, *etb;
    PyErr_Fetch(&etype, &eval, &etb);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
    __pyx_pw_5pysam_9libctabix_9TabixFile_11__dealloc__(o);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
    PyErr_Restore(etype, eval, etb);
  }
  Py_CLEAR(p->filename_index);
  Py_CLEAR(p->parser);
  Py_CLEAR(p->encoding);
  PyObject_GC_Track(o);
  if (likely(__pyx_ptype_5pysam_10libchtslib_HTSFile)) __Pyx_PyType_GetSlot(__pyx_ptype_5pysam_10libchtslib_HTSFile, tp_dealloc, destructor)(o); else __Pyx_call_next_tp_dealloc(o, __pyx_tp_dealloc_5pysam_9libctabix_TabixFile);
}

static int __pyx_tp_traverse_5pysam_9libctabix_TabixFile(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_TabixFile *p = (struct __pyx_obj_5pysam_9libctabix_TabixFile *)o;
  e = ((likely(__pyx_ptype_5pysam_10libchtslib_HTSFile)) ? ((__pyx_ptype_5pysam_10libchtslib_HTSFile->tp_traverse) ? __pyx_ptype_5pysam_10libchtslib_HTSFile->tp_traverse(o, v, a) : 0) : __Pyx_call_next_tp_traverse(o, v, a, __pyx_tp_traverse_5pysam_9libctabix_TabixFile)); if (e) return e;
  if (p->filename_index) {
    e = (*v)(p->filename_index, a); if (e) return e;
  }
  if (p->parser) {
    e = (*v)(((PyObject *)p->parser), a); if (e) return e;
  }
  if (p->encoding) {
    e = (*v)(p->encoding, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_TabixFile(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_TabixFile *p = (struct __pyx_obj_5pysam_9libctabix_TabixFile *)o;
  if (likely(__pyx_ptype_5pysam_10libchtslib_HTSFile)) { if (__pyx_ptype_5pysam_10libchtslib_HTSFile->tp_clear) __pyx_ptype_5pysam_10libchtslib_HTSFile->tp_clear(o); } else __Pyx_call_next_tp_clear(o, __pyx_tp_clear_5pysam_9libctabix_TabixFile);
  tmp = ((PyObject*)p->filename_index);
  p->filename_index = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->parser);
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->encoding);
  p->encoding = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_getprop_5pysam_9libctabix_9TabixFile_header(PyObject *o, CYTHON_UNUSED void *x) {
  return __pyx_pw_5pysam_9libctabix_9TabixFile_6header_1__get__(o);
}

static PyObject *__pyx_getprop_5pysam_9libctabix_9TabixFile_contigs(PyObject *o, CYTHON_UNUSED void *x) {
  return __pyx_pw_5pysam_9libctabix_9TabixFile_7contigs_1__get__(o);
}

static PyObject *__pyx_getprop_5pysam_9libctabix_9TabixFile_filename_index(PyObject *o, CYTHON_UNUSED void *x) {
  return __pyx_pw_5pysam_9libctabix_9TabixFile_14filename_index_1__get__(o);
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_TabixFile[] = {
  {"_open", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_3_open, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_2_open},
  {"_dup", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_5_dup, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_4_dup},
  {"fetch", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_7fetch, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_6fetch},
  {"close", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_9close, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_8close},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_13__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_12__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9TabixFile_15__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9TabixFile_14__setstate_cython__},
  {0, 0, 0, 0}
};

static struct PyGetSetDef __pyx_getsets_5pysam_9libctabix_TabixFile[] = {
  {(char *)"header", __pyx_getprop_5pysam_9libctabix_9TabixFile_header, 0, (char *)PyDoc_STR("the file header.\n\n        The file header consists of the lines at the beginning of a\n        file that are prefixed by the comment character ``#``.\n       \n        .. note::\n            The header is returned as an iterator presenting lines\n            without the newline character.\n        "), 0},
  {(char *)"contigs", __pyx_getprop_5pysam_9libctabix_9TabixFile_contigs, 0, (char *)PyDoc_STR("list of chromosome names"), 0},
  {(char *)"filename_index", __pyx_getprop_5pysam_9libctabix_9TabixFile_filename_index, 0, (char *)0, 0},
  {0, 0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_TabixFile_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_TabixFile},
  {Py_tp_doc, (void *)PyDoc_STR("Random access to bgzf formatted files that\n    have been indexed by :term:`tabix`.\n\n    The file is automatically opened. The index file of file\n    ``<filename>`` is expected to be called ``<filename>.tbi``\n    by default (see parameter `index`).\n    \n    Parameters\n    ----------\n    \n    filename : string\n        Filename of bgzf file to be opened.\n\n    index : string\n        The filename of the index. If not set, the default is to\n        assume that the index is called ``filename.tbi``\n\n    mode : char\n        The file opening mode. Currently, only ``r`` is permitted.\n        \n    parser : :class:`pysam.Parser`\n    \n        sets the default parser for this tabix file. If `parser`\n        is None, the results are returned as an unparsed string.\n        Otherwise, `parser` is assumed to be a functor that will return\n        parsed data (see for example :class:`~pysam.asTuple` and\n        :class:`~pysam.asGTF`).\n\n    encoding : string\n\n        The encoding passed to the parser\n\n    threads: integer\n        Number of threads to use for decompressing Tabix files.\n        (Default=1)\n\n\n    Raises\n    ------\n    \n    ValueError\n        if index file is missing.\n\n    IOError\n        if file could not be opened\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_TabixFile},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_TabixFile},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_TabixFile},
  {Py_tp_getset, (void *)__pyx_getsets_5pysam_9libctabix_TabixFile},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_TabixFile},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_TabixFile_spec = {
  "pysam.libctabix.TabixFile",
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixFile),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC|Py_TPFLAGS_HAVE_FINALIZE,
  __pyx_type_5pysam_9libctabix_TabixFile_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_TabixFile = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""TabixFile", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixFile), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_TabixFile, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC|Py_TPFLAGS_HAVE_FINALIZE, /*tp_flags*/
  PyDoc_STR("Random access to bgzf formatted files that\n    have been indexed by :term:`tabix`.\n\n    The file is automatically opened. The index file of file\n    ``<filename>`` is expected to be called ``<filename>.tbi``\n    by default (see parameter `index`).\n    \n    Parameters\n    ----------\n    \n    filename : string\n        Filename of bgzf file to be opened.\n\n    index : string\n        The filename of the index. If not set, the default is to\n        assume that the index is called ``filename.tbi``\n\n    mode : char\n        The file opening mode. Currently, only ``r`` is permitted.\n        \n    parser : :class:`pysam.Parser`\n    \n        sets the default parser for this tabix file. If `parser`\n        is None, the results are returned as an unparsed string.\n        Otherwise, `parser` is assumed to be a functor that will return\n        parsed data (see for example :class:`~pysam.asTuple` and\n        :class:`~pysam.asGTF`).\n\n    encoding : string\n\n        The encoding passed to the parser\n\n    threads: integer\n        Number of threads to use for decompressing Tabix files.\n        (Default=1)\n\n\n    Raises\n    ------\n    \n    ValueError\n        if index file is missing.\n\n    IOError\n        if file could not be opened\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_TabixFile, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_TabixFile, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_TabixFile, /*tp_methods*/
  0, /*tp_members*/
  __pyx_getsets_5pysam_9libctabix_TabixFile, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  0, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_TabixFile, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_Parser __pyx_vtable_5pysam_9libctabix_Parser;

static PyObject *__pyx_tp_new_5pysam_9libctabix_Parser(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_Parser *p;
  PyObject *o;
  #if CYTHON_COMPILING_IN_LIMITED_API
  allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
  o = alloc_func(t, 0);
  #else
  if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
    o = (*t->tp_alloc)(t, 0);
  } else {
    o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
  }
  if (unlikely(!o)) return 0;
  #endif
  p = ((struct __pyx_obj_5pysam_9libctabix_Parser *)o);
  p->__pyx_vtab = __pyx_vtabptr_5pysam_9libctabix_Parser;
  p->encoding = Py_None; Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_Parser(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_Parser *p = (struct __pyx_obj_5pysam_9libctabix_Parser *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_Parser) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  Py_CLEAR(p->encoding);
  #if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
  (*Py_TYPE(o)->tp_free)(o);
  #else
  {
    freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
    if (tp_free) tp_free(o);
  }
  #endif
}

static int __pyx_tp_traverse_5pysam_9libctabix_Parser(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_Parser *p = (struct __pyx_obj_5pysam_9libctabix_Parser *)o;
  if (p->encoding) {
    e = (*v)(p->encoding, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_Parser(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_Parser *p = (struct __pyx_obj_5pysam_9libctabix_Parser *)o;
  tmp = ((PyObject*)p->encoding);
  p->encoding = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_Parser[] = {
  {"set_encoding", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_3set_encoding, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_2set_encoding},
  {"get_encoding", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_5get_encoding, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_4get_encoding},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_8__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6Parser_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6Parser_10__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_Parser_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_Parser},
  {Py_tp_call, (void *)__pyx_pw_5pysam_9libctabix_6Parser_7__call__},
  {Py_tp_doc, (void *)PyDoc_STR("Parser(encoding=u'ascii')")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_Parser},
  {Py_tp_init, (void *)__pyx_pw_5pysam_9libctabix_6Parser_1__init__},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_Parser},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_Parser_spec = {
  "pysam.libctabix.Parser",
  sizeof(struct __pyx_obj_5pysam_9libctabix_Parser),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_Parser_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_Parser = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""Parser", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_Parser), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("Parser(encoding=u'ascii')"), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_Parser, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_Parser, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_asTuple __pyx_vtable_5pysam_9libctabix_asTuple;

static PyObject *__pyx_tp_new_5pysam_9libctabix_asTuple(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_asTuple *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_Parser(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_asTuple *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_Parser*)__pyx_vtabptr_5pysam_9libctabix_asTuple;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_asTuple[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_7asTuple_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_7asTuple___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_7asTuple_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_7asTuple_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_asTuple_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("converts a :term:`tabix row` into a python tuple.\n\n    A field in a row is accessed by numeric index.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_asTuple},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_asTuple},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_asTuple_spec = {
  "pysam.libctabix.asTuple",
  sizeof(struct __pyx_obj_5pysam_9libctabix_asTuple),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_asTuple_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_asTuple = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""asTuple", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_asTuple), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  #else
  0, /*tp_call*/
  #endif
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("converts a :term:`tabix row` into a python tuple.\n\n    A field in a row is accessed by numeric index.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_asTuple, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_asTuple, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_asGTF __pyx_vtable_5pysam_9libctabix_asGTF;

static PyObject *__pyx_tp_new_5pysam_9libctabix_asGTF(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_asGTF *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_Parser(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_asGTF *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_Parser*)__pyx_vtabptr_5pysam_9libctabix_asGTF;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_asGTF[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asGTF_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asGTF___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asGTF_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asGTF_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_asGTF_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("converts a :term:`tabix row` into a GTF record with the following\n    fields:\n   \n    +----------+----------+-------------------------------+\n    |*Column*  |*Name*    |*Content*                      |\n    +----------+----------+-------------------------------+\n    |1         |contig    |the chromosome name            |\n    +----------+----------+-------------------------------+\n    |2         |feature   |The feature type               |\n    +----------+----------+-------------------------------+\n    |3         |source    |The feature source             |\n    +----------+----------+-------------------------------+\n    |4         |start     |genomic start coordinate       |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |5         |end       |genomic end coordinate         |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |6         |score     |feature score                  |\n    +----------+----------+-------------------------------+\n    |7         |strand    |strand                         |\n    +----------+----------+-------------------------------+\n    |8         |frame     |frame                          |\n    +----------+----------+-------------------------------+\n    |9         |attributes|the attribute field            |\n    +----------+----------+-------------------------------+\n\n    GTF formatted entries also define the following fields that\n    are derived from the attributes field:\n\n    +--------------------+------------------------------+\n    |*Name*              |*Content*                     |\n    +--------------------+------------------------------+\n    |gene_id             |the gene identifier           |\n    +--------------------+------------------------------+\n    |transcript_id       |the transcript identifier     |\n    +--------------------+-------------------""-----------+\n\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_asGTF},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_asGTF},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_asGTF_spec = {
  "pysam.libctabix.asGTF",
  sizeof(struct __pyx_obj_5pysam_9libctabix_asGTF),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_asGTF_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_asGTF = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""asGTF", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_asGTF), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  #else
  0, /*tp_call*/
  #endif
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("converts a :term:`tabix row` into a GTF record with the following\n    fields:\n   \n    +----------+----------+-------------------------------+\n    |*Column*  |*Name*    |*Content*                      |\n    +----------+----------+-------------------------------+\n    |1         |contig    |the chromosome name            |\n    +----------+----------+-------------------------------+\n    |2         |feature   |The feature type               |\n    +----------+----------+-------------------------------+\n    |3         |source    |The feature source             |\n    +----------+----------+-------------------------------+\n    |4         |start     |genomic start coordinate       |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |5         |end       |genomic end coordinate         |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |6         |score     |feature score                  |\n    +----------+----------+-------------------------------+\n    |7         |strand    |strand                         |\n    +----------+----------+-------------------------------+\n    |8         |frame     |frame                          |\n    +----------+----------+-------------------------------+\n    |9         |attributes|the attribute field            |\n    +----------+----------+-------------------------------+\n\n    GTF formatted entries also define the following fields that\n    are derived from the attributes field:\n\n    +--------------------+------------------------------+\n    |*Name*              |*Content*                     |\n    +--------------------+------------------------------+\n    |gene_id             |the gene identifier           |\n    +--------------------+------------------------------+\n    |transcript_id       |the transcript identifier     |\n    +--------------------+-------------------""-----------+\n\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_asGTF, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_asGTF, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_asGFF3 __pyx_vtable_5pysam_9libctabix_asGFF3;

static PyObject *__pyx_tp_new_5pysam_9libctabix_asGFF3(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_asGFF3 *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_Parser(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_asGFF3 *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_Parser*)__pyx_vtabptr_5pysam_9libctabix_asGFF3;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_asGFF3[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6asGFF3_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6asGFF3___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_6asGFF3_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_6asGFF3_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_asGFF3_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("converts a :term:`tabix row` into a GFF record with the following\n    fields:\n   \n    +----------+----------+-------------------------------+\n    |*Column*  |*Name*    |*Content*                      |\n    +----------+----------+-------------------------------+\n    |1         |contig    |the chromosome name            |\n    +----------+----------+-------------------------------+\n    |2         |feature   |The feature type               |\n    +----------+----------+-------------------------------+\n    |3         |source    |The feature source             |\n    +----------+----------+-------------------------------+\n    |4         |start     |genomic start coordinate       |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |5         |end       |genomic end coordinate         |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |6         |score     |feature score                  |\n    +----------+----------+-------------------------------+\n    |7         |strand    |strand                         |\n    +----------+----------+-------------------------------+\n    |8         |frame     |frame                          |\n    +----------+----------+-------------------------------+\n    |9         |attributes|the attribute field            |\n    +----------+----------+-------------------------------+\n\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_asGFF3},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_asGFF3},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_asGFF3_spec = {
  "pysam.libctabix.asGFF3",
  sizeof(struct __pyx_obj_5pysam_9libctabix_asGFF3),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_asGFF3_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_asGFF3 = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""asGFF3", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_asGFF3), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  #else
  0, /*tp_call*/
  #endif
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("converts a :term:`tabix row` into a GFF record with the following\n    fields:\n   \n    +----------+----------+-------------------------------+\n    |*Column*  |*Name*    |*Content*                      |\n    +----------+----------+-------------------------------+\n    |1         |contig    |the chromosome name            |\n    +----------+----------+-------------------------------+\n    |2         |feature   |The feature type               |\n    +----------+----------+-------------------------------+\n    |3         |source    |The feature source             |\n    +----------+----------+-------------------------------+\n    |4         |start     |genomic start coordinate       |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |5         |end       |genomic end coordinate         |\n    |          |          |(0-based)                      |\n    +----------+----------+-------------------------------+\n    |6         |score     |feature score                  |\n    +----------+----------+-------------------------------+\n    |7         |strand    |strand                         |\n    +----------+----------+-------------------------------+\n    |8         |frame     |frame                          |\n    +----------+----------+-------------------------------+\n    |9         |attributes|the attribute field            |\n    +----------+----------+-------------------------------+\n\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_asGFF3, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_asGFF3, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_asBed __pyx_vtable_5pysam_9libctabix_asBed;

static PyObject *__pyx_tp_new_5pysam_9libctabix_asBed(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_asBed *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_Parser(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_asBed *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_Parser*)__pyx_vtabptr_5pysam_9libctabix_asBed;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_asBed[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asBed_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asBed___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asBed_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asBed_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_asBed_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("converts a :term:`tabix row` into a bed record\n    with the following fields:\n\n    +-----------+-----------+------------------------------------------+\n    |*Column*   |*Field*    |*Contents*                                |\n    |           |           |                                          |\n    +-----------+-----------+------------------------------------------+\n    |1          |contig     |contig                                    |\n    |           |           |                                          |\n    +-----------+-----------+------------------------------------------+\n    |2          |start      |genomic start coordinate (zero-based)     |\n    +-----------+-----------+------------------------------------------+\n    |3          |end        |genomic end coordinate plus one           |\n    |           |           |(zero-based)                              |\n    +-----------+-----------+------------------------------------------+\n    |4          |name       |name of feature.                          |\n    +-----------+-----------+------------------------------------------+\n    |5          |score      |score of feature                          |\n    +-----------+-----------+------------------------------------------+\n    |6          |strand     |strand of feature                         |\n    +-----------+-----------+------------------------------------------+\n    |7          |thickStart |thickStart                                |\n    +-----------+-----------+------------------------------------------+\n    |8          |thickEnd   |thickEnd                                  |\n    +-----------+-----------+------------------------------------------+\n    |9          |itemRGB    |itemRGB                                   |\n    +-----------+-----------+------------------------------------------+\n    |10         |blockCount |number of bocks                           |\n    +-----------+-----------+---------------------------------------""---+\n    |11         |blockSizes |',' separated string of block sizes       |\n    +-----------+-----------+------------------------------------------+\n    |12         |blockStarts|',' separated string of block genomic     |\n    |           |           |start positions                           |\n    +-----------+-----------+------------------------------------------+\n\n    Only the first three fields are required. Additional\n    fields are optional, but if one is defined, all the preceding\n    need to be defined as well.\n\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_asBed},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_asBed},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_asBed_spec = {
  "pysam.libctabix.asBed",
  sizeof(struct __pyx_obj_5pysam_9libctabix_asBed),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_asBed_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_asBed = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""asBed", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_asBed), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  #else
  0, /*tp_call*/
  #endif
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("converts a :term:`tabix row` into a bed record\n    with the following fields:\n\n    +-----------+-----------+------------------------------------------+\n    |*Column*   |*Field*    |*Contents*                                |\n    |           |           |                                          |\n    +-----------+-----------+------------------------------------------+\n    |1          |contig     |contig                                    |\n    |           |           |                                          |\n    +-----------+-----------+------------------------------------------+\n    |2          |start      |genomic start coordinate (zero-based)     |\n    +-----------+-----------+------------------------------------------+\n    |3          |end        |genomic end coordinate plus one           |\n    |           |           |(zero-based)                              |\n    +-----------+-----------+------------------------------------------+\n    |4          |name       |name of feature.                          |\n    +-----------+-----------+------------------------------------------+\n    |5          |score      |score of feature                          |\n    +-----------+-----------+------------------------------------------+\n    |6          |strand     |strand of feature                         |\n    +-----------+-----------+------------------------------------------+\n    |7          |thickStart |thickStart                                |\n    +-----------+-----------+------------------------------------------+\n    |8          |thickEnd   |thickEnd                                  |\n    +-----------+-----------+------------------------------------------+\n    |9          |itemRGB    |itemRGB                                   |\n    +-----------+-----------+------------------------------------------+\n    |10         |blockCount |number of bocks                           |\n    +-----------+-----------+---------------------------------------""---+\n    |11         |blockSizes |',' separated string of block sizes       |\n    +-----------+-----------+------------------------------------------+\n    |12         |blockStarts|',' separated string of block genomic     |\n    |           |           |start positions                           |\n    +-----------+-----------+------------------------------------------+\n\n    Only the first three fields are required. Additional\n    fields are optional, but if one is defined, all the preceding\n    need to be defined as well.\n\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_asBed, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_asBed, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_asVCF __pyx_vtable_5pysam_9libctabix_asVCF;

static PyObject *__pyx_tp_new_5pysam_9libctabix_asVCF(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_asVCF *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_Parser(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_asVCF *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_Parser*)__pyx_vtabptr_5pysam_9libctabix_asVCF;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_asVCF[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asVCF_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asVCF___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_5asVCF_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_5asVCF_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_asVCF_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("converts a :term:`tabix row` into a VCF record with\n    the following fields:\n    \n    +----------+---------+------------------------------------+\n    |*Column*  |*Field*  |*Contents*                          |\n    |          |         |                                    |\n    +----------+---------+------------------------------------+\n    |1         |contig   |chromosome                          |\n    +----------+---------+------------------------------------+\n    |2         |pos      |chromosomal position, zero-based    |\n    +----------+---------+------------------------------------+\n    |3         |id       |id                                  |\n    +----------+---------+------------------------------------+\n    |4         |ref      |reference allele                    |\n    +----------+---------+------------------------------------+\n    |5         |alt      |alternate alleles                   |\n    +----------+---------+------------------------------------+\n    |6         |qual     |quality                             |\n    +----------+---------+------------------------------------+\n    |7         |filter   |filter                              |\n    +----------+---------+------------------------------------+\n    |8         |info     |info                                |\n    +----------+---------+------------------------------------+\n    |9         |format   |format specifier.                   |\n    +----------+---------+------------------------------------+\n\n    Access to genotypes is via index::\n\n        contig = vcf.contig\n        first_sample_genotype = vcf[0]\n        second_sample_genotype = vcf[1]\n\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_Parser},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_Parser},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_asVCF},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_asVCF},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_asVCF_spec = {
  "pysam.libctabix.asVCF",
  sizeof(struct __pyx_obj_5pysam_9libctabix_asVCF),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_asVCF_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_asVCF = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""asVCF", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_asVCF), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_Parser, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_7__call__, /*tp_call*/
  #else
  0, /*tp_call*/
  #endif
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("converts a :term:`tabix row` into a VCF record with\n    the following fields:\n    \n    +----------+---------+------------------------------------+\n    |*Column*  |*Field*  |*Contents*                          |\n    |          |         |                                    |\n    +----------+---------+------------------------------------+\n    |1         |contig   |chromosome                          |\n    +----------+---------+------------------------------------+\n    |2         |pos      |chromosomal position, zero-based    |\n    +----------+---------+------------------------------------+\n    |3         |id       |id                                  |\n    +----------+---------+------------------------------------+\n    |4         |ref      |reference allele                    |\n    +----------+---------+------------------------------------+\n    |5         |alt      |alternate alleles                   |\n    +----------+---------+------------------------------------+\n    |6         |qual     |quality                             |\n    +----------+---------+------------------------------------+\n    |7         |filter   |filter                              |\n    +----------+---------+------------------------------------+\n    |8         |info     |info                                |\n    +----------+---------+------------------------------------+\n    |9         |format   |format specifier.                   |\n    +----------+---------+------------------------------------+\n\n    Access to genotypes is via index::\n\n        contig = vcf.contig\n        first_sample_genotype = vcf[0]\n        second_sample_genotype = vcf[1]\n\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_Parser, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_Parser, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_asVCF, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_6Parser_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_asVCF, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator __pyx_vtable_5pysam_9libctabix_TabixIterator;

static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixIterator(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_TabixIterator *p;
  PyObject *o;
  #if CYTHON_COMPILING_IN_LIMITED_API
  allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
  o = alloc_func(t, 0);
  #else
  if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
    o = (*t->tp_alloc)(t, 0);
  } else {
    o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
  }
  if (unlikely(!o)) return 0;
  #endif
  p = ((struct __pyx_obj_5pysam_9libctabix_TabixIterator *)o);
  p->__pyx_vtab = __pyx_vtabptr_5pysam_9libctabix_TabixIterator;
  p->tabixfile = ((struct __pyx_obj_5pysam_9libctabix_TabixFile *)Py_None); Py_INCREF(Py_None);
  p->encoding = Py_None; Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_TabixIterator(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_TabixIterator *p = (struct __pyx_obj_5pysam_9libctabix_TabixIterator *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_TabixIterator) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  {
    PyObject *etype, *eval, *etb;
    PyErr_Fetch(&etype, &eval, &etb);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
    __pyx_pw_5pysam_9libctabix_13TabixIterator_7__dealloc__(o);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
    PyErr_Restore(etype, eval, etb);
  }
  Py_CLEAR(p->tabixfile);
  Py_CLEAR(p->encoding);
  #if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
  (*Py_TYPE(o)->tp_free)(o);
  #else
  {
    freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
    if (tp_free) tp_free(o);
  }
  #endif
}

static int __pyx_tp_traverse_5pysam_9libctabix_TabixIterator(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_TabixIterator *p = (struct __pyx_obj_5pysam_9libctabix_TabixIterator *)o;
  if (p->tabixfile) {
    e = (*v)(((PyObject *)p->tabixfile), a); if (e) return e;
  }
  if (p->encoding) {
    e = (*v)(p->encoding, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_TabixIterator(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_TabixIterator *p = (struct __pyx_obj_5pysam_9libctabix_TabixIterator *)o;
  tmp = ((PyObject*)p->tabixfile);
  p->tabixfile = ((struct __pyx_obj_5pysam_9libctabix_TabixFile *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->encoding);
  p->encoding = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_TabixIterator[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libctabix_13TabixIterator_4__next__},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13TabixIterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13TabixIterator_8__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_13TabixIterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_13TabixIterator_10__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_TabixIterator_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_TabixIterator},
  {Py_tp_doc, (void *)PyDoc_STR("TabixIterator(encoding=u'ascii')\niterates over rows in *tabixfile* in region\n    given by *tid*, *start* and *end*.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_TabixIterator},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_TabixIterator},
  {Py_tp_iter, (void *)__pyx_pw_5pysam_9libctabix_13TabixIterator_3__iter__},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_TabixIterator},
  {Py_tp_init, (void *)__pyx_pw_5pysam_9libctabix_13TabixIterator_1__init__},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_TabixIterator},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_TabixIterator_spec = {
  "pysam.libctabix.TabixIterator",
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixIterator),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_TabixIterator_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_TabixIterator = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""TabixIterator", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixIterator), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_TabixIterator, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("TabixIterator(encoding=u'ascii')\niterates over rows in *tabixfile* in region\n    given by *tid*, *start* and *end*.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_TabixIterator, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_TabixIterator, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  __pyx_pw_5pysam_9libctabix_13TabixIterator_3__iter__, /*tp_iter*/
  __pyx_pw_5pysam_9libctabix_13TabixIterator_5__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_TabixIterator, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  __pyx_pw_5pysam_9libctabix_13TabixIterator_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_TabixIterator, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_TabixIteratorParsed __pyx_vtable_5pysam_9libctabix_TabixIteratorParsed;

static PyObject *__pyx_tp_new_5pysam_9libctabix_TabixIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_TabixIterator(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_TabixIterator*)__pyx_vtabptr_5pysam_9libctabix_TabixIteratorParsed;
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_TabixIteratorParsed(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_TabixIteratorParsed) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  Py_CLEAR(p->parser);
  PyObject_GC_Track(o);
  __pyx_tp_dealloc_5pysam_9libctabix_TabixIterator(o);
}

static int __pyx_tp_traverse_5pysam_9libctabix_TabixIteratorParsed(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)o;
  e = __pyx_tp_traverse_5pysam_9libctabix_TabixIterator(o, v, a); if (e) return e;
  if (p->parser) {
    e = (*v)(((PyObject *)p->parser), a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_TabixIteratorParsed(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed *)o;
  __pyx_tp_clear_5pysam_9libctabix_TabixIterator(o);
  tmp = ((PyObject*)p->parser);
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_TabixIteratorParsed[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_2__next__},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_4__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_6__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_TabixIteratorParsed_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_TabixIteratorParsed},
  {Py_tp_doc, (void *)PyDoc_STR("TabixIteratorParsed(Parser parser)\niterates over mapped reads in a region.\n\n    The *parser* determines the encoding.\n\n    Returns parsed data.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_TabixIteratorParsed},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_TabixIteratorParsed},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_TabixIteratorParsed},
  {Py_tp_init, (void *)__pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_1__init__},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_TabixIteratorParsed},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_TabixIteratorParsed_spec = {
  "pysam.libctabix.TabixIteratorParsed",
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_TabixIteratorParsed_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_TabixIteratorParsed = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""TabixIteratorParsed", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_TabixIteratorParsed), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_TabixIteratorParsed, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("TabixIteratorParsed(Parser parser)\niterates over mapped reads in a region.\n\n    The *parser* determines the encoding.\n\n    Returns parsed data.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_TabixIteratorParsed, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_TabixIteratorParsed, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_13TabixIterator_3__iter__, /*tp_iter*/
  #else
  0, /*tp_iter*/
  #endif
  __pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_3__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_TabixIteratorParsed, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  __pyx_pw_5pysam_9libctabix_19TabixIteratorParsed_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_TabixIteratorParsed, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator __pyx_vtable_5pysam_9libctabix_GZIterator;

static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIterator(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_GZIterator *p;
  PyObject *o;
  #if CYTHON_COMPILING_IN_LIMITED_API
  allocfunc alloc_func = (allocfunc)PyType_GetSlot(t, Py_tp_alloc);
  o = alloc_func(t, 0);
  #else
  if (likely(!__Pyx_PyType_HasFeature(t, Py_TPFLAGS_IS_ABSTRACT))) {
    o = (*t->tp_alloc)(t, 0);
  } else {
    o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
  }
  if (unlikely(!o)) return 0;
  #endif
  p = ((struct __pyx_obj_5pysam_9libctabix_GZIterator *)o);
  p->__pyx_vtab = __pyx_vtabptr_5pysam_9libctabix_GZIterator;
  p->_filename = Py_None; Py_INCREF(Py_None);
  p->encoding = Py_None; Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_GZIterator(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_GZIterator *p = (struct __pyx_obj_5pysam_9libctabix_GZIterator *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_GZIterator) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  {
    PyObject *etype, *eval, *etb;
    PyErr_Fetch(&etype, &eval, &etb);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) + 1);
    __pyx_pw_5pysam_9libctabix_10GZIterator_3__dealloc__(o);
    __Pyx_SET_REFCNT(o, Py_REFCNT(o) - 1);
    PyErr_Restore(etype, eval, etb);
  }
  Py_CLEAR(p->_filename);
  Py_CLEAR(p->encoding);
  #if CYTHON_USE_TYPE_SLOTS || CYTHON_COMPILING_IN_PYPY
  (*Py_TYPE(o)->tp_free)(o);
  #else
  {
    freefunc tp_free = (freefunc)PyType_GetSlot(Py_TYPE(o), Py_tp_free);
    if (tp_free) tp_free(o);
  }
  #endif
}

static int __pyx_tp_traverse_5pysam_9libctabix_GZIterator(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_GZIterator *p = (struct __pyx_obj_5pysam_9libctabix_GZIterator *)o;
  if (p->_filename) {
    e = (*v)(p->_filename, a); if (e) return e;
  }
  if (p->encoding) {
    e = (*v)(p->encoding, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_GZIterator(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_GZIterator *p = (struct __pyx_obj_5pysam_9libctabix_GZIterator *)o;
  tmp = ((PyObject*)p->_filename);
  p->_filename = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->encoding);
  p->encoding = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_10GZIterator_7__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_10GZIterator_7__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_GZIterator[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_10GZIterator_7__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libctabix_10GZIterator_6__next__},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_10GZIterator_9__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_10GZIterator_8__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_10GZIterator_11__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_10GZIterator_10__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_GZIterator_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_GZIterator},
  {Py_tp_doc, (void *)PyDoc_STR("GZIterator(filename, int buffer_size=65536, encoding=u'ascii')")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_GZIterator},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_GZIterator},
  {Py_tp_iter, (void *)__pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_10GZIterator_7__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_GZIterator},
  {Py_tp_init, (void *)__pyx_pw_5pysam_9libctabix_10GZIterator_1__init__},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_GZIterator},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_GZIterator_spec = {
  "pysam.libctabix.GZIterator",
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIterator),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_GZIterator_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_GZIterator = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""GZIterator", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIterator), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_GZIterator, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("GZIterator(filename, int buffer_size=65536, encoding=u'ascii')"), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_GZIterator, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_GZIterator, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  __pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__, /*tp_iter*/
  __pyx_pw_5pysam_9libctabix_10GZIterator_7__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_GZIterator, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  __pyx_pw_5pysam_9libctabix_10GZIterator_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_GZIterator, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorHead __pyx_vtable_5pysam_9libctabix_GZIteratorHead;

static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIteratorHead(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_GZIterator(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_GZIteratorHead *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator*)__pyx_vtabptr_5pysam_9libctabix_GZIteratorHead;
  return o;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_GZIteratorHead[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libctabix_14GZIteratorHead___next__},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_14GZIteratorHead_2__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_14GZIteratorHead_4__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_GZIteratorHead_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("iterate line-by-line through gzip (or bgzip)\n    compressed file returning comments at top of file.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_GZIterator},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_GZIterator},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_GZIteratorHead},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_GZIteratorHead},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_GZIteratorHead_spec = {
  "pysam.libctabix.GZIteratorHead",
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIteratorHead),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_GZIteratorHead_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_GZIteratorHead = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""GZIteratorHead", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIteratorHead), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_GZIterator, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("iterate line-by-line through gzip (or bgzip)\n    compressed file returning comments at top of file.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_GZIterator, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_GZIterator, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__, /*tp_iter*/
  #else
  0, /*tp_iter*/
  #endif
  __pyx_pw_5pysam_9libctabix_14GZIteratorHead_1__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_GZIteratorHead, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_10GZIterator_1__init__, /*tp_init*/
  #else
  0, /*tp_init*/
  #endif
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_GZIteratorHead, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_GZIteratorParsed __pyx_vtable_5pysam_9libctabix_GZIteratorParsed;

static PyObject *__pyx_tp_new_5pysam_9libctabix_GZIteratorParsed(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_GZIterator(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)o);
  p->__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_9libctabix_GZIterator*)__pyx_vtabptr_5pysam_9libctabix_GZIteratorParsed;
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5pysam_9libctabix_GZIteratorParsed(PyObject *o) {
  struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely((PY_VERSION_HEX >= 0x03080000 || __Pyx_PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE)) && __Pyx_PyObject_GetSlot(o, tp_finalize, destructor)) && !__Pyx_PyObject_GC_IsFinalized(o)) {
    if (__Pyx_PyObject_GetSlot(o, tp_dealloc, destructor) == __pyx_tp_dealloc_5pysam_9libctabix_GZIteratorParsed) {
      if (PyObject_CallFinalizerFromDealloc(o)) return;
    }
  }
  #endif
  PyObject_GC_UnTrack(o);
  Py_CLEAR(p->parser);
  PyObject_GC_Track(o);
  __pyx_tp_dealloc_5pysam_9libctabix_GZIterator(o);
}

static int __pyx_tp_traverse_5pysam_9libctabix_GZIteratorParsed(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)o;
  e = __pyx_tp_traverse_5pysam_9libctabix_GZIterator(o, v, a); if (e) return e;
  if (p->parser) {
    e = (*v)(((PyObject *)p->parser), a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5pysam_9libctabix_GZIteratorParsed(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *p = (struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed *)o;
  __pyx_tp_clear_5pysam_9libctabix_GZIterator(o);
  tmp = ((PyObject*)p->parser);
  p->parser = ((struct __pyx_obj_5pysam_9libctabix_Parser *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyObject *__pyx_specialmethod___pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__(PyObject *self, CYTHON_UNUSED PyObject *arg) {
  PyObject *res = __pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__(self);
  if (!res && !PyErr_Occurred()) { PyErr_SetNone(PyExc_StopIteration); }
  return res;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_GZIteratorParsed[] = {
  {"__next__", (PyCFunction)__pyx_specialmethod___pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__, METH_NOARGS|METH_COEXIST, __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_2__next__},
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_4__reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_6__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_GZIteratorParsed_slots[] = {
  {Py_tp_dealloc, (void *)__pyx_tp_dealloc_5pysam_9libctabix_GZIteratorParsed},
  {Py_tp_doc, (void *)PyDoc_STR("GZIteratorParsed(parser)\niterate line-by-line through gzip (or bgzip)\n    compressed file returning comments at top of file.\n    ")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_GZIteratorParsed},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_GZIteratorParsed},
  {Py_tp_iternext, (void *)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_GZIteratorParsed},
  {Py_tp_init, (void *)__pyx_pw_5pysam_9libctabix_16GZIteratorParsed_1__init__},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_GZIteratorParsed},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_GZIteratorParsed_spec = {
  "pysam.libctabix.GZIteratorParsed",
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC,
  __pyx_type_5pysam_9libctabix_GZIteratorParsed_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_GZIteratorParsed = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""GZIteratorParsed", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_GZIteratorParsed), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_GZIteratorParsed, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  PyDoc_STR("GZIteratorParsed(parser)\niterate line-by-line through gzip (or bgzip)\n    compressed file returning comments at top of file.\n    "), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_GZIteratorParsed, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_GZIteratorParsed, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  #if CYTHON_COMPILING_IN_PYPY || 0
  __pyx_pw_5pysam_9libctabix_10GZIterator_5__iter__, /*tp_iter*/
  #else
  0, /*tp_iter*/
  #endif
  __pyx_pw_5pysam_9libctabix_16GZIteratorParsed_3__next__, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_GZIteratorParsed, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  __pyx_pw_5pysam_9libctabix_16GZIteratorParsed_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_GZIteratorParsed, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif
static struct __pyx_vtabstruct_5pysam_9libctabix_Tabixfile __pyx_vtable_5pysam_9libctabix_Tabixfile;

static PyObject *__pyx_tp_new_5pysam_9libctabix_Tabixfile(PyTypeObject *t, PyObject *a, PyObject *k) {
  struct __pyx_obj_5pysam_9libctabix_Tabixfile *p;
  PyObject *o = __pyx_tp_new_5pysam_9libctabix_TabixFile(t, a, k);
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5pysam_9libctabix_Tabixfile *)o);
  p->__pyx_base.__pyx_base.__pyx_vtab = (struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile*)__pyx_vtabptr_5pysam_9libctabix_Tabixfile;
  return o;
}

static PyMethodDef __pyx_methods_5pysam_9libctabix_Tabixfile[] = {
  {"__reduce_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9Tabixfile_1__reduce_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9Tabixfile___reduce_cython__},
  {"__setstate_cython__", (PyCFunction)(void*)(__Pyx_PyCFunction_FastCallWithKeywords)__pyx_pw_5pysam_9libctabix_9Tabixfile_3__setstate_cython__, __Pyx_METH_FASTCALL|METH_KEYWORDS, __pyx_doc_5pysam_9libctabix_9Tabixfile_2__setstate_cython__},
  {0, 0, 0, 0}
};
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_type_5pysam_9libctabix_Tabixfile_slots[] = {
  {Py_tp_doc, (void *)PyDoc_STR("Tabixfile is deprecated: use TabixFile instead")},
  {Py_tp_traverse, (void *)__pyx_tp_traverse_5pysam_9libctabix_TabixFile},
  {Py_tp_clear, (void *)__pyx_tp_clear_5pysam_9libctabix_TabixFile},
  {Py_tp_methods, (void *)__pyx_methods_5pysam_9libctabix_Tabixfile},
  {Py_tp_new, (void *)__pyx_tp_new_5pysam_9libctabix_Tabixfile},
  {0, 0},
};
static PyType_Spec __pyx_type_5pysam_9libctabix_Tabixfile_spec = {
  "pysam.libctabix.Tabixfile",
  sizeof(struct __pyx_obj_5pysam_9libctabix_Tabixfile),
  0,
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC|Py_TPFLAGS_HAVE_FINALIZE,
  __pyx_type_5pysam_9libctabix_Tabixfile_slots,
};
#else

static PyTypeObject __pyx_type_5pysam_9libctabix_Tabixfile = {
  PyVarObject_HEAD_INIT(0, 0)
  "pysam.libctabix.""Tabixfile", /*tp_name*/
  sizeof(struct __pyx_obj_5pysam_9libctabix_Tabixfile), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5pysam_9libctabix_TabixFile, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC|Py_TPFLAGS_HAVE_FINALIZE, /*tp_flags*/
  PyDoc_STR("Tabixfile is deprecated: use TabixFile instead"), /*tp_doc*/
  __pyx_tp_traverse_5pysam_9libctabix_TabixFile, /*tp_traverse*/
  __pyx_tp_clear_5pysam_9libctabix_TabixFile, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5pysam_9libctabix_Tabixfile, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  #if !CYTHON_USE_TYPE_SPECS
  0, /*tp_dictoffset*/
  #endif
  0, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5pysam_9libctabix_Tabixfile, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  #if CYTHON_USE_TP_FINALIZE
  0, /*tp_finalize*/
  #else
  NULL, /*tp_finalize*/
  #endif
  #endif
  #if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
  0, /*tp_vectorcall*/
  #endif
  #if __PYX_NEED_TP_PRINT_SLOT == 1
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030C0000
  0, /*tp_watched*/
  #endif
  #if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
  0, /*tp_pypy_flags*/
  #endif
};
#endif

static PyMethodDef __pyx_methods[] = {
  {0, 0, 0, 0}
};
#ifndef CYTHON_SMALL_CODE
#if defined(__clang__)
    #define CYTHON_SMALL_CODE
#elif defined(__GNUC__) && (__GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR__ >= 3))
    #define CYTHON_SMALL_CODE __attribute__((cold))
#else
    #define CYTHON_SMALL_CODE
#endif
#endif
/* #### Code section: pystring_table ### */

static int __Pyx_CreateStringTabAndInitStrings(void) {
  __Pyx_StringTabEntry __pyx_string_tab[] = {
    {&__pyx_n_s_AssertionError, __pyx_k_AssertionError, sizeof(__pyx_k_AssertionError), 0, 0, 1, 1},
    {&__pyx_kp_u_Could_not_open_file, __pyx_k_Could_not_open_file, sizeof(__pyx_k_Could_not_open_file), 0, 1, 0, 0},
    {&__pyx_n_s_EmptyIterator, __pyx_k_EmptyIterator, sizeof(__pyx_k_EmptyIterator), 0, 0, 1, 1},
    {&__pyx_n_s_EmptyIterator___iter, __pyx_k_EmptyIterator___iter, sizeof(__pyx_k_EmptyIterator___iter), 0, 0, 1, 1},
    {&__pyx_n_s_EmptyIterator___next, __pyx_k_EmptyIterator___next, sizeof(__pyx_k_EmptyIterator___next), 0, 0, 1, 1},
    {&__pyx_kp_u_Filename_s_already_exists_use_fo, __pyx_k_Filename_s_already_exists_use_fo, sizeof(__pyx_k_Filename_s_already_exists_use_fo), 0, 1, 0, 0},
    {&__pyx_n_s_GZIterator, __pyx_k_GZIterator, sizeof(__pyx_k_GZIterator), 0, 0, 1, 1},
    {&__pyx_n_u_GZIterator, __pyx_k_GZIterator, sizeof(__pyx_k_GZIterator), 0, 1, 0, 1},
    {&__pyx_n_s_GZIteratorHead, __pyx_k_GZIteratorHead, sizeof(__pyx_k_GZIteratorHead), 0, 0, 1, 1},
    {&__pyx_n_u_GZIteratorHead, __pyx_k_GZIteratorHead, sizeof(__pyx_k_GZIteratorHead), 0, 1, 0, 1},
    {&__pyx_n_s_GZIteratorHead___reduce_cython, __pyx_k_GZIteratorHead___reduce_cython, sizeof(__pyx_k_GZIteratorHead___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_GZIteratorHead___setstate_cython, __pyx_k_GZIteratorHead___setstate_cython, sizeof(__pyx_k_GZIteratorHead___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_GZIteratorParsed, __pyx_k_GZIteratorParsed, sizeof(__pyx_k_GZIteratorParsed), 0, 0, 1, 1},
    {&__pyx_n_s_GZIteratorParsed___reduce_cython, __pyx_k_GZIteratorParsed___reduce_cython, sizeof(__pyx_k_GZIteratorParsed___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_GZIteratorParsed___setstate_cyth, __pyx_k_GZIteratorParsed___setstate_cyth, sizeof(__pyx_k_GZIteratorParsed___setstate_cyth), 0, 0, 1, 1},
    {&__pyx_n_s_GZIterator___reduce_cython, __pyx_k_GZIterator___reduce_cython, sizeof(__pyx_k_GZIterator___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_GZIterator___setstate_cython, __pyx_k_GZIterator___setstate_cython, sizeof(__pyx_k_GZIterator___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_IOError, __pyx_k_IOError, sizeof(__pyx_k_IOError), 0, 0, 1, 1},
    {&__pyx_kp_u_I_O_operation_on_closed_file, __pyx_k_I_O_operation_on_closed_file, sizeof(__pyx_k_I_O_operation_on_closed_file), 0, 1, 0, 0},
    {&__pyx_kp_u_I_O_operation_on_closed_file_2, __pyx_k_I_O_operation_on_closed_file_2, sizeof(__pyx_k_I_O_operation_on_closed_file_2), 0, 1, 0, 0},
    {&__pyx_kp_s_Incompatible_checksums_0x_x_vs_0, __pyx_k_Incompatible_checksums_0x_x_vs_0, sizeof(__pyx_k_Incompatible_checksums_0x_x_vs_0), 0, 0, 1, 0},
    {&__pyx_n_s_KeyError, __pyx_k_KeyError, sizeof(__pyx_k_KeyError), 0, 0, 1, 1},
    {&__pyx_n_s_MemoryError, __pyx_k_MemoryError, sizeof(__pyx_k_MemoryError), 0, 0, 1, 1},
    {&__pyx_kp_u_No_such_file_or_directory_s, __pyx_k_No_such_file_or_directory_s, sizeof(__pyx_k_No_such_file_or_directory_s), 0, 1, 0, 0},
    {&__pyx_n_s_NotImplementedError, __pyx_k_NotImplementedError, sizeof(__pyx_k_NotImplementedError), 0, 0, 1, 1},
    {&__pyx_n_s_OSError, __pyx_k_OSError, sizeof(__pyx_k_OSError), 0, 0, 1, 1},
    {&__pyx_n_s_O_RDONLY, __pyx_k_O_RDONLY, sizeof(__pyx_k_O_RDONLY), 0, 0, 1, 1},
    {&__pyx_n_s_Parser, __pyx_k_Parser, sizeof(__pyx_k_Parser), 0, 0, 1, 1},
    {&__pyx_n_s_Parser___reduce_cython, __pyx_k_Parser___reduce_cython, sizeof(__pyx_k_Parser___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_Parser___setstate_cython, __pyx_k_Parser___setstate_cython, sizeof(__pyx_k_Parser___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_Parser_get_encoding, __pyx_k_Parser_get_encoding, sizeof(__pyx_k_Parser_get_encoding), 0, 0, 1, 1},
    {&__pyx_n_s_Parser_set_encoding, __pyx_k_Parser_set_encoding, sizeof(__pyx_k_Parser_set_encoding), 0, 0, 1, 1},
    {&__pyx_n_s_PickleError, __pyx_k_PickleError, sizeof(__pyx_k_PickleError), 0, 0, 1, 1},
    {&__pyx_n_s_StopIteration, __pyx_k_StopIteration, sizeof(__pyx_k_StopIteration), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile, __pyx_k_TabixFile, sizeof(__pyx_k_TabixFile), 0, 0, 1, 1},
    {&__pyx_n_u_TabixFile, __pyx_k_TabixFile, sizeof(__pyx_k_TabixFile), 0, 1, 0, 1},
    {&__pyx_n_s_TabixFile___reduce_cython, __pyx_k_TabixFile___reduce_cython, sizeof(__pyx_k_TabixFile___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile___setstate_cython, __pyx_k_TabixFile___setstate_cython, sizeof(__pyx_k_TabixFile___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile__dup, __pyx_k_TabixFile__dup, sizeof(__pyx_k_TabixFile__dup), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile__open, __pyx_k_TabixFile__open, sizeof(__pyx_k_TabixFile__open), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile_close, __pyx_k_TabixFile_close, sizeof(__pyx_k_TabixFile_close), 0, 0, 1, 1},
    {&__pyx_n_s_TabixFile_fetch, __pyx_k_TabixFile_fetch, sizeof(__pyx_k_TabixFile_fetch), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIterator, __pyx_k_TabixIterator, sizeof(__pyx_k_TabixIterator), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIteratorParsed, __pyx_k_TabixIteratorParsed, sizeof(__pyx_k_TabixIteratorParsed), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIteratorParsed___reduce_cyt, __pyx_k_TabixIteratorParsed___reduce_cyt, sizeof(__pyx_k_TabixIteratorParsed___reduce_cyt), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIteratorParsed___setstate_c, __pyx_k_TabixIteratorParsed___setstate_c, sizeof(__pyx_k_TabixIteratorParsed___setstate_c), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIterator___reduce_cython, __pyx_k_TabixIterator___reduce_cython, sizeof(__pyx_k_TabixIterator___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_TabixIterator___setstate_cython, __pyx_k_TabixIterator___setstate_cython, sizeof(__pyx_k_TabixIterator___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_Tabixfile, __pyx_k_Tabixfile, sizeof(__pyx_k_Tabixfile), 0, 0, 1, 1},
    {&__pyx_n_u_Tabixfile, __pyx_k_Tabixfile, sizeof(__pyx_k_Tabixfile), 0, 1, 0, 1},
    {&__pyx_n_s_Tabixfile___reduce_cython, __pyx_k_Tabixfile___reduce_cython, sizeof(__pyx_k_Tabixfile___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_Tabixfile___setstate_cython, __pyx_k_Tabixfile___setstate_cython, sizeof(__pyx_k_Tabixfile___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_TypeError, __pyx_k_TypeError, sizeof(__pyx_k_TypeError), 0, 0, 1, 1},
    {&__pyx_n_s_ValueError, __pyx_k_ValueError, sizeof(__pyx_k_ValueError), 0, 0, 1, 1},
    {&__pyx_n_s_WINDOW_SIZE, __pyx_k_WINDOW_SIZE, sizeof(__pyx_k_WINDOW_SIZE), 0, 0, 1, 1},
    {&__pyx_kp_b__16, __pyx_k__16, sizeof(__pyx_k__16), 0, 0, 0, 0},
    {&__pyx_kp_u__39, __pyx_k__39, sizeof(__pyx_k__39), 0, 1, 0, 0},
    {&__pyx_kp_u__42, __pyx_k__42, sizeof(__pyx_k__42), 0, 1, 0, 0},
    {&__pyx_kp_u__43, __pyx_k__43, sizeof(__pyx_k__43), 0, 1, 0, 0},
    {&__pyx_kp_u__44, __pyx_k__44, sizeof(__pyx_k__44), 0, 1, 0, 0},
    {&__pyx_kp_u__56, __pyx_k__56, sizeof(__pyx_k__56), 0, 1, 0, 0},
    {&__pyx_n_s__62, __pyx_k__62, sizeof(__pyx_k__62), 0, 0, 1, 1},
    {&__pyx_n_s__78, __pyx_k__78, sizeof(__pyx_k__78), 0, 0, 1, 1},
    {&__pyx_n_s_a, __pyx_k_a, sizeof(__pyx_k_a), 0, 0, 1, 1},
    {&__pyx_n_s_all, __pyx_k_all, sizeof(__pyx_k_all), 0, 0, 1, 1},
    {&__pyx_n_s_asBed, __pyx_k_asBed, sizeof(__pyx_k_asBed), 0, 0, 1, 1},
    {&__pyx_n_u_asBed, __pyx_k_asBed, sizeof(__pyx_k_asBed), 0, 1, 0, 1},
    {&__pyx_n_s_asBed___reduce_cython, __pyx_k_asBed___reduce_cython, sizeof(__pyx_k_asBed___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asBed___setstate_cython, __pyx_k_asBed___setstate_cython, sizeof(__pyx_k_asBed___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asGFF3, __pyx_k_asGFF3, sizeof(__pyx_k_asGFF3), 0, 0, 1, 1},
    {&__pyx_n_u_asGFF3, __pyx_k_asGFF3, sizeof(__pyx_k_asGFF3), 0, 1, 0, 1},
    {&__pyx_n_s_asGFF3___reduce_cython, __pyx_k_asGFF3___reduce_cython, sizeof(__pyx_k_asGFF3___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asGFF3___setstate_cython, __pyx_k_asGFF3___setstate_cython, sizeof(__pyx_k_asGFF3___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asGTF, __pyx_k_asGTF, sizeof(__pyx_k_asGTF), 0, 0, 1, 1},
    {&__pyx_n_u_asGTF, __pyx_k_asGTF, sizeof(__pyx_k_asGTF), 0, 1, 0, 1},
    {&__pyx_n_s_asGTF___reduce_cython, __pyx_k_asGTF___reduce_cython, sizeof(__pyx_k_asGTF___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asGTF___setstate_cython, __pyx_k_asGTF___setstate_cython, sizeof(__pyx_k_asGTF___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asTuple, __pyx_k_asTuple, sizeof(__pyx_k_asTuple), 0, 0, 1, 1},
    {&__pyx_n_u_asTuple, __pyx_k_asTuple, sizeof(__pyx_k_asTuple), 0, 1, 0, 1},
    {&__pyx_n_s_asTuple___reduce_cython, __pyx_k_asTuple___reduce_cython, sizeof(__pyx_k_asTuple___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asTuple___setstate_cython, __pyx_k_asTuple___setstate_cython, sizeof(__pyx_k_asTuple___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asVCF, __pyx_k_asVCF, sizeof(__pyx_k_asVCF), 0, 0, 1, 1},
    {&__pyx_n_u_asVCF, __pyx_k_asVCF, sizeof(__pyx_k_asVCF), 0, 1, 0, 1},
    {&__pyx_n_s_asVCF___reduce_cython, __pyx_k_asVCF___reduce_cython, sizeof(__pyx_k_asVCF___reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_asVCF___setstate_cython, __pyx_k_asVCF___setstate_cython, sizeof(__pyx_k_asVCF___setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_u_ascii, __pyx_k_ascii, sizeof(__pyx_k_ascii), 0, 1, 0, 1},
    {&__pyx_n_s_asyncio_coroutines, __pyx_k_asyncio_coroutines, sizeof(__pyx_k_asyncio_coroutines), 0, 0, 1, 1},
    {&__pyx_n_s_b, __pyx_k_b, sizeof(__pyx_k_b), 0, 0, 1, 1},
    {&__pyx_n_u_bcf, __pyx_k_bcf, sizeof(__pyx_k_bcf), 0, 1, 0, 1},
    {&__pyx_n_u_bed, __pyx_k_bed, sizeof(__pyx_k_bed), 0, 1, 0, 1},
    {&__pyx_n_s_buffer, __pyx_k_buffer, sizeof(__pyx_k_buffer), 0, 0, 1, 1},
    {&__pyx_n_s_buffer_size, __pyx_k_buffer_size, sizeof(__pyx_k_buffer_size), 0, 0, 1, 1},
    {&__pyx_kp_u_building_of_index_for_failed, __pyx_k_building_of_index_for_failed, sizeof(__pyx_k_building_of_index_for_failed), 0, 1, 0, 0},
    {&__pyx_n_s_bytes_cpy, __pyx_k_bytes_cpy, sizeof(__pyx_k_bytes_cpy), 0, 0, 1, 1},
    {&__pyx_n_s_c, __pyx_k_c, sizeof(__pyx_k_c), 0, 0, 1, 1},
    {&__pyx_n_s_cfilename, __pyx_k_cfilename, sizeof(__pyx_k_cfilename), 0, 0, 1, 1},
    {&__pyx_n_s_cfilename_index, __pyx_k_cfilename_index, sizeof(__pyx_k_cfilename_index), 0, 0, 1, 1},
    {&__pyx_n_s_cfn, __pyx_k_cfn, sizeof(__pyx_k_cfn), 0, 0, 1, 1},
    {&__pyx_n_s_cline_in_traceback, __pyx_k_cline_in_traceback, sizeof(__pyx_k_cline_in_traceback), 0, 0, 1, 1},
    {&__pyx_n_s_close, __pyx_k_close, sizeof(__pyx_k_close), 0, 0, 1, 1},
    {&__pyx_n_s_closed, __pyx_k_closed, sizeof(__pyx_k_closed), 0, 0, 1, 1},
    {&__pyx_n_s_conf, __pyx_k_conf, sizeof(__pyx_k_conf), 0, 0, 1, 1},
    {&__pyx_n_s_conf_data, __pyx_k_conf_data, sizeof(__pyx_k_conf_data), 0, 0, 1, 1},
    {&__pyx_n_s_contigs, __pyx_k_contigs, sizeof(__pyx_k_contigs), 0, 0, 1, 1},
    {&__pyx_kp_u_could_not_create_iterator_for_re, __pyx_k_could_not_create_iterator_for_re, sizeof(__pyx_k_could_not_create_iterator_for_re), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_create_iterator_possib, __pyx_k_could_not_create_iterator_possib, sizeof(__pyx_k_could_not_create_iterator_possib), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_load_tbi_csi_index_of, __pyx_k_could_not_load_tbi_csi_index_of, sizeof(__pyx_k_could_not_load_tbi_csi_index_of), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_open_file_s, __pyx_k_could_not_open_file_s, sizeof(__pyx_k_could_not_open_file_s), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_open_for_reading_heade, __pyx_k_could_not_open_for_reading_heade, sizeof(__pyx_k_could_not_open_for_reading_heade), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_open_index_for_s, __pyx_k_could_not_open_index_for_s, sizeof(__pyx_k_could_not_open_index_for_s), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_open_s_for_reading, __pyx_k_could_not_open_s_for_reading, sizeof(__pyx_k_could_not_open_s_for_reading), 0, 1, 0, 0},
    {&__pyx_kp_u_could_not_open_s_for_writing, __pyx_k_could_not_open_s_for_writing, sizeof(__pyx_k_could_not_open_s_for_writing), 0, 1, 0, 0},
    {&__pyx_n_s_cpy, __pyx_k_cpy, sizeof(__pyx_k_cpy), 0, 0, 1, 1},
    {&__pyx_n_s_csi, __pyx_k_csi, sizeof(__pyx_k_csi), 0, 0, 1, 1},
    {&__pyx_kp_u_csi_2, __pyx_k_csi_2, sizeof(__pyx_k_csi_2), 0, 1, 0, 0},
    {&__pyx_n_s_cstr, __pyx_k_cstr, sizeof(__pyx_k_cstr), 0, 0, 1, 1},
    {&__pyx_n_s_dict, __pyx_k_dict, sizeof(__pyx_k_dict), 0, 0, 1, 1},
    {&__pyx_n_s_dict_2, __pyx_k_dict_2, sizeof(__pyx_k_dict_2), 0, 0, 1, 1},
    {&__pyx_kp_u_disable, __pyx_k_disable, sizeof(__pyx_k_disable), 0, 1, 0, 0},
    {&__pyx_n_s_doc, __pyx_k_doc, sizeof(__pyx_k_doc), 0, 0, 1, 1},
    {&__pyx_n_s_dup, __pyx_k_dup, sizeof(__pyx_k_dup), 0, 0, 1, 1},
    {&__pyx_kp_s_empty_iterator, __pyx_k_empty_iterator, sizeof(__pyx_k_empty_iterator), 0, 0, 1, 0},
    {&__pyx_kp_u_enable, __pyx_k_enable, sizeof(__pyx_k_enable), 0, 1, 0, 0},
    {&__pyx_n_s_encoding, __pyx_k_encoding, sizeof(__pyx_k_encoding), 0, 0, 1, 1},
    {&__pyx_n_s_end, __pyx_k_end, sizeof(__pyx_k_end), 0, 0, 1, 1},
    {&__pyx_n_s_end_col, __pyx_k_end_col, sizeof(__pyx_k_end_col), 0, 0, 1, 1},
    {&__pyx_kp_u_end_out_of_range_i, __pyx_k_end_out_of_range_i, sizeof(__pyx_k_end_out_of_range_i), 0, 1, 0, 0},
    {&__pyx_kp_u_error_i_when_closing_file_s, __pyx_k_error_i_when_closing_file_s, sizeof(__pyx_k_error_i_when_closing_file_s), 0, 1, 0, 0},
    {&__pyx_kp_u_error_i_when_writing_to_file_s, __pyx_k_error_i_when_writing_to_file_s, sizeof(__pyx_k_error_i_when_writing_to_file_s), 0, 1, 0, 0},
    {&__pyx_n_s_exists, __pyx_k_exists, sizeof(__pyx_k_exists), 0, 0, 1, 1},
    {&__pyx_n_s_fd_src, __pyx_k_fd_src, sizeof(__pyx_k_fd_src), 0, 0, 1, 1},
    {&__pyx_n_s_fetch, __pyx_k_fetch, sizeof(__pyx_k_fetch), 0, 0, 1, 1},
    {&__pyx_kp_u_file_s_not_found, __pyx_k_file_s_not_found, sizeof(__pyx_k_file_s_not_found), 0, 1, 0, 0},
    {&__pyx_n_s_filename, __pyx_k_filename, sizeof(__pyx_k_filename), 0, 0, 1, 1},
    {&__pyx_n_s_filename_in, __pyx_k_filename_in, sizeof(__pyx_k_filename_in), 0, 0, 1, 1},
    {&__pyx_n_s_filename_index, __pyx_k_filename_index, sizeof(__pyx_k_filename_index), 0, 0, 1, 1},
    {&__pyx_n_s_filename_out, __pyx_k_filename_out, sizeof(__pyx_k_filename_out), 0, 0, 1, 1},
    {&__pyx_kp_u_filename_s_already_exists_use_fo, __pyx_k_filename_s_already_exists_use_fo, sizeof(__pyx_k_filename_s_already_exists_use_fo), 0, 1, 0, 0},
    {&__pyx_n_s_fileobj, __pyx_k_fileobj, sizeof(__pyx_k_fileobj), 0, 0, 1, 1},
    {&__pyx_n_s_fmt, __pyx_k_fmt, sizeof(__pyx_k_fmt), 0, 0, 1, 1},
    {&__pyx_n_s_fn, __pyx_k_fn, sizeof(__pyx_k_fn), 0, 0, 1, 1},
    {&__pyx_n_s_fn_index, __pyx_k_fn_index, sizeof(__pyx_k_fn_index), 0, 0, 1, 1},
    {&__pyx_n_s_fnidx, __pyx_k_fnidx, sizeof(__pyx_k_fnidx), 0, 0, 1, 1},
    {&__pyx_n_s_force, __pyx_k_force, sizeof(__pyx_k_force), 0, 0, 1, 1},
    {&__pyx_n_s_format, __pyx_k_format, sizeof(__pyx_k_format), 0, 0, 1, 1},
    {&__pyx_n_s_fp, __pyx_k_fp, sizeof(__pyx_k_fp), 0, 0, 1, 1},
    {&__pyx_kp_u_gc, __pyx_k_gc, sizeof(__pyx_k_gc), 0, 1, 0, 0},
    {&__pyx_n_s_get_encoding, __pyx_k_get_encoding, sizeof(__pyx_k_get_encoding), 0, 0, 1, 1},
    {&__pyx_n_s_getstate, __pyx_k_getstate, sizeof(__pyx_k_getstate), 0, 0, 1, 1},
    {&__pyx_n_u_gff, __pyx_k_gff, sizeof(__pyx_k_gff), 0, 1, 0, 1},
    {&__pyx_kp_u_gz, __pyx_k_gz, sizeof(__pyx_k_gz), 0, 1, 0, 0},
    {&__pyx_n_s_import, __pyx_k_import, sizeof(__pyx_k_import), 0, 0, 1, 1},
    {&__pyx_kp_u_incomplete_line_at_s, __pyx_k_incomplete_line_at_s, sizeof(__pyx_k_incomplete_line_at_s), 0, 1, 0, 0},
    {&__pyx_n_s_index, __pyx_k_index, sizeof(__pyx_k_index), 0, 0, 1, 1},
    {&__pyx_kp_u_index_s_not_found, __pyx_k_index_s_not_found, sizeof(__pyx_k_index_s_not_found), 0, 1, 0, 0},
    {&__pyx_n_s_infile, __pyx_k_infile, sizeof(__pyx_k_infile), 0, 0, 1, 1},
    {&__pyx_n_s_init, __pyx_k_init, sizeof(__pyx_k_init), 0, 0, 1, 1},
    {&__pyx_n_s_init_subclass, __pyx_k_init_subclass, sizeof(__pyx_k_init_subclass), 0, 0, 1, 1},
    {&__pyx_n_s_initializing, __pyx_k_initializing, sizeof(__pyx_k_initializing), 0, 0, 1, 1},
    {&__pyx_kp_u_invalid_file_opening_mode_s, __pyx_k_invalid_file_opening_mode_s, sizeof(__pyx_k_invalid_file_opening_mode_s), 0, 1, 0, 0},
    {&__pyx_n_s_is_coroutine, __pyx_k_is_coroutine, sizeof(__pyx_k_is_coroutine), 0, 0, 1, 1},
    {&__pyx_n_s_is_empty, __pyx_k_is_empty, sizeof(__pyx_k_is_empty), 0, 0, 1, 1},
    {&__pyx_n_s_is_open, __pyx_k_is_open, sizeof(__pyx_k_is_open), 0, 0, 1, 1},
    {&__pyx_kp_u_isenabled, __pyx_k_isenabled, sizeof(__pyx_k_isenabled), 0, 1, 0, 0},
    {&__pyx_n_s_iter, __pyx_k_iter, sizeof(__pyx_k_iter), 0, 0, 1, 1},
    {&__pyx_kp_s_iterate_over_infile_Permits_the, __pyx_k_iterate_over_infile_Permits_the, sizeof(__pyx_k_iterate_over_infile_Permits_the), 0, 0, 1, 0},
    {&__pyx_kp_u_iteration_on_closed_file, __pyx_k_iteration_on_closed_file, sizeof(__pyx_k_iteration_on_closed_file), 0, 1, 0, 0},
    {&__pyx_n_s_itr, __pyx_k_itr, sizeof(__pyx_k_itr), 0, 0, 1, 1},
    {&__pyx_n_s_keep_original, __pyx_k_keep_original, sizeof(__pyx_k_keep_original), 0, 0, 1, 1},
    {&__pyx_n_s_keys, __pyx_k_keys, sizeof(__pyx_k_keys), 0, 0, 1, 1},
    {&__pyx_n_s_length, __pyx_k_length, sizeof(__pyx_k_length), 0, 0, 1, 1},
    {&__pyx_n_s_line, __pyx_k_line, sizeof(__pyx_k_line), 0, 0, 1, 1},
    {&__pyx_n_s_line_skip, __pyx_k_line_skip, sizeof(__pyx_k_line_skip), 0, 0, 1, 1},
    {&__pyx_n_s_main, __pyx_k_main, sizeof(__pyx_k_main), 0, 0, 1, 1},
    {&__pyx_n_s_meta_char, __pyx_k_meta_char, sizeof(__pyx_k_meta_char), 0, 0, 1, 1},
    {&__pyx_n_s_metaclass, __pyx_k_metaclass, sizeof(__pyx_k_metaclass), 0, 0, 1, 1},
    {&__pyx_n_s_min_shift, __pyx_k_min_shift, sizeof(__pyx_k_min_shift), 0, 0, 1, 1},
    {&__pyx_n_s_mode, __pyx_k_mode, sizeof(__pyx_k_mode), 0, 0, 1, 1},
    {&__pyx_n_s_module, __pyx_k_module, sizeof(__pyx_k_module), 0, 0, 1, 1},
    {&__pyx_n_s_multiple_iterators, __pyx_k_multiple_iterators, sizeof(__pyx_k_multiple_iterators), 0, 0, 1, 1},
    {&__pyx_n_s_name, __pyx_k_name, sizeof(__pyx_k_name), 0, 0, 1, 1},
    {&__pyx_n_s_nbytes, __pyx_k_nbytes, sizeof(__pyx_k_nbytes), 0, 0, 1, 1},
    {&__pyx_kp_u_neither_preset_nor_seq_col_start, __pyx_k_neither_preset_nor_seq_col_start, sizeof(__pyx_k_neither_preset_nor_seq_col_start), 0, 1, 0, 0},
    {&__pyx_n_s_new, __pyx_k_new, sizeof(__pyx_k_new), 0, 0, 1, 1},
    {&__pyx_n_s_next, __pyx_k_next, sizeof(__pyx_k_next), 0, 0, 1, 1},
    {&__pyx_kp_s_no_default___reduce___due_to_non, __pyx_k_no_default___reduce___due_to_non, sizeof(__pyx_k_no_default___reduce___due_to_non), 0, 0, 1, 0},
    {&__pyx_n_s_open, __pyx_k_open, sizeof(__pyx_k_open), 0, 0, 1, 1},
    {&__pyx_n_s_os, __pyx_k_os, sizeof(__pyx_k_os), 0, 0, 1, 1},
    {&__pyx_kp_u_parse_method_of_s_not_implemente, __pyx_k_parse_method_of_s_not_implemente, sizeof(__pyx_k_parse_method_of_s_not_implemente), 0, 1, 0, 0},
    {&__pyx_n_s_parser, __pyx_k_parser, sizeof(__pyx_k_parser), 0, 0, 1, 1},
    {&__pyx_n_s_path, __pyx_k_path, sizeof(__pyx_k_path), 0, 0, 1, 1},
    {&__pyx_n_s_pickle, __pyx_k_pickle, sizeof(__pyx_k_pickle), 0, 0, 1, 1},
    {&__pyx_n_s_prepare, __pyx_k_prepare, sizeof(__pyx_k_prepare), 0, 0, 1, 1},
    {&__pyx_n_s_preset, __pyx_k_preset, sizeof(__pyx_k_preset), 0, 0, 1, 1},
    {&__pyx_n_s_preset2conf, __pyx_k_preset2conf, sizeof(__pyx_k_preset2conf), 0, 0, 1, 1},
    {&__pyx_n_u_psltbl, __pyx_k_psltbl, sizeof(__pyx_k_psltbl), 0, 1, 0, 1},
    {&__pyx_n_s_pysam_libctabix, __pyx_k_pysam_libctabix, sizeof(__pyx_k_pysam_libctabix), 0, 0, 1, 1},
    {&__pyx_kp_s_pysam_libctabix_pyx, __pyx_k_pysam_libctabix_pyx, sizeof(__pyx_k_pysam_libctabix_pyx), 0, 0, 1, 0},
    {&__pyx_n_s_pyx_PickleError, __pyx_k_pyx_PickleError, sizeof(__pyx_k_pyx_PickleError), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_checksum, __pyx_k_pyx_checksum, sizeof(__pyx_k_pyx_checksum), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_result, __pyx_k_pyx_result, sizeof(__pyx_k_pyx_result), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_state, __pyx_k_pyx_state, sizeof(__pyx_k_pyx_state), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_type, __pyx_k_pyx_type, sizeof(__pyx_k_pyx_type), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_Parser, __pyx_k_pyx_unpickle_Parser, sizeof(__pyx_k_pyx_unpickle_Parser), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_asBed, __pyx_k_pyx_unpickle_asBed, sizeof(__pyx_k_pyx_unpickle_asBed), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_asGFF3, __pyx_k_pyx_unpickle_asGFF3, sizeof(__pyx_k_pyx_unpickle_asGFF3), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_asGTF, __pyx_k_pyx_unpickle_asGTF, sizeof(__pyx_k_pyx_unpickle_asGTF), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_asTuple, __pyx_k_pyx_unpickle_asTuple, sizeof(__pyx_k_pyx_unpickle_asTuple), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_unpickle_asVCF, __pyx_k_pyx_unpickle_asVCF, sizeof(__pyx_k_pyx_unpickle_asVCF), 0, 0, 1, 1},
    {&__pyx_n_s_pyx_vtable, __pyx_k_pyx_vtable, sizeof(__pyx_k_pyx_vtable), 0, 0, 1, 1},
    {&__pyx_n_s_qualname, __pyx_k_qualname, sizeof(__pyx_k_qualname), 0, 0, 1, 1},
    {&__pyx_n_s_r, __pyx_k_r, sizeof(__pyx_k_r), 0, 0, 1, 1},
    {&__pyx_n_u_r, __pyx_k_r, sizeof(__pyx_k_r), 0, 1, 0, 1},
    {&__pyx_n_s_readline, __pyx_k_readline, sizeof(__pyx_k_readline), 0, 0, 1, 1},
    {&__pyx_n_s_reduce, __pyx_k_reduce, sizeof(__pyx_k_reduce), 0, 0, 1, 1},
    {&__pyx_n_s_reduce_cython, __pyx_k_reduce_cython, sizeof(__pyx_k_reduce_cython), 0, 0, 1, 1},
    {&__pyx_n_s_reduce_ex, __pyx_k_reduce_ex, sizeof(__pyx_k_reduce_ex), 0, 0, 1, 1},
    {&__pyx_n_s_reference, __pyx_k_reference, sizeof(__pyx_k_reference), 0, 0, 1, 1},
    {&__pyx_n_s_region, __pyx_k_region, sizeof(__pyx_k_region), 0, 0, 1, 1},
    {&__pyx_n_s_retval, __pyx_k_retval, sizeof(__pyx_k_retval), 0, 0, 1, 1},
    {&__pyx_kp_u_s, __pyx_k_s, sizeof(__pyx_k_s), 0, 1, 0, 0},
    {&__pyx_n_s_s_2, __pyx_k_s_2, sizeof(__pyx_k_s_2), 0, 0, 1, 1},
    {&__pyx_kp_u_s_i, __pyx_k_s_i, sizeof(__pyx_k_s_i), 0, 1, 0, 0},
    {&__pyx_kp_u_s_i_i, __pyx_k_s_i_i, sizeof(__pyx_k_s_i_i), 0, 1, 0, 0},
    {&__pyx_n_u_sam, __pyx_k_sam, sizeof(__pyx_k_sam), 0, 1, 0, 1},
    {&__pyx_n_s_self, __pyx_k_self, sizeof(__pyx_k_self), 0, 0, 1, 1},
    {&__pyx_kp_s_self_gzipfile_self_kstream_canno, __pyx_k_self_gzipfile_self_kstream_canno, sizeof(__pyx_k_self_gzipfile_self_kstream_canno), 0, 0, 1, 0},
    {&__pyx_kp_s_self_iterator_cannot_be_converte, __pyx_k_self_iterator_cannot_be_converte, sizeof(__pyx_k_self_iterator_cannot_be_converte), 0, 0, 1, 0},
    {&__pyx_n_s_seq_col, __pyx_k_seq_col, sizeof(__pyx_k_seq_col), 0, 0, 1, 1},
    {&__pyx_n_s_set_encoding, __pyx_k_set_encoding, sizeof(__pyx_k_set_encoding), 0, 0, 1, 1},
    {&__pyx_n_s_set_name, __pyx_k_set_name, sizeof(__pyx_k_set_name), 0, 0, 1, 1},
    {&__pyx_n_s_setstate, __pyx_k_setstate, sizeof(__pyx_k_setstate), 0, 0, 1, 1},
    {&__pyx_n_s_setstate_cython, __pyx_k_setstate_cython, sizeof(__pyx_k_setstate_cython), 0, 0, 1, 1},
    {&__pyx_n_s_spec, __pyx_k_spec, sizeof(__pyx_k_spec), 0, 0, 1, 1},
    {&__pyx_n_s_start, __pyx_k_start, sizeof(__pyx_k_start), 0, 0, 1, 1},
    {&__pyx_n_s_start_col, __pyx_k_start_col, sizeof(__pyx_k_start_col), 0, 0, 1, 1},
    {&__pyx_kp_u_start_i_end_i, __pyx_k_start_i_end_i, sizeof(__pyx_k_start_i_end_i), 0, 1, 0, 0},
    {&__pyx_kp_u_start_out_of_range_i, __pyx_k_start_out_of_range_i, sizeof(__pyx_k_start_out_of_range_i), 0, 1, 0, 0},
    {&__pyx_n_s_state, __pyx_k_state, sizeof(__pyx_k_state), 0, 0, 1, 1},
    {&__pyx_kp_s_stringsource, __pyx_k_stringsource, sizeof(__pyx_k_stringsource), 0, 0, 1, 0},
    {&__pyx_n_s_suffix, __pyx_k_suffix, sizeof(__pyx_k_suffix), 0, 0, 1, 1},
    {&__pyx_n_s_super, __pyx_k_super, sizeof(__pyx_k_super), 0, 0, 1, 1},
    {&__pyx_n_s_sys, __pyx_k_sys, sizeof(__pyx_k_sys), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_compress, __pyx_k_tabix_compress, sizeof(__pyx_k_tabix_compress), 0, 0, 1, 1},
    {&__pyx_n_u_tabix_compress, __pyx_k_tabix_compress, sizeof(__pyx_k_tabix_compress), 0, 1, 0, 1},
    {&__pyx_n_s_tabix_file_iterator, __pyx_k_tabix_file_iterator, sizeof(__pyx_k_tabix_file_iterator), 0, 0, 1, 1},
    {&__pyx_n_u_tabix_file_iterator, __pyx_k_tabix_file_iterator, sizeof(__pyx_k_tabix_file_iterator), 0, 1, 0, 1},
    {&__pyx_n_s_tabix_file_iterator___reduce_cyt, __pyx_k_tabix_file_iterator___reduce_cyt, sizeof(__pyx_k_tabix_file_iterator___reduce_cyt), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_file_iterator___setstate_c, __pyx_k_tabix_file_iterator___setstate_c, sizeof(__pyx_k_tabix_file_iterator___setstate_c), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_generic_iterator, __pyx_k_tabix_generic_iterator, sizeof(__pyx_k_tabix_generic_iterator), 0, 0, 1, 1},
    {&__pyx_n_u_tabix_generic_iterator, __pyx_k_tabix_generic_iterator, sizeof(__pyx_k_tabix_generic_iterator), 0, 1, 0, 1},
    {&__pyx_n_s_tabix_generic_iterator___init, __pyx_k_tabix_generic_iterator___init, sizeof(__pyx_k_tabix_generic_iterator___init), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_generic_iterator___iter, __pyx_k_tabix_generic_iterator___iter, sizeof(__pyx_k_tabix_generic_iterator___iter), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_generic_iterator___next, __pyx_k_tabix_generic_iterator___next, sizeof(__pyx_k_tabix_generic_iterator___next), 0, 0, 1, 1},
    {&__pyx_n_s_tabix_index, __pyx_k_tabix_index, sizeof(__pyx_k_tabix_index), 0, 0, 1, 1},
    {&__pyx_n_u_tabix_index, __pyx_k_tabix_index, sizeof(__pyx_k_tabix_index), 0, 1, 0, 1},
    {&__pyx_n_s_tabix_iterator, __pyx_k_tabix_iterator, sizeof(__pyx_k_tabix_iterator), 0, 0, 1, 1},
    {&__pyx_n_u_tabix_iterator, __pyx_k_tabix_iterator, sizeof(__pyx_k_tabix_iterator), 0, 1, 0, 1},
    {&__pyx_kp_u_tbi, __pyx_k_tbi, sizeof(__pyx_k_tbi), 0, 1, 0, 0},
    {&__pyx_n_s_tell, __pyx_k_tell, sizeof(__pyx_k_tell), 0, 0, 1, 1},
    {&__pyx_n_s_test, __pyx_k_test, sizeof(__pyx_k_test), 0, 0, 1, 1},
    {&__pyx_n_s_threads, __pyx_k_threads, sizeof(__pyx_k_threads), 0, 0, 1, 1},
    {&__pyx_kp_u_unknown_preset, __pyx_k_unknown_preset, sizeof(__pyx_k_unknown_preset), 0, 1, 0, 0},
    {&__pyx_n_s_unlink, __pyx_k_unlink, sizeof(__pyx_k_unlink), 0, 0, 1, 1},
    {&__pyx_n_s_update, __pyx_k_update, sizeof(__pyx_k_update), 0, 0, 1, 1},
    {&__pyx_n_s_use_setstate, __pyx_k_use_setstate, sizeof(__pyx_k_use_setstate), 0, 0, 1, 1},
    {&__pyx_kp_u_valid_presets_are, __pyx_k_valid_presets_are, sizeof(__pyx_k_valid_presets_are), 0, 1, 0, 0},
    {&__pyx_n_u_vcf, __pyx_k_vcf, sizeof(__pyx_k_vcf), 0, 1, 0, 1},
    {&__pyx_kp_u_writing_failed, __pyx_k_writing_failed, sizeof(__pyx_k_writing_failed), 0, 1, 0, 0},
    {&__pyx_n_s_zerobased, __pyx_k_zerobased, sizeof(__pyx_k_zerobased), 0, 0, 1, 1},
    {0, 0, 0, 0, 0, 0, 0}
  };
  return __Pyx_InitStrings(__pyx_string_tab);
}
/* #### Code section: cached_builtins ### */
static CYTHON_SMALL_CODE int __Pyx_InitCachedBuiltins(void) {
  __pyx_builtin_NotImplementedError = __Pyx_GetBuiltinName(__pyx_n_s_NotImplementedError); if (!__pyx_builtin_NotImplementedError) __PYX_ERR(0, 94, __pyx_L1_error)
  __pyx_builtin_ValueError = __Pyx_GetBuiltinName(__pyx_n_s_ValueError); if (!__pyx_builtin_ValueError) __PYX_ERR(0, 361, __pyx_L1_error)
  __pyx_builtin_IOError = __Pyx_GetBuiltinName(__pyx_n_s_IOError); if (!__pyx_builtin_IOError) __PYX_ERR(0, 378, __pyx_L1_error)
  __pyx_builtin_OSError = __Pyx_GetBuiltinName(__pyx_n_s_OSError); if (!__pyx_builtin_OSError) __PYX_ERR(0, 560, __pyx_L1_error)
  __pyx_builtin_TypeError = __Pyx_GetBuiltinName(__pyx_n_s_TypeError); if (!__pyx_builtin_TypeError) __PYX_ERR(1, 2, __pyx_L1_error)
  __pyx_builtin_StopIteration = __Pyx_GetBuiltinName(__pyx_n_s_StopIteration); if (!__pyx_builtin_StopIteration) __PYX_ERR(0, 671, __pyx_L1_error)
  __pyx_builtin_KeyError = __Pyx_GetBuiltinName(__pyx_n_s_KeyError); if (!__pyx_builtin_KeyError) __PYX_ERR(0, 971, __pyx_L1_error)
  __pyx_builtin_AssertionError = __Pyx_GetBuiltinName(__pyx_n_s_AssertionError); if (!__pyx_builtin_AssertionError) __PYX_ERR(0, 1218, __pyx_L1_error)
  __pyx_builtin_MemoryError = __Pyx_GetBuiltinName(__pyx_n_s_MemoryError); if (!__pyx_builtin_MemoryError) __PYX_ERR(3, 120, __pyx_L1_error)
  return 0;
  __pyx_L1_error:;
  return -1;
}
/* #### Code section: cached_constants ### */

static CYTHON_SMALL_CODE int __Pyx_InitCachedConstants(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_InitCachedConstants", 0);

  /* "pysam/libctabix.pyx":444
 *         '''
 *         if not self.is_open():
 *             raise ValueError("I/O operation on closed file")             # <<<<<<<<<<<<<<
 * 
 *         # convert coordinates to region string, which is one-based
 */
  __pyx_tuple__19 = PyTuple_Pack(1, __pyx_kp_u_I_O_operation_on_closed_file); if (unlikely(!__pyx_tuple__19)) __PYX_ERR(0, 444, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__19);
  __Pyx_GIVEREF(__pyx_tuple__19);

  /* "pysam/libctabix.pyx":499
 *                     # when accessing a tabix file created prior tabix 1.0
 *                     # the full-file iterator is empty.
 *                     raise ValueError(             # <<<<<<<<<<<<<<
 *                         "could not create iterator, possible "
 *                         "tabix version mismatch")
 */
  __pyx_tuple__20 = PyTuple_Pack(1, __pyx_kp_u_could_not_create_iterator_possib); if (unlikely(!__pyx_tuple__20)) __PYX_ERR(0, 499, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__20);
  __Pyx_GIVEREF(__pyx_tuple__20);

  /* "pysam/libctabix.pyx":669
 *         cdef int retval = self.__cnext__()
 *         if retval == -5:
 *             raise IOError("iteration on closed file")             # <<<<<<<<<<<<<<
 *         elif retval < 0:
 *             raise StopIteration
 */
  __pyx_tuple__24 = PyTuple_Pack(1, __pyx_kp_u_iteration_on_closed_file); if (unlikely(!__pyx_tuple__24)) __PYX_ERR(0, 669, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__24);
  __Pyx_GIVEREF(__pyx_tuple__24);

  /* "pysam/libctabix.pyx":861
 *         if r < 0:
 *             free(buffer)
 *             raise IOError("writing failed")             # <<<<<<<<<<<<<<
 * 
 *     free(buffer)
 */
  __pyx_tuple__38 = PyTuple_Pack(1, __pyx_kp_u_writing_failed); if (unlikely(!__pyx_tuple__38)) __PYX_ERR(0, 861, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__38);
  __Pyx_GIVEREF(__pyx_tuple__38);

  /* "pysam/libctabix.pyx":932
 *     if preset is None and \
 *        (seq_col is None or start_col is None or end_col is None):
 *         raise ValueError(             # <<<<<<<<<<<<<<
 *             "neither preset nor seq_col,start_col and end_col given")
 * 
 */
  __pyx_tuple__41 = PyTuple_Pack(1, __pyx_kp_u_neither_preset_nor_seq_col_start); if (unlikely(!__pyx_tuple__41)) __PYX_ERR(0, 932, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__41);
  __Pyx_GIVEREF(__pyx_tuple__41);

  /* "pysam/libctabix.pyx":1110
 * 
 *         if infile.closed:
 *             raise ValueError("I/O operation on closed file.")             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */
  __pyx_tuple__45 = PyTuple_Pack(1, __pyx_kp_u_I_O_operation_on_closed_file_2); if (unlikely(!__pyx_tuple__45)) __PYX_ERR(0, 1110, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__45);
  __Pyx_GIVEREF(__pyx_tuple__45);

  /* "(tree fragment)":4
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 *     if __pyx_checksum not in (0xe8424ea, 0x14a9dc0, 0x84bea1f):             # <<<<<<<<<<<<<<
 *         from pickle import PickleError as __pyx_PickleError
 *         raise __pyx_PickleError, "Incompatible checksums (0x%x vs (0xe8424ea, 0x14a9dc0, 0x84bea1f) = (encoding))" % __pyx_checksum
 */
  __pyx_tuple__55 = PyTuple_Pack(3, __pyx_int_243541226, __pyx_int_21667264, __pyx_int_139192863); if (unlikely(!__pyx_tuple__55)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__55);
  __Pyx_GIVEREF(__pyx_tuple__55);

  /* "pysam/libctabix.pyx":87
 *         self.encoding = encoding
 * 
 *     def set_encoding(self, encoding):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */
  __pyx_tuple__63 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_encoding); if (unlikely(!__pyx_tuple__63)) __PYX_ERR(0, 87, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__63);
  __Pyx_GIVEREF(__pyx_tuple__63);
  __pyx_codeobj_ = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__63, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_set_encoding, 87, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj_)) __PYX_ERR(0, 87, __pyx_L1_error)

  /* "pysam/libctabix.pyx":90
 *         self.encoding = encoding
 * 
 *     def get_encoding(self):             # <<<<<<<<<<<<<<
 *         return self.encoding
 * 
 */
  __pyx_tuple__64 = PyTuple_Pack(1, __pyx_n_s_self); if (unlikely(!__pyx_tuple__64)) __PYX_ERR(0, 90, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__64);
  __Pyx_GIVEREF(__pyx_tuple__64);
  __pyx_codeobj__2 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_get_encoding, 90, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__2)) __PYX_ERR(0, 90, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_tuple__65 = PyTuple_Pack(4, __pyx_n_s_self, __pyx_n_s_state, __pyx_n_s_dict_2, __pyx_n_s_use_setstate); if (unlikely(!__pyx_tuple__65)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__65);
  __Pyx_GIVEREF(__pyx_tuple__65);
  __pyx_codeobj__3 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__3)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)
 */
  __pyx_tuple__66 = PyTuple_Pack(2, __pyx_n_s_self, __pyx_n_s_pyx_state); if (unlikely(!__pyx_tuple__66)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__66);
  __Pyx_GIVEREF(__pyx_tuple__66);
  __pyx_codeobj__4 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__4)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_codeobj__5 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__5)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)
 */
  __pyx_codeobj__6 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__6)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_codeobj__7 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__7)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)
 */
  __pyx_codeobj__8 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__8)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_codeobj__9 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__9)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)
 */
  __pyx_codeobj__10 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__10)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_codeobj__11 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__11)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)
 */
  __pyx_codeobj__12 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__12)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_codeobj__13 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 4, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__65, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__13)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)
 */
  __pyx_codeobj__14 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 16, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__14)) __PYX_ERR(1, 16, __pyx_L1_error)

  /* "pysam/libctabix.pyx":352
 *         self.encoding = encoding
 * 
 *     def _open( self,             # <<<<<<<<<<<<<<
 *                filename,
 *                mode='r',
 */
  __pyx_tuple__67 = PyTuple_Pack(8, __pyx_n_s_self, __pyx_n_s_filename, __pyx_n_s_mode, __pyx_n_s_index, __pyx_n_s_threads, __pyx_n_s_filename_index, __pyx_n_s_cfilename, __pyx_n_s_cfilename_index); if (unlikely(!__pyx_tuple__67)) __PYX_ERR(0, 352, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__67);
  __Pyx_GIVEREF(__pyx_tuple__67);
  __pyx_codeobj__15 = (PyObject*)__Pyx_PyCode_New(5, 0, 0, 8, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__67, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_open, 352, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__15)) __PYX_ERR(0, 352, __pyx_L1_error)
  __pyx_tuple__68 = PyTuple_Pack(3, __pyx_n_u_r, Py_None, __pyx_int_1); if (unlikely(!__pyx_tuple__68)) __PYX_ERR(0, 352, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__68);
  __Pyx_GIVEREF(__pyx_tuple__68);

  /* "pysam/libctabix.pyx":404
 *             self.start_offset = self.tell()
 * 
 *     def _dup(self):             # <<<<<<<<<<<<<<
 *         '''return a copy of this tabix file.
 * 
 */
  __pyx_codeobj__17 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_dup, 404, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__17)) __PYX_ERR(0, 404, __pyx_L1_error)

  /* "pysam/libctabix.pyx":416
 *                          encoding=self.encoding)
 * 
 *     def fetch(self,             # <<<<<<<<<<<<<<
 *               reference=None,
 *               start=None,
 */
  __pyx_tuple__69 = PyTuple_Pack(12, __pyx_n_s_self, __pyx_n_s_reference, __pyx_n_s_start, __pyx_n_s_end, __pyx_n_s_region, __pyx_n_s_parser, __pyx_n_s_multiple_iterators, __pyx_n_s_itr, __pyx_n_s_cstr, __pyx_n_s_fileobj, __pyx_n_s_s_2, __pyx_n_s_a); if (unlikely(!__pyx_tuple__69)) __PYX_ERR(0, 416, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__69);
  __Pyx_GIVEREF(__pyx_tuple__69);
  __pyx_codeobj__18 = (PyObject*)__Pyx_PyCode_New(7, 0, 0, 12, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__69, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_fetch, 416, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__18)) __PYX_ERR(0, 416, __pyx_L1_error)
  __pyx_tuple__70 = PyTuple_Pack(6, Py_None, Py_None, Py_None, Py_None, Py_None, Py_False); if (unlikely(!__pyx_tuple__70)) __PYX_ERR(0, 416, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__70);
  __Pyx_GIVEREF(__pyx_tuple__70);

  /* "pysam/libctabix.pyx":598
 *             return result
 * 
 *     def close(self):             # <<<<<<<<<<<<<<
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 */
  __pyx_codeobj__21 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_close, 598, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__21)) __PYX_ERR(0, 598, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__22 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__22)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_codeobj__23 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__23)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__25 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__25)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __pyx_codeobj__26 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__26)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "pysam/libctabix.pyx":685
 *     '''empty iterator'''
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */
  __pyx_codeobj__27 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_iter, 685, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__27)) __PYX_ERR(0, 685, __pyx_L1_error)

  /* "pysam/libctabix.pyx":688
 *         return self
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         raise StopIteration()
 * 
 */
  __pyx_codeobj__28 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_next, 688, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__28)) __PYX_ERR(0, 688, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__29 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__29)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __pyx_codeobj__30 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__30)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__31 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__31)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_codeobj__32 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__32)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__33 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__33)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_codeobj__34 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__34)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__35 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__35)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_codeobj__36 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__36)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "pysam/libctabix.pyx":813
 * 
 * 
 * def tabix_compress(filename_in,             # <<<<<<<<<<<<<<
 *                    filename_out,
 *                    force=False):
 */
  __pyx_tuple__71 = PyTuple_Pack(13, __pyx_n_s_filename_in, __pyx_n_s_filename_out, __pyx_n_s_force, __pyx_n_s_WINDOW_SIZE, __pyx_n_s_c, __pyx_n_s_r, __pyx_n_s_buffer, __pyx_n_s_fp, __pyx_n_s_fd_src, __pyx_n_s_is_empty, __pyx_n_s_O_RDONLY, __pyx_n_s_fn, __pyx_n_s_cfn); if (unlikely(!__pyx_tuple__71)) __PYX_ERR(0, 813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__71);
  __Pyx_GIVEREF(__pyx_tuple__71);
  __pyx_codeobj__37 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 13, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__71, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_tabix_compress, 813, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__37)) __PYX_ERR(0, 813, __pyx_L1_error)
  __pyx_tuple__72 = PyTuple_Pack(1, ((PyObject *)Py_False)); if (unlikely(!__pyx_tuple__72)) __PYX_ERR(0, 813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__72);
  __Pyx_GIVEREF(__pyx_tuple__72);

  /* "pysam/libctabix.pyx":875
 * 
 * 
 * def tabix_index(filename,             # <<<<<<<<<<<<<<
 *                 force=False,
 *                 seq_col=None,
 */
  __pyx_tuple__73 = PyTuple_Pack(24, __pyx_n_s_filename, __pyx_n_s_force, __pyx_n_s_seq_col, __pyx_n_s_start_col, __pyx_n_s_end_col, __pyx_n_s_preset, __pyx_n_s_meta_char, __pyx_n_s_line_skip, __pyx_n_s_zerobased, __pyx_n_s_min_shift, __pyx_n_s_index, __pyx_n_s_keep_original, __pyx_n_s_csi, __pyx_n_s_fn, __pyx_n_s_cfn, __pyx_n_s_fp, __pyx_n_s_fmt, __pyx_n_s_preset2conf, __pyx_n_s_conf_data, __pyx_n_s_conf, __pyx_n_s_suffix, __pyx_n_s_fn_index, __pyx_n_s_fnidx, __pyx_n_s_retval); if (unlikely(!__pyx_tuple__73)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__73);
  __Pyx_GIVEREF(__pyx_tuple__73);
  __pyx_codeobj__40 = (PyObject*)__Pyx_PyCode_New(13, 0, 0, 24, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__73, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_tabix_index, 875, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__40)) __PYX_ERR(0, 875, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__46 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__46)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_codeobj__47 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__47)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1185
 *     Permits the use of file-like objects for example from the gzip module.
 *     '''
 *     def __init__(self, infile, parser):             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */
  __pyx_tuple__74 = PyTuple_Pack(3, __pyx_n_s_self, __pyx_n_s_infile, __pyx_n_s_parser); if (unlikely(!__pyx_tuple__74)) __PYX_ERR(0, 1185, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__74);
  __Pyx_GIVEREF(__pyx_tuple__74);
  __pyx_codeobj__48 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 3, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__74, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_init, 1185, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__48)) __PYX_ERR(0, 1185, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1192
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */
  __pyx_codeobj__49 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_iter, 1192, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__49)) __PYX_ERR(0, 1192, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1196
 * 
 *     # cython version - required for python 3
 *     def __next__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */
  __pyx_tuple__75 = PyTuple_Pack(8, __pyx_n_s_self, __pyx_n_s_b, __pyx_n_s_cpy, __pyx_n_s_nbytes, __pyx_n_s_encoding, __pyx_n_s_line, __pyx_n_s_s_2, __pyx_n_s_bytes_cpy); if (unlikely(!__pyx_tuple__75)) __PYX_ERR(0, 1196, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__75);
  __Pyx_GIVEREF(__pyx_tuple__75);
  __pyx_codeobj__50 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 8, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__75, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_next, 1196, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__50)) __PYX_ERR(0, 1196, __pyx_L1_error)

  /* "pysam/libctabix.pyx":1240
 * 
 * 
 * def tabix_iterator(infile, parser):             # <<<<<<<<<<<<<<
 *     """return an iterator over all entries in a file.
 * 
 */
  __pyx_tuple__76 = PyTuple_Pack(2, __pyx_n_s_infile, __pyx_n_s_parser); if (unlikely(!__pyx_tuple__76)) __PYX_ERR(0, 1240, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__76);
  __Pyx_GIVEREF(__pyx_tuple__76);
  __pyx_codeobj__51 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__76, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_pysam_libctabix_pyx, __pyx_n_s_tabix_iterator, 1240, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__51)) __PYX_ERR(0, 1240, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_codeobj__52 = (PyObject*)__Pyx_PyCode_New(1, 0, 0, 1, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__64, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_reduce_cython, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__52)) __PYX_ERR(1, 1, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_codeobj__53 = (PyObject*)__Pyx_PyCode_New(2, 0, 0, 2, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__66, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_setstate_cython, 3, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__53)) __PYX_ERR(1, 3, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __pyx_unpickle_Parser(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */
  __pyx_tuple__77 = PyTuple_Pack(5, __pyx_n_s_pyx_type, __pyx_n_s_pyx_checksum, __pyx_n_s_pyx_state, __pyx_n_s_pyx_PickleError, __pyx_n_s_pyx_result); if (unlikely(!__pyx_tuple__77)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__77);
  __Pyx_GIVEREF(__pyx_tuple__77);
  __pyx_codeobj__54 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_Parser, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__54)) __PYX_ERR(1, 1, __pyx_L1_error)
  __pyx_codeobj__57 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_asTuple, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__57)) __PYX_ERR(1, 1, __pyx_L1_error)
  __pyx_codeobj__58 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_asGFF3, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__58)) __PYX_ERR(1, 1, __pyx_L1_error)
  __pyx_codeobj__59 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_asGTF, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__59)) __PYX_ERR(1, 1, __pyx_L1_error)
  __pyx_codeobj__60 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_asBed, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__60)) __PYX_ERR(1, 1, __pyx_L1_error)
  __pyx_codeobj__61 = (PyObject*)__Pyx_PyCode_New(3, 0, 0, 5, 0, CO_OPTIMIZED|CO_NEWLOCALS, __pyx_empty_bytes, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_tuple__77, __pyx_empty_tuple, __pyx_empty_tuple, __pyx_kp_s_stringsource, __pyx_n_s_pyx_unpickle_asVCF, 1, __pyx_empty_bytes); if (unlikely(!__pyx_codeobj__61)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_RefNannyFinishContext();
  return -1;
}
/* #### Code section: init_constants ### */

static CYTHON_SMALL_CODE int __Pyx_InitConstants(void) {
  __pyx_umethod_PyDict_Type_keys.type = (PyObject*)&PyDict_Type;
  __pyx_umethod_PyDict_Type_keys.method_name = &__pyx_n_s_keys;
  if (__Pyx_CreateStringTabAndInitStrings() < 0) __PYX_ERR(0, 1, __pyx_L1_error);
  __pyx_int_0 = PyInt_FromLong(0); if (unlikely(!__pyx_int_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_1 = PyInt_FromLong(1); if (unlikely(!__pyx_int_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_2 = PyInt_FromLong(2); if (unlikely(!__pyx_int_2)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_3 = PyInt_FromLong(3); if (unlikely(!__pyx_int_3)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_4 = PyInt_FromLong(4); if (unlikely(!__pyx_int_4)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_5 = PyInt_FromLong(5); if (unlikely(!__pyx_int_5)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_15 = PyInt_FromLong(15); if (unlikely(!__pyx_int_15)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_17 = PyInt_FromLong(17); if (unlikely(!__pyx_int_17)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_18 = PyInt_FromLong(18); if (unlikely(!__pyx_int_18)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_35 = PyInt_FromLong(35); if (unlikely(!__pyx_int_35)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_64 = PyInt_FromLong(64); if (unlikely(!__pyx_int_64)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_21667264 = PyInt_FromLong(21667264L); if (unlikely(!__pyx_int_21667264)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_139192863 = PyInt_FromLong(139192863L); if (unlikely(!__pyx_int_139192863)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_243541226 = PyInt_FromLong(243541226L); if (unlikely(!__pyx_int_243541226)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_neg_1 = PyInt_FromLong(-1); if (unlikely(!__pyx_int_neg_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  return 0;
  __pyx_L1_error:;
  return -1;
}
/* #### Code section: init_globals ### */

static CYTHON_SMALL_CODE int __Pyx_InitGlobals(void) {
  /* AssertionsEnabled.init */
  if (likely(__Pyx_init_assertions_enabled() == 0)); else

if (unlikely(PyErr_Occurred())) __PYX_ERR(0, 1, __pyx_L1_error)

  return 0;
  __pyx_L1_error:;
  return -1;
}
/* #### Code section: init_module ### */

static CYTHON_SMALL_CODE int __Pyx_modinit_global_init_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_variable_export_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_function_export_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_type_init_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_type_import_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_variable_import_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_function_import_code(void); /*proto*/

static int __Pyx_modinit_global_init_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_global_init_code", 0);
  /*--- Global init code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_variable_export_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_variable_export_code", 0);
  /*--- Variable export code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_function_export_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_function_export_code", 0);
  /*--- Function export code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_type_init_code(void) {
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__Pyx_modinit_type_init_code", 0);
  /*--- Type init code ---*/
  __pyx_vtabptr_5pysam_9libctabix_tabix_file_iterator = &__pyx_vtable_5pysam_9libctabix_tabix_file_iterator;
  __pyx_vtable_5pysam_9libctabix_tabix_file_iterator.__pyx___cnext__ = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_tabix_file_iterator *))__pyx_f_5pysam_9libctabix_19tabix_file_iterator___cnext__;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_ptype_5pysam_9libctabix_tabix_file_iterator = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_tabix_file_iterator_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libctabix_tabix_file_iterator)) __PYX_ERR(0, 1100, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_tabix_file_iterator_spec, __pyx_ptype_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_tabix_file_iterator = &__pyx_type_5pysam_9libctabix_tabix_file_iterator;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_tabix_file_iterator->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_tabix_file_iterator->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_tabix_file_iterator->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_tabix_file_iterator->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_tabix_file_iterator, __pyx_vtabptr_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_tabix_file_iterator, (PyObject *) __pyx_ptype_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_tabix_file_iterator) < 0) __PYX_ERR(0, 1100, __pyx_L1_error)
  #endif
  __pyx_t_1 = PyImport_ImportModule("pysam.libchtslib"); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_5pysam_10libchtslib_HTSFile = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libchtslib", "HTSFile", sizeof(struct __pyx_obj_5pysam_10libchtslib_HTSFile), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_10libchtslib_HTSFile),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_10libchtslib_HTSFile) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_vtabptr_5pysam_10libchtslib_HTSFile = (struct __pyx_vtabstruct_5pysam_10libchtslib_HTSFile*)__Pyx_GetVtable(__pyx_ptype_5pysam_10libchtslib_HTSFile); if (unlikely(!__pyx_vtabptr_5pysam_10libchtslib_HTSFile)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_vtabptr_5pysam_9libctabix_TabixFile = &__pyx_vtable_5pysam_9libctabix_TabixFile;
  __pyx_vtable_5pysam_9libctabix_TabixFile.__pyx_base = *__pyx_vtabptr_5pysam_10libchtslib_HTSFile;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_10libchtslib_HTSFile); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 287, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_TabixFile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_TabixFile_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_TabixFile)) __PYX_ERR(0, 287, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_TabixFile_spec, __pyx_ptype_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_TabixFile = &__pyx_type_5pysam_9libctabix_TabixFile;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_TabixFile->tp_base = __pyx_ptype_5pysam_10libchtslib_HTSFile;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_TabixFile->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_TabixFile->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_TabixFile->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_TabixFile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_TabixFile, __pyx_vtabptr_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_TabixFile, (PyObject *) __pyx_ptype_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_TabixFile) < 0) __PYX_ERR(0, 287, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_Parser = &__pyx_vtable_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_Parser.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_6Parser_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_ptype_5pysam_9libctabix_Parser = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_Parser_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libctabix_Parser)) __PYX_ERR(0, 82, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_Parser_spec, __pyx_ptype_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_Parser = &__pyx_type_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_Parser->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_Parser->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_Parser->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_Parser->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_Parser, __pyx_vtabptr_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_Parser, (PyObject *) __pyx_ptype_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_Parser) < 0) __PYX_ERR(0, 82, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_asTuple = &__pyx_vtable_5pysam_9libctabix_asTuple;
  __pyx_vtable_5pysam_9libctabix_asTuple.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_asTuple.__pyx_base.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_7asTuple_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_Parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 101, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_asTuple = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_asTuple_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_asTuple)) __PYX_ERR(0, 101, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_asTuple_spec, __pyx_ptype_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_asTuple = &__pyx_type_5pysam_9libctabix_asTuple;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_asTuple->tp_base = __pyx_ptype_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_asTuple->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_asTuple->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_asTuple->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_asTuple->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_asTuple, __pyx_vtabptr_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_asTuple, (PyObject *) __pyx_ptype_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_asTuple) < 0) __PYX_ERR(0, 101, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_asGTF = &__pyx_vtable_5pysam_9libctabix_asGTF;
  __pyx_vtable_5pysam_9libctabix_asGTF.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_asGTF.__pyx_base.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_5asGTF_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_Parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 151, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_asGTF = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_asGTF_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_asGTF)) __PYX_ERR(0, 151, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_asGTF_spec, __pyx_ptype_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_asGTF = &__pyx_type_5pysam_9libctabix_asGTF;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_asGTF->tp_base = __pyx_ptype_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_asGTF->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_asGTF->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_asGTF->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_asGTF->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_asGTF, __pyx_vtabptr_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_asGTF, (PyObject *) __pyx_ptype_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_asGTF) < 0) __PYX_ERR(0, 151, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_asGFF3 = &__pyx_vtable_5pysam_9libctabix_asGFF3;
  __pyx_vtable_5pysam_9libctabix_asGFF3.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_asGFF3.__pyx_base.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_6asGFF3_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_Parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_asGFF3 = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_asGFF3_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_asGFF3)) __PYX_ERR(0, 115, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_asGFF3_spec, __pyx_ptype_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_asGFF3 = &__pyx_type_5pysam_9libctabix_asGFF3;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_asGFF3->tp_base = __pyx_ptype_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_asGFF3->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_asGFF3->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_asGFF3->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_asGFF3->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_asGFF3, __pyx_vtabptr_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_asGFF3, (PyObject *) __pyx_ptype_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_asGFF3) < 0) __PYX_ERR(0, 115, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_asBed = &__pyx_vtable_5pysam_9libctabix_asBed;
  __pyx_vtable_5pysam_9libctabix_asBed.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_asBed.__pyx_base.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_5asBed_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_Parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 198, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_asBed = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_asBed_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_asBed)) __PYX_ERR(0, 198, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_asBed_spec, __pyx_ptype_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_asBed = &__pyx_type_5pysam_9libctabix_asBed;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_asBed->tp_base = __pyx_ptype_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_asBed->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_asBed->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_asBed->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_asBed->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_asBed, __pyx_vtabptr_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_asBed, (PyObject *) __pyx_ptype_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_asBed) < 0) __PYX_ERR(0, 198, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_asVCF = &__pyx_vtable_5pysam_9libctabix_asVCF;
  __pyx_vtable_5pysam_9libctabix_asVCF.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_Parser;
  __pyx_vtable_5pysam_9libctabix_asVCF.__pyx_base.parse = (PyObject *(*)(struct __pyx_obj_5pysam_9libctabix_Parser *, char *, int))__pyx_f_5pysam_9libctabix_5asVCF_parse;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_Parser); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 246, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_asVCF = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_asVCF_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_asVCF)) __PYX_ERR(0, 246, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_asVCF_spec, __pyx_ptype_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_asVCF = &__pyx_type_5pysam_9libctabix_asVCF;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_asVCF->tp_base = __pyx_ptype_5pysam_9libctabix_Parser;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_asVCF->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_asVCF->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_asVCF->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_asVCF->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_asVCF, __pyx_vtabptr_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_asVCF, (PyObject *) __pyx_ptype_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_asVCF) < 0) __PYX_ERR(0, 246, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_TabixIterator = &__pyx_vtable_5pysam_9libctabix_TabixIterator;
  __pyx_vtable_5pysam_9libctabix_TabixIterator.__pyx___cnext__ = (int (*)(struct __pyx_obj_5pysam_9libctabix_TabixIterator *))__pyx_f_5pysam_9libctabix_13TabixIterator___cnext__;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_ptype_5pysam_9libctabix_TabixIterator = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_TabixIterator_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libctabix_TabixIterator)) __PYX_ERR(0, 619, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_TabixIterator_spec, __pyx_ptype_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_TabixIterator = &__pyx_type_5pysam_9libctabix_TabixIterator;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_TabixIterator->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_TabixIterator->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_TabixIterator->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_TabixIterator->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIterator, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 619, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_13TabixIterator_4__next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_13TabixIterator_4__next__.doc = __pyx_doc_5pysam_9libctabix_13TabixIterator_4__next__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_13TabixIterator_4__next__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_TabixIterator, __pyx_vtabptr_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_TabixIterator, (PyObject *) __pyx_ptype_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_TabixIterator) < 0) __PYX_ERR(0, 619, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_TabixIteratorParsed = &__pyx_vtable_5pysam_9libctabix_TabixIteratorParsed;
  __pyx_vtable_5pysam_9libctabix_TabixIteratorParsed.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_TabixIterator;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 692, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_TabixIteratorParsed_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed)) __PYX_ERR(0, 692, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_TabixIteratorParsed_spec, __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed = &__pyx_type_5pysam_9libctabix_TabixIteratorParsed;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed->tp_base = __pyx_ptype_5pysam_9libctabix_TabixIterator;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 692, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_19TabixIteratorParsed_2__next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_19TabixIteratorParsed_2__next__.doc = __pyx_doc_5pysam_9libctabix_19TabixIteratorParsed_2__next__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_19TabixIteratorParsed_2__next__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed, __pyx_vtabptr_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_TabixIteratorParsed, (PyObject *) __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_TabixIteratorParsed) < 0) __PYX_ERR(0, 692, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_GZIterator = &__pyx_vtable_5pysam_9libctabix_GZIterator;
  __pyx_vtable_5pysam_9libctabix_GZIterator.__pyx___cnext__ = (int (*)(struct __pyx_obj_5pysam_9libctabix_GZIterator *))__pyx_f_5pysam_9libctabix_10GZIterator___cnext__;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_ptype_5pysam_9libctabix_GZIterator = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_GZIterator_spec, NULL); if (unlikely(!__pyx_ptype_5pysam_9libctabix_GZIterator)) __PYX_ERR(0, 722, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_GZIterator_spec, __pyx_ptype_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_GZIterator = &__pyx_type_5pysam_9libctabix_GZIterator;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_GZIterator->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_GZIterator->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_GZIterator->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_GZIterator->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_GZIterator, "__init__"); if (unlikely(!wrapper)) __PYX_ERR(0, 722, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_10GZIterator___init__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_10GZIterator___init__.doc = __pyx_doc_5pysam_9libctabix_10GZIterator___init__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_10GZIterator___init__;
    }
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_GZIterator, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 722, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_10GZIterator_6__next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_10GZIterator_6__next__.doc = __pyx_doc_5pysam_9libctabix_10GZIterator_6__next__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_10GZIterator_6__next__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_GZIterator, __pyx_vtabptr_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_GZIterator, (PyObject *) __pyx_ptype_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_GZIterator) < 0) __PYX_ERR(0, 722, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_GZIteratorHead = &__pyx_vtable_5pysam_9libctabix_GZIteratorHead;
  __pyx_vtable_5pysam_9libctabix_GZIteratorHead.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_GZIterator;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_GZIterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 777, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_GZIteratorHead = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_GZIteratorHead_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_GZIteratorHead)) __PYX_ERR(0, 777, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_GZIteratorHead_spec, __pyx_ptype_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_GZIteratorHead = &__pyx_type_5pysam_9libctabix_GZIteratorHead;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_GZIteratorHead->tp_base = __pyx_ptype_5pysam_9libctabix_GZIterator;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_GZIteratorHead->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_GZIteratorHead->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_GZIteratorHead->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_GZIteratorHead->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_GZIteratorHead, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 777, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_14GZIteratorHead___next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_14GZIteratorHead___next__.doc = __pyx_doc_5pysam_9libctabix_14GZIteratorHead___next__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_14GZIteratorHead___next__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_GZIteratorHead, __pyx_vtabptr_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_GZIteratorHead, (PyObject *) __pyx_ptype_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_GZIteratorHead) < 0) __PYX_ERR(0, 777, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_GZIteratorParsed = &__pyx_vtable_5pysam_9libctabix_GZIteratorParsed;
  __pyx_vtable_5pysam_9libctabix_GZIteratorParsed.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_GZIterator;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_GZIterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 794, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_GZIteratorParsed = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_GZIteratorParsed_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_GZIteratorParsed)) __PYX_ERR(0, 794, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_GZIteratorParsed_spec, __pyx_ptype_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_GZIteratorParsed = &__pyx_type_5pysam_9libctabix_GZIteratorParsed;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_GZIteratorParsed->tp_base = __pyx_ptype_5pysam_9libctabix_GZIterator;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_GZIteratorParsed->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_GZIteratorParsed->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_GZIteratorParsed->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_GZIteratorParsed->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  #if CYTHON_UPDATE_DESCRIPTOR_DOC
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)__pyx_ptype_5pysam_9libctabix_GZIteratorParsed, "__next__"); if (unlikely(!wrapper)) __PYX_ERR(0, 794, __pyx_L1_error)
    if (__Pyx_IS_TYPE(wrapper, &PyWrapperDescr_Type)) {
      __pyx_wrapperbase_5pysam_9libctabix_16GZIteratorParsed_2__next__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5pysam_9libctabix_16GZIteratorParsed_2__next__.doc = __pyx_doc_5pysam_9libctabix_16GZIteratorParsed_2__next__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5pysam_9libctabix_16GZIteratorParsed_2__next__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_GZIteratorParsed, __pyx_vtabptr_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_GZIteratorParsed, (PyObject *) __pyx_ptype_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_GZIteratorParsed) < 0) __PYX_ERR(0, 794, __pyx_L1_error)
  #endif
  __pyx_vtabptr_5pysam_9libctabix_Tabixfile = &__pyx_vtable_5pysam_9libctabix_Tabixfile;
  __pyx_vtable_5pysam_9libctabix_Tabixfile.__pyx_base = *__pyx_vtabptr_5pysam_9libctabix_TabixFile;
  #if CYTHON_USE_TYPE_SPECS
  __pyx_t_2 = PyTuple_Pack(1, (PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1253, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_ptype_5pysam_9libctabix_Tabixfile = (PyTypeObject *) __Pyx_PyType_FromModuleAndSpec(__pyx_m, &__pyx_type_5pysam_9libctabix_Tabixfile_spec, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_ptype_5pysam_9libctabix_Tabixfile)) __PYX_ERR(0, 1253, __pyx_L1_error)
  if (__Pyx_fix_up_extension_type_from_spec(&__pyx_type_5pysam_9libctabix_Tabixfile_spec, __pyx_ptype_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #else
  __pyx_ptype_5pysam_9libctabix_Tabixfile = &__pyx_type_5pysam_9libctabix_Tabixfile;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  __pyx_ptype_5pysam_9libctabix_Tabixfile->tp_base = __pyx_ptype_5pysam_9libctabix_TabixFile;
  #endif
  #if !CYTHON_USE_TYPE_SPECS
  if (__Pyx_PyType_Ready(__pyx_ptype_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #endif
  #if PY_MAJOR_VERSION < 3
  __pyx_ptype_5pysam_9libctabix_Tabixfile->tp_print = 0;
  #endif
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_ptype_5pysam_9libctabix_Tabixfile->tp_dictoffset && __pyx_ptype_5pysam_9libctabix_Tabixfile->tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_ptype_5pysam_9libctabix_Tabixfile->tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #endif
  if (__Pyx_SetVtable(__pyx_ptype_5pysam_9libctabix_Tabixfile, __pyx_vtabptr_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_MergeVtables(__pyx_ptype_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #endif
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_Tabixfile, (PyObject *) __pyx_ptype_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #if !CYTHON_COMPILING_IN_LIMITED_API
  if (__Pyx_setup_reduce((PyObject *) __pyx_ptype_5pysam_9libctabix_Tabixfile) < 0) __PYX_ERR(0, 1253, __pyx_L1_error)
  #endif
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_RefNannyFinishContext();
  return -1;
}

static int __Pyx_modinit_type_import_code(void) {
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__Pyx_modinit_type_import_code", 0);
  /*--- Type import code ---*/
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(5, 9, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_4type_type = __Pyx_ImportType_3_0_2(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "type", 
  #if defined(PYPY_VERSION_NUM) && PYPY_VERSION_NUM < 0x050B0000
  sizeof(PyTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(PyTypeObject),
  #elif CYTHON_COMPILING_IN_LIMITED_API
  sizeof(PyTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(PyTypeObject),
  #else
  sizeof(PyHeapTypeObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(PyHeapTypeObject),
  #endif
  __Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_7cpython_4type_type) __PYX_ERR(5, 9, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(6, 8, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_4bool_bool = __Pyx_ImportType_3_0_2(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "bool", sizeof(PyBoolObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(PyBoolObject),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_7cpython_4bool_bool) __PYX_ERR(6, 8, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(7, 15, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_7complex_complex = __Pyx_ImportType_3_0_2(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "complex", sizeof(PyComplexObject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(PyComplexObject),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_7cpython_7complex_complex) __PYX_ERR(7, 15, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule("pysam.libctabixproxies"); if (unlikely(!__pyx_t_1)) __PYX_ERR(8, 5, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_5pysam_16libctabixproxies_TupleProxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "TupleProxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_TupleProxy) __PYX_ERR(8, 5, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_TupleProxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_TupleProxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_TupleProxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_TupleProxy)) __PYX_ERR(8, 5, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "TupleProxyIterator", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxyIterator), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_TupleProxyIterator),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_TupleProxyIterator) __PYX_ERR(8, 27, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "NamedTupleProxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_NamedTupleProxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy) __PYX_ERR(8, 32, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_NamedTupleProxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_NamedTupleProxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_NamedTupleProxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_NamedTupleProxy)) __PYX_ERR(8, 32, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_GTFProxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "GTFProxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_GTFProxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_GTFProxy) __PYX_ERR(8, 36, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_GTFProxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_GTFProxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_GTFProxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_GTFProxy)) __PYX_ERR(8, 36, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "GFF3Proxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_GFF3Proxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy) __PYX_ERR(8, 42, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_GFF3Proxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_GFF3Proxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_GFF3Proxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_GFF3Proxy)) __PYX_ERR(8, 42, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_BedProxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "BedProxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_BedProxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_BedProxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_BedProxy) __PYX_ERR(8, 46, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_BedProxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_BedProxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_BedProxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_BedProxy)) __PYX_ERR(8, 46, __pyx_L1_error)
  __pyx_ptype_5pysam_16libctabixproxies_VCFProxy = __Pyx_ImportType_3_0_2(__pyx_t_1, "pysam.libctabixproxies", "VCFProxy", sizeof(struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(struct __pyx_obj_5pysam_16libctabixproxies_VCFProxy),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_5pysam_16libctabixproxies_VCFProxy) __PYX_ERR(8, 58, __pyx_L1_error)
  __pyx_vtabptr_5pysam_16libctabixproxies_VCFProxy = (struct __pyx_vtabstruct_5pysam_16libctabixproxies_VCFProxy*)__Pyx_GetVtable(__pyx_ptype_5pysam_16libctabixproxies_VCFProxy); if (unlikely(!__pyx_vtabptr_5pysam_16libctabixproxies_VCFProxy)) __PYX_ERR(8, 58, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule("array"); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 69, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_5array_array = __Pyx_ImportType_3_0_2(__pyx_t_1, "array", "array", sizeof(arrayobject), __PYX_GET_STRUCT_ALIGNMENT_3_0_2(arrayobject),__Pyx_ImportType_CheckSize_Warn_3_0_2); if (!__pyx_ptype_7cpython_5array_array) __PYX_ERR(3, 69, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_RefNannyFinishContext();
  return -1;
}

static int __Pyx_modinit_variable_import_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_variable_import_code", 0);
  /*--- Variable import code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_function_import_code(void) {
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannySetupContext("__Pyx_modinit_function_import_code", 0);
  /*--- Function import code ---*/
  __pyx_t_1 = PyImport_ImportModule("pysam.libcutils"); if (!__pyx_t_1) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (__Pyx_ImportFunction_3_0_2(__pyx_t_1, "charptr_to_str", (void (**)(void))&__pyx_f_5pysam_9libcutils_charptr_to_str, "PyObject *(char const *, struct __pyx_opt_args_5pysam_9libcutils_charptr_to_str *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  if (__Pyx_ImportFunction_3_0_2(__pyx_t_1, "force_str", (void (**)(void))&__pyx_f_5pysam_9libcutils_force_str, "PyObject *(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_str *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  if (__Pyx_ImportFunction_3_0_2(__pyx_t_1, "force_bytes", (void (**)(void))&__pyx_f_5pysam_9libcutils_force_bytes, "PyObject *(PyObject *, struct __pyx_opt_args_5pysam_9libcutils_force_bytes *__pyx_optional_args)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  if (__Pyx_ImportFunction_3_0_2(__pyx_t_1, "encode_filename", (void (**)(void))&__pyx_f_5pysam_9libcutils_encode_filename, "PyObject *(PyObject *)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  if (__Pyx_ImportFunction_3_0_2(__pyx_t_1, "from_string_and_size", (void (**)(void))&__pyx_f_5pysam_9libcutils_from_string_and_size, "PyObject *(char const *, size_t)") < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_RefNannyFinishContext();
  return -1;
}


#if PY_MAJOR_VERSION >= 3
#if CYTHON_PEP489_MULTI_PHASE_INIT
static PyObject* __pyx_pymod_create(PyObject *spec, PyModuleDef *def); /*proto*/
static int __pyx_pymod_exec_libctabix(PyObject* module); /*proto*/
static PyModuleDef_Slot __pyx_moduledef_slots[] = {
  {Py_mod_create, (void*)__pyx_pymod_create},
  {Py_mod_exec, (void*)__pyx_pymod_exec_libctabix},
  {0, NULL}
};
#endif

#ifdef __cplusplus
namespace {
  struct PyModuleDef __pyx_moduledef =
  #else
  static struct PyModuleDef __pyx_moduledef =
  #endif
  {
      PyModuleDef_HEAD_INIT,
      "libctabix",
      0, /* m_doc */
    #if CYTHON_PEP489_MULTI_PHASE_INIT
      0, /* m_size */
    #elif CYTHON_USE_MODULE_STATE
      sizeof(__pyx_mstate), /* m_size */
    #else
      -1, /* m_size */
    #endif
      __pyx_methods /* m_methods */,
    #if CYTHON_PEP489_MULTI_PHASE_INIT
      __pyx_moduledef_slots, /* m_slots */
    #else
      NULL, /* m_reload */
    #endif
    #if CYTHON_USE_MODULE_STATE
      __pyx_m_traverse, /* m_traverse */
      __pyx_m_clear, /* m_clear */
      NULL /* m_free */
    #else
      NULL, /* m_traverse */
      NULL, /* m_clear */
      NULL /* m_free */
    #endif
  };
  #ifdef __cplusplus
} /* anonymous namespace */
#endif
#endif

#ifndef CYTHON_NO_PYINIT_EXPORT
#define __Pyx_PyMODINIT_FUNC PyMODINIT_FUNC
#elif PY_MAJOR_VERSION < 3
#ifdef __cplusplus
#define __Pyx_PyMODINIT_FUNC extern "C" void
#else
#define __Pyx_PyMODINIT_FUNC void
#endif
#else
#ifdef __cplusplus
#define __Pyx_PyMODINIT_FUNC extern "C" PyObject *
#else
#define __Pyx_PyMODINIT_FUNC PyObject *
#endif
#endif


#if PY_MAJOR_VERSION < 3
__Pyx_PyMODINIT_FUNC initlibctabix(void) CYTHON_SMALL_CODE; /*proto*/
__Pyx_PyMODINIT_FUNC initlibctabix(void)
#else
__Pyx_PyMODINIT_FUNC PyInit_libctabix(void) CYTHON_SMALL_CODE; /*proto*/
__Pyx_PyMODINIT_FUNC PyInit_libctabix(void)
#if CYTHON_PEP489_MULTI_PHASE_INIT
{
  return PyModuleDef_Init(&__pyx_moduledef);
}
static CYTHON_SMALL_CODE int __Pyx_check_single_interpreter(void) {
    #if PY_VERSION_HEX >= 0x030700A1
    static PY_INT64_T main_interpreter_id = -1;
    PY_INT64_T current_id = PyInterpreterState_GetID(PyThreadState_Get()->interp);
    if (main_interpreter_id == -1) {
        main_interpreter_id = current_id;
        return (unlikely(current_id == -1)) ? -1 : 0;
    } else if (unlikely(main_interpreter_id != current_id))
    #else
    static PyInterpreterState *main_interpreter = NULL;
    PyInterpreterState *current_interpreter = PyThreadState_Get()->interp;
    if (!main_interpreter) {
        main_interpreter = current_interpreter;
    } else if (unlikely(main_interpreter != current_interpreter))
    #endif
    {
        PyErr_SetString(
            PyExc_ImportError,
            "Interpreter change detected - this module can only be loaded into one interpreter per process.");
        return -1;
    }
    return 0;
}
#if CYTHON_COMPILING_IN_LIMITED_API
static CYTHON_SMALL_CODE int __Pyx_copy_spec_to_module(PyObject *spec, PyObject *module, const char* from_name, const char* to_name, int allow_none)
#else
static CYTHON_SMALL_CODE int __Pyx_copy_spec_to_module(PyObject *spec, PyObject *moddict, const char* from_name, const char* to_name, int allow_none)
#endif
{
    PyObject *value = PyObject_GetAttrString(spec, from_name);
    int result = 0;
    if (likely(value)) {
        if (allow_none || value != Py_None) {
#if CYTHON_COMPILING_IN_LIMITED_API
            result = PyModule_AddObject(module, to_name, value);
#else
            result = PyDict_SetItemString(moddict, to_name, value);
#endif
        }
        Py_DECREF(value);
    } else if (PyErr_ExceptionMatches(PyExc_AttributeError)) {
        PyErr_Clear();
    } else {
        result = -1;
    }
    return result;
}
static CYTHON_SMALL_CODE PyObject* __pyx_pymod_create(PyObject *spec, PyModuleDef *def) {
    PyObject *module = NULL, *moddict, *modname;
    CYTHON_UNUSED_VAR(def);
    if (__Pyx_check_single_interpreter())
        return NULL;
    if (__pyx_m)
        return __Pyx_NewRef(__pyx_m);
    modname = PyObject_GetAttrString(spec, "name");
    if (unlikely(!modname)) goto bad;
    module = PyModule_NewObject(modname);
    Py_DECREF(modname);
    if (unlikely(!module)) goto bad;
#if CYTHON_COMPILING_IN_LIMITED_API
    moddict = module;
#else
    moddict = PyModule_GetDict(module);
    if (unlikely(!moddict)) goto bad;
#endif
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "loader", "__loader__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "origin", "__file__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "parent", "__package__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "submodule_search_locations", "__path__", 0) < 0)) goto bad;
    return module;
bad:
    Py_XDECREF(module);
    return NULL;
}


static CYTHON_SMALL_CODE int __pyx_pymod_exec_libctabix(PyObject *__pyx_pyinit_module)
#endif
#endif
{
  int stringtab_initialized = 0;
  #if CYTHON_USE_MODULE_STATE
  int pystate_addmodule_run = 0;
  #endif
  __Pyx_TraceDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_lineno = 0;
  const char *__pyx_filename = NULL;
  int __pyx_clineno = 0;
  __Pyx_RefNannyDeclarations
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  if (__pyx_m) {
    if (__pyx_m == __pyx_pyinit_module) return 0;
    PyErr_SetString(PyExc_RuntimeError, "Module 'libctabix' has already been imported. Re-initialisation is not supported.");
    return -1;
  }
  #elif PY_MAJOR_VERSION >= 3
  if (__pyx_m) return __Pyx_NewRef(__pyx_m);
  #endif
  /*--- Module creation code ---*/
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  __pyx_m = __pyx_pyinit_module;
  Py_INCREF(__pyx_m);
  #else
  #if PY_MAJOR_VERSION < 3
  __pyx_m = Py_InitModule4("libctabix", __pyx_methods, 0, 0, PYTHON_API_VERSION); Py_XINCREF(__pyx_m);
  if (unlikely(!__pyx_m)) __PYX_ERR(0, 1, __pyx_L1_error)
  #elif CYTHON_USE_MODULE_STATE
  __pyx_t_1 = PyModule_Create(&__pyx_moduledef); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  {
    int add_module_result = PyState_AddModule(__pyx_t_1, &__pyx_moduledef);
    __pyx_t_1 = 0; /* transfer ownership from __pyx_t_1 to libctabix pseudovariable */
    if (unlikely((add_module_result < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
    pystate_addmodule_run = 1;
  }
  #else
  __pyx_m = PyModule_Create(&__pyx_moduledef);
  if (unlikely(!__pyx_m)) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #endif
  CYTHON_UNUSED_VAR(__pyx_t_1);
  __pyx_d = PyModule_GetDict(__pyx_m); if (unlikely(!__pyx_d)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_d);
  __pyx_b = PyImport_AddModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_b)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_b);
  __pyx_cython_runtime = PyImport_AddModule((char *) "cython_runtime"); if (unlikely(!__pyx_cython_runtime)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_cython_runtime);
  if (PyObject_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #if CYTHON_REFNANNY
__Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
if (!__Pyx_RefNanny) {
  PyErr_Clear();
  __Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
  if (!__Pyx_RefNanny)
      Py_FatalError("failed to import 'refnanny' module");
}
#endif
  __Pyx_RefNannySetupContext("__Pyx_PyMODINIT_FUNC PyInit_libctabix(void)", 0);
  if (__Pyx_check_binary_version() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #ifdef __Pxy_PyFrame_Initialize_Offsets
  __Pxy_PyFrame_Initialize_Offsets();
  #endif
  __pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_empty_unicode = PyUnicode_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_unicode)) __PYX_ERR(0, 1, __pyx_L1_error)
  #ifdef __Pyx_CyFunction_USED
  if (__pyx_CyFunction_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_FusedFunction_USED
  if (__pyx_FusedFunction_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_Coroutine_USED
  if (__pyx_Coroutine_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_Generator_USED
  if (__pyx_Generator_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_AsyncGen_USED
  if (__pyx_AsyncGen_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_StopAsyncIteration_USED
  if (__pyx_StopAsyncIteration_init(__pyx_m) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  /*--- Library function declarations ---*/
  /*--- Threads initialization code ---*/
  #if defined(WITH_THREAD) && PY_VERSION_HEX < 0x030700F0 && defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
  PyEval_InitThreads();
  #endif
  /*--- Initialize various global constants etc. ---*/
  if (__Pyx_InitConstants() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  stringtab_initialized = 1;
  if (__Pyx_InitGlobals() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #if PY_MAJOR_VERSION < 3 && (__PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT)
  if (__Pyx_init_sys_getdefaultencoding_params() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  if (__pyx_module_is_main_pysam__libctabix) {
    if (PyObject_SetAttr(__pyx_m, __pyx_n_s_name, __pyx_n_s_main) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  }
  #if PY_MAJOR_VERSION >= 3
  {
    PyObject *modules = PyImport_GetModuleDict(); if (unlikely(!modules)) __PYX_ERR(0, 1, __pyx_L1_error)
    if (!PyDict_GetItemString(modules, "pysam.libctabix")) {
      if (unlikely((PyDict_SetItemString(modules, "pysam.libctabix", __pyx_m) < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
    }
  }
  #endif
  /*--- Builtin init code ---*/
  if (__Pyx_InitCachedBuiltins() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  /*--- Constants init code ---*/
  if (__Pyx_InitCachedConstants() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  /*--- Global type/function init code ---*/
  (void)__Pyx_modinit_global_init_code();
  (void)__Pyx_modinit_variable_export_code();
  (void)__Pyx_modinit_function_export_code();
  if (unlikely((__Pyx_modinit_type_init_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
  if (unlikely((__Pyx_modinit_type_import_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
  (void)__Pyx_modinit_variable_import_code();
  if (unlikely((__Pyx_modinit_function_import_code() < 0))) __PYX_ERR(0, 1, __pyx_L1_error)
  /*--- Execution code ---*/
  #if defined(__Pyx_Generator_USED) || defined(__Pyx_Coroutine_USED)
  if (__Pyx_patch_abc() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  __Pyx_TraceCall("__Pyx_PyMODINIT_FUNC PyInit_libctabix(void)", __pyx_f[0], 1, 0, __PYX_ERR(0, 1, __pyx_L1_error));

  /* "pysam/libctabix.pyx":57
 * #
 * ###############################################################################
 * import os             # <<<<<<<<<<<<<<
 * import sys
 * 
 */
  __pyx_t_2 = __Pyx_ImportDottedModule(__pyx_n_s_os, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 57, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_os, __pyx_t_2) < 0) __PYX_ERR(0, 57, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":58
 * ###############################################################################
 * import os
 * import sys             # <<<<<<<<<<<<<<
 * 
 * from libc.stdio cimport printf, fprintf, stderr
 */
  __pyx_t_2 = __Pyx_ImportDottedModule(__pyx_n_s_sys, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 58, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_sys, __pyx_t_2) < 0) __PYX_ERR(0, 58, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":87
 *         self.encoding = encoding
 * 
 *     def set_encoding(self, encoding):             # <<<<<<<<<<<<<<
 *         self.encoding = encoding
 * 
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6Parser_3set_encoding, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Parser_set_encoding, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj_)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 87, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_Parser, __pyx_n_s_set_encoding, __pyx_t_2) < 0) __PYX_ERR(0, 87, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_Parser);

  /* "pysam/libctabix.pyx":90
 *         self.encoding = encoding
 * 
 *     def get_encoding(self):             # <<<<<<<<<<<<<<
 *         return self.encoding
 * 
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6Parser_5get_encoding, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Parser_get_encoding, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__2)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 90, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_Parser, __pyx_n_s_get_encoding, __pyx_t_2) < 0) __PYX_ERR(0, 90, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_Parser);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6Parser_9__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Parser___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__3)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_Parser, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_Parser);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_Parser, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_Parser__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6Parser_11__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Parser___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__4)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_Parser, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_Parser);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_7asTuple_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asTuple___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__5)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asTuple, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asTuple);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asTuple, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asTuple__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_7asTuple_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asTuple___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__6)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asTuple, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asTuple);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6asGFF3_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asGFF3___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__7)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asGFF3, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asGFF3);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGFF3, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGFF3__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_6asGFF3_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asGFF3___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__8)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asGFF3, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asGFF3);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asGTF_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asGTF___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__9)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asGTF, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asGTF);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asGTF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asGTF__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asGTF_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asGTF___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__10)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asGTF, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asGTF);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asBed_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asBed___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__11)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asBed, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asBed);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asBed, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asBed__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asBed_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asBed___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__12)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asBed, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asBed);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     cdef tuple state
 *     cdef object _dict
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asVCF_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asVCF___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__13)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asVCF, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asVCF);

  /* "(tree fragment)":16
 *     else:
 *         return __pyx_unpickle_asVCF, (type(self), 0xe8424ea, state)
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_unpickle_asVCF__set_state(self, __pyx_state)
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5asVCF_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_asVCF___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__14)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_asVCF, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 16, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_asVCF);

  /* "pysam/libctabix.pyx":352
 *         self.encoding = encoding
 * 
 *     def _open( self,             # <<<<<<<<<<<<<<
 *                filename,
 *                mode='r',
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_3_open, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile__open, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__15)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 352, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__68);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile, __pyx_n_s_open, __pyx_t_2) < 0) __PYX_ERR(0, 352, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_TabixFile);

  /* "pysam/libctabix.pyx":404
 *             self.start_offset = self.tell()
 * 
 *     def _dup(self):             # <<<<<<<<<<<<<<
 *         '''return a copy of this tabix file.
 * 
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_5_dup, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile__dup, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__17)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 404, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile, __pyx_n_s_dup, __pyx_t_2) < 0) __PYX_ERR(0, 404, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_TabixFile);

  /* "pysam/libctabix.pyx":416
 *                          encoding=self.encoding)
 * 
 *     def fetch(self,             # <<<<<<<<<<<<<<
 *               reference=None,
 *               start=None,
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_7fetch, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile_fetch, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__18)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 416, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__70);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile, __pyx_n_s_fetch, __pyx_t_2) < 0) __PYX_ERR(0, 416, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_TabixFile);

  /* "pysam/libctabix.pyx":598
 *             return result
 * 
 *     def close(self):             # <<<<<<<<<<<<<<
 *         '''
 *         closes the :class:`pysam.TabixFile`.'''
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_9close, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile_close, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__21)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 598, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (__Pyx_SetItemOnTypeDict((PyObject *)__pyx_ptype_5pysam_9libctabix_TabixFile, __pyx_n_s_close, __pyx_t_2) < 0) __PYX_ERR(0, 598, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  PyType_Modified(__pyx_ptype_5pysam_9libctabix_TabixFile);

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_13__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__22)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9TabixFile_15__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixFile___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__23)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_13TabixIterator_9__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixIterator___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__25)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_13TabixIterator_11__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixIterator___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__26)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":682
 * 
 * 
 * class EmptyIterator:             # <<<<<<<<<<<<<<
 *     '''empty iterator'''
 * 
 */
  __pyx_t_2 = __Pyx_Py3MetaclassPrepare((PyObject *) NULL, __pyx_empty_tuple, __pyx_n_s_EmptyIterator, __pyx_n_s_EmptyIterator, (PyObject *) NULL, __pyx_n_s_pysam_libctabix, __pyx_kp_s_empty_iterator); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 682, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);

  /* "pysam/libctabix.pyx":685
 *     '''empty iterator'''
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_13EmptyIterator_1__iter__, 0, __pyx_n_s_EmptyIterator___iter, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__27)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 685, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (__Pyx_SetNameInClass(__pyx_t_2, __pyx_n_s_iter, __pyx_t_3) < 0) __PYX_ERR(0, 685, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":688
 *         return self
 * 
 *     def __next__(self):             # <<<<<<<<<<<<<<
 *         raise StopIteration()
 * 
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_13EmptyIterator_3__next__, 0, __pyx_n_s_EmptyIterator___next, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__28)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 688, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (__Pyx_SetNameInClass(__pyx_t_2, __pyx_n_s_next, __pyx_t_3) < 0) __PYX_ERR(0, 688, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":682
 * 
 * 
 * class EmptyIterator:             # <<<<<<<<<<<<<<
 *     '''empty iterator'''
 * 
 */
  __pyx_t_3 = __Pyx_Py3ClassCreate(((PyObject*)&PyType_Type), __pyx_n_s_EmptyIterator, __pyx_empty_tuple, __pyx_t_2, NULL, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 682, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_EmptyIterator, __pyx_t_3) < 0) __PYX_ERR(0, 682, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_19TabixIteratorParsed_5__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixIteratorParsed___reduce_cyt, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__29)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.iterator cannot be converted to a Python object for pickling"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_19TabixIteratorParsed_7__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_TabixIteratorParsed___setstate_c, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__30)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_10GZIterator_9__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIterator___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__31)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_10GZIterator_11__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIterator___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__32)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_14GZIteratorHead_3__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIteratorHead___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__33)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_14GZIteratorHead_5__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIteratorHead___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__34)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_16GZIteratorParsed_5__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIteratorParsed___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__35)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_2) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "self.gzipfile,self.kstream cannot be converted to a Python object for pickling"
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_16GZIteratorParsed_7__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_GZIteratorParsed___setstate_cyth, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__36)); if (unlikely(!__pyx_t_2)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_2) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":813
 * 
 * 
 * def tabix_compress(filename_in,             # <<<<<<<<<<<<<<
 *                    filename_out,
 *                    force=False):
 */
  __pyx_t_2 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_1tabix_compress, 0, __pyx_n_s_tabix_compress, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__37)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_CyFunction_SetDefaultsTuple(__pyx_t_2, __pyx_tuple__72);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_tabix_compress, __pyx_t_2) < 0) __PYX_ERR(0, 813, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "pysam/libctabix.pyx":882
 *                 preset=None,
 *                 meta_char="#",
 *                 int line_skip=0,             # <<<<<<<<<<<<<<
 *                 zerobased=False,
 *                 int min_shift=-1,
 */
  __pyx_t_2 = __Pyx_PyInt_From_int(((int)0)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 882, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);

  /* "pysam/libctabix.pyx":884
 *                 int line_skip=0,
 *                 zerobased=False,
 *                 int min_shift=-1,             # <<<<<<<<<<<<<<
 *                 index=None,
 *                 keep_original=False,
 */
  __pyx_t_3 = __Pyx_PyInt_From_int(((int)-1)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 884, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);

  /* "pysam/libctabix.pyx":875
 * 
 * 
 * def tabix_index(filename,             # <<<<<<<<<<<<<<
 *                 force=False,
 *                 seq_col=None,
 */
  __pyx_t_4 = PyTuple_New(12); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_INCREF(((PyObject *)Py_False));
  __Pyx_GIVEREF(((PyObject *)Py_False));
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 0, ((PyObject *)Py_False))) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 1, Py_None)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 2, Py_None)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 3, Py_None)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 4, Py_None)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(((PyObject*)__pyx_kp_u__39));
  __Pyx_GIVEREF(((PyObject*)__pyx_kp_u__39));
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 5, ((PyObject*)__pyx_kp_u__39))) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_GIVEREF(__pyx_t_2);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 6, __pyx_t_2)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(((PyObject *)Py_False));
  __Pyx_GIVEREF(((PyObject *)Py_False));
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 7, ((PyObject *)Py_False))) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_GIVEREF(__pyx_t_3);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 8, __pyx_t_3)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 9, Py_None)) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(((PyObject *)Py_False));
  __Pyx_GIVEREF(((PyObject *)Py_False));
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 10, ((PyObject *)Py_False))) __PYX_ERR(0, 875, __pyx_L1_error);
  __Pyx_INCREF(((PyObject *)Py_False));
  __Pyx_GIVEREF(((PyObject *)Py_False));
  if (__Pyx_PyTuple_SET_ITEM(__pyx_t_4, 11, ((PyObject *)Py_False))) __PYX_ERR(0, 875, __pyx_L1_error);
  __pyx_t_2 = 0;
  __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_3tabix_index, 0, __pyx_n_s_tabix_index, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__40)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_CyFunction_SetDefaultsTuple(__pyx_t_3, __pyx_t_4);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_tabix_index, __pyx_t_3) < 0) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_19tabix_file_iterator_9__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_tabix_file_iterator___reduce_cyt, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__46)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_19tabix_file_iterator_11__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_tabix_file_iterator___setstate_c, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__47)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_3) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":1180
 * 
 * 
 * class tabix_generic_iterator:             # <<<<<<<<<<<<<<
 *     '''iterate over ``infile``.
 * 
 */
  __pyx_t_3 = __Pyx_Py3MetaclassPrepare((PyObject *) NULL, __pyx_empty_tuple, __pyx_n_s_tabix_generic_iterator, __pyx_n_s_tabix_generic_iterator, (PyObject *) NULL, __pyx_n_s_pysam_libctabix, __pyx_kp_s_iterate_over_infile_Permits_the); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);

  /* "pysam/libctabix.pyx":1185
 *     Permits the use of file-like objects for example from the gzip module.
 *     '''
 *     def __init__(self, infile, parser):             # <<<<<<<<<<<<<<
 * 
 *         self.infile = infile
 */
  __pyx_t_4 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_1__init__, 0, __pyx_n_s_tabix_generic_iterator___init, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__48)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1185, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (__Pyx_SetNameInClass(__pyx_t_3, __pyx_n_s_init, __pyx_t_4) < 0) __PYX_ERR(0, 1185, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "pysam/libctabix.pyx":1192
 *         self.parser = parser
 * 
 *     def __iter__(self):             # <<<<<<<<<<<<<<
 *         return self
 * 
 */
  __pyx_t_4 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_3__iter__, 0, __pyx_n_s_tabix_generic_iterator___iter, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__49)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1192, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (__Pyx_SetNameInClass(__pyx_t_3, __pyx_n_s_iter, __pyx_t_4) < 0) __PYX_ERR(0, 1192, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "pysam/libctabix.pyx":1196
 * 
 *     # cython version - required for python 3
 *     def __next__(self):             # <<<<<<<<<<<<<<
 * 
 *         cdef char * b
 */
  __pyx_t_4 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_22tabix_generic_iterator_5__next__, 0, __pyx_n_s_tabix_generic_iterator___next, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__50)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1196, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (__Pyx_SetNameInClass(__pyx_t_3, __pyx_n_s_next, __pyx_t_4) < 0) __PYX_ERR(0, 1196, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "pysam/libctabix.pyx":1180
 * 
 * 
 * class tabix_generic_iterator:             # <<<<<<<<<<<<<<
 *     '''iterate over ``infile``.
 * 
 */
  __pyx_t_4 = __Pyx_Py3ClassCreate(((PyObject*)&PyType_Type), __pyx_n_s_tabix_generic_iterator, __pyx_empty_tuple, __pyx_t_3, NULL, 0, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_tabix_generic_iterator, __pyx_t_4) < 0) __PYX_ERR(0, 1180, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":1240
 * 
 * 
 * def tabix_iterator(infile, parser):             # <<<<<<<<<<<<<<
 *     """return an iterator over all entries in a file.
 * 
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_5tabix_iterator, 0, __pyx_n_s_tabix_iterator, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__51)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1240, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_tabix_iterator, __pyx_t_3) < 0) __PYX_ERR(0, 1240, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9Tabixfile_1__reduce_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Tabixfile___reduce_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__52)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_reduce_cython, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError, "no default __reduce__ due to non-trivial __cinit__"
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9Tabixfile_3__setstate_cython__, __Pyx_CYFUNCTION_CCLASS, __pyx_n_s_Tabixfile___setstate_cython, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__53)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_setstate_cython, __pyx_t_3) < 0) __PYX_ERR(1, 3, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":1258
 * 
 * 
 * __all__ = [             # <<<<<<<<<<<<<<
 *     "tabix_index",
 *     "tabix_compress",
 */
  __pyx_t_3 = PyList_New(14); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1258, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_INCREF(__pyx_n_u_tabix_index);
  __Pyx_GIVEREF(__pyx_n_u_tabix_index);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 0, __pyx_n_u_tabix_index)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_tabix_compress);
  __Pyx_GIVEREF(__pyx_n_u_tabix_compress);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 1, __pyx_n_u_tabix_compress)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_TabixFile);
  __Pyx_GIVEREF(__pyx_n_u_TabixFile);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 2, __pyx_n_u_TabixFile)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_Tabixfile);
  __Pyx_GIVEREF(__pyx_n_u_Tabixfile);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 3, __pyx_n_u_Tabixfile)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_asTuple);
  __Pyx_GIVEREF(__pyx_n_u_asTuple);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 4, __pyx_n_u_asTuple)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_asGTF);
  __Pyx_GIVEREF(__pyx_n_u_asGTF);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 5, __pyx_n_u_asGTF)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_asGFF3);
  __Pyx_GIVEREF(__pyx_n_u_asGFF3);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 6, __pyx_n_u_asGFF3)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_asVCF);
  __Pyx_GIVEREF(__pyx_n_u_asVCF);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 7, __pyx_n_u_asVCF)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_asBed);
  __Pyx_GIVEREF(__pyx_n_u_asBed);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 8, __pyx_n_u_asBed)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_GZIterator);
  __Pyx_GIVEREF(__pyx_n_u_GZIterator);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 9, __pyx_n_u_GZIterator)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_GZIteratorHead);
  __Pyx_GIVEREF(__pyx_n_u_GZIteratorHead);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 10, __pyx_n_u_GZIteratorHead)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_tabix_iterator);
  __Pyx_GIVEREF(__pyx_n_u_tabix_iterator);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 11, __pyx_n_u_tabix_iterator)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_tabix_generic_iterator);
  __Pyx_GIVEREF(__pyx_n_u_tabix_generic_iterator);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 12, __pyx_n_u_tabix_generic_iterator)) __PYX_ERR(0, 1258, __pyx_L1_error);
  __Pyx_INCREF(__pyx_n_u_tabix_file_iterator);
  __Pyx_GIVEREF(__pyx_n_u_tabix_file_iterator);
  if (__Pyx_PyList_SET_ITEM(__pyx_t_3, 13, __pyx_n_u_tabix_file_iterator)) __PYX_ERR(0, 1258, __pyx_L1_error);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_all, __pyx_t_3) < 0) __PYX_ERR(0, 1258, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_Parser(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_7__pyx_unpickle_Parser, 0, __pyx_n_s_pyx_unpickle_Parser, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__54)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_Parser, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":11
 *         __pyx_unpickle_Parser__set_state(<Parser> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_Parser__set_state(Parser __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_9__pyx_unpickle_asTuple, 0, __pyx_n_s_pyx_unpickle_asTuple, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__57)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_asTuple, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asGFF3(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_11__pyx_unpickle_asGFF3, 0, __pyx_n_s_pyx_unpickle_asGFF3, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__58)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_asGFF3, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":11
 *         __pyx_unpickle_asGFF3__set_state(<asGFF3> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asGFF3__set_state(asGFF3 __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_13__pyx_unpickle_asGTF, 0, __pyx_n_s_pyx_unpickle_asGTF, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__59)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_asGTF, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":1
 * def __pyx_unpickle_asBed(__pyx_type, long __pyx_checksum, __pyx_state):             # <<<<<<<<<<<<<<
 *     cdef object __pyx_PickleError
 *     cdef object __pyx_result
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_15__pyx_unpickle_asBed, 0, __pyx_n_s_pyx_unpickle_asBed, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__60)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_asBed, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "(tree fragment)":11
 *         __pyx_unpickle_asBed__set_state(<asBed> __pyx_result, __pyx_state)
 *     return __pyx_result
 * cdef __pyx_unpickle_asBed__set_state(asBed __pyx_result, tuple __pyx_state):             # <<<<<<<<<<<<<<
 *     __pyx_result.encoding = __pyx_state[0]
 *     if len(__pyx_state) > 1 and hasattr(__pyx_result, '__dict__'):
 */
  __pyx_t_3 = __Pyx_CyFunction_New(&__pyx_mdef_5pysam_9libctabix_17__pyx_unpickle_asVCF, 0, __pyx_n_s_pyx_unpickle_asVCF, NULL, __pyx_n_s_pysam_libctabix, __pyx_d, ((PyObject *)__pyx_codeobj__61)); if (unlikely(!__pyx_t_3)) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pyx_unpickle_asVCF, __pyx_t_3) < 0) __PYX_ERR(1, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "pysam/libctabix.pyx":1
 * # cython: language_level=3             # <<<<<<<<<<<<<<
 * # cython: embedsignature=True
 * # cython: profile=True
 */
  __pyx_t_3 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_test, __pyx_t_3) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_TraceReturn(Py_None, 0);

  /*--- Wrapped vars code ---*/

  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  if (__pyx_m) {
    if (__pyx_d && stringtab_initialized) {
      __Pyx_AddTraceback("init pysam.libctabix", __pyx_clineno, __pyx_lineno, __pyx_filename);
    }
    #if !CYTHON_USE_MODULE_STATE
    Py_CLEAR(__pyx_m);
    #else
    Py_DECREF(__pyx_m);
    if (pystate_addmodule_run) {
      PyObject *tp, *value, *tb;
      PyErr_Fetch(&tp, &value, &tb);
      PyState_RemoveModule(&__pyx_moduledef);
      PyErr_Restore(tp, value, tb);
    }
    #endif
  } else if (!PyErr_Occurred()) {
    PyErr_SetString(PyExc_ImportError, "init pysam.libctabix");
  }
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  return (__pyx_m != NULL) ? 0 : -1;
  #elif PY_MAJOR_VERSION >= 3
  return __pyx_m;
  #else
  return;
  #endif
}
/* #### Code section: cleanup_globals ### */
/* #### Code section: cleanup_module ### */
/* #### Code section: main_method ### */
/* #### Code section: utility_code_pragmas ### */
#ifdef _MSC_VER
#pragma warning( push )
/* Warning 4127: conditional expression is constant
 * Cython uses constant conditional expressions to allow in inline functions to be optimized at
 * compile-time, so this warning is not useful
 */
#pragma warning( disable : 4127 )
#endif



/* #### Code section: utility_code_def ### */

/* --- Runtime support code --- */
/* Refnanny */
#if CYTHON_REFNANNY
static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname) {
    PyObject *m = NULL, *p = NULL;
    void *r = NULL;
    m = PyImport_ImportModule(modname);
    if (!m) goto end;
    p = PyObject_GetAttrString(m, "RefNannyAPI");
    if (!p) goto end;
    r = PyLong_AsVoidPtr(p);
end:
    Py_XDECREF(p);
    Py_XDECREF(m);
    return (__Pyx_RefNannyAPIStruct *)r;
}
#endif

/* PyErrExceptionMatches */
#if CYTHON_FAST_THREAD_STATE
static int __Pyx_PyErr_ExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
    Py_ssize_t i, n;
    n = PyTuple_GET_SIZE(tuple);
#if PY_MAJOR_VERSION >= 3
    for (i=0; i<n; i++) {
        if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
    }
#endif
    for (i=0; i<n; i++) {
        if (__Pyx_PyErr_GivenExceptionMatches(exc_type, PyTuple_GET_ITEM(tuple, i))) return 1;
    }
    return 0;
}
static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err) {
    int result;
    PyObject *exc_type;
#if PY_VERSION_HEX >= 0x030C00A6
    PyObject *current_exception = tstate->current_exception;
    if (unlikely(!current_exception)) return 0;
    exc_type = (PyObject*) Py_TYPE(current_exception);
    if (exc_type == err) return 1;
#else
    exc_type = tstate->curexc_type;
    if (exc_type == err) return 1;
    if (unlikely(!exc_type)) return 0;
#endif
    #if CYTHON_AVOID_BORROWED_REFS
    Py_INCREF(exc_type);
    #endif
    if (unlikely(PyTuple_Check(err))) {
        result = __Pyx_PyErr_ExceptionMatchesTuple(exc_type, err);
    } else {
        result = __Pyx_PyErr_GivenExceptionMatches(exc_type, err);
    }
    #if CYTHON_AVOID_BORROWED_REFS
    Py_DECREF(exc_type);
    #endif
    return result;
}
#endif

/* PyErrFetchRestore */
#if CYTHON_FAST_THREAD_STATE
static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
#if PY_VERSION_HEX >= 0x030C00A6
    PyObject *tmp_value;
    assert(type == NULL || (value != NULL && type == (PyObject*) Py_TYPE(value)));
    if (value) {
        #if CYTHON_COMPILING_IN_CPYTHON
        if (unlikely(((PyBaseExceptionObject*) value)->traceback != tb))
        #endif
            PyException_SetTraceback(value, tb);
    }
    tmp_value = tstate->current_exception;
    tstate->current_exception = value;
    Py_XDECREF(tmp_value);
#else
    PyObject *tmp_type, *tmp_value, *tmp_tb;
    tmp_type = tstate->curexc_type;
    tmp_value = tstate->curexc_value;
    tmp_tb = tstate->curexc_traceback;
    tstate->curexc_type = type;
    tstate->curexc_value = value;
    tstate->curexc_traceback = tb;
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
#endif
}
static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
#if PY_VERSION_HEX >= 0x030C00A6
    PyObject* exc_value;
    exc_value = tstate->current_exception;
    tstate->current_exception = 0;
    *value = exc_value;
    *type = NULL;
    *tb = NULL;
    if (exc_value) {
        *type = (PyObject*) Py_TYPE(exc_value);
        Py_INCREF(*type);
        #if CYTHON_COMPILING_IN_CPYTHON
        *tb = ((PyBaseExceptionObject*) exc_value)->traceback;
        Py_XINCREF(*tb);
        #else
        *tb = PyException_GetTraceback(exc_value);
        #endif
    }
#else
    *type = tstate->curexc_type;
    *value = tstate->curexc_value;
    *tb = tstate->curexc_traceback;
    tstate->curexc_type = 0;
    tstate->curexc_value = 0;
    tstate->curexc_traceback = 0;
#endif
}
#endif

/* PyObjectGetAttrStr */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name) {
    PyTypeObject* tp = Py_TYPE(obj);
    if (likely(tp->tp_getattro))
        return tp->tp_getattro(obj, attr_name);
#if PY_MAJOR_VERSION < 3
    if (likely(tp->tp_getattr))
        return tp->tp_getattr(obj, PyString_AS_STRING(attr_name));
#endif
    return PyObject_GetAttr(obj, attr_name);
}
#endif

/* PyObjectGetAttrStrNoError */
static void __Pyx_PyObject_GetAttrStr_ClearAttributeError(void) {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    if (likely(__Pyx_PyErr_ExceptionMatches(PyExc_AttributeError)))
        __Pyx_PyErr_Clear();
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStrNoError(PyObject* obj, PyObject* attr_name) {
    PyObject *result;
#if CYTHON_COMPILING_IN_CPYTHON && CYTHON_USE_TYPE_SLOTS && PY_VERSION_HEX >= 0x030700B1
    PyTypeObject* tp = Py_TYPE(obj);
    if (likely(tp->tp_getattro == PyObject_GenericGetAttr)) {
        return _PyObject_GenericGetAttrWithDict(obj, attr_name, NULL, 1);
    }
#endif
    result = __Pyx_PyObject_GetAttrStr(obj, attr_name);
    if (unlikely(!result)) {
        __Pyx_PyObject_GetAttrStr_ClearAttributeError();
    }
    return result;
}

/* GetBuiltinName */
static PyObject *__Pyx_GetBuiltinName(PyObject *name) {
    PyObject* result = __Pyx_PyObject_GetAttrStrNoError(__pyx_b, name);
    if (unlikely(!result) && !PyErr_Occurred()) {
        PyErr_Format(PyExc_NameError,
#if PY_MAJOR_VERSION >= 3
            "name '%U' is not defined", name);
#else
            "name '%.200s' is not defined", PyString_AS_STRING(name));
#endif
    }
    return result;
}

/* TupleAndListFromArray */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE void __Pyx_copy_object_array(PyObject *const *CYTHON_RESTRICT src, PyObject** CYTHON_RESTRICT dest, Py_ssize_t length) {
    PyObject *v;
    Py_ssize_t i;
    for (i = 0; i < length; i++) {
        v = dest[i] = src[i];
        Py_INCREF(v);
    }
}
static CYTHON_INLINE PyObject *
__Pyx_PyTuple_FromArray(PyObject *const *src, Py_ssize_t n)
{
    PyObject *res;
    if (n <= 0) {
        Py_INCREF(__pyx_empty_tuple);
        return __pyx_empty_tuple;
    }
    res = PyTuple_New(n);
    if (unlikely(res == NULL)) return NULL;
    __Pyx_copy_object_array(src, ((PyTupleObject*)res)->ob_item, n);
    return res;
}
static CYTHON_INLINE PyObject *
__Pyx_PyList_FromArray(PyObject *const *src, Py_ssize_t n)
{
    PyObject *res;
    if (n <= 0) {
        return PyList_New(0);
    }
    res = PyList_New(n);
    if (unlikely(res == NULL)) return NULL;
    __Pyx_copy_object_array(src, ((PyListObject*)res)->ob_item, n);
    return res;
}
#endif

/* BytesEquals */
static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals) {
#if CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API
    return PyObject_RichCompareBool(s1, s2, equals);
#else
    if (s1 == s2) {
        return (equals == Py_EQ);
    } else if (PyBytes_CheckExact(s1) & PyBytes_CheckExact(s2)) {
        const char *ps1, *ps2;
        Py_ssize_t length = PyBytes_GET_SIZE(s1);
        if (length != PyBytes_GET_SIZE(s2))
            return (equals == Py_NE);
        ps1 = PyBytes_AS_STRING(s1);
        ps2 = PyBytes_AS_STRING(s2);
        if (ps1[0] != ps2[0]) {
            return (equals == Py_NE);
        } else if (length == 1) {
            return (equals == Py_EQ);
        } else {
            int result;
#if CYTHON_USE_UNICODE_INTERNALS && (PY_VERSION_HEX < 0x030B0000)
            Py_hash_t hash1, hash2;
            hash1 = ((PyBytesObject*)s1)->ob_shash;
            hash2 = ((PyBytesObject*)s2)->ob_shash;
            if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
                return (equals == Py_NE);
            }
#endif
            result = memcmp(ps1, ps2, (size_t)length);
            return (equals == Py_EQ) ? (result == 0) : (result != 0);
        }
    } else if ((s1 == Py_None) & PyBytes_CheckExact(s2)) {
        return (equals == Py_NE);
    } else if ((s2 == Py_None) & PyBytes_CheckExact(s1)) {
        return (equals == Py_NE);
    } else {
        int result;
        PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
        if (!py_result)
            return -1;
        result = __Pyx_PyObject_IsTrue(py_result);
        Py_DECREF(py_result);
        return result;
    }
#endif
}

/* UnicodeEquals */
static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals) {
#if CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API
    return PyObject_RichCompareBool(s1, s2, equals);
#else
#if PY_MAJOR_VERSION < 3
    PyObject* owned_ref = NULL;
#endif
    int s1_is_unicode, s2_is_unicode;
    if (s1 == s2) {
        goto return_eq;
    }
    s1_is_unicode = PyUnicode_CheckExact(s1);
    s2_is_unicode = PyUnicode_CheckExact(s2);
#if PY_MAJOR_VERSION < 3
    if ((s1_is_unicode & (!s2_is_unicode)) && PyString_CheckExact(s2)) {
        owned_ref = PyUnicode_FromObject(s2);
        if (unlikely(!owned_ref))
            return -1;
        s2 = owned_ref;
        s2_is_unicode = 1;
    } else if ((s2_is_unicode & (!s1_is_unicode)) && PyString_CheckExact(s1)) {
        owned_ref = PyUnicode_FromObject(s1);
        if (unlikely(!owned_ref))
            return -1;
        s1 = owned_ref;
        s1_is_unicode = 1;
    } else if (((!s2_is_unicode) & (!s1_is_unicode))) {
        return __Pyx_PyBytes_Equals(s1, s2, equals);
    }
#endif
    if (s1_is_unicode & s2_is_unicode) {
        Py_ssize_t length;
        int kind;
        void *data1, *data2;
        if (unlikely(__Pyx_PyUnicode_READY(s1) < 0) || unlikely(__Pyx_PyUnicode_READY(s2) < 0))
            return -1;
        length = __Pyx_PyUnicode_GET_LENGTH(s1);
        if (length != __Pyx_PyUnicode_GET_LENGTH(s2)) {
            goto return_ne;
        }
#if CYTHON_USE_UNICODE_INTERNALS
        {
            Py_hash_t hash1, hash2;
        #if CYTHON_PEP393_ENABLED
            hash1 = ((PyASCIIObject*)s1)->hash;
            hash2 = ((PyASCIIObject*)s2)->hash;
        #else
            hash1 = ((PyUnicodeObject*)s1)->hash;
            hash2 = ((PyUnicodeObject*)s2)->hash;
        #endif
            if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
                goto return_ne;
            }
        }
#endif
        kind = __Pyx_PyUnicode_KIND(s1);
        if (kind != __Pyx_PyUnicode_KIND(s2)) {
            goto return_ne;
        }
        data1 = __Pyx_PyUnicode_DATA(s1);
        data2 = __Pyx_PyUnicode_DATA(s2);
        if (__Pyx_PyUnicode_READ(kind, data1, 0) != __Pyx_PyUnicode_READ(kind, data2, 0)) {
            goto return_ne;
        } else if (length == 1) {
            goto return_eq;
        } else {
            int result = memcmp(data1, data2, (size_t)(length * kind));
            #if PY_MAJOR_VERSION < 3
            Py_XDECREF(owned_ref);
            #endif
            return (equals == Py_EQ) ? (result == 0) : (result != 0);
        }
    } else if ((s1 == Py_None) & s2_is_unicode) {
        goto return_ne;
    } else if ((s2 == Py_None) & s1_is_unicode) {
        goto return_ne;
    } else {
        int result;
        PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
        #if PY_MAJOR_VERSION < 3
        Py_XDECREF(owned_ref);
        #endif
        if (!py_result)
            return -1;
        result = __Pyx_PyObject_IsTrue(py_result);
        Py_DECREF(py_result);
        return result;
    }
return_eq:
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(owned_ref);
    #endif
    return (equals == Py_EQ);
return_ne:
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(owned_ref);
    #endif
    return (equals == Py_NE);
#endif
}

/* fastcall */
#if CYTHON_METH_FASTCALL
static CYTHON_INLINE PyObject * __Pyx_GetKwValue_FASTCALL(PyObject *kwnames, PyObject *const *kwvalues, PyObject *s)
{
    Py_ssize_t i, n = PyTuple_GET_SIZE(kwnames);
    for (i = 0; i < n; i++)
    {
        if (s == PyTuple_GET_ITEM(kwnames, i)) return kwvalues[i];
    }
    for (i = 0; i < n; i++)
    {
        int eq = __Pyx_PyUnicode_Equals(s, PyTuple_GET_ITEM(kwnames, i), Py_EQ);
        if (unlikely(eq != 0)) {
            if (unlikely(eq < 0)) return NULL;  // error
            return kwvalues[i];
        }
    }
    return NULL;  // not found (no exception set)
}
#endif

/* RaiseDoubleKeywords */
static void __Pyx_RaiseDoubleKeywordsError(
    const char* func_name,
    PyObject* kw_name)
{
    PyErr_Format(PyExc_TypeError,
        #if PY_MAJOR_VERSION >= 3
        "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
        #else
        "%s() got multiple values for keyword argument '%s'", func_name,
        PyString_AsString(kw_name));
        #endif
}

/* ParseKeywords */
static int __Pyx_ParseOptionalKeywords(
    PyObject *kwds,
    PyObject *const *kwvalues,
    PyObject **argnames[],
    PyObject *kwds2,
    PyObject *values[],
    Py_ssize_t num_pos_args,
    const char* function_name)
{
    PyObject *key = 0, *value = 0;
    Py_ssize_t pos = 0;
    PyObject*** name;
    PyObject*** first_kw_arg = argnames + num_pos_args;
    int kwds_is_tuple = CYTHON_METH_FASTCALL && likely(PyTuple_Check(kwds));
    while (1) {
        Py_XDECREF(key); key = NULL;
        Py_XDECREF(value); value = NULL;
        if (kwds_is_tuple) {
            Py_ssize_t size;
#if CYTHON_ASSUME_SAFE_MACROS
            size = PyTuple_GET_SIZE(kwds);
#else
            size = PyTuple_Size(kwds);
            if (size < 0) goto bad;
#endif
            if (pos >= size) break;
#if CYTHON_AVOID_BORROWED_REFS
            key = __Pyx_PySequence_ITEM(kwds, pos);
            if (!key) goto bad;
#elif CYTHON_ASSUME_SAFE_MACROS
            key = PyTuple_GET_ITEM(kwds, pos);
#else
            key = PyTuple_GetItem(kwds, pos);
            if (!key) goto bad;
#endif
            value = kwvalues[pos];
            pos++;
        }
        else
        {
            if (!PyDict_Next(kwds, &pos, &key, &value)) break;
#if CYTHON_AVOID_BORROWED_REFS
            Py_INCREF(key);
#endif
        }
        name = first_kw_arg;
        while (*name && (**name != key)) name++;
        if (*name) {
            values[name-argnames] = value;
#if CYTHON_AVOID_BORROWED_REFS
            Py_INCREF(value); // transfer ownership of value to values
            Py_DECREF(key);
#endif
            key = NULL;
            value = NULL;
            continue;
        }
#if !CYTHON_AVOID_BORROWED_REFS
        Py_INCREF(key);
#endif
        Py_INCREF(value);
        name = first_kw_arg;
        #if PY_MAJOR_VERSION < 3
        if (likely(PyString_Check(key))) {
            while (*name) {
                if ((CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**name) == PyString_GET_SIZE(key))
                        && _PyString_Eq(**name, key)) {
                    values[name-argnames] = value;
#if CYTHON_AVOID_BORROWED_REFS
                    value = NULL;  // ownership transferred to values
#endif
                    break;
                }
                name++;
            }
            if (*name) continue;
            else {
                PyObject*** argname = argnames;
                while (argname != first_kw_arg) {
                    if ((**argname == key) || (
                            (CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**argname) == PyString_GET_SIZE(key))
                             && _PyString_Eq(**argname, key))) {
                        goto arg_passed_twice;
                    }
                    argname++;
                }
            }
        } else
        #endif
        if (likely(PyUnicode_Check(key))) {
            while (*name) {
                int cmp = (
                #if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
                    (__Pyx_PyUnicode_GET_LENGTH(**name) != __Pyx_PyUnicode_GET_LENGTH(key)) ? 1 :
                #endif
                    PyUnicode_Compare(**name, key)
                );
                if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
                if (cmp == 0) {
                    values[name-argnames] = value;
#if CYTHON_AVOID_BORROWED_REFS
                    value = NULL; // ownership transferred to values
#endif
                    break;
                }
                name++;
            }
            if (*name) continue;
            else {
                PyObject*** argname = argnames;
                while (argname != first_kw_arg) {
                    int cmp = (**argname == key) ? 0 :
                    #if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
                        (__Pyx_PyUnicode_GET_LENGTH(**argname) != __Pyx_PyUnicode_GET_LENGTH(key)) ? 1 :
                    #endif
                        PyUnicode_Compare(**argname, key);
                    if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
                    if (cmp == 0) goto arg_passed_twice;
                    argname++;
                }
            }
        } else
            goto invalid_keyword_type;
        if (kwds2) {
            if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
        } else {
            goto invalid_keyword;
        }
    }
    Py_XDECREF(key);
    Py_XDECREF(value);
    return 0;
arg_passed_twice:
    __Pyx_RaiseDoubleKeywordsError(function_name, key);
    goto bad;
invalid_keyword_type:
    PyErr_Format(PyExc_TypeError,
        "%.200s() keywords must be strings", function_name);
    goto bad;
invalid_keyword:
    #if PY_MAJOR_VERSION < 3
    PyErr_Format(PyExc_TypeError,
        "%.200s() got an unexpected keyword argument '%.200s'",
        function_name, PyString_AsString(key));
    #else
    PyErr_Format(PyExc_TypeError,
        "%s() got an unexpected keyword argument '%U'",
        function_name, key);
    #endif
bad:
    Py_XDECREF(key);
    Py_XDECREF(value);
    return -1;
}

/* RaiseArgTupleInvalid */
static void __Pyx_RaiseArgtupleInvalid(
    const char* func_name,
    int exact,
    Py_ssize_t num_min,
    Py_ssize_t num_max,
    Py_ssize_t num_found)
{
    Py_ssize_t num_expected;
    const char *more_or_less;
    if (num_found < num_min) {
        num_expected = num_min;
        more_or_less = "at least";
    } else {
        num_expected = num_max;
        more_or_less = "at most";
    }
    if (exact) {
        more_or_less = "exactly";
    }
    PyErr_Format(PyExc_TypeError,
                 "%.200s() takes %.8s %" CYTHON_FORMAT_SSIZE_T "d positional argument%.1s (%" CYTHON_FORMAT_SSIZE_T "d given)",
                 func_name, more_or_less, num_expected,
                 (num_expected == 1) ? "" : "s", num_found);
}

/* Profile */
#if CYTHON_PROFILE
static int __Pyx_TraceSetupAndCall(PyCodeObject** code,
                                   PyFrameObject** frame,
                                   PyThreadState* tstate,
                                   const char *funcname,
                                   const char *srcfile,
                                   int firstlineno) {
    PyObject *type, *value, *traceback;
    int retval;
    if (*frame == NULL || !CYTHON_PROFILE_REUSE_FRAME) {
        if (*code == NULL) {
            *code = __Pyx_createFrameCodeObject(funcname, srcfile, firstlineno);
            if (*code == NULL) return 0;
        }
        *frame = PyFrame_New(
            tstate,                          /*PyThreadState *tstate*/
            *code,                           /*PyCodeObject *code*/
            __pyx_d,                  /*PyObject *globals*/
            0                                /*PyObject *locals*/
        );
        if (*frame == NULL) return 0;
        if (CYTHON_TRACE && (*frame)->f_trace == NULL) {
            Py_INCREF(Py_None);
            (*frame)->f_trace = Py_None;
        }
#if PY_VERSION_HEX < 0x030400B1
    } else {
        (*frame)->f_tstate = tstate;
#endif
    }
    __Pyx_PyFrame_SetLineNumber(*frame, firstlineno);
    retval = 1;
    __Pyx_EnterTracing(tstate);
    __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
    #if CYTHON_TRACE
    if (tstate->c_tracefunc)
        retval = tstate->c_tracefunc(tstate->c_traceobj, *frame, PyTrace_CALL, NULL) == 0;
    if (retval && tstate->c_profilefunc)
    #endif
        retval = tstate->c_profilefunc(tstate->c_profileobj, *frame, PyTrace_CALL, NULL) == 0;
    __Pyx_LeaveTracing(tstate);
    if (retval) {
        __Pyx_ErrRestoreInState(tstate, type, value, traceback);
        return __Pyx_IsTracing(tstate, 0, 0) && retval;
    } else {
        Py_XDECREF(type);
        Py_XDECREF(value);
        Py_XDECREF(traceback);
        return -1;
    }
}
static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno) {
    PyCodeObject *py_code = 0;
#if PY_MAJOR_VERSION >= 3
    py_code = PyCode_NewEmpty(srcfile, funcname, firstlineno);
    if (likely(py_code)) {
        py_code->co_flags |= CO_OPTIMIZED | CO_NEWLOCALS;
    }
#else
    PyObject *py_srcfile = 0;
    PyObject *py_funcname = 0;
    py_funcname = PyString_FromString(funcname);
    if (unlikely(!py_funcname)) goto bad;
    py_srcfile = PyString_FromString(srcfile);
    if (unlikely(!py_srcfile)) goto bad;
    py_code = PyCode_New(
        0,
        0,
        0,
        CO_OPTIMIZED | CO_NEWLOCALS,
        __pyx_empty_bytes,     /*PyObject *code,*/
        __pyx_empty_tuple,     /*PyObject *consts,*/
        __pyx_empty_tuple,     /*PyObject *names,*/
        __pyx_empty_tuple,     /*PyObject *varnames,*/
        __pyx_empty_tuple,     /*PyObject *freevars,*/
        __pyx_empty_tuple,     /*PyObject *cellvars,*/
        py_srcfile,       /*PyObject *filename,*/
        py_funcname,      /*PyObject *name,*/
        firstlineno,
        __pyx_empty_bytes      /*PyObject *lnotab*/
    );
bad:
    Py_XDECREF(py_srcfile);
    Py_XDECREF(py_funcname);
#endif
    return py_code;
}
#endif

/* KeywordStringCheck */
static int __Pyx_CheckKeywordStrings(
    PyObject *kw,
    const char* function_name,
    int kw_allowed)
{
    PyObject* key = 0;
    Py_ssize_t pos = 0;
#if CYTHON_COMPILING_IN_PYPY
    if (!kw_allowed && PyDict_Next(kw, &pos, &key, 0))
        goto invalid_keyword;
    return 1;
#else
    if (CYTHON_METH_FASTCALL && likely(PyTuple_Check(kw))) {
        Py_ssize_t kwsize;
#if CYTHON_ASSUME_SAFE_MACROS
        kwsize = PyTuple_GET_SIZE(kw);
#else
        kwsize = PyTuple_Size(kw);
        if (kwsize < 0) return 0;
#endif
        if (unlikely(kwsize == 0))
            return 1;
        if (!kw_allowed) {
#if CYTHON_ASSUME_SAFE_MACROS
            key = PyTuple_GET_ITEM(kw, 0);
#else
            key = PyTuple_GetItem(kw, pos);
            if (!key) return 0;
#endif
            goto invalid_keyword;
        }
#if PY_VERSION_HEX < 0x03090000
        for (pos = 0; pos < kwsize; pos++) {
#if CYTHON_ASSUME_SAFE_MACROS
            key = PyTuple_GET_ITEM(kw, pos);
#else
            key = PyTuple_GetItem(kw, pos);
            if (!key) return 0;
#endif
            if (unlikely(!PyUnicode_Check(key)))
                goto invalid_keyword_type;
        }
#endif
        return 1;
    }
    while (PyDict_Next(kw, &pos, &key, 0)) {
        #if PY_MAJOR_VERSION < 3
        if (unlikely(!PyString_Check(key)))
        #endif
            if (unlikely(!PyUnicode_Check(key)))
                goto invalid_keyword_type;
    }
    if (!kw_allowed && unlikely(key))
        goto invalid_keyword;
    return 1;
invalid_keyword_type:
    PyErr_Format(PyExc_TypeError,
        "%.200s() keywords must be strings", function_name);
    return 0;
#endif
invalid_keyword:
    #if PY_MAJOR_VERSION < 3
    PyErr_Format(PyExc_TypeError,
        "%.200s() got an unexpected keyword argument '%.200s'",
        function_name, PyString_AsString(key));
    #else
    PyErr_Format(PyExc_TypeError,
        "%s() got an unexpected keyword argument '%U'",
        function_name, key);
    #endif
    return 0;
}

/* PyFunctionFastCall */
#if CYTHON_FAST_PYCALL && !CYTHON_VECTORCALL
static PyObject* __Pyx_PyFunction_FastCallNoKw(PyCodeObject *co, PyObject **args, Py_ssize_t na,
                                               PyObject *globals) {
    PyFrameObject *f;
    PyThreadState *tstate = __Pyx_PyThreadState_Current;
    PyObject **fastlocals;
    Py_ssize_t i;
    PyObject *result;
    assert(globals != NULL);
    /* XXX Perhaps we should create a specialized
       PyFrame_New() that doesn't take locals, but does
       take builtins without sanity checking them.
       */
    assert(tstate != NULL);
    f = PyFrame_New(tstate, co, globals, NULL);
    if (f == NULL) {
        return NULL;
    }
    fastlocals = __Pyx_PyFrame_GetLocalsplus(f);
    for (i = 0; i < na; i++) {
        Py_INCREF(*args);
        fastlocals[i] = *args++;
    }
    result = PyEval_EvalFrameEx(f,0);
    ++tstate->recursion_depth;
    Py_DECREF(f);
    --tstate->recursion_depth;
    return result;
}
static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs) {
    PyCodeObject *co = (PyCodeObject *)PyFunction_GET_CODE(func);
    PyObject *globals = PyFunction_GET_GLOBALS(func);
    PyObject *argdefs = PyFunction_GET_DEFAULTS(func);
    PyObject *closure;
#if PY_MAJOR_VERSION >= 3
    PyObject *kwdefs;
#endif
    PyObject *kwtuple, **k;
    PyObject **d;
    Py_ssize_t nd;
    Py_ssize_t nk;
    PyObject *result;
    assert(kwargs == NULL || PyDict_Check(kwargs));
    nk = kwargs ? PyDict_Size(kwargs) : 0;
    if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object"))) {
        return NULL;
    }
    if (
#if PY_MAJOR_VERSION >= 3
            co->co_kwonlyargcount == 0 &&
#endif
            likely(kwargs == NULL || nk == 0) &&
            co->co_flags == (CO_OPTIMIZED | CO_NEWLOCALS | CO_NOFREE)) {
        if (argdefs == NULL && co->co_argcount == nargs) {
            result = __Pyx_PyFunction_FastCallNoKw(co, args, nargs, globals);
            goto done;
        }
        else if (nargs == 0 && argdefs != NULL
                 && co->co_argcount == Py_SIZE(argdefs)) {
            /* function called with no arguments, but all parameters have
               a default value: use default values as arguments .*/
            args = &PyTuple_GET_ITEM(argdefs, 0);
            result =__Pyx_PyFunction_FastCallNoKw(co, args, Py_SIZE(argdefs), globals);
            goto done;
        }
    }
    if (kwargs != NULL) {
        Py_ssize_t pos, i;
        kwtuple = PyTuple_New(2 * nk);
        if (kwtuple == NULL) {
            result = NULL;
            goto done;
        }
        k = &PyTuple_GET_ITEM(kwtuple, 0);
        pos = i = 0;
        while (PyDict_Next(kwargs, &pos, &k[i], &k[i+1])) {
            Py_INCREF(k[i]);
            Py_INCREF(k[i+1]);
            i += 2;
        }
        nk = i / 2;
    }
    else {
        kwtuple = NULL;
        k = NULL;
    }
    closure = PyFunction_GET_CLOSURE(func);
#if PY_MAJOR_VERSION >= 3
    kwdefs = PyFunction_GET_KW_DEFAULTS(func);
#endif
    if (argdefs != NULL) {
        d = &PyTuple_GET_ITEM(argdefs, 0);
        nd = Py_SIZE(argdefs);
    }
    else {
        d = NULL;
        nd = 0;
    }
#if PY_MAJOR_VERSION >= 3
    result = PyEval_EvalCodeEx((PyObject*)co, globals, (PyObject *)NULL,
                               args, (int)nargs,
                               k, (int)nk,
                               d, (int)nd, kwdefs, closure);
#else
    result = PyEval_EvalCodeEx(co, globals, (PyObject *)NULL,
                               args, (int)nargs,
                               k, (int)nk,
                               d, (int)nd, closure);
#endif
    Py_XDECREF(kwtuple);
done:
    Py_LeaveRecursiveCall();
    return result;
}
#endif

/* PyObjectCall */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw) {
    PyObject *result;
    ternaryfunc call = Py_TYPE(func)->tp_call;
    if (unlikely(!call))
        return PyObject_Call(func, arg, kw);
    if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
        return NULL;
    result = (*call)(func, arg, kw);
    Py_LeaveRecursiveCall();
    if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
        PyErr_SetString(
            PyExc_SystemError,
            "NULL result without error in PyObject_Call");
    }
    return result;
}
#endif

/* PyObjectCallMethO */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg) {
    PyObject *self, *result;
    PyCFunction cfunc;
    cfunc = PyCFunction_GET_FUNCTION(func);
    self = PyCFunction_GET_SELF(func);
    if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
        return NULL;
    result = cfunc(self, arg);
    Py_LeaveRecursiveCall();
    if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
        PyErr_SetString(
            PyExc_SystemError,
            "NULL result without error in PyObject_Call");
    }
    return result;
}
#endif

/* PyObjectFastCall */
static PyObject* __Pyx_PyObject_FastCall_fallback(PyObject *func, PyObject **args, size_t nargs, PyObject *kwargs) {
    PyObject *argstuple;
    PyObject *result = 0;
    size_t i;
    argstuple = PyTuple_New((Py_ssize_t)nargs);
    if (unlikely(!argstuple)) return NULL;
    for (i = 0; i < nargs; i++) {
        Py_INCREF(args[i]);
        if (__Pyx_PyTuple_SET_ITEM(argstuple, (Py_ssize_t)i, args[i]) < 0) goto bad;
    }
    result = __Pyx_PyObject_Call(func, argstuple, kwargs);
  bad:
    Py_DECREF(argstuple);
    return result;
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_FastCallDict(PyObject *func, PyObject **args, size_t _nargs, PyObject *kwargs) {
    Py_ssize_t nargs = __Pyx_PyVectorcall_NARGS(_nargs);
#if CYTHON_COMPILING_IN_CPYTHON
    if (nargs == 0 && kwargs == NULL) {
#if defined(__Pyx_CyFunction_USED) && defined(NDEBUG)
        if (__Pyx_IsCyOrPyCFunction(func))
#else
        if (PyCFunction_Check(func))
#endif
        {
            if (likely(PyCFunction_GET_FLAGS(func) & METH_NOARGS)) {
                return __Pyx_PyObject_CallMethO(func, NULL);
            }
        }
    }
    else if (nargs == 1 && kwargs == NULL) {
        if (PyCFunction_Check(func))
        {
            if (likely(PyCFunction_GET_FLAGS(func) & METH_O)) {
                return __Pyx_PyObject_CallMethO(func, args[0]);
            }
        }
    }
#endif
    #if PY_VERSION_HEX < 0x030800B1
    #if CYTHON_FAST_PYCCALL
    if (PyCFunction_Check(func)) {
        if (kwargs) {
            return _PyCFunction_FastCallDict(func, args, nargs, kwargs);
        } else {
            return _PyCFunction_FastCallKeywords(func, args, nargs, NULL);
        }
    }
    #if PY_VERSION_HEX >= 0x030700A1
    if (!kwargs && __Pyx_IS_TYPE(func, &PyMethodDescr_Type)) {
        return _PyMethodDescr_FastCallKeywords(func, args, nargs, NULL);
    }
    #endif
    #endif
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(func)) {
        return __Pyx_PyFunction_FastCallDict(func, args, nargs, kwargs);
    }
    #endif
    #endif
    #if CYTHON_VECTORCALL
    #if Py_VERSION_HEX < 0x03090000
    vectorcallfunc f = _PyVectorcall_Function(func);
    #else
    vectorcallfunc f = PyVectorcall_Function(func);
    #endif
    if (f) {
        return f(func, args, (size_t)nargs, kwargs);
    }
    #elif defined(__Pyx_CyFunction_USED) && CYTHON_BACKPORT_VECTORCALL
    if (__Pyx_CyFunction_CheckExact(func)) {
        __pyx_vectorcallfunc f = __Pyx_CyFunction_func_vectorcall(func);
        if (f) return f(func, args, (size_t)nargs, kwargs);
    }
    #endif
    if (nargs == 0) {
        return __Pyx_PyObject_Call(func, __pyx_empty_tuple, kwargs);
    }
    return __Pyx_PyObject_FastCall_fallback(func, args, (size_t)nargs, kwargs);
}

/* PyObjectCallOneArg */
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg) {
    PyObject *args[2] = {NULL, arg};
    return __Pyx_PyObject_FastCall(func, args+1, 1 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
}

/* RaiseException */
#if PY_MAJOR_VERSION < 3
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause) {
    __Pyx_PyThreadState_declare
    CYTHON_UNUSED_VAR(cause);
    Py_XINCREF(type);
    if (!value || value == Py_None)
        value = NULL;
    else
        Py_INCREF(value);
    if (!tb || tb == Py_None)
        tb = NULL;
    else {
        Py_INCREF(tb);
        if (!PyTraceBack_Check(tb)) {
            PyErr_SetString(PyExc_TypeError,
                "raise: arg 3 must be a traceback or None");
            goto raise_error;
        }
    }
    if (PyType_Check(type)) {
#if CYTHON_COMPILING_IN_PYPY
        if (!value) {
            Py_INCREF(Py_None);
            value = Py_None;
        }
#endif
        PyErr_NormalizeException(&type, &value, &tb);
    } else {
        if (value) {
            PyErr_SetString(PyExc_TypeError,
                "instance exception may not have a separate value");
            goto raise_error;
        }
        value = type;
        type = (PyObject*) Py_TYPE(type);
        Py_INCREF(type);
        if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
            PyErr_SetString(PyExc_TypeError,
                "raise: exception class must be a subclass of BaseException");
            goto raise_error;
        }
    }
    __Pyx_PyThreadState_assign
    __Pyx_ErrRestore(type, value, tb);
    return;
raise_error:
    Py_XDECREF(value);
    Py_XDECREF(type);
    Py_XDECREF(tb);
    return;
}
#else
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause) {
    PyObject* owned_instance = NULL;
    if (tb == Py_None) {
        tb = 0;
    } else if (tb && !PyTraceBack_Check(tb)) {
        PyErr_SetString(PyExc_TypeError,
            "raise: arg 3 must be a traceback or None");
        goto bad;
    }
    if (value == Py_None)
        value = 0;
    if (PyExceptionInstance_Check(type)) {
        if (value) {
            PyErr_SetString(PyExc_TypeError,
                "instance exception may not have a separate value");
            goto bad;
        }
        value = type;
        type = (PyObject*) Py_TYPE(value);
    } else if (PyExceptionClass_Check(type)) {
        PyObject *instance_class = NULL;
        if (value && PyExceptionInstance_Check(value)) {
            instance_class = (PyObject*) Py_TYPE(value);
            if (instance_class != type) {
                int is_subclass = PyObject_IsSubclass(instance_class, type);
                if (!is_subclass) {
                    instance_class = NULL;
                } else if (unlikely(is_subclass == -1)) {
                    goto bad;
                } else {
                    type = instance_class;
                }
            }
        }
        if (!instance_class) {
            PyObject *args;
            if (!value)
                args = PyTuple_New(0);
            else if (PyTuple_Check(value)) {
                Py_INCREF(value);
                args = value;
            } else
                args = PyTuple_Pack(1, value);
            if (!args)
                goto bad;
            owned_instance = PyObject_Call(type, args, NULL);
            Py_DECREF(args);
            if (!owned_instance)
                goto bad;
            value = owned_instance;
            if (!PyExceptionInstance_Check(value)) {
                PyErr_Format(PyExc_TypeError,
                             "calling %R should have returned an instance of "
                             "BaseException, not %R",
                             type, Py_TYPE(value));
                goto bad;
            }
        }
    } else {
        PyErr_SetString(PyExc_TypeError,
            "raise: exception class must be a subclass of BaseException");
        goto bad;
    }
    if (cause) {
        PyObject *fixed_cause;
        if (cause == Py_None) {
            fixed_cause = NULL;
        } else if (PyExceptionClass_Check(cause)) {
            fixed_cause = PyObject_CallObject(cause, NULL);
            if (fixed_cause == NULL)
                goto bad;
        } else if (PyExceptionInstance_Check(cause)) {
            fixed_cause = cause;
            Py_INCREF(fixed_cause);
        } else {
            PyErr_SetString(PyExc_TypeError,
                            "exception causes must derive from "
                            "BaseException");
            goto bad;
        }
        PyException_SetCause(value, fixed_cause);
    }
    PyErr_SetObject(type, value);
    if (tb) {
      #if PY_VERSION_HEX >= 0x030C00A6
        PyException_SetTraceback(value, tb);
      #elif CYTHON_FAST_THREAD_STATE
        PyThreadState *tstate = __Pyx_PyThreadState_Current;
        PyObject* tmp_tb = tstate->curexc_traceback;
        if (tb != tmp_tb) {
            Py_INCREF(tb);
            tstate->curexc_traceback = tb;
            Py_XDECREF(tmp_tb);
        }
#else
        PyObject *tmp_type, *tmp_value, *tmp_tb;
        PyErr_Fetch(&tmp_type, &tmp_value, &tmp_tb);
        Py_INCREF(tb);
        PyErr_Restore(tmp_type, tmp_value, tb);
        Py_XDECREF(tmp_tb);
#endif
    }
bad:
    Py_XDECREF(owned_instance);
    return;
}
#endif

/* GetAttr3 */
static PyObject *__Pyx_GetAttr3Default(PyObject *d) {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    if (unlikely(!__Pyx_PyErr_ExceptionMatches(PyExc_AttributeError)))
        return NULL;
    __Pyx_PyErr_Clear();
    Py_INCREF(d);
    return d;
}
static CYTHON_INLINE PyObject *__Pyx_GetAttr3(PyObject *o, PyObject *n, PyObject *d) {
    PyObject *r;
#if CYTHON_USE_TYPE_SLOTS
    if (likely(PyString_Check(n))) {
        r = __Pyx_PyObject_GetAttrStrNoError(o, n);
        if (unlikely(!r) && likely(!PyErr_Occurred())) {
            r = __Pyx_NewRef(d);
        }
        return r;
    }
#endif
    r = PyObject_GetAttr(o, n);
    return (likely(r)) ? r : __Pyx_GetAttr3Default(d);
}

/* PyDictVersioning */
#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj) {
    PyObject *dict = Py_TYPE(obj)->tp_dict;
    return likely(dict) ? __PYX_GET_DICT_VERSION(dict) : 0;
}
static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj) {
    PyObject **dictptr = NULL;
    Py_ssize_t offset = Py_TYPE(obj)->tp_dictoffset;
    if (offset) {
#if CYTHON_COMPILING_IN_CPYTHON
        dictptr = (likely(offset > 0)) ? (PyObject **) ((char *)obj + offset) : _PyObject_GetDictPtr(obj);
#else
        dictptr = _PyObject_GetDictPtr(obj);
#endif
    }
    return (dictptr && *dictptr) ? __PYX_GET_DICT_VERSION(*dictptr) : 0;
}
static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version) {
    PyObject *dict = Py_TYPE(obj)->tp_dict;
    if (unlikely(!dict) || unlikely(tp_dict_version != __PYX_GET_DICT_VERSION(dict)))
        return 0;
    return obj_dict_version == __Pyx_get_object_dict_version(obj);
}
#endif

/* GetModuleGlobalName */
#if CYTHON_USE_DICT_VERSIONS
static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value)
#else
static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name)
#endif
{
    PyObject *result;
#if !CYTHON_AVOID_BORROWED_REFS
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030500A1
    result = _PyDict_GetItem_KnownHash(__pyx_d, name, ((PyASCIIObject *) name)->hash);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    } else if (unlikely(PyErr_Occurred())) {
        return NULL;
    }
#elif CYTHON_COMPILING_IN_LIMITED_API
    if (unlikely(!__pyx_m)) {
        return NULL;
    }
    result = PyObject_GetAttr(__pyx_m, name);
    if (likely(result)) {
        return result;
    }
#else
    result = PyDict_GetItem(__pyx_d, name);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    }
#endif
#else
    result = PyObject_GetItem(__pyx_d, name);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    }
    PyErr_Clear();
#endif
    return __Pyx_GetBuiltinName(name);
}

/* RaiseUnexpectedTypeError */
static int
__Pyx_RaiseUnexpectedTypeError(const char *expected, PyObject *obj)
{
    __Pyx_TypeName obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
    PyErr_Format(PyExc_TypeError, "Expected %s, got " __Pyx_FMT_TYPENAME,
                 expected, obj_type_name);
    __Pyx_DECREF_TypeName(obj_type_name);
    return 0;
}

/* ExtTypeTest */
static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type) {
    __Pyx_TypeName obj_type_name;
    __Pyx_TypeName type_name;
    if (unlikely(!type)) {
        PyErr_SetString(PyExc_SystemError, "Missing type object");
        return 0;
    }
    if (likely(__Pyx_TypeCheck(obj, type)))
        return 1;
    obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
    type_name = __Pyx_PyType_GetName(type);
    PyErr_Format(PyExc_TypeError,
                 "Cannot convert " __Pyx_FMT_TYPENAME " to " __Pyx_FMT_TYPENAME,
                 obj_type_name, type_name);
    __Pyx_DECREF_TypeName(obj_type_name);
    __Pyx_DECREF_TypeName(type_name);
    return 0;
}

/* PyIntBinop */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_AddObjC(PyObject *op1, PyObject *op2, long intval, int inplace, int zerodivision_check) {
    CYTHON_MAYBE_UNUSED_VAR(intval);
    CYTHON_MAYBE_UNUSED_VAR(inplace);
    CYTHON_UNUSED_VAR(zerodivision_check);
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        const long b = intval;
        long x;
        long a = PyInt_AS_LONG(op1);
        
            x = (long)((unsigned long)a + (unsigned long)b);
            if (likely((x^a) >= 0 || (x^b) >= 0))
                return PyInt_FromLong(x);
            return PyLong_Type.tp_as_number->nb_add(op1, op2);
    }
    #endif
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(PyLong_CheckExact(op1))) {
        const long b = intval;
        long a, x;
#ifdef HAVE_LONG_LONG
        const PY_LONG_LONG llb = intval;
        PY_LONG_LONG lla, llx;
#endif
        if (unlikely(__Pyx_PyLong_IsZero(op1))) {
            return __Pyx_NewRef(op2);
        }
        if (likely(__Pyx_PyLong_IsCompact(op1))) {
            a = __Pyx_PyLong_CompactValue(op1);
        } else {
            const digit* digits = __Pyx_PyLong_Digits(op1);
            const Py_ssize_t size = __Pyx_PyLong_SignedDigitCount(op1);
            switch (size) {
                case -2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                case 2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = (long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                case -3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                case 3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = (long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                case -4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                case 4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = (long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    #ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
                    #endif
                    }
                    CYTHON_FALLTHROUGH;
                default: return PyLong_Type.tp_as_number->nb_add(op1, op2);
            }
        }
                x = a + b;
            return PyLong_FromLong(x);
#ifdef HAVE_LONG_LONG
        long_long:
                llx = lla + llb;
            return PyLong_FromLongLong(llx);
#endif
        
        
    }
    #endif
    if (PyFloat_CheckExact(op1)) {
        const long b = intval;
#if CYTHON_COMPILING_IN_LIMITED_API
        double a = __pyx_PyFloat_AsDouble(op1);
#else
        double a = PyFloat_AS_DOUBLE(op1);
#endif
            double result;
            
            PyFPE_START_PROTECT("add", return NULL)
            result = ((double)a) + (double)b;
            PyFPE_END_PROTECT(result)
            return PyFloat_FromDouble(result);
    }
    return (inplace ? PyNumber_InPlaceAdd : PyNumber_Add)(op1, op2);
}
#endif

/* WriteUnraisableException */
static void __Pyx_WriteUnraisable(const char *name, int clineno,
                                  int lineno, const char *filename,
                                  int full_traceback, int nogil) {
    PyObject *old_exc, *old_val, *old_tb;
    PyObject *ctx;
    __Pyx_PyThreadState_declare
#ifdef WITH_THREAD
    PyGILState_STATE state;
    if (nogil)
        state = PyGILState_Ensure();
    else state = (PyGILState_STATE)0;
#endif
    CYTHON_UNUSED_VAR(clineno);
    CYTHON_UNUSED_VAR(lineno);
    CYTHON_UNUSED_VAR(filename);
    CYTHON_MAYBE_UNUSED_VAR(nogil);
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
    if (full_traceback) {
        Py_XINCREF(old_exc);
        Py_XINCREF(old_val);
        Py_XINCREF(old_tb);
        __Pyx_ErrRestore(old_exc, old_val, old_tb);
        PyErr_PrintEx(1);
    }
    #if PY_MAJOR_VERSION < 3
    ctx = PyString_FromString(name);
    #else
    ctx = PyUnicode_FromString(name);
    #endif
    __Pyx_ErrRestore(old_exc, old_val, old_tb);
    if (!ctx) {
        PyErr_WriteUnraisable(Py_None);
    } else {
        PyErr_WriteUnraisable(ctx);
        Py_DECREF(ctx);
    }
#ifdef WITH_THREAD
    if (nogil)
        PyGILState_Release(state);
#endif
}

/* PyObjectCallNoArg */
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func) {
    PyObject *arg = NULL;
    return __Pyx_PyObject_FastCall(func, (&arg)+1, 0 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
}

/* ArgTypeTest */
static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact)
{
    __Pyx_TypeName type_name;
    __Pyx_TypeName obj_type_name;
    if (unlikely(!type)) {
        PyErr_SetString(PyExc_SystemError, "Missing type object");
        return 0;
    }
    else if (exact) {
        #if PY_MAJOR_VERSION == 2
        if ((type == &PyBaseString_Type) && likely(__Pyx_PyBaseString_CheckExact(obj))) return 1;
        #endif
    }
    else {
        if (likely(__Pyx_TypeCheck(obj, type))) return 1;
    }
    type_name = __Pyx_PyType_GetName(type);
    obj_type_name = __Pyx_PyType_GetName(Py_TYPE(obj));
    PyErr_Format(PyExc_TypeError,
        "Argument '%.200s' has incorrect type (expected " __Pyx_FMT_TYPENAME
        ", got " __Pyx_FMT_TYPENAME ")", name, type_name, obj_type_name);
    __Pyx_DECREF_TypeName(type_name);
    __Pyx_DECREF_TypeName(obj_type_name);
    return 0;
}

/* PyObjectFormatAndDecref */
static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatSimpleAndDecref(PyObject* s, PyObject* f) {
    if (unlikely(!s)) return NULL;
    if (likely(PyUnicode_CheckExact(s))) return s;
    #if PY_MAJOR_VERSION < 3
    if (likely(PyString_CheckExact(s))) {
        PyObject *result = PyUnicode_FromEncodedObject(s, NULL, "strict");
        Py_DECREF(s);
        return result;
    }
    #endif
    return __Pyx_PyObject_FormatAndDecref(s, f);
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_FormatAndDecref(PyObject* s, PyObject* f) {
    PyObject *result = PyObject_Format(s, f);
    Py_DECREF(s);
    return result;
}

/* JoinPyUnicode */
static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
                                      Py_UCS4 max_char) {
#if CYTHON_USE_UNICODE_INTERNALS && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    PyObject *result_uval;
    int result_ukind, kind_shift;
    Py_ssize_t i, char_pos;
    void *result_udata;
    CYTHON_MAYBE_UNUSED_VAR(max_char);
#if CYTHON_PEP393_ENABLED
    result_uval = PyUnicode_New(result_ulength, max_char);
    if (unlikely(!result_uval)) return NULL;
    result_ukind = (max_char <= 255) ? PyUnicode_1BYTE_KIND : (max_char <= 65535) ? PyUnicode_2BYTE_KIND : PyUnicode_4BYTE_KIND;
    kind_shift = (result_ukind == PyUnicode_4BYTE_KIND) ? 2 : result_ukind - 1;
    result_udata = PyUnicode_DATA(result_uval);
#else
    result_uval = PyUnicode_FromUnicode(NULL, result_ulength);
    if (unlikely(!result_uval)) return NULL;
    result_ukind = sizeof(Py_UNICODE);
    kind_shift = (result_ukind == 4) ? 2 : result_ukind - 1;
    result_udata = PyUnicode_AS_UNICODE(result_uval);
#endif
    assert(kind_shift == 2 || kind_shift == 1 || kind_shift == 0);
    char_pos = 0;
    for (i=0; i < value_count; i++) {
        int ukind;
        Py_ssize_t ulength;
        void *udata;
        PyObject *uval = PyTuple_GET_ITEM(value_tuple, i);
        if (unlikely(__Pyx_PyUnicode_READY(uval)))
            goto bad;
        ulength = __Pyx_PyUnicode_GET_LENGTH(uval);
        if (unlikely(!ulength))
            continue;
        if (unlikely((PY_SSIZE_T_MAX >> kind_shift) - ulength < char_pos))
            goto overflow;
        ukind = __Pyx_PyUnicode_KIND(uval);
        udata = __Pyx_PyUnicode_DATA(uval);
        if (!CYTHON_PEP393_ENABLED || ukind == result_ukind) {
            memcpy((char *)result_udata + (char_pos << kind_shift), udata, (size_t) (ulength << kind_shift));
        } else {
            #if PY_VERSION_HEX >= 0x030D0000
            if (unlikely(PyUnicode_CopyCharacters(result_uval, char_pos, uval, 0, ulength) < 0)) goto bad;
            #elif CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030300F0 || defined(_PyUnicode_FastCopyCharacters)
            _PyUnicode_FastCopyCharacters(result_uval, char_pos, uval, 0, ulength);
            #else
            Py_ssize_t j;
            for (j=0; j < ulength; j++) {
                Py_UCS4 uchar = __Pyx_PyUnicode_READ(ukind, udata, j);
                __Pyx_PyUnicode_WRITE(result_ukind, result_udata, char_pos+j, uchar);
            }
            #endif
        }
        char_pos += ulength;
    }
    return result_uval;
overflow:
    PyErr_SetString(PyExc_OverflowError, "join() result is too long for a Python string");
bad:
    Py_DECREF(result_uval);
    return NULL;
#else
    CYTHON_UNUSED_VAR(max_char);
    CYTHON_UNUSED_VAR(result_ulength);
    CYTHON_UNUSED_VAR(value_count);
    return PyUnicode_Join(__pyx_empty_unicode, value_tuple);
#endif
}

/* DictGetItem */
#if PY_MAJOR_VERSION >= 3 && !CYTHON_COMPILING_IN_PYPY
static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
    PyObject *value;
    value = PyDict_GetItemWithError(d, key);
    if (unlikely(!value)) {
        if (!PyErr_Occurred()) {
            if (unlikely(PyTuple_Check(key))) {
                PyObject* args = PyTuple_Pack(1, key);
                if (likely(args)) {
                    PyErr_SetObject(PyExc_KeyError, args);
                    Py_DECREF(args);
                }
            } else {
                PyErr_SetObject(PyExc_KeyError, key);
            }
        }
        return NULL;
    }
    Py_INCREF(value);
    return value;
}
#endif

/* GetTopmostException */
#if CYTHON_USE_EXC_INFO_STACK && CYTHON_FAST_THREAD_STATE
static _PyErr_StackItem *
__Pyx_PyErr_GetTopmostException(PyThreadState *tstate)
{
    _PyErr_StackItem *exc_info = tstate->exc_info;
    while ((exc_info->exc_value == NULL || exc_info->exc_value == Py_None) &&
           exc_info->previous_item != NULL)
    {
        exc_info = exc_info->previous_item;
    }
    return exc_info;
}
#endif

/* SaveResetException */
#if CYTHON_FAST_THREAD_STATE
static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
  #if CYTHON_USE_EXC_INFO_STACK && PY_VERSION_HEX >= 0x030B00a4
    _PyErr_StackItem *exc_info = __Pyx_PyErr_GetTopmostException(tstate);
    PyObject *exc_value = exc_info->exc_value;
    if (exc_value == NULL || exc_value == Py_None) {
        *value = NULL;
        *type = NULL;
        *tb = NULL;
    } else {
        *value = exc_value;
        Py_INCREF(*value);
        *type = (PyObject*) Py_TYPE(exc_value);
        Py_INCREF(*type);
        *tb = PyException_GetTraceback(exc_value);
    }
  #elif CYTHON_USE_EXC_INFO_STACK
    _PyErr_StackItem *exc_info = __Pyx_PyErr_GetTopmostException(tstate);
    *type = exc_info->exc_type;
    *value = exc_info->exc_value;
    *tb = exc_info->exc_traceback;
    Py_XINCREF(*type);
    Py_XINCREF(*value);
    Py_XINCREF(*tb);
  #else
    *type = tstate->exc_type;
    *value = tstate->exc_value;
    *tb = tstate->exc_traceback;
    Py_XINCREF(*type);
    Py_XINCREF(*value);
    Py_XINCREF(*tb);
  #endif
}
static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
  #if CYTHON_USE_EXC_INFO_STACK && PY_VERSION_HEX >= 0x030B00a4
    _PyErr_StackItem *exc_info = tstate->exc_info;
    PyObject *tmp_value = exc_info->exc_value;
    exc_info->exc_value = value;
    Py_XDECREF(tmp_value);
    Py_XDECREF(type);
    Py_XDECREF(tb);
  #else
    PyObject *tmp_type, *tmp_value, *tmp_tb;
    #if CYTHON_USE_EXC_INFO_STACK
    _PyErr_StackItem *exc_info = tstate->exc_info;
    tmp_type = exc_info->exc_type;
    tmp_value = exc_info->exc_value;
    tmp_tb = exc_info->exc_traceback;
    exc_info->exc_type = type;
    exc_info->exc_value = value;
    exc_info->exc_traceback = tb;
    #else
    tmp_type = tstate->exc_type;
    tmp_value = tstate->exc_value;
    tmp_tb = tstate->exc_traceback;
    tstate->exc_type = type;
    tstate->exc_value = value;
    tstate->exc_traceback = tb;
    #endif
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
  #endif
}
#endif

/* GetException */
#if CYTHON_FAST_THREAD_STATE
static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb)
#else
static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb)
#endif
{
    PyObject *local_type = NULL, *local_value, *local_tb = NULL;
#if CYTHON_FAST_THREAD_STATE
    PyObject *tmp_type, *tmp_value, *tmp_tb;
  #if PY_VERSION_HEX >= 0x030C00A6
    local_value = tstate->current_exception;
    tstate->current_exception = 0;
    if (likely(local_value)) {
        local_type = (PyObject*) Py_TYPE(local_value);
        Py_INCREF(local_type);
        local_tb = PyException_GetTraceback(local_value);
    }
  #else
    local_type = tstate->curexc_type;
    local_value = tstate->curexc_value;
    local_tb = tstate->curexc_traceback;
    tstate->curexc_type = 0;
    tstate->curexc_value = 0;
    tstate->curexc_traceback = 0;
  #endif
#else
    PyErr_Fetch(&local_type, &local_value, &local_tb);
#endif
    PyErr_NormalizeException(&local_type, &local_value, &local_tb);
#if CYTHON_FAST_THREAD_STATE && PY_VERSION_HEX >= 0x030C00A6
    if (unlikely(tstate->current_exception))
#elif CYTHON_FAST_THREAD_STATE
    if (unlikely(tstate->curexc_type))
#else
    if (unlikely(PyErr_Occurred()))
#endif
        goto bad;
    #if PY_MAJOR_VERSION >= 3
    if (local_tb) {
        if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
            goto bad;
    }
    #endif
    Py_XINCREF(local_tb);
    Py_XINCREF(local_type);
    Py_XINCREF(local_value);
    *type = local_type;
    *value = local_value;
    *tb = local_tb;
#if CYTHON_FAST_THREAD_STATE
    #if CYTHON_USE_EXC_INFO_STACK
    {
        _PyErr_StackItem *exc_info = tstate->exc_info;
      #if PY_VERSION_HEX >= 0x030B00a4
        tmp_value = exc_info->exc_value;
        exc_info->exc_value = local_value;
        tmp_type = NULL;
        tmp_tb = NULL;
        Py_XDECREF(local_type);
        Py_XDECREF(local_tb);
      #else
        tmp_type = exc_info->exc_type;
        tmp_value = exc_info->exc_value;
        tmp_tb = exc_info->exc_traceback;
        exc_info->exc_type = local_type;
        exc_info->exc_value = local_value;
        exc_info->exc_traceback = local_tb;
      #endif
    }
    #else
    tmp_type = tstate->exc_type;
    tmp_value = tstate->exc_value;
    tmp_tb = tstate->exc_traceback;
    tstate->exc_type = local_type;
    tstate->exc_value = local_value;
    tstate->exc_traceback = local_tb;
    #endif
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
#else
    PyErr_SetExcInfo(local_type, local_value, local_tb);
#endif
    return 0;
bad:
    *type = 0;
    *value = 0;
    *tb = 0;
    Py_XDECREF(local_type);
    Py_XDECREF(local_value);
    Py_XDECREF(local_tb);
    return -1;
}

/* UnpackUnboundCMethod */
static PyObject *__Pyx_SelflessCall(PyObject *method, PyObject *args, PyObject *kwargs) {
    PyObject *selfless_args = PyTuple_GetSlice(args, 1, PyTuple_Size(args));
    if (unlikely(!selfless_args)) return NULL;
    PyObject *result = PyObject_Call(method, selfless_args, kwargs);
    Py_DECREF(selfless_args);
    return result;
}
static PyMethodDef __Pyx_UnboundCMethod_Def = {
     "CythonUnboundCMethod",
     __PYX_REINTERPRET_FUNCION(PyCFunction, __Pyx_SelflessCall),
     METH_VARARGS | METH_KEYWORDS,
     NULL
};
static int __Pyx_TryUnpackUnboundCMethod(__Pyx_CachedCFunction* target) {
    PyObject *method;
    method = __Pyx_PyObject_GetAttrStr(target->type, *target->method_name);
    if (unlikely(!method))
        return -1;
    target->method = method;
#if CYTHON_COMPILING_IN_CPYTHON
    #if PY_MAJOR_VERSION >= 3
    if (likely(__Pyx_TypeCheck(method, &PyMethodDescr_Type)))
    #else
    if (likely(!PyCFunction_Check(method)))
    #endif
    {
        PyMethodDescrObject *descr = (PyMethodDescrObject*) method;
        target->func = descr->d_method->ml_meth;
        target->flag = descr->d_method->ml_flags & ~(METH_CLASS | METH_STATIC | METH_COEXIST | METH_STACKLESS);
    } else
#endif
#if defined(CYTHON_COMPILING_IN_PYPY)
#elif PY_VERSION_HEX >= 0x03090000
    if (PyCFunction_CheckExact(method))
#else
    if (PyCFunction_Check(method))
#endif
    {
        PyObject *self;
        int self_found;
#if CYTHON_COMPILING_IN_LIMITED_API || CYTHON_COMPILING_IN_PYPY
        self = PyObject_GetAttrString(method, "__self__");
        if (!self) {
            PyErr_Clear();
        }
#else
        self = PyCFunction_GET_SELF(method);
#endif
        self_found = (self && self != Py_None);
#if CYTHON_COMPILING_IN_LIMITED_API || CYTHON_COMPILING_IN_PYPY
        Py_XDECREF(self);
#endif
        if (self_found) {
            PyObject *unbound_method = PyCFunction_New(&__Pyx_UnboundCMethod_Def, method);
            if (unlikely(!unbound_method)) return -1;
            Py_DECREF(method);
            target->method = unbound_method;
        }
    }
    return 0;
}

/* CallUnboundCMethod0 */
static PyObject* __Pyx__CallUnboundCMethod0(__Pyx_CachedCFunction* cfunc, PyObject* self) {
    PyObject *args, *result = NULL;
    if (unlikely(!cfunc->method) && unlikely(__Pyx_TryUnpackUnboundCMethod(cfunc) < 0)) return NULL;
#if CYTHON_ASSUME_SAFE_MACROS
    args = PyTuple_New(1);
    if (unlikely(!args)) goto bad;
    Py_INCREF(self);
    PyTuple_SET_ITEM(args, 0, self);
#else
    args = PyTuple_Pack(1, self);
    if (unlikely(!args)) goto bad;
#endif
    result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
    Py_DECREF(args);
bad:
    return result;
}

/* py_dict_keys */
static CYTHON_INLINE PyObject* __Pyx_PyDict_Keys(PyObject* d) {
    if (PY_MAJOR_VERSION >= 3)
        return __Pyx_CallUnboundCMethod0(&__pyx_umethod_PyDict_Type_keys, d);
    else
        return PyDict_Keys(d);
}

/* UnicodeAsUCS4 */
static CYTHON_INLINE Py_UCS4 __Pyx_PyUnicode_AsPy_UCS4(PyObject* x) {
   Py_ssize_t length;
   #if CYTHON_PEP393_ENABLED
   length = PyUnicode_GET_LENGTH(x);
   if (likely(length == 1)) {
       return PyUnicode_READ_CHAR(x, 0);
   }
   #else
   length = PyUnicode_GET_SIZE(x);
   if (likely(length == 1)) {
       return PyUnicode_AS_UNICODE(x)[0];
   }
   #if Py_UNICODE_SIZE == 2
   else if (PyUnicode_GET_SIZE(x) == 2) {
       Py_UCS4 high_val = PyUnicode_AS_UNICODE(x)[0];
       if (high_val >= 0xD800 && high_val <= 0xDBFF) {
           Py_UCS4 low_val = PyUnicode_AS_UNICODE(x)[1];
           if (low_val >= 0xDC00 && low_val <= 0xDFFF) {
               return 0x10000 + (((high_val & ((1<<10)-1)) << 10) | (low_val & ((1<<10)-1)));
           }
       }
   }
   #endif
   #endif
   PyErr_Format(PyExc_ValueError,
                "only single character unicode strings can be converted to Py_UCS4, "
                "got length %" CYTHON_FORMAT_SSIZE_T "d", length);
   return (Py_UCS4)-1;
}

/* object_ord */
static long __Pyx__PyObject_Ord(PyObject* c) {
    Py_ssize_t size;
    if (PyBytes_Check(c)) {
        size = PyBytes_GET_SIZE(c);
        if (likely(size == 1)) {
            return (unsigned char) PyBytes_AS_STRING(c)[0];
        }
#if PY_MAJOR_VERSION < 3
    } else if (PyUnicode_Check(c)) {
        return (long)__Pyx_PyUnicode_AsPy_UCS4(c);
#endif
#if (!CYTHON_COMPILING_IN_PYPY) || (defined(PyByteArray_AS_STRING) && defined(PyByteArray_GET_SIZE))
    } else if (PyByteArray_Check(c)) {
        size = PyByteArray_GET_SIZE(c);
        if (likely(size == 1)) {
            return (unsigned char) PyByteArray_AS_STRING(c)[0];
        }
#endif
    } else {
        __Pyx_TypeName c_type_name = __Pyx_PyType_GetName(Py_TYPE(c));
        PyErr_Format(PyExc_TypeError,
            "ord() expected string of length 1, but " __Pyx_FMT_TYPENAME " found",
            c_type_name);
        __Pyx_DECREF_TypeName(c_type_name);
        return (long)(Py_UCS4)-1;
    }
    PyErr_Format(PyExc_TypeError,
        "ord() expected a character, but string of length %zd found", size);
    return (long)(Py_UCS4)-1;
}

/* RaiseTooManyValuesToUnpack */
static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
    PyErr_Format(PyExc_ValueError,
                 "too many values to unpack (expected %" CYTHON_FORMAT_SSIZE_T "d)", expected);
}

/* RaiseNeedMoreValuesToUnpack */
static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
    PyErr_Format(PyExc_ValueError,
                 "need more than %" CYTHON_FORMAT_SSIZE_T "d value%.1s to unpack",
                 index, (index == 1) ? "" : "s");
}

/* IterFinish */
static CYTHON_INLINE int __Pyx_IterFinish(void) {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    PyObject* exc_type = __Pyx_PyErr_CurrentExceptionType();
    if (unlikely(exc_type)) {
        if (unlikely(!__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration)))
            return -1;
        __Pyx_PyErr_Clear();
        return 0;
    }
    return 0;
}

/* UnpackItemEndCheck */
static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected) {
    if (unlikely(retval)) {
        Py_DECREF(retval);
        __Pyx_RaiseTooManyValuesError(expected);
        return -1;
    }
    return __Pyx_IterFinish();
}

/* PyObjectSetAttrStr */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE int __Pyx_PyObject_SetAttrStr(PyObject* obj, PyObject* attr_name, PyObject* value) {
    PyTypeObject* tp = Py_TYPE(obj);
    if (likely(tp->tp_setattro))
        return tp->tp_setattro(obj, attr_name, value);
#if PY_MAJOR_VERSION < 3
    if (likely(tp->tp_setattr))
        return tp->tp_setattr(obj, PyString_AS_STRING(attr_name), value);
#endif
    return PyObject_SetAttr(obj, attr_name, value);
}
#endif

/* Import */
static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level) {
    PyObject *module = 0;
    PyObject *empty_dict = 0;
    PyObject *empty_list = 0;
    #if PY_MAJOR_VERSION < 3
    PyObject *py_import;
    py_import = __Pyx_PyObject_GetAttrStr(__pyx_b, __pyx_n_s_import);
    if (unlikely(!py_import))
        goto bad;
    if (!from_list) {
        empty_list = PyList_New(0);
        if (unlikely(!empty_list))
            goto bad;
        from_list = empty_list;
    }
    #endif
    empty_dict = PyDict_New();
    if (unlikely(!empty_dict))
        goto bad;
    {
        #if PY_MAJOR_VERSION >= 3
        if (level == -1) {
            if ((1) && (strchr(__Pyx_MODULE_NAME, '.'))) {
                module = PyImport_ImportModuleLevelObject(
                    name, __pyx_d, empty_dict, from_list, 1);
                if (unlikely(!module)) {
                    if (unlikely(!PyErr_ExceptionMatches(PyExc_ImportError)))
                        goto bad;
                    PyErr_Clear();
                }
            }
            level = 0;
        }
        #endif
        if (!module) {
            #if PY_MAJOR_VERSION < 3
            PyObject *py_level = PyInt_FromLong(level);
            if (unlikely(!py_level))
                goto bad;
            module = PyObject_CallFunctionObjArgs(py_import,
                name, __pyx_d, empty_dict, from_list, py_level, (PyObject *)NULL);
            Py_DECREF(py_level);
            #else
            module = PyImport_ImportModuleLevelObject(
                name, __pyx_d, empty_dict, from_list, level);
            #endif
        }
    }
bad:
    Py_XDECREF(empty_dict);
    Py_XDECREF(empty_list);
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(py_import);
    #endif
    return module;
}

/* ImportFrom */
static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name) {
    PyObject* value = __Pyx_PyObject_GetAttrStr(module, name);
    if (unlikely(!value) && PyErr_ExceptionMatches(PyExc_AttributeError)) {
        const char* module_name_str = 0;
        PyObject* module_name = 0;
        PyObject* module_dot = 0;
        PyObject* full_name = 0;
        PyErr_Clear();
        module_name_str = PyModule_GetName(module);
        if (unlikely(!module_name_str)) { goto modbad; }
        module_name = PyUnicode_FromString(module_name_str);
        if (unlikely(!module_name)) { goto modbad; }
        module_dot = PyUnicode_Concat(module_name, __pyx_kp_u__56);
        if (unlikely(!module_dot)) { goto modbad; }
        full_name = PyUnicode_Concat(module_dot, name);
        if (unlikely(!full_name)) { goto modbad; }
        #if PY_VERSION_HEX < 0x030700A1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM  < 0x07030400)
        {
            PyObject *modules = PyImport_GetModuleDict();
            if (unlikely(!modules))
                goto modbad;
            value = PyObject_GetItem(modules, full_name);
        }
        #else
        value = PyImport_GetModule(full_name);
        #endif
      modbad:
        Py_XDECREF(full_name);
        Py_XDECREF(module_dot);
        Py_XDECREF(module_name);
    }
    if (unlikely(!value)) {
        PyErr_Format(PyExc_ImportError,
        #if PY_MAJOR_VERSION < 3
            "cannot import name %.230s", PyString_AS_STRING(name));
        #else
            "cannot import name %S", name);
        #endif
    }
    return value;
}

/* GetItemInt */
static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
    PyObject *r;
    if (unlikely(!j)) return NULL;
    r = PyObject_GetItem(o, j);
    Py_DECREF(j);
    return r;
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
                                                              CYTHON_NCP_UNUSED int wraparound,
                                                              CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    Py_ssize_t wrapped_i = i;
    if (wraparound & unlikely(i < 0)) {
        wrapped_i += PyList_GET_SIZE(o);
    }
    if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyList_GET_SIZE(o)))) {
        PyObject *r = PyList_GET_ITEM(o, wrapped_i);
        Py_INCREF(r);
        return r;
    }
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
#else
    return PySequence_GetItem(o, i);
#endif
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
                                                              CYTHON_NCP_UNUSED int wraparound,
                                                              CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    Py_ssize_t wrapped_i = i;
    if (wraparound & unlikely(i < 0)) {
        wrapped_i += PyTuple_GET_SIZE(o);
    }
    if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyTuple_GET_SIZE(o)))) {
        PyObject *r = PyTuple_GET_ITEM(o, wrapped_i);
        Py_INCREF(r);
        return r;
    }
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
#else
    return PySequence_GetItem(o, i);
#endif
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i, int is_list,
                                                     CYTHON_NCP_UNUSED int wraparound,
                                                     CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS && CYTHON_USE_TYPE_SLOTS
    if (is_list || PyList_CheckExact(o)) {
        Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyList_GET_SIZE(o);
        if ((!boundscheck) || (likely(__Pyx_is_valid_index(n, PyList_GET_SIZE(o))))) {
            PyObject *r = PyList_GET_ITEM(o, n);
            Py_INCREF(r);
            return r;
        }
    }
    else if (PyTuple_CheckExact(o)) {
        Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyTuple_GET_SIZE(o);
        if ((!boundscheck) || likely(__Pyx_is_valid_index(n, PyTuple_GET_SIZE(o)))) {
            PyObject *r = PyTuple_GET_ITEM(o, n);
            Py_INCREF(r);
            return r;
        }
    } else {
        PyMappingMethods *mm = Py_TYPE(o)->tp_as_mapping;
        PySequenceMethods *sm = Py_TYPE(o)->tp_as_sequence;
        if (mm && mm->mp_subscript) {
            PyObject *r, *key = PyInt_FromSsize_t(i);
            if (unlikely(!key)) return NULL;
            r = mm->mp_subscript(o, key);
            Py_DECREF(key);
            return r;
        }
        if (likely(sm && sm->sq_item)) {
            if (wraparound && unlikely(i < 0) && likely(sm->sq_length)) {
                Py_ssize_t l = sm->sq_length(o);
                if (likely(l >= 0)) {
                    i += l;
                } else {
                    if (!PyErr_ExceptionMatches(PyExc_OverflowError))
                        return NULL;
                    PyErr_Clear();
                }
            }
            return sm->sq_item(o, i);
        }
    }
#else
    if (is_list || PySequence_Check(o)) {
        return PySequence_GetItem(o, i);
    }
#endif
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
}

/* GetAttr */
static CYTHON_INLINE PyObject *__Pyx_GetAttr(PyObject *o, PyObject *n) {
#if CYTHON_USE_TYPE_SLOTS
#if PY_MAJOR_VERSION >= 3
    if (likely(PyUnicode_Check(n)))
#else
    if (likely(PyString_Check(n)))
#endif
        return __Pyx_PyObject_GetAttrStr(o, n);
#endif
    return PyObject_GetAttr(o, n);
}

/* HasAttr */
static CYTHON_INLINE int __Pyx_HasAttr(PyObject *o, PyObject *n) {
    PyObject *r;
    if (unlikely(!__Pyx_PyBaseString_Check(n))) {
        PyErr_SetString(PyExc_TypeError,
                        "hasattr(): attribute name must be string");
        return -1;
    }
    r = __Pyx_GetAttr(o, n);
    if (!r) {
        PyErr_Clear();
        return 0;
    } else {
        Py_DECREF(r);
        return 1;
    }
}

/* CallNextTpDealloc */
static void __Pyx_call_next_tp_dealloc(PyObject* obj, destructor current_tp_dealloc) {
    PyTypeObject* type = Py_TYPE(obj);
    destructor tp_dealloc = NULL;
    while (type && __Pyx_PyType_GetSlot(type, tp_dealloc, destructor) != current_tp_dealloc)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    while (type && (tp_dealloc = __Pyx_PyType_GetSlot(type, tp_dealloc, destructor)) == current_tp_dealloc)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    if (type)
        tp_dealloc(obj);
}

/* CallNextTpTraverse */
static int __Pyx_call_next_tp_traverse(PyObject* obj, visitproc v, void *a, traverseproc current_tp_traverse) {
    PyTypeObject* type = Py_TYPE(obj);
    traverseproc tp_traverse = NULL;
    while (type && __Pyx_PyType_GetSlot(type, tp_traverse, traverseproc) != current_tp_traverse)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    while (type && (tp_traverse = __Pyx_PyType_GetSlot(type, tp_traverse, traverseproc)) == current_tp_traverse)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    if (type && tp_traverse)
        return tp_traverse(obj, v, a);
    return 0;
}

/* CallNextTpClear */
static void __Pyx_call_next_tp_clear(PyObject* obj, inquiry current_tp_clear) {
    PyTypeObject* type = Py_TYPE(obj);
    inquiry tp_clear = NULL;
    while (type && __Pyx_PyType_GetSlot(type, tp_clear, inquiry) != current_tp_clear)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    while (type && (tp_clear = __Pyx_PyType_GetSlot(type, tp_clear, inquiry)) == current_tp_clear)
        type = __Pyx_PyType_GetSlot(type, tp_base, PyTypeObject*);
    if (type && tp_clear)
        tp_clear(obj);
}

/* FixUpExtensionType */
#if CYTHON_USE_TYPE_SPECS
static int __Pyx_fix_up_extension_type_from_spec(PyType_Spec *spec, PyTypeObject *type) {
#if PY_VERSION_HEX > 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
    CYTHON_UNUSED_VAR(spec);
    CYTHON_UNUSED_VAR(type);
#else
    const PyType_Slot *slot = spec->slots;
    while (slot && slot->slot && slot->slot != Py_tp_members)
        slot++;
    if (slot && slot->slot == Py_tp_members) {
        int changed = 0;
#if !(PY_VERSION_HEX <= 0x030900b1 && CYTHON_COMPILING_IN_CPYTHON)
        const
#endif
            PyMemberDef *memb = (PyMemberDef*) slot->pfunc;
        while (memb && memb->name) {
            if (memb->name[0] == '_' && memb->name[1] == '_') {
#if PY_VERSION_HEX < 0x030900b1
                if (strcmp(memb->name, "__weaklistoffset__") == 0) {
                    assert(memb->type == T_PYSSIZET);
                    assert(memb->flags == READONLY);
                    type->tp_weaklistoffset = memb->offset;
                    changed = 1;
                }
                else if (strcmp(memb->name, "__dictoffset__") == 0) {
                    assert(memb->type == T_PYSSIZET);
                    assert(memb->flags == READONLY);
                    type->tp_dictoffset = memb->offset;
                    changed = 1;
                }
#if CYTHON_METH_FASTCALL
                else if (strcmp(memb->name, "__vectorcalloffset__") == 0) {
                    assert(memb->type == T_PYSSIZET);
                    assert(memb->flags == READONLY);
#if PY_VERSION_HEX >= 0x030800b4
                    type->tp_vectorcall_offset = memb->offset;
#else
                    type->tp_print = (printfunc) memb->offset;
#endif
                    changed = 1;
                }
#endif
#else
                if ((0));
#endif
#if PY_VERSION_HEX <= 0x030900b1 && CYTHON_COMPILING_IN_CPYTHON
                else if (strcmp(memb->name, "__module__") == 0) {
                    PyObject *descr;
                    assert(memb->type == T_OBJECT);
                    assert(memb->flags == 0 || memb->flags == READONLY);
                    descr = PyDescr_NewMember(type, memb);
                    if (unlikely(!descr))
                        return -1;
                    if (unlikely(PyDict_SetItem(type->tp_dict, PyDescr_NAME(descr), descr) < 0)) {
                        Py_DECREF(descr);
                        return -1;
                    }
                    Py_DECREF(descr);
                    changed = 1;
                }
#endif
            }
            memb++;
        }
        if (changed)
            PyType_Modified(type);
    }
#endif
    return 0;
}
#endif

/* PyObjectGetMethod */
static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method) {
    PyObject *attr;
#if CYTHON_UNPACK_METHODS && CYTHON_COMPILING_IN_CPYTHON && CYTHON_USE_PYTYPE_LOOKUP
    __Pyx_TypeName type_name;
    PyTypeObject *tp = Py_TYPE(obj);
    PyObject *descr;
    descrgetfunc f = NULL;
    PyObject **dictptr, *dict;
    int meth_found = 0;
    assert (*method == NULL);
    if (unlikely(tp->tp_getattro != PyObject_GenericGetAttr)) {
        attr = __Pyx_PyObject_GetAttrStr(obj, name);
        goto try_unpack;
    }
    if (unlikely(tp->tp_dict == NULL) && unlikely(PyType_Ready(tp) < 0)) {
        return 0;
    }
    descr = _PyType_Lookup(tp, name);
    if (likely(descr != NULL)) {
        Py_INCREF(descr);
#if defined(Py_TPFLAGS_METHOD_DESCRIPTOR) && Py_TPFLAGS_METHOD_DESCRIPTOR
        if (__Pyx_PyType_HasFeature(Py_TYPE(descr), Py_TPFLAGS_METHOD_DESCRIPTOR))
#elif PY_MAJOR_VERSION >= 3
        #ifdef __Pyx_CyFunction_USED
        if (likely(PyFunction_Check(descr) || __Pyx_IS_TYPE(descr, &PyMethodDescr_Type) || __Pyx_CyFunction_Check(descr)))
        #else
        if (likely(PyFunction_Check(descr) || __Pyx_IS_TYPE(descr, &PyMethodDescr_Type)))
        #endif
#else
        #ifdef __Pyx_CyFunction_USED
        if (likely(PyFunction_Check(descr) || __Pyx_CyFunction_Check(descr)))
        #else
        if (likely(PyFunction_Check(descr)))
        #endif
#endif
        {
            meth_found = 1;
        } else {
            f = Py_TYPE(descr)->tp_descr_get;
            if (f != NULL && PyDescr_IsData(descr)) {
                attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
                Py_DECREF(descr);
                goto try_unpack;
            }
        }
    }
    dictptr = _PyObject_GetDictPtr(obj);
    if (dictptr != NULL && (dict = *dictptr) != NULL) {
        Py_INCREF(dict);
        attr = __Pyx_PyDict_GetItemStr(dict, name);
        if (attr != NULL) {
            Py_INCREF(attr);
            Py_DECREF(dict);
            Py_XDECREF(descr);
            goto try_unpack;
        }
        Py_DECREF(dict);
    }
    if (meth_found) {
        *method = descr;
        return 1;
    }
    if (f != NULL) {
        attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
        Py_DECREF(descr);
        goto try_unpack;
    }
    if (likely(descr != NULL)) {
        *method = descr;
        return 0;
    }
    type_name = __Pyx_PyType_GetName(tp);
    PyErr_Format(PyExc_AttributeError,
#if PY_MAJOR_VERSION >= 3
                 "'" __Pyx_FMT_TYPENAME "' object has no attribute '%U'",
                 type_name, name);
#else
                 "'" __Pyx_FMT_TYPENAME "' object has no attribute '%.400s'",
                 type_name, PyString_AS_STRING(name));
#endif
    __Pyx_DECREF_TypeName(type_name);
    return 0;
#else
    attr = __Pyx_PyObject_GetAttrStr(obj, name);
    goto try_unpack;
#endif
try_unpack:
#if CYTHON_UNPACK_METHODS
    if (likely(attr) && PyMethod_Check(attr) && likely(PyMethod_GET_SELF(attr) == obj)) {
        PyObject *function = PyMethod_GET_FUNCTION(attr);
        Py_INCREF(function);
        Py_DECREF(attr);
        *method = function;
        return 1;
    }
#endif
    *method = attr;
    return 0;
}

/* PyObjectCallMethod0 */
static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name) {
    PyObject *method = NULL, *result = NULL;
    int is_method = __Pyx_PyObject_GetMethod(obj, method_name, &method);
    if (likely(is_method)) {
        result = __Pyx_PyObject_CallOneArg(method, obj);
        Py_DECREF(method);
        return result;
    }
    if (unlikely(!method)) goto bad;
    result = __Pyx_PyObject_CallNoArg(method);
    Py_DECREF(method);
bad:
    return result;
}

/* ValidateBasesTuple */
#if CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API || CYTHON_USE_TYPE_SPECS
static int __Pyx_validate_bases_tuple(const char *type_name, Py_ssize_t dictoffset, PyObject *bases) {
    Py_ssize_t i, n;
#if CYTHON_ASSUME_SAFE_MACROS
    n = PyTuple_GET_SIZE(bases);
#else
    n = PyTuple_Size(bases);
    if (n < 0) return -1;
#endif
    for (i = 1; i < n; i++)
    {
#if CYTHON_AVOID_BORROWED_REFS
        PyObject *b0 = PySequence_GetItem(bases, i);
        if (!b0) return -1;
#elif CYTHON_ASSUME_SAFE_MACROS
        PyObject *b0 = PyTuple_GET_ITEM(bases, i);
#else
        PyObject *b0 = PyTuple_GetItem(bases, i);
        if (!b0) return -1;
#endif
        PyTypeObject *b;
#if PY_MAJOR_VERSION < 3
        if (PyClass_Check(b0))
        {
            PyErr_Format(PyExc_TypeError, "base class '%.200s' is an old-style class",
                         PyString_AS_STRING(((PyClassObject*)b0)->cl_name));
#if CYTHON_AVOID_BORROWED_REFS
            Py_DECREF(b0);
#endif
            return -1;
        }
#endif
        b = (PyTypeObject*) b0;
        if (!__Pyx_PyType_HasFeature(b, Py_TPFLAGS_HEAPTYPE))
        {
            __Pyx_TypeName b_name = __Pyx_PyType_GetName(b);
            PyErr_Format(PyExc_TypeError,
                "base class '" __Pyx_FMT_TYPENAME "' is not a heap type", b_name);
            __Pyx_DECREF_TypeName(b_name);
#if CYTHON_AVOID_BORROWED_REFS
            Py_DECREF(b0);
#endif
            return -1;
        }
#if !CYTHON_USE_TYPE_SLOTS
        if (dictoffset == 0) {
            PyErr_Format(PyExc_TypeError,
                "extension type '%s.200s': "
                "unable to validate whether bases have a __dict__ "
                "when CYTHON_USE_TYPE_SLOTS is off "
                "(likely because you are building in the limited API). "
                "Therefore, all extension types with multiple bases "
                "must add 'cdef dict __dict__' in this compilation mode",
                type_name);
#if CYTHON_AVOID_BORROWED_REFS
            Py_DECREF(b0);
#endif
            return -1;
        }
#else
        if (dictoffset == 0 && b->tp_dictoffset)
        {
            __Pyx_TypeName b_name = __Pyx_PyType_GetName(b);
            PyErr_Format(PyExc_TypeError,
                "extension type '%.200s' has no __dict__ slot, "
                "but base type '" __Pyx_FMT_TYPENAME "' has: "
                "either add 'cdef dict __dict__' to the extension type "
                "or add '__slots__ = [...]' to the base type",
                type_name, b_name);
            __Pyx_DECREF_TypeName(b_name);
#if CYTHON_AVOID_BORROWED_REFS
            Py_DECREF(b0);
#endif
            return -1;
        }
#endif
#if CYTHON_AVOID_BORROWED_REFS
        Py_DECREF(b0);
#endif
    }
    return 0;
}
#endif

/* PyType_Ready */
static int __Pyx_PyType_Ready(PyTypeObject *t) {
#if CYTHON_USE_TYPE_SPECS || !(CYTHON_COMPILING_IN_CPYTHON || CYTHON_COMPILING_IN_LIMITED_API) || defined(PYSTON_MAJOR_VERSION)
    (void)__Pyx_PyObject_CallMethod0;
#if CYTHON_USE_TYPE_SPECS
    (void)__Pyx_validate_bases_tuple;
#endif
    return PyType_Ready(t);
#else
    int r;
    PyObject *bases = __Pyx_PyType_GetSlot(t, tp_bases, PyObject*);
    if (bases && unlikely(__Pyx_validate_bases_tuple(t->tp_name, t->tp_dictoffset, bases) == -1))
        return -1;
#if PY_VERSION_HEX >= 0x03050000 && !defined(PYSTON_MAJOR_VERSION)
    {
        int gc_was_enabled;
    #if PY_VERSION_HEX >= 0x030A00b1
        gc_was_enabled = PyGC_Disable();
        (void)__Pyx_PyObject_CallMethod0;
    #else
        PyObject *ret, *py_status;
        PyObject *gc = NULL;
        #if PY_VERSION_HEX >= 0x030700a1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM+0 >= 0x07030400)
        gc = PyImport_GetModule(__pyx_kp_u_gc);
        #endif
        if (unlikely(!gc)) gc = PyImport_Import(__pyx_kp_u_gc);
        if (unlikely(!gc)) return -1;
        py_status = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_isenabled);
        if (unlikely(!py_status)) {
            Py_DECREF(gc);
            return -1;
        }
        gc_was_enabled = __Pyx_PyObject_IsTrue(py_status);
        Py_DECREF(py_status);
        if (gc_was_enabled > 0) {
            ret = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_disable);
            if (unlikely(!ret)) {
                Py_DECREF(gc);
                return -1;
            }
            Py_DECREF(ret);
        } else if (unlikely(gc_was_enabled == -1)) {
            Py_DECREF(gc);
            return -1;
        }
    #endif
        t->tp_flags |= Py_TPFLAGS_HEAPTYPE;
#if PY_VERSION_HEX >= 0x030A0000
        t->tp_flags |= Py_TPFLAGS_IMMUTABLETYPE;
#endif
#else
        (void)__Pyx_PyObject_CallMethod0;
#endif
    r = PyType_Ready(t);
#if PY_VERSION_HEX >= 0x03050000 && !defined(PYSTON_MAJOR_VERSION)
        t->tp_flags &= ~Py_TPFLAGS_HEAPTYPE;
    #if PY_VERSION_HEX >= 0x030A00b1
        if (gc_was_enabled)
            PyGC_Enable();
    #else
        if (gc_was_enabled) {
            PyObject *tp, *v, *tb;
            PyErr_Fetch(&tp, &v, &tb);
            ret = __Pyx_PyObject_CallMethod0(gc, __pyx_kp_u_enable);
            if (likely(ret || r == -1)) {
                Py_XDECREF(ret);
                PyErr_Restore(tp, v, tb);
            } else {
                Py_XDECREF(tp);
                Py_XDECREF(v);
                Py_XDECREF(tb);
                r = -1;
            }
        }
        Py_DECREF(gc);
    #endif
    }
#endif
    return r;
#endif
}

/* PyObject_GenericGetAttrNoDict */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject *__Pyx_RaiseGenericGetAttributeError(PyTypeObject *tp, PyObject *attr_name) {
    __Pyx_TypeName type_name = __Pyx_PyType_GetName(tp);
    PyErr_Format(PyExc_AttributeError,
#if PY_MAJOR_VERSION >= 3
                 "'" __Pyx_FMT_TYPENAME "' object has no attribute '%U'",
                 type_name, attr_name);
#else
                 "'" __Pyx_FMT_TYPENAME "' object has no attribute '%.400s'",
                 type_name, PyString_AS_STRING(attr_name));
#endif
    __Pyx_DECREF_TypeName(type_name);
    return NULL;
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name) {
    PyObject *descr;
    PyTypeObject *tp = Py_TYPE(obj);
    if (unlikely(!PyString_Check(attr_name))) {
        return PyObject_GenericGetAttr(obj, attr_name);
    }
    assert(!tp->tp_dictoffset);
    descr = _PyType_Lookup(tp, attr_name);
    if (unlikely(!descr)) {
        return __Pyx_RaiseGenericGetAttributeError(tp, attr_name);
    }
    Py_INCREF(descr);
    #if PY_MAJOR_VERSION < 3
    if (likely(PyType_HasFeature(Py_TYPE(descr), Py_TPFLAGS_HAVE_CLASS)))
    #endif
    {
        descrgetfunc f = Py_TYPE(descr)->tp_descr_get;
        if (unlikely(f)) {
            PyObject *res = f(descr, obj, (PyObject *)tp);
            Py_DECREF(descr);
            return res;
        }
    }
    return descr;
}
#endif

/* PyObject_GenericGetAttr */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name) {
    if (unlikely(Py_TYPE(obj)->tp_dictoffset)) {
        return PyObject_GenericGetAttr(obj, attr_name);
    }
    return __Pyx_PyObject_GenericGetAttrNoDict(obj, attr_name);
}
#endif

/* SetVTable */
static int __Pyx_SetVtable(PyTypeObject *type, void *vtable) {
    PyObject *ob = PyCapsule_New(vtable, 0, 0);
    if (unlikely(!ob))
        goto bad;
#if CYTHON_COMPILING_IN_LIMITED_API
    if (unlikely(PyObject_SetAttr((PyObject *) type, __pyx_n_s_pyx_vtable, ob) < 0))
#else
    if (unlikely(PyDict_SetItem(type->tp_dict, __pyx_n_s_pyx_vtable, ob) < 0))
#endif
        goto bad;
    Py_DECREF(ob);
    return 0;
bad:
    Py_XDECREF(ob);
    return -1;
}

/* GetVTable */
static void* __Pyx_GetVtable(PyTypeObject *type) {
    void* ptr;
#if CYTHON_COMPILING_IN_LIMITED_API
    PyObject *ob = PyObject_GetAttr((PyObject *)type, __pyx_n_s_pyx_vtable);
#else
    PyObject *ob = PyObject_GetItem(type->tp_dict, __pyx_n_s_pyx_vtable);
#endif
    if (!ob)
        goto bad;
    ptr = PyCapsule_GetPointer(ob, 0);
    if (!ptr && !PyErr_Occurred())
        PyErr_SetString(PyExc_RuntimeError, "invalid vtable found for imported type");
    Py_DECREF(ob);
    return ptr;
bad:
    Py_XDECREF(ob);
    return NULL;
}

/* MergeVTables */
#if !CYTHON_COMPILING_IN_LIMITED_API
static int __Pyx_MergeVtables(PyTypeObject *type) {
    int i;
    void** base_vtables;
    __Pyx_TypeName tp_base_name;
    __Pyx_TypeName base_name;
    void* unknown = (void*)-1;
    PyObject* bases = type->tp_bases;
    int base_depth = 0;
    {
        PyTypeObject* base = type->tp_base;
        while (base) {
            base_depth += 1;
            base = base->tp_base;
        }
    }
    base_vtables = (void**) malloc(sizeof(void*) * (size_t)(base_depth + 1));
    base_vtables[0] = unknown;
    for (i = 1; i < PyTuple_GET_SIZE(bases); i++) {
        void* base_vtable = __Pyx_GetVtable(((PyTypeObject*)PyTuple_GET_ITEM(bases, i)));
        if (base_vtable != NULL) {
            int j;
            PyTypeObject* base = type->tp_base;
            for (j = 0; j < base_depth; j++) {
                if (base_vtables[j] == unknown) {
                    base_vtables[j] = __Pyx_GetVtable(base);
                    base_vtables[j + 1] = unknown;
                }
                if (base_vtables[j] == base_vtable) {
                    break;
                } else if (base_vtables[j] == NULL) {
                    goto bad;
                }
                base = base->tp_base;
            }
        }
    }
    PyErr_Clear();
    free(base_vtables);
    return 0;
bad:
    tp_base_name = __Pyx_PyType_GetName(type->tp_base);
    base_name = __Pyx_PyType_GetName((PyTypeObject*)PyTuple_GET_ITEM(bases, i));
    PyErr_Format(PyExc_TypeError,
        "multiple bases have vtable conflict: '" __Pyx_FMT_TYPENAME "' and '" __Pyx_FMT_TYPENAME "'", tp_base_name, base_name);
    __Pyx_DECREF_TypeName(tp_base_name);
    __Pyx_DECREF_TypeName(base_name);
    free(base_vtables);
    return -1;
}
#endif

/* SetupReduce */
#if !CYTHON_COMPILING_IN_LIMITED_API
static int __Pyx_setup_reduce_is_named(PyObject* meth, PyObject* name) {
  int ret;
  PyObject *name_attr;
  name_attr = __Pyx_PyObject_GetAttrStrNoError(meth, __pyx_n_s_name);
  if (likely(name_attr)) {
      ret = PyObject_RichCompareBool(name_attr, name, Py_EQ);
  } else {
      ret = -1;
  }
  if (unlikely(ret < 0)) {
      PyErr_Clear();
      ret = 0;
  }
  Py_XDECREF(name_attr);
  return ret;
}
static int __Pyx_setup_reduce(PyObject* type_obj) {
    int ret = 0;
    PyObject *object_reduce = NULL;
    PyObject *object_getstate = NULL;
    PyObject *object_reduce_ex = NULL;
    PyObject *reduce = NULL;
    PyObject *reduce_ex = NULL;
    PyObject *reduce_cython = NULL;
    PyObject *setstate = NULL;
    PyObject *setstate_cython = NULL;
    PyObject *getstate = NULL;
#if CYTHON_USE_PYTYPE_LOOKUP
    getstate = _PyType_Lookup((PyTypeObject*)type_obj, __pyx_n_s_getstate);
#else
    getstate = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_getstate);
    if (!getstate && PyErr_Occurred()) {
        goto __PYX_BAD;
    }
#endif
    if (getstate) {
#if CYTHON_USE_PYTYPE_LOOKUP
        object_getstate = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_getstate);
#else
        object_getstate = __Pyx_PyObject_GetAttrStrNoError((PyObject*)&PyBaseObject_Type, __pyx_n_s_getstate);
        if (!object_getstate && PyErr_Occurred()) {
            goto __PYX_BAD;
        }
#endif
        if (object_getstate != getstate) {
            goto __PYX_GOOD;
        }
    }
#if CYTHON_USE_PYTYPE_LOOKUP
    object_reduce_ex = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto __PYX_BAD;
#else
    object_reduce_ex = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto __PYX_BAD;
#endif
    reduce_ex = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce_ex); if (unlikely(!reduce_ex)) goto __PYX_BAD;
    if (reduce_ex == object_reduce_ex) {
#if CYTHON_USE_PYTYPE_LOOKUP
        object_reduce = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto __PYX_BAD;
#else
        object_reduce = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto __PYX_BAD;
#endif
        reduce = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce); if (unlikely(!reduce)) goto __PYX_BAD;
        if (reduce == object_reduce || __Pyx_setup_reduce_is_named(reduce, __pyx_n_s_reduce_cython)) {
            reduce_cython = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_reduce_cython);
            if (likely(reduce_cython)) {
                ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce, reduce_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
                ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
            } else if (reduce == object_reduce || PyErr_Occurred()) {
                goto __PYX_BAD;
            }
            setstate = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_setstate);
            if (!setstate) PyErr_Clear();
            if (!setstate || __Pyx_setup_reduce_is_named(setstate, __pyx_n_s_setstate_cython)) {
                setstate_cython = __Pyx_PyObject_GetAttrStrNoError(type_obj, __pyx_n_s_setstate_cython);
                if (likely(setstate_cython)) {
                    ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate, setstate_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
                    ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate_cython); if (unlikely(ret < 0)) goto __PYX_BAD;
                } else if (!setstate || PyErr_Occurred()) {
                    goto __PYX_BAD;
                }
            }
            PyType_Modified((PyTypeObject*)type_obj);
        }
    }
    goto __PYX_GOOD;
__PYX_BAD:
    if (!PyErr_Occurred()) {
        __Pyx_TypeName type_obj_name =
            __Pyx_PyType_GetName((PyTypeObject*)type_obj);
        PyErr_Format(PyExc_RuntimeError,
            "Unable to initialize pickling for " __Pyx_FMT_TYPENAME, type_obj_name);
        __Pyx_DECREF_TypeName(type_obj_name);
    }
    ret = -1;
__PYX_GOOD:
#if !CYTHON_USE_PYTYPE_LOOKUP
    Py_XDECREF(object_reduce);
    Py_XDECREF(object_reduce_ex);
    Py_XDECREF(object_getstate);
    Py_XDECREF(getstate);
#endif
    Py_XDECREF(reduce);
    Py_XDECREF(reduce_ex);
    Py_XDECREF(reduce_cython);
    Py_XDECREF(setstate);
    Py_XDECREF(setstate_cython);
    return ret;
}
#endif

/* TypeImport */
#ifndef __PYX_HAVE_RT_ImportType_3_0_2
#define __PYX_HAVE_RT_ImportType_3_0_2
static PyTypeObject *__Pyx_ImportType_3_0_2(PyObject *module, const char *module_name, const char *class_name,
    size_t size, size_t alignment, enum __Pyx_ImportType_CheckSize_3_0_2 check_size)
{
    PyObject *result = 0;
    char warning[200];
    Py_ssize_t basicsize;
    Py_ssize_t itemsize;
#if CYTHON_COMPILING_IN_LIMITED_API
    PyObject *py_basicsize;
    PyObject *py_itemsize;
#endif
    result = PyObject_GetAttrString(module, class_name);
    if (!result)
        goto bad;
    if (!PyType_Check(result)) {
        PyErr_Format(PyExc_TypeError,
            "%.200s.%.200s is not a type object",
            module_name, class_name);
        goto bad;
    }
#if !CYTHON_COMPILING_IN_LIMITED_API
    basicsize = ((PyTypeObject *)result)->tp_basicsize;
    itemsize = ((PyTypeObject *)result)->tp_itemsize;
#else
    py_basicsize = PyObject_GetAttrString(result, "__basicsize__");
    if (!py_basicsize)
        goto bad;
    basicsize = PyLong_AsSsize_t(py_basicsize);
    Py_DECREF(py_basicsize);
    py_basicsize = 0;
    if (basicsize == (Py_ssize_t)-1 && PyErr_Occurred())
        goto bad;
    py_itemsize = PyObject_GetAttrString(result, "__itemsize__");
    if (!py_itemsize)
        goto bad;
    itemsize = PyLong_AsSsize_t(py_itemsize);
    Py_DECREF(py_itemsize);
    py_itemsize = 0;
    if (itemsize == (Py_ssize_t)-1 && PyErr_Occurred())
        goto bad;
#endif
    if (itemsize) {
        if (size % alignment) {
            alignment = size % alignment;
        }
        if (itemsize < (Py_ssize_t)alignment)
            itemsize = (Py_ssize_t)alignment;
    }
    if ((size_t)(basicsize + itemsize) < size) {
        PyErr_Format(PyExc_ValueError,
            "%.200s.%.200s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd from PyObject",
            module_name, class_name, size, basicsize+itemsize);
        goto bad;
    }
    if (check_size == __Pyx_ImportType_CheckSize_Error_3_0_2 &&
            ((size_t)basicsize > size || (size_t)(basicsize + itemsize) < size)) {
        PyErr_Format(PyExc_ValueError,
            "%.200s.%.200s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd-%zd from PyObject",
            module_name, class_name, size, basicsize, basicsize+itemsize);
        goto bad;
    }
    else if (check_size == __Pyx_ImportType_CheckSize_Warn_3_0_2 && (size_t)basicsize > size) {
        PyOS_snprintf(warning, sizeof(warning),
            "%s.%s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd from PyObject",
            module_name, class_name, size, basicsize);
        if (PyErr_WarnEx(NULL, warning, 0) < 0) goto bad;
    }
    return (PyTypeObject *)result;
bad:
    Py_XDECREF(result);
    return NULL;
}
#endif

/* ImportDottedModule */
#if PY_MAJOR_VERSION >= 3
static PyObject *__Pyx__ImportDottedModule_Error(PyObject *name, PyObject *parts_tuple, Py_ssize_t count) {
    PyObject *partial_name = NULL, *slice = NULL, *sep = NULL;
    if (unlikely(PyErr_Occurred())) {
        PyErr_Clear();
    }
    if (likely(PyTuple_GET_SIZE(parts_tuple) == count)) {
        partial_name = name;
    } else {
        slice = PySequence_GetSlice(parts_tuple, 0, count);
        if (unlikely(!slice))
            goto bad;
        sep = PyUnicode_FromStringAndSize(".", 1);
        if (unlikely(!sep))
            goto bad;
        partial_name = PyUnicode_Join(sep, slice);
    }
    PyErr_Format(
#if PY_MAJOR_VERSION < 3
        PyExc_ImportError,
        "No module named '%s'", PyString_AS_STRING(partial_name));
#else
#if PY_VERSION_HEX >= 0x030600B1
        PyExc_ModuleNotFoundError,
#else
        PyExc_ImportError,
#endif
        "No module named '%U'", partial_name);
#endif
bad:
    Py_XDECREF(sep);
    Py_XDECREF(slice);
    Py_XDECREF(partial_name);
    return NULL;
}
#endif
#if PY_MAJOR_VERSION >= 3
static PyObject *__Pyx__ImportDottedModule_Lookup(PyObject *name) {
    PyObject *imported_module;
#if PY_VERSION_HEX < 0x030700A1 || (CYTHON_COMPILING_IN_PYPY && PYPY_VERSION_NUM  < 0x07030400)
    PyObject *modules = PyImport_GetModuleDict();
    if (unlikely(!modules))
        return NULL;
    imported_module = __Pyx_PyDict_GetItemStr(modules, name);
    Py_XINCREF(imported_module);
#else
    imported_module = PyImport_GetModule(name);
#endif
    return imported_module;
}
#endif
#if PY_MAJOR_VERSION >= 3
static PyObject *__Pyx_ImportDottedModule_WalkParts(PyObject *module, PyObject *name, PyObject *parts_tuple) {
    Py_ssize_t i, nparts;
    nparts = PyTuple_GET_SIZE(parts_tuple);
    for (i=1; i < nparts && module; i++) {
        PyObject *part, *submodule;
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        part = PyTuple_GET_ITEM(parts_tuple, i);
#else
        part = PySequence_ITEM(parts_tuple, i);
#endif
        submodule = __Pyx_PyObject_GetAttrStrNoError(module, part);
#if !(CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS)
        Py_DECREF(part);
#endif
        Py_DECREF(module);
        module = submodule;
    }
    if (unlikely(!module)) {
        return __Pyx__ImportDottedModule_Error(name, parts_tuple, i);
    }
    return module;
}
#endif
static PyObject *__Pyx__ImportDottedModule(PyObject *name, PyObject *parts_tuple) {
#if PY_MAJOR_VERSION < 3
    PyObject *module, *from_list, *star = __pyx_n_s__62;
    CYTHON_UNUSED_VAR(parts_tuple);
    from_list = PyList_New(1);
    if (unlikely(!from_list))
        return NULL;
    Py_INCREF(star);
    PyList_SET_ITEM(from_list, 0, star);
    module = __Pyx_Import(name, from_list, 0);
    Py_DECREF(from_list);
    return module;
#else
    PyObject *imported_module;
    PyObject *module = __Pyx_Import(name, NULL, 0);
    if (!parts_tuple || unlikely(!module))
        return module;
    imported_module = __Pyx__ImportDottedModule_Lookup(name);
    if (likely(imported_module)) {
        Py_DECREF(module);
        return imported_module;
    }
    PyErr_Clear();
    return __Pyx_ImportDottedModule_WalkParts(module, name, parts_tuple);
#endif
}
static PyObject *__Pyx_ImportDottedModule(PyObject *name, PyObject *parts_tuple) {
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030400B1
    PyObject *module = __Pyx__ImportDottedModule_Lookup(name);
    if (likely(module)) {
        PyObject *spec = __Pyx_PyObject_GetAttrStrNoError(module, __pyx_n_s_spec);
        if (likely(spec)) {
            PyObject *unsafe = __Pyx_PyObject_GetAttrStrNoError(spec, __pyx_n_s_initializing);
            if (likely(!unsafe || !__Pyx_PyObject_IsTrue(unsafe))) {
                Py_DECREF(spec);
                spec = NULL;
            }
            Py_XDECREF(unsafe);
        }
        if (likely(!spec)) {
            PyErr_Clear();
            return module;
        }
        Py_DECREF(spec);
        Py_DECREF(module);
    } else if (PyErr_Occurred()) {
        PyErr_Clear();
    }
#endif
    return __Pyx__ImportDottedModule(name, parts_tuple);
}

/* FetchSharedCythonModule */
static PyObject *__Pyx_FetchSharedCythonABIModule(void) {
    PyObject *abi_module = PyImport_AddModule((char*) __PYX_ABI_MODULE_NAME);
    if (unlikely(!abi_module)) return NULL;
    Py_INCREF(abi_module);
    return abi_module;
}

/* FetchCommonType */
static int __Pyx_VerifyCachedType(PyObject *cached_type,
                               const char *name,
                               Py_ssize_t basicsize,
                               Py_ssize_t expected_basicsize) {
    if (!PyType_Check(cached_type)) {
        PyErr_Format(PyExc_TypeError,
            "Shared Cython type %.200s is not a type object", name);
        return -1;
    }
    if (basicsize != expected_basicsize) {
        PyErr_Format(PyExc_TypeError,
            "Shared Cython type %.200s has the wrong size, try recompiling",
            name);
        return -1;
    }
    return 0;
}
#if !CYTHON_USE_TYPE_SPECS
static PyTypeObject* __Pyx_FetchCommonType(PyTypeObject* type) {
    PyObject* abi_module;
    const char* object_name;
    PyTypeObject *cached_type = NULL;
    abi_module = __Pyx_FetchSharedCythonABIModule();
    if (!abi_module) return NULL;
    object_name = strrchr(type->tp_name, '.');
    object_name = object_name ? object_name+1 : type->tp_name;
    cached_type = (PyTypeObject*) PyObject_GetAttrString(abi_module, object_name);
    if (cached_type) {
        if (__Pyx_VerifyCachedType(
              (PyObject *)cached_type,
              object_name,
              cached_type->tp_basicsize,
              type->tp_basicsize) < 0) {
            goto bad;
        }
        goto done;
    }
    if (!PyErr_ExceptionMatches(PyExc_AttributeError)) goto bad;
    PyErr_Clear();
    if (PyType_Ready(type) < 0) goto bad;
    if (PyObject_SetAttrString(abi_module, object_name, (PyObject *)type) < 0)
        goto bad;
    Py_INCREF(type);
    cached_type = type;
done:
    Py_DECREF(abi_module);
    return cached_type;
bad:
    Py_XDECREF(cached_type);
    cached_type = NULL;
    goto done;
}
#else
static PyTypeObject *__Pyx_FetchCommonTypeFromSpec(PyObject *module, PyType_Spec *spec, PyObject *bases) {
    PyObject *abi_module, *cached_type = NULL;
    const char* object_name = strrchr(spec->name, '.');
    object_name = object_name ? object_name+1 : spec->name;
    abi_module = __Pyx_FetchSharedCythonABIModule();
    if (!abi_module) return NULL;
    cached_type = PyObject_GetAttrString(abi_module, object_name);
    if (cached_type) {
        Py_ssize_t basicsize;
#if CYTHON_COMPILING_IN_LIMITED_API
        PyObject *py_basicsize;
        py_basicsize = PyObject_GetAttrString(cached_type, "__basicsize__");
        if (unlikely(!py_basicsize)) goto bad;
        basicsize = PyLong_AsSsize_t(py_basicsize);
        Py_DECREF(py_basicsize);
        py_basicsize = 0;
        if (unlikely(basicsize == (Py_ssize_t)-1) && PyErr_Occurred()) goto bad;
#else
        basicsize = likely(PyType_Check(cached_type)) ? ((PyTypeObject*) cached_type)->tp_basicsize : -1;
#endif
        if (__Pyx_VerifyCachedType(
              cached_type,
              object_name,
              basicsize,
              spec->basicsize) < 0) {
            goto bad;
        }
        goto done;
    }
    if (!PyErr_ExceptionMatches(PyExc_AttributeError)) goto bad;
    PyErr_Clear();
    CYTHON_UNUSED_VAR(module);
    cached_type = __Pyx_PyType_FromModuleAndSpec(abi_module, spec, bases);
    if (unlikely(!cached_type)) goto bad;
    if (unlikely(__Pyx_fix_up_extension_type_from_spec(spec, (PyTypeObject *) cached_type) < 0)) goto bad;
    if (PyObject_SetAttrString(abi_module, object_name, cached_type) < 0) goto bad;
done:
    Py_DECREF(abi_module);
    assert(cached_type == NULL || PyType_Check(cached_type));
    return (PyTypeObject *) cached_type;
bad:
    Py_XDECREF(cached_type);
    cached_type = NULL;
    goto done;
}
#endif

/* PyVectorcallFastCallDict */
#if CYTHON_METH_FASTCALL
static PyObject *__Pyx_PyVectorcall_FastCallDict_kw(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw)
{
    PyObject *res = NULL;
    PyObject *kwnames;
    PyObject **newargs;
    PyObject **kwvalues;
    Py_ssize_t i, pos;
    size_t j;
    PyObject *key, *value;
    unsigned long keys_are_strings;
    Py_ssize_t nkw = PyDict_GET_SIZE(kw);
    newargs = (PyObject **)PyMem_Malloc((nargs + (size_t)nkw) * sizeof(args[0]));
    if (unlikely(newargs == NULL)) {
        PyErr_NoMemory();
        return NULL;
    }
    for (j = 0; j < nargs; j++) newargs[j] = args[j];
    kwnames = PyTuple_New(nkw);
    if (unlikely(kwnames == NULL)) {
        PyMem_Free(newargs);
        return NULL;
    }
    kwvalues = newargs + nargs;
    pos = i = 0;
    keys_are_strings = Py_TPFLAGS_UNICODE_SUBCLASS;
    while (PyDict_Next(kw, &pos, &key, &value)) {
        keys_are_strings &= Py_TYPE(key)->tp_flags;
        Py_INCREF(key);
        Py_INCREF(value);
        PyTuple_SET_ITEM(kwnames, i, key);
        kwvalues[i] = value;
        i++;
    }
    if (unlikely(!keys_are_strings)) {
        PyErr_SetString(PyExc_TypeError, "keywords must be strings");
        goto cleanup;
    }
    res = vc(func, newargs, nargs, kwnames);
cleanup:
    Py_DECREF(kwnames);
    for (i = 0; i < nkw; i++)
        Py_DECREF(kwvalues[i]);
    PyMem_Free(newargs);
    return res;
}
static CYTHON_INLINE PyObject *__Pyx_PyVectorcall_FastCallDict(PyObject *func, __pyx_vectorcallfunc vc, PyObject *const *args, size_t nargs, PyObject *kw)
{
    if (likely(kw == NULL) || PyDict_GET_SIZE(kw) == 0) {
        return vc(func, args, nargs, NULL);
    }
    return __Pyx_PyVectorcall_FastCallDict_kw(func, vc, args, nargs, kw);
}
#endif

/* CythonFunctionShared */
static CYTHON_INLINE void __Pyx__CyFunction_SetClassObj(__pyx_CyFunctionObject* f, PyObject* classobj) {
#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
    __Pyx_Py_XDECREF_SET(
        __Pyx_CyFunction_GetClassObj(f),
            ((classobj) ? __Pyx_NewRef(classobj) : NULL));
#else
    __Pyx_Py_XDECREF_SET(
        ((PyCMethodObject *) (f))->mm_class,
        (PyTypeObject*)((classobj) ? __Pyx_NewRef(classobj) : NULL));
#endif
}
static PyObject *
__Pyx_CyFunction_get_doc(__pyx_CyFunctionObject *op, void *closure)
{
    CYTHON_UNUSED_VAR(closure);
    if (unlikely(op->func_doc == NULL)) {
#if CYTHON_COMPILING_IN_LIMITED_API
        op->func_doc = PyObject_GetAttrString(op->func, "__doc__");
        if (unlikely(!op->func_doc)) return NULL;
#else
        if (((PyCFunctionObject*)op)->m_ml->ml_doc) {
#if PY_MAJOR_VERSION >= 3
            op->func_doc = PyUnicode_FromString(((PyCFunctionObject*)op)->m_ml->ml_doc);
#else
            op->func_doc = PyString_FromString(((PyCFunctionObject*)op)->m_ml->ml_doc);
#endif
            if (unlikely(op->func_doc == NULL))
                return NULL;
        } else {
            Py_INCREF(Py_None);
            return Py_None;
        }
#endif
    }
    Py_INCREF(op->func_doc);
    return op->func_doc;
}
static int
__Pyx_CyFunction_set_doc(__pyx_CyFunctionObject *op, PyObject *value, void *context)
{
    CYTHON_UNUSED_VAR(context);
    if (value == NULL) {
        value = Py_None;
    }
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->func_doc, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_name(__pyx_CyFunctionObject *op, void *context)
{
    CYTHON_UNUSED_VAR(context);
    if (unlikely(op->func_name == NULL)) {
#if CYTHON_COMPILING_IN_LIMITED_API
        op->func_name = PyObject_GetAttrString(op->func, "__name__");
#elif PY_MAJOR_VERSION >= 3
        op->func_name = PyUnicode_InternFromString(((PyCFunctionObject*)op)->m_ml->ml_name);
#else
        op->func_name = PyString_InternFromString(((PyCFunctionObject*)op)->m_ml->ml_name);
#endif
        if (unlikely(op->func_name == NULL))
            return NULL;
    }
    Py_INCREF(op->func_name);
    return op->func_name;
}
static int
__Pyx_CyFunction_set_name(__pyx_CyFunctionObject *op, PyObject *value, void *context)
{
    CYTHON_UNUSED_VAR(context);
#if PY_MAJOR_VERSION >= 3
    if (unlikely(value == NULL || !PyUnicode_Check(value)))
#else
    if (unlikely(value == NULL || !PyString_Check(value)))
#endif
    {
        PyErr_SetString(PyExc_TypeError,
                        "__name__ must be set to a string object");
        return -1;
    }
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->func_name, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_qualname(__pyx_CyFunctionObject *op, void *context)
{
    CYTHON_UNUSED_VAR(context);
    Py_INCREF(op->func_qualname);
    return op->func_qualname;
}
static int
__Pyx_CyFunction_set_qualname(__pyx_CyFunctionObject *op, PyObject *value, void *context)
{
    CYTHON_UNUSED_VAR(context);
#if PY_MAJOR_VERSION >= 3
    if (unlikely(value == NULL || !PyUnicode_Check(value)))
#else
    if (unlikely(value == NULL || !PyString_Check(value)))
#endif
    {
        PyErr_SetString(PyExc_TypeError,
                        "__qualname__ must be set to a string object");
        return -1;
    }
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->func_qualname, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_dict(__pyx_CyFunctionObject *op, void *context)
{
    CYTHON_UNUSED_VAR(context);
    if (unlikely(op->func_dict == NULL)) {
        op->func_dict = PyDict_New();
        if (unlikely(op->func_dict == NULL))
            return NULL;
    }
    Py_INCREF(op->func_dict);
    return op->func_dict;
}
static int
__Pyx_CyFunction_set_dict(__pyx_CyFunctionObject *op, PyObject *value, void *context)
{
    CYTHON_UNUSED_VAR(context);
    if (unlikely(value == NULL)) {
        PyErr_SetString(PyExc_TypeError,
               "function's dictionary may not be deleted");
        return -1;
    }
    if (unlikely(!PyDict_Check(value))) {
        PyErr_SetString(PyExc_TypeError,
               "setting function's dictionary to a non-dict");
        return -1;
    }
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->func_dict, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_globals(__pyx_CyFunctionObject *op, void *context)
{
    CYTHON_UNUSED_VAR(context);
    Py_INCREF(op->func_globals);
    return op->func_globals;
}
static PyObject *
__Pyx_CyFunction_get_closure(__pyx_CyFunctionObject *op, void *context)
{
    CYTHON_UNUSED_VAR(op);
    CYTHON_UNUSED_VAR(context);
    Py_INCREF(Py_None);
    return Py_None;
}
static PyObject *
__Pyx_CyFunction_get_code(__pyx_CyFunctionObject *op, void *context)
{
    PyObject* result = (op->func_code) ? op->func_code : Py_None;
    CYTHON_UNUSED_VAR(context);
    Py_INCREF(result);
    return result;
}
static int
__Pyx_CyFunction_init_defaults(__pyx_CyFunctionObject *op) {
    int result = 0;
    PyObject *res = op->defaults_getter((PyObject *) op);
    if (unlikely(!res))
        return -1;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    op->defaults_tuple = PyTuple_GET_ITEM(res, 0);
    Py_INCREF(op->defaults_tuple);
    op->defaults_kwdict = PyTuple_GET_ITEM(res, 1);
    Py_INCREF(op->defaults_kwdict);
    #else
    op->defaults_tuple = __Pyx_PySequence_ITEM(res, 0);
    if (unlikely(!op->defaults_tuple)) result = -1;
    else {
        op->defaults_kwdict = __Pyx_PySequence_ITEM(res, 1);
        if (unlikely(!op->defaults_kwdict)) result = -1;
    }
    #endif
    Py_DECREF(res);
    return result;
}
static int
__Pyx_CyFunction_set_defaults(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
    CYTHON_UNUSED_VAR(context);
    if (!value) {
        value = Py_None;
    } else if (unlikely(value != Py_None && !PyTuple_Check(value))) {
        PyErr_SetString(PyExc_TypeError,
                        "__defaults__ must be set to a tuple object");
        return -1;
    }
    PyErr_WarnEx(PyExc_RuntimeWarning, "changes to cyfunction.__defaults__ will not "
                 "currently affect the values used in function calls", 1);
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->defaults_tuple, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_defaults(__pyx_CyFunctionObject *op, void *context) {
    PyObject* result = op->defaults_tuple;
    CYTHON_UNUSED_VAR(context);
    if (unlikely(!result)) {
        if (op->defaults_getter) {
            if (unlikely(__Pyx_CyFunction_init_defaults(op) < 0)) return NULL;
            result = op->defaults_tuple;
        } else {
            result = Py_None;
        }
    }
    Py_INCREF(result);
    return result;
}
static int
__Pyx_CyFunction_set_kwdefaults(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
    CYTHON_UNUSED_VAR(context);
    if (!value) {
        value = Py_None;
    } else if (unlikely(value != Py_None && !PyDict_Check(value))) {
        PyErr_SetString(PyExc_TypeError,
                        "__kwdefaults__ must be set to a dict object");
        return -1;
    }
    PyErr_WarnEx(PyExc_RuntimeWarning, "changes to cyfunction.__kwdefaults__ will not "
                 "currently affect the values used in function calls", 1);
    Py_INCREF(value);
    __Pyx_Py_XDECREF_SET(op->defaults_kwdict, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_kwdefaults(__pyx_CyFunctionObject *op, void *context) {
    PyObject* result = op->defaults_kwdict;
    CYTHON_UNUSED_VAR(context);
    if (unlikely(!result)) {
        if (op->defaults_getter) {
            if (unlikely(__Pyx_CyFunction_init_defaults(op) < 0)) return NULL;
            result = op->defaults_kwdict;
        } else {
            result = Py_None;
        }
    }
    Py_INCREF(result);
    return result;
}
static int
__Pyx_CyFunction_set_annotations(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
    CYTHON_UNUSED_VAR(context);
    if (!value || value == Py_None) {
        value = NULL;
    } else if (unlikely(!PyDict_Check(value))) {
        PyErr_SetString(PyExc_TypeError,
                        "__annotations__ must be set to a dict object");
        return -1;
    }
    Py_XINCREF(value);
    __Pyx_Py_XDECREF_SET(op->func_annotations, value);
    return 0;
}
static PyObject *
__Pyx_CyFunction_get_annotations(__pyx_CyFunctionObject *op, void *context) {
    PyObject* result = op->func_annotations;
    CYTHON_UNUSED_VAR(context);
    if (unlikely(!result)) {
        result = PyDict_New();
        if (unlikely(!result)) return NULL;
        op->func_annotations = result;
    }
    Py_INCREF(result);
    return result;
}
static PyObject *
__Pyx_CyFunction_get_is_coroutine(__pyx_CyFunctionObject *op, void *context) {
    int is_coroutine;
    CYTHON_UNUSED_VAR(context);
    if (op->func_is_coroutine) {
        return __Pyx_NewRef(op->func_is_coroutine);
    }
    is_coroutine = op->flags & __Pyx_CYFUNCTION_COROUTINE;
#if PY_VERSION_HEX >= 0x03050000
    if (is_coroutine) {
        PyObject *module, *fromlist, *marker = __pyx_n_s_is_coroutine;
        fromlist = PyList_New(1);
        if (unlikely(!fromlist)) return NULL;
        Py_INCREF(marker);
#if CYTHON_ASSUME_SAFE_MACROS
        PyList_SET_ITEM(fromlist, 0, marker);
#else
        if (unlikely(PyList_SetItem(fromlist, 0, marker) < 0)) {
            Py_DECREF(marker);
            Py_DECREF(fromlist);
            return NULL;
        }
#endif
        module = PyImport_ImportModuleLevelObject(__pyx_n_s_asyncio_coroutines, NULL, NULL, fromlist, 0);
        Py_DECREF(fromlist);
        if (unlikely(!module)) goto ignore;
        op->func_is_coroutine = __Pyx_PyObject_GetAttrStr(module, marker);
        Py_DECREF(module);
        if (likely(op->func_is_coroutine)) {
            return __Pyx_NewRef(op->func_is_coroutine);
        }
ignore:
        PyErr_Clear();
    }
#endif
    op->func_is_coroutine = __Pyx_PyBool_FromLong(is_coroutine);
    return __Pyx_NewRef(op->func_is_coroutine);
}
#if CYTHON_COMPILING_IN_LIMITED_API
static PyObject *
__Pyx_CyFunction_get_module(__pyx_CyFunctionObject *op, void *context) {
    CYTHON_UNUSED_VAR(context);
    return PyObject_GetAttrString(op->func, "__module__");
}
static int
__Pyx_CyFunction_set_module(__pyx_CyFunctionObject *op, PyObject* value, void *context) {
    CYTHON_UNUSED_VAR(context);
    return PyObject_SetAttrString(op->func, "__module__", value);
}
#endif
static PyGetSetDef __pyx_CyFunction_getsets[] = {
    {(char *) "func_doc", (getter)__Pyx_CyFunction_get_doc, (setter)__Pyx_CyFunction_set_doc, 0, 0},
    {(char *) "__doc__",  (getter)__Pyx_CyFunction_get_doc, (setter)__Pyx_CyFunction_set_doc, 0, 0},
    {(char *) "func_name", (getter)__Pyx_CyFunction_get_name, (setter)__Pyx_CyFunction_set_name, 0, 0},
    {(char *) "__name__", (getter)__Pyx_CyFunction_get_name, (setter)__Pyx_CyFunction_set_name, 0, 0},
    {(char *) "__qualname__", (getter)__Pyx_CyFunction_get_qualname, (setter)__Pyx_CyFunction_set_qualname, 0, 0},
    {(char *) "func_dict", (getter)__Pyx_CyFunction_get_dict, (setter)__Pyx_CyFunction_set_dict, 0, 0},
    {(char *) "__dict__", (getter)__Pyx_CyFunction_get_dict, (setter)__Pyx_CyFunction_set_dict, 0, 0},
    {(char *) "func_globals", (getter)__Pyx_CyFunction_get_globals, 0, 0, 0},
    {(char *) "__globals__", (getter)__Pyx_CyFunction_get_globals, 0, 0, 0},
    {(char *) "func_closure", (getter)__Pyx_CyFunction_get_closure, 0, 0, 0},
    {(char *) "__closure__", (getter)__Pyx_CyFunction_get_closure, 0, 0, 0},
    {(char *) "func_code", (getter)__Pyx_CyFunction_get_code, 0, 0, 0},
    {(char *) "__code__", (getter)__Pyx_CyFunction_get_code, 0, 0, 0},
    {(char *) "func_defaults", (getter)__Pyx_CyFunction_get_defaults, (setter)__Pyx_CyFunction_set_defaults, 0, 0},
    {(char *) "__defaults__", (getter)__Pyx_CyFunction_get_defaults, (setter)__Pyx_CyFunction_set_defaults, 0, 0},
    {(char *) "__kwdefaults__", (getter)__Pyx_CyFunction_get_kwdefaults, (setter)__Pyx_CyFunction_set_kwdefaults, 0, 0},
    {(char *) "__annotations__", (getter)__Pyx_CyFunction_get_annotations, (setter)__Pyx_CyFunction_set_annotations, 0, 0},
    {(char *) "_is_coroutine", (getter)__Pyx_CyFunction_get_is_coroutine, 0, 0, 0},
#if CYTHON_COMPILING_IN_LIMITED_API
    {"__module__", (getter)__Pyx_CyFunction_get_module, (setter)__Pyx_CyFunction_set_module, 0, 0},
#endif
    {0, 0, 0, 0, 0}
};
static PyMemberDef __pyx_CyFunction_members[] = {
#if !CYTHON_COMPILING_IN_LIMITED_API
    {(char *) "__module__", T_OBJECT, offsetof(PyCFunctionObject, m_module), 0, 0},
#endif
#if CYTHON_USE_TYPE_SPECS
    {(char *) "__dictoffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_dict), READONLY, 0},
#if CYTHON_METH_FASTCALL
#if CYTHON_BACKPORT_VECTORCALL
    {(char *) "__vectorcalloffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_vectorcall), READONLY, 0},
#else
#if !CYTHON_COMPILING_IN_LIMITED_API
    {(char *) "__vectorcalloffset__", T_PYSSIZET, offsetof(PyCFunctionObject, vectorcall), READONLY, 0},
#endif
#endif
#endif
#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
    {(char *) "__weaklistoffset__", T_PYSSIZET, offsetof(__pyx_CyFunctionObject, func_weakreflist), READONLY, 0},
#else
    {(char *) "__weaklistoffset__", T_PYSSIZET, offsetof(PyCFunctionObject, m_weakreflist), READONLY, 0},
#endif
#endif
    {0, 0, 0,  0, 0}
};
static PyObject *
__Pyx_CyFunction_reduce(__pyx_CyFunctionObject *m, PyObject *args)
{
    CYTHON_UNUSED_VAR(args);
#if PY_MAJOR_VERSION >= 3
    Py_INCREF(m->func_qualname);
    return m->func_qualname;
#else
    return PyString_FromString(((PyCFunctionObject*)m)->m_ml->ml_name);
#endif
}
static PyMethodDef __pyx_CyFunction_methods[] = {
    {"__reduce__", (PyCFunction)__Pyx_CyFunction_reduce, METH_VARARGS, 0},
    {0, 0, 0, 0}
};
#if PY_VERSION_HEX < 0x030500A0 || CYTHON_COMPILING_IN_LIMITED_API
#define __Pyx_CyFunction_weakreflist(cyfunc) ((cyfunc)->func_weakreflist)
#else
#define __Pyx_CyFunction_weakreflist(cyfunc) (((PyCFunctionObject*)cyfunc)->m_weakreflist)
#endif
static PyObject *__Pyx_CyFunction_Init(__pyx_CyFunctionObject *op, PyMethodDef *ml, int flags, PyObject* qualname,
                                       PyObject *closure, PyObject *module, PyObject* globals, PyObject* code) {
#if !CYTHON_COMPILING_IN_LIMITED_API
    PyCFunctionObject *cf = (PyCFunctionObject*) op;
#endif
    if (unlikely(op == NULL))
        return NULL;
#if CYTHON_COMPILING_IN_LIMITED_API
    op->func = PyCFunction_NewEx(ml, (PyObject*)op, module);
    if (unlikely(!op->func)) return NULL;
#endif
    op->flags = flags;
    __Pyx_CyFunction_weakreflist(op) = NULL;
#if !CYTHON_COMPILING_IN_LIMITED_API
    cf->m_ml = ml;
    cf->m_self = (PyObject *) op;
#endif
    Py_XINCREF(closure);
    op->func_closure = closure;
#if !CYTHON_COMPILING_IN_LIMITED_API
    Py_XINCREF(module);
    cf->m_module = module;
#endif
    op->func_dict = NULL;
    op->func_name = NULL;
    Py_INCREF(qualname);
    op->func_qualname = qualname;
    op->func_doc = NULL;
#if PY_VERSION_HEX < 0x030900B1 || CYTHON_COMPILING_IN_LIMITED_API
    op->func_classobj = NULL;
#else
    ((PyCMethodObject*)op)->mm_class = NULL;
#endif
    op->func_globals = globals;
    Py_INCREF(op->func_globals);
    Py_XINCREF(code);
    op->func_code = code;
    op->defaults_pyobjects = 0;
    op->defaults_size = 0;
    op->defaults = NULL;
    op->defaults_tuple = NULL;
    op->defaults_kwdict = NULL;
    op->defaults_getter = NULL;
    op->func_annotations = NULL;
    op->func_is_coroutine = NULL;
#if CYTHON_METH_FASTCALL
    switch (ml->ml_flags & (METH_VARARGS | METH_FASTCALL | METH_NOARGS | METH_O | METH_KEYWORDS | METH_METHOD)) {
    case METH_NOARGS:
        __Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_NOARGS;
        break;
    case METH_O:
        __Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_O;
        break;
    case METH_METHOD | METH_FASTCALL | METH_KEYWORDS:
        __Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD;
        break;
    case METH_FASTCALL | METH_KEYWORDS:
        __Pyx_CyFunction_func_vectorcall(op) = __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS;
        break;
    case METH_VARARGS | METH_KEYWORDS:
        __Pyx_CyFunction_func_vectorcall(op) = NULL;
        break;
    default:
        PyErr_SetString(PyExc_SystemError, "Bad call flags for CyFunction");
        Py_DECREF(op);
        return NULL;
    }
#endif
    return (PyObject *) op;
}
static int
__Pyx_CyFunction_clear(__pyx_CyFunctionObject *m)
{
    Py_CLEAR(m->func_closure);
#if CYTHON_COMPILING_IN_LIMITED_API
    Py_CLEAR(m->func);
#else
    Py_CLEAR(((PyCFunctionObject*)m)->m_module);
#endif
    Py_CLEAR(m->func_dict);
    Py_CLEAR(m->func_name);
    Py_CLEAR(m->func_qualname);
    Py_CLEAR(m->func_doc);
    Py_CLEAR(m->func_globals);
    Py_CLEAR(m->func_code);
#if !CYTHON_COMPILING_IN_LIMITED_API
#if PY_VERSION_HEX < 0x030900B1
    Py_CLEAR(__Pyx_CyFunction_GetClassObj(m));
#else
    {
        PyObject *cls = (PyObject*) ((PyCMethodObject *) (m))->mm_class;
        ((PyCMethodObject *) (m))->mm_class = NULL;
        Py_XDECREF(cls);
    }
#endif
#endif
    Py_CLEAR(m->defaults_tuple);
    Py_CLEAR(m->defaults_kwdict);
    Py_CLEAR(m->func_annotations);
    Py_CLEAR(m->func_is_coroutine);
    if (m->defaults) {
        PyObject **pydefaults = __Pyx_CyFunction_Defaults(PyObject *, m);
        int i;
        for (i = 0; i < m->defaults_pyobjects; i++)
            Py_XDECREF(pydefaults[i]);
        PyObject_Free(m->defaults);
        m->defaults = NULL;
    }
    return 0;
}
static void __Pyx__CyFunction_dealloc(__pyx_CyFunctionObject *m)
{
    if (__Pyx_CyFunction_weakreflist(m) != NULL)
        PyObject_ClearWeakRefs((PyObject *) m);
    __Pyx_CyFunction_clear(m);
    __Pyx_PyHeapTypeObject_GC_Del(m);
}
static void __Pyx_CyFunction_dealloc(__pyx_CyFunctionObject *m)
{
    PyObject_GC_UnTrack(m);
    __Pyx__CyFunction_dealloc(m);
}
static int __Pyx_CyFunction_traverse(__pyx_CyFunctionObject *m, visitproc visit, void *arg)
{
    Py_VISIT(m->func_closure);
#if CYTHON_COMPILING_IN_LIMITED_API
    Py_VISIT(m->func);
#else
    Py_VISIT(((PyCFunctionObject*)m)->m_module);
#endif
    Py_VISIT(m->func_dict);
    Py_VISIT(m->func_name);
    Py_VISIT(m->func_qualname);
    Py_VISIT(m->func_doc);
    Py_VISIT(m->func_globals);
    Py_VISIT(m->func_code);
#if !CYTHON_COMPILING_IN_LIMITED_API
    Py_VISIT(__Pyx_CyFunction_GetClassObj(m));
#endif
    Py_VISIT(m->defaults_tuple);
    Py_VISIT(m->defaults_kwdict);
    Py_VISIT(m->func_is_coroutine);
    if (m->defaults) {
        PyObject **pydefaults = __Pyx_CyFunction_Defaults(PyObject *, m);
        int i;
        for (i = 0; i < m->defaults_pyobjects; i++)
            Py_VISIT(pydefaults[i]);
    }
    return 0;
}
static PyObject*
__Pyx_CyFunction_repr(__pyx_CyFunctionObject *op)
{
#if PY_MAJOR_VERSION >= 3
    return PyUnicode_FromFormat("<cyfunction %U at %p>",
                                op->func_qualname, (void *)op);
#else
    return PyString_FromFormat("<cyfunction %s at %p>",
                               PyString_AsString(op->func_qualname), (void *)op);
#endif
}
static PyObject * __Pyx_CyFunction_CallMethod(PyObject *func, PyObject *self, PyObject *arg, PyObject *kw) {
#if CYTHON_COMPILING_IN_LIMITED_API
    PyObject *f = ((__pyx_CyFunctionObject*)func)->func;
    PyObject *py_name = NULL;
    PyCFunction meth;
    int flags;
    meth = PyCFunction_GetFunction(f);
    if (unlikely(!meth)) return NULL;
    flags = PyCFunction_GetFlags(f);
    if (unlikely(flags < 0)) return NULL;
#else
    PyCFunctionObject* f = (PyCFunctionObject*)func;
    PyCFunction meth = f->m_ml->ml_meth;
    int flags = f->m_ml->ml_flags;
#endif
    Py_ssize_t size;
    switch (flags & (METH_VARARGS | METH_KEYWORDS | METH_NOARGS | METH_O)) {
    case METH_VARARGS:
        if (likely(kw == NULL || PyDict_Size(kw) == 0))
            return (*meth)(self, arg);
        break;
    case METH_VARARGS | METH_KEYWORDS:
        return (*(PyCFunctionWithKeywords)(void*)meth)(self, arg, kw);
    case METH_NOARGS:
        if (likely(kw == NULL || PyDict_Size(kw) == 0)) {
#if CYTHON_ASSUME_SAFE_MACROS
            size = PyTuple_GET_SIZE(arg);
#else
            size = PyTuple_Size(arg);
            if (unlikely(size < 0)) return NULL;
#endif
            if (likely(size == 0))
                return (*meth)(self, NULL);
#if CYTHON_COMPILING_IN_LIMITED_API
            py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
            if (!py_name) return NULL;
            PyErr_Format(PyExc_TypeError,
                "%.200S() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
                py_name, size);
            Py_DECREF(py_name);
#else
            PyErr_Format(PyExc_TypeError,
                "%.200s() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
                f->m_ml->ml_name, size);
#endif
            return NULL;
        }
        break;
    case METH_O:
        if (likely(kw == NULL || PyDict_Size(kw) == 0)) {
#if CYTHON_ASSUME_SAFE_MACROS
            size = PyTuple_GET_SIZE(arg);
#else
            size = PyTuple_Size(arg);
            if (unlikely(size < 0)) return NULL;
#endif
            if (likely(size == 1)) {
                PyObject *result, *arg0;
                #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
                arg0 = PyTuple_GET_ITEM(arg, 0);
                #else
                arg0 = __Pyx_PySequence_ITEM(arg, 0); if (unlikely(!arg0)) return NULL;
                #endif
                result = (*meth)(self, arg0);
                #if !(CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS)
                Py_DECREF(arg0);
                #endif
                return result;
            }
#if CYTHON_COMPILING_IN_LIMITED_API
            py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
            if (!py_name) return NULL;
            PyErr_Format(PyExc_TypeError,
                "%.200S() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
                py_name, size);
            Py_DECREF(py_name);
#else
            PyErr_Format(PyExc_TypeError,
                "%.200s() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
                f->m_ml->ml_name, size);
#endif
            return NULL;
        }
        break;
    default:
        PyErr_SetString(PyExc_SystemError, "Bad call flags for CyFunction");
        return NULL;
    }
#if CYTHON_COMPILING_IN_LIMITED_API
    py_name = __Pyx_CyFunction_get_name((__pyx_CyFunctionObject*)func, NULL);
    if (!py_name) return NULL;
    PyErr_Format(PyExc_TypeError, "%.200S() takes no keyword arguments",
                 py_name);
    Py_DECREF(py_name);
#else
    PyErr_Format(PyExc_TypeError, "%.200s() takes no keyword arguments",
                 f->m_ml->ml_name);
#endif
    return NULL;
}
static CYTHON_INLINE PyObject *__Pyx_CyFunction_Call(PyObject *func, PyObject *arg, PyObject *kw) {
    PyObject *self, *result;
#if CYTHON_COMPILING_IN_LIMITED_API
    self = PyCFunction_GetSelf(((__pyx_CyFunctionObject*)func)->func);
    if (unlikely(!self) && PyErr_Occurred()) return NULL;
#else
    self = ((PyCFunctionObject*)func)->m_self;
#endif
    result = __Pyx_CyFunction_CallMethod(func, self, arg, kw);
    return result;
}
static PyObject *__Pyx_CyFunction_CallAsMethod(PyObject *func, PyObject *args, PyObject *kw) {
    PyObject *result;
    __pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *) func;
#if CYTHON_METH_FASTCALL
     __pyx_vectorcallfunc vc = __Pyx_CyFunction_func_vectorcall(cyfunc);
    if (vc) {
#if CYTHON_ASSUME_SAFE_MACROS
        return __Pyx_PyVectorcall_FastCallDict(func, vc, &PyTuple_GET_ITEM(args, 0), (size_t)PyTuple_GET_SIZE(args), kw);
#else
        (void) &__Pyx_PyVectorcall_FastCallDict;
        return PyVectorcall_Call(func, args, kw);
#endif
    }
#endif
    if ((cyfunc->flags & __Pyx_CYFUNCTION_CCLASS) && !(cyfunc->flags & __Pyx_CYFUNCTION_STATICMETHOD)) {
        Py_ssize_t argc;
        PyObject *new_args;
        PyObject *self;
#if CYTHON_ASSUME_SAFE_MACROS
        argc = PyTuple_GET_SIZE(args);
#else
        argc = PyTuple_Size(args);
        if (unlikely(!argc) < 0) return NULL;
#endif
        new_args = PyTuple_GetSlice(args, 1, argc);
        if (unlikely(!new_args))
            return NULL;
        self = PyTuple_GetItem(args, 0);
        if (unlikely(!self)) {
            Py_DECREF(new_args);
#if PY_MAJOR_VERSION > 2
            PyErr_Format(PyExc_TypeError,
                         "unbound method %.200S() needs an argument",
                         cyfunc->func_qualname);
#else
            PyErr_SetString(PyExc_TypeError,
                            "unbound method needs an argument");
#endif
            return NULL;
        }
        result = __Pyx_CyFunction_CallMethod(func, self, new_args, kw);
        Py_DECREF(new_args);
    } else {
        result = __Pyx_CyFunction_Call(func, args, kw);
    }
    return result;
}
#if CYTHON_METH_FASTCALL
static CYTHON_INLINE int __Pyx_CyFunction_Vectorcall_CheckArgs(__pyx_CyFunctionObject *cyfunc, Py_ssize_t nargs, PyObject *kwnames)
{
    int ret = 0;
    if ((cyfunc->flags & __Pyx_CYFUNCTION_CCLASS) && !(cyfunc->flags & __Pyx_CYFUNCTION_STATICMETHOD)) {
        if (unlikely(nargs < 1)) {
            PyErr_Format(PyExc_TypeError, "%.200s() needs an argument",
                         ((PyCFunctionObject*)cyfunc)->m_ml->ml_name);
            return -1;
        }
        ret = 1;
    }
    if (unlikely(kwnames) && unlikely(PyTuple_GET_SIZE(kwnames))) {
        PyErr_Format(PyExc_TypeError,
                     "%.200s() takes no keyword arguments", ((PyCFunctionObject*)cyfunc)->m_ml->ml_name);
        return -1;
    }
    return ret;
}
static PyObject * __Pyx_CyFunction_Vectorcall_NOARGS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
{
    __pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
    PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
#if CYTHON_BACKPORT_VECTORCALL
    Py_ssize_t nargs = (Py_ssize_t)nargsf;
#else
    Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
#endif
    PyObject *self;
    switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, kwnames)) {
    case 1:
        self = args[0];
        args += 1;
        nargs -= 1;
        break;
    case 0:
        self = ((PyCFunctionObject*)cyfunc)->m_self;
        break;
    default:
        return NULL;
    }
    if (unlikely(nargs != 0)) {
        PyErr_Format(PyExc_TypeError,
            "%.200s() takes no arguments (%" CYTHON_FORMAT_SSIZE_T "d given)",
            def->ml_name, nargs);
        return NULL;
    }
    return def->ml_meth(self, NULL);
}
static PyObject * __Pyx_CyFunction_Vectorcall_O(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
{
    __pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
    PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
#if CYTHON_BACKPORT_VECTORCALL
    Py_ssize_t nargs = (Py_ssize_t)nargsf;
#else
    Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
#endif
    PyObject *self;
    switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, kwnames)) {
    case 1:
        self = args[0];
        args += 1;
        nargs -= 1;
        break;
    case 0:
        self = ((PyCFunctionObject*)cyfunc)->m_self;
        break;
    default:
        return NULL;
    }
    if (unlikely(nargs != 1)) {
        PyErr_Format(PyExc_TypeError,
            "%.200s() takes exactly one argument (%" CYTHON_FORMAT_SSIZE_T "d given)",
            def->ml_name, nargs);
        return NULL;
    }
    return def->ml_meth(self, args[0]);
}
static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
{
    __pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
    PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
#if CYTHON_BACKPORT_VECTORCALL
    Py_ssize_t nargs = (Py_ssize_t)nargsf;
#else
    Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
#endif
    PyObject *self;
    switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, NULL)) {
    case 1:
        self = args[0];
        args += 1;
        nargs -= 1;
        break;
    case 0:
        self = ((PyCFunctionObject*)cyfunc)->m_self;
        break;
    default:
        return NULL;
    }
    return ((_PyCFunctionFastWithKeywords)(void(*)(void))def->ml_meth)(self, args, nargs, kwnames);
}
static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
{
    __pyx_CyFunctionObject *cyfunc = (__pyx_CyFunctionObject *)func;
    PyMethodDef* def = ((PyCFunctionObject*)cyfunc)->m_ml;
    PyTypeObject *cls = (PyTypeObject *) __Pyx_CyFunction_GetClassObj(cyfunc);
#if CYTHON_BACKPORT_VECTORCALL
    Py_ssize_t nargs = (Py_ssize_t)nargsf;
#else
    Py_ssize_t nargs = PyVectorcall_NARGS(nargsf);
#endif
    PyObject *self;
    switch (__Pyx_CyFunction_Vectorcall_CheckArgs(cyfunc, nargs, NULL)) {
    case 1:
        self = args[0];
        args += 1;
        nargs -= 1;
        break;
    case 0:
        self = ((PyCFunctionObject*)cyfunc)->m_self;
        break;
    default:
        return NULL;
    }
    return ((__Pyx_PyCMethod)(void(*)(void))def->ml_meth)(self, cls, args, (size_t)nargs, kwnames);
}
#endif
#if CYTHON_USE_TYPE_SPECS
static PyType_Slot __pyx_CyFunctionType_slots[] = {
    {Py_tp_dealloc, (void *)__Pyx_CyFunction_dealloc},
    {Py_tp_repr, (void *)__Pyx_CyFunction_repr},
    {Py_tp_call, (void *)__Pyx_CyFunction_CallAsMethod},
    {Py_tp_traverse, (void *)__Pyx_CyFunction_traverse},
    {Py_tp_clear, (void *)__Pyx_CyFunction_clear},
    {Py_tp_methods, (void *)__pyx_CyFunction_methods},
    {Py_tp_members, (void *)__pyx_CyFunction_members},
    {Py_tp_getset, (void *)__pyx_CyFunction_getsets},
    {Py_tp_descr_get, (void *)__Pyx_PyMethod_New},
    {0, 0},
};
static PyType_Spec __pyx_CyFunctionType_spec = {
    __PYX_TYPE_MODULE_PREFIX "cython_function_or_method",
    sizeof(__pyx_CyFunctionObject),
    0,
#ifdef Py_TPFLAGS_METHOD_DESCRIPTOR
    Py_TPFLAGS_METHOD_DESCRIPTOR |
#endif
#if (defined(_Py_TPFLAGS_HAVE_VECTORCALL) && CYTHON_METH_FASTCALL)
    _Py_TPFLAGS_HAVE_VECTORCALL |
#endif
    Py_TPFLAGS_DEFAULT | Py_TPFLAGS_HAVE_GC | Py_TPFLAGS_BASETYPE,
    __pyx_CyFunctionType_slots
};
#else
static PyTypeObject __pyx_CyFunctionType_type = {
    PyVarObject_HEAD_INIT(0, 0)
    __PYX_TYPE_MODULE_PREFIX "cython_function_or_method",
    sizeof(__pyx_CyFunctionObject),
    0,
    (destructor) __Pyx_CyFunction_dealloc,
#if !CYTHON_METH_FASTCALL
    0,
#elif CYTHON_BACKPORT_VECTORCALL
    (printfunc)offsetof(__pyx_CyFunctionObject, func_vectorcall),
#else
    offsetof(PyCFunctionObject, vectorcall),
#endif
    0,
    0,
#if PY_MAJOR_VERSION < 3
    0,
#else
    0,
#endif
    (reprfunc) __Pyx_CyFunction_repr,
    0,
    0,
    0,
    0,
    __Pyx_CyFunction_CallAsMethod,
    0,
    0,
    0,
    0,
#ifdef Py_TPFLAGS_METHOD_DESCRIPTOR
    Py_TPFLAGS_METHOD_DESCRIPTOR |
#endif
#if defined(_Py_TPFLAGS_HAVE_VECTORCALL) && CYTHON_METH_FASTCALL
    _Py_TPFLAGS_HAVE_VECTORCALL |
#endif
    Py_TPFLAGS_DEFAULT | Py_TPFLAGS_HAVE_GC | Py_TPFLAGS_BASETYPE,
    0,
    (traverseproc) __Pyx_CyFunction_traverse,
    (inquiry) __Pyx_CyFunction_clear,
    0,
#if PY_VERSION_HEX < 0x030500A0
    offsetof(__pyx_CyFunctionObject, func_weakreflist),
#else
    offsetof(PyCFunctionObject, m_weakreflist),
#endif
    0,
    0,
    __pyx_CyFunction_methods,
    __pyx_CyFunction_members,
    __pyx_CyFunction_getsets,
    0,
    0,
    __Pyx_PyMethod_New,
    0,
    offsetof(__pyx_CyFunctionObject, func_dict),
    0,
    0,
    0,
    0,
    0,
    0,
    0,
    0,
    0,
    0,
    0,
    0,
#if PY_VERSION_HEX >= 0x030400a1
    0,
#endif
#if PY_VERSION_HEX >= 0x030800b1 && (!CYTHON_COMPILING_IN_PYPY || PYPY_VERSION_NUM >= 0x07030800)
    0,
#endif
#if __PYX_NEED_TP_PRINT_SLOT
    0,
#endif
#if PY_VERSION_HEX >= 0x030C0000
    0,
#endif
#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX >= 0x03090000 && PY_VERSION_HEX < 0x030a0000
    0,
#endif
};
#endif
static int __pyx_CyFunction_init(PyObject *module) {
#if CYTHON_USE_TYPE_SPECS
    __pyx_CyFunctionType = __Pyx_FetchCommonTypeFromSpec(module, &__pyx_CyFunctionType_spec, NULL);
#else
    CYTHON_UNUSED_VAR(module);
    __pyx_CyFunctionType = __Pyx_FetchCommonType(&__pyx_CyFunctionType_type);
#endif
    if (unlikely(__pyx_CyFunctionType == NULL)) {
        return -1;
    }
    return 0;
}
static CYTHON_INLINE void *__Pyx_CyFunction_InitDefaults(PyObject *func, size_t size, int pyobjects) {
    __pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
    m->defaults = PyObject_Malloc(size);
    if (unlikely(!m->defaults))
        return PyErr_NoMemory();
    memset(m->defaults, 0, size);
    m->defaults_pyobjects = pyobjects;
    m->defaults_size = size;
    return m->defaults;
}
static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsTuple(PyObject *func, PyObject *tuple) {
    __pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
    m->defaults_tuple = tuple;
    Py_INCREF(tuple);
}
static CYTHON_INLINE void __Pyx_CyFunction_SetDefaultsKwDict(PyObject *func, PyObject *dict) {
    __pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
    m->defaults_kwdict = dict;
    Py_INCREF(dict);
}
static CYTHON_INLINE void __Pyx_CyFunction_SetAnnotationsDict(PyObject *func, PyObject *dict) {
    __pyx_CyFunctionObject *m = (__pyx_CyFunctionObject *) func;
    m->func_annotations = dict;
    Py_INCREF(dict);
}

/* CythonFunction */
static PyObject *__Pyx_CyFunction_New(PyMethodDef *ml, int flags, PyObject* qualname,
                                      PyObject *closure, PyObject *module, PyObject* globals, PyObject* code) {
    PyObject *op = __Pyx_CyFunction_Init(
        PyObject_GC_New(__pyx_CyFunctionObject, __pyx_CyFunctionType),
        ml, flags, qualname, closure, module, globals, code
    );
    if (likely(op)) {
        PyObject_GC_Track(op);
    }
    return op;
}

/* CalculateMetaclass */
static PyObject *__Pyx_CalculateMetaclass(PyTypeObject *metaclass, PyObject *bases) {
    Py_ssize_t i, nbases;
#if CYTHON_ASSUME_SAFE_MACROS
    nbases = PyTuple_GET_SIZE(bases);
#else
    nbases = PyTuple_Size(bases);
    if (nbases < 0) return NULL;
#endif
    for (i=0; i < nbases; i++) {
        PyTypeObject *tmptype;
#if CYTHON_ASSUME_SAFE_MACROS
        PyObject *tmp = PyTuple_GET_ITEM(bases, i);
#else
        PyObject *tmp = PyTuple_GetItem(bases, i);
        if (!tmp) return NULL;
#endif
        tmptype = Py_TYPE(tmp);
#if PY_MAJOR_VERSION < 3
        if (tmptype == &PyClass_Type)
            continue;
#endif
        if (!metaclass) {
            metaclass = tmptype;
            continue;
        }
        if (PyType_IsSubtype(metaclass, tmptype))
            continue;
        if (PyType_IsSubtype(tmptype, metaclass)) {
            metaclass = tmptype;
            continue;
        }
        PyErr_SetString(PyExc_TypeError,
                        "metaclass conflict: "
                        "the metaclass of a derived class "
                        "must be a (non-strict) subclass "
                        "of the metaclasses of all its bases");
        return NULL;
    }
    if (!metaclass) {
#if PY_MAJOR_VERSION < 3
        metaclass = &PyClass_Type;
#else
        metaclass = &PyType_Type;
#endif
    }
    Py_INCREF((PyObject*) metaclass);
    return (PyObject*) metaclass;
}

/* PyObjectCall2Args */
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2) {
    PyObject *args[3] = {NULL, arg1, arg2};
    return __Pyx_PyObject_FastCall(function, args+1, 2 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET);
}

/* PyObjectLookupSpecial */
#if CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject* __Pyx__PyObject_LookupSpecial(PyObject* obj, PyObject* attr_name, int with_error) {
    PyObject *res;
    PyTypeObject *tp = Py_TYPE(obj);
#if PY_MAJOR_VERSION < 3
    if (unlikely(PyInstance_Check(obj)))
        return with_error ? __Pyx_PyObject_GetAttrStr(obj, attr_name) : __Pyx_PyObject_GetAttrStrNoError(obj, attr_name);
#endif
    res = _PyType_Lookup(tp, attr_name);
    if (likely(res)) {
        descrgetfunc f = Py_TYPE(res)->tp_descr_get;
        if (!f) {
            Py_INCREF(res);
        } else {
            res = f(res, obj, (PyObject *)tp);
        }
    } else if (with_error) {
        PyErr_SetObject(PyExc_AttributeError, attr_name);
    }
    return res;
}
#endif

/* Py3ClassCreate */
static PyObject *__Pyx_Py3MetaclassPrepare(PyObject *metaclass, PyObject *bases, PyObject *name,
                                           PyObject *qualname, PyObject *mkw, PyObject *modname, PyObject *doc) {
    PyObject *ns;
    if (metaclass) {
        PyObject *prep = __Pyx_PyObject_GetAttrStrNoError(metaclass, __pyx_n_s_prepare);
        if (prep) {
            PyObject *pargs[3] = {NULL, name, bases};
            ns = __Pyx_PyObject_FastCallDict(prep, pargs+1, 2 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET, mkw);
            Py_DECREF(prep);
        } else {
            if (unlikely(PyErr_Occurred()))
                return NULL;
            ns = PyDict_New();
        }
    } else {
        ns = PyDict_New();
    }
    if (unlikely(!ns))
        return NULL;
    if (unlikely(PyObject_SetItem(ns, __pyx_n_s_module, modname) < 0)) goto bad;
#if PY_VERSION_HEX >= 0x03030000
    if (unlikely(PyObject_SetItem(ns, __pyx_n_s_qualname, qualname) < 0)) goto bad;
#else
    CYTHON_MAYBE_UNUSED_VAR(qualname);
#endif
    if (unlikely(doc && PyObject_SetItem(ns, __pyx_n_s_doc, doc) < 0)) goto bad;
    return ns;
bad:
    Py_DECREF(ns);
    return NULL;
}
#if PY_VERSION_HEX < 0x030600A4 && CYTHON_PEP487_INIT_SUBCLASS
static int __Pyx_SetNamesPEP487(PyObject *type_obj) {
    PyTypeObject *type = (PyTypeObject*) type_obj;
    PyObject *names_to_set, *key, *value, *set_name, *tmp;
    Py_ssize_t i = 0;
#if CYTHON_USE_TYPE_SLOTS
    names_to_set = PyDict_Copy(type->tp_dict);
#else
    {
        PyObject *d = PyObject_GetAttr(type_obj, __pyx_n_s_dict);
        names_to_set = NULL;
        if (likely(d)) {
            PyObject *names_to_set = PyDict_New();
            int ret = likely(names_to_set) ? PyDict_Update(names_to_set, d) : -1;
            Py_DECREF(d);
            if (unlikely(ret < 0))
                Py_CLEAR(names_to_set);
        }
    }
#endif
    if (unlikely(names_to_set == NULL))
        goto bad;
    while (PyDict_Next(names_to_set, &i, &key, &value)) {
        set_name = __Pyx_PyObject_LookupSpecialNoError(value, __pyx_n_s_set_name);
        if (unlikely(set_name != NULL)) {
            tmp = __Pyx_PyObject_Call2Args(set_name, type_obj, key);
            Py_DECREF(set_name);
            if (unlikely(tmp == NULL)) {
                __Pyx_TypeName value_type_name =
                    __Pyx_PyType_GetName(Py_TYPE(value));
                __Pyx_TypeName type_name = __Pyx_PyType_GetName(type);
                PyErr_Format(PyExc_RuntimeError,
#if PY_MAJOR_VERSION >= 3
                    "Error calling __set_name__ on '" __Pyx_FMT_TYPENAME "' instance %R " "in '" __Pyx_FMT_TYPENAME "'",
                    value_type_name, key, type_name);
#else
                    "Error calling __set_name__ on '" __Pyx_FMT_TYPENAME "' instance %.100s in '" __Pyx_FMT_TYPENAME "'",
                    value_type_name,
                    PyString_Check(key) ? PyString_AS_STRING(key) : "?",
                    type_name);
#endif
                goto bad;
            } else {
                Py_DECREF(tmp);
            }
        }
        else if (unlikely(PyErr_Occurred())) {
            goto bad;
        }
    }
    Py_DECREF(names_to_set);
    return 0;
bad:
    Py_XDECREF(names_to_set);
    return -1;
}
static PyObject *__Pyx_InitSubclassPEP487(PyObject *type_obj, PyObject *mkw) {
#if CYTHON_USE_TYPE_SLOTS && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    PyTypeObject *type = (PyTypeObject*) type_obj;
    PyObject *mro = type->tp_mro;
    Py_ssize_t i, nbases;
    if (unlikely(!mro)) goto done;
    (void) &__Pyx_GetBuiltinName;
    Py_INCREF(mro);
    nbases = PyTuple_GET_SIZE(mro);
    assert(PyTuple_GET_ITEM(mro, 0) == type_obj);
    for (i = 1; i < nbases-1; i++) {
        PyObject *base, *dict, *meth;
        base = PyTuple_GET_ITEM(mro, i);
        dict = ((PyTypeObject *)base)->tp_dict;
        meth = __Pyx_PyDict_GetItemStrWithError(dict, __pyx_n_s_init_subclass);
        if (unlikely(meth)) {
            descrgetfunc f = Py_TYPE(meth)->tp_descr_get;
            PyObject *res;
            Py_INCREF(meth);
            if (likely(f)) {
                res = f(meth, NULL, type_obj);
                Py_DECREF(meth);
                if (unlikely(!res)) goto bad;
                meth = res;
            }
            res = __Pyx_PyObject_FastCallDict(meth, NULL, 0, mkw);
            Py_DECREF(meth);
            if (unlikely(!res)) goto bad;
            Py_DECREF(res);
            goto done;
        } else if (unlikely(PyErr_Occurred())) {
            goto bad;
        }
    }
done:
    Py_XDECREF(mro);
    return type_obj;
bad:
    Py_XDECREF(mro);
    Py_DECREF(type_obj);
    return NULL;
#else
    PyObject *super_type, *super, *func, *res;
#if CYTHON_COMPILING_IN_PYPY && !defined(PySuper_Type)
    super_type = __Pyx_GetBuiltinName(__pyx_n_s_super);
#else
    super_type = (PyObject*) &PySuper_Type;
    (void) &__Pyx_GetBuiltinName;
#endif
    super = likely(super_type) ? __Pyx_PyObject_Call2Args(super_type, type_obj, type_obj) : NULL;
#if CYTHON_COMPILING_IN_PYPY && !defined(PySuper_Type)
    Py_XDECREF(super_type);
#endif
    if (unlikely(!super)) {
        Py_CLEAR(type_obj);
        goto done;
    }
    func = __Pyx_PyObject_GetAttrStrNoError(super, __pyx_n_s_init_subclass);
    Py_DECREF(super);
    if (likely(!func)) {
        if (unlikely(PyErr_Occurred()))
            Py_CLEAR(type_obj);
        goto done;
    }
    res = __Pyx_PyObject_FastCallDict(func, NULL, 0, mkw);
    Py_DECREF(func);
    if (unlikely(!res))
        Py_CLEAR(type_obj);
    Py_XDECREF(res);
done:
    return type_obj;
#endif
}
#endif
static PyObject *__Pyx_Py3ClassCreate(PyObject *metaclass, PyObject *name, PyObject *bases,
                                      PyObject *dict, PyObject *mkw,
                                      int calculate_metaclass, int allow_py2_metaclass) {
    PyObject *result;
    PyObject *owned_metaclass = NULL;
    PyObject *margs[4] = {NULL, name, bases, dict};
    if (allow_py2_metaclass) {
        owned_metaclass = PyObject_GetItem(dict, __pyx_n_s_metaclass);
        if (owned_metaclass) {
            metaclass = owned_metaclass;
        } else if (likely(PyErr_ExceptionMatches(PyExc_KeyError))) {
            PyErr_Clear();
        } else {
            return NULL;
        }
    }
    if (calculate_metaclass && (!metaclass || PyType_Check(metaclass))) {
        metaclass = __Pyx_CalculateMetaclass((PyTypeObject*) metaclass, bases);
        Py_XDECREF(owned_metaclass);
        if (unlikely(!metaclass))
            return NULL;
        owned_metaclass = metaclass;
    }
    result = __Pyx_PyObject_FastCallDict(metaclass, margs+1, 3 | __Pyx_PY_VECTORCALL_ARGUMENTS_OFFSET,
#if PY_VERSION_HEX < 0x030600A4
        (metaclass == (PyObject*)&PyType_Type) ? NULL : mkw
#else
        mkw
#endif
    );
    Py_XDECREF(owned_metaclass);
#if PY_VERSION_HEX < 0x030600A4 && CYTHON_PEP487_INIT_SUBCLASS
    if (likely(result) && likely(PyType_Check(result))) {
        if (unlikely(__Pyx_SetNamesPEP487(result) < 0)) {
            Py_CLEAR(result);
        } else {
            result = __Pyx_InitSubclassPEP487(result, mkw);
        }
    }
#else
    (void) &__Pyx_GetBuiltinName;
#endif
    return result;
}

/* CLineInTraceback */
#ifndef CYTHON_CLINE_IN_TRACEBACK
static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line) {
    PyObject *use_cline;
    PyObject *ptype, *pvalue, *ptraceback;
#if CYTHON_COMPILING_IN_CPYTHON
    PyObject **cython_runtime_dict;
#endif
    CYTHON_MAYBE_UNUSED_VAR(tstate);
    if (unlikely(!__pyx_cython_runtime)) {
        return c_line;
    }
    __Pyx_ErrFetchInState(tstate, &ptype, &pvalue, &ptraceback);
#if CYTHON_COMPILING_IN_CPYTHON
    cython_runtime_dict = _PyObject_GetDictPtr(__pyx_cython_runtime);
    if (likely(cython_runtime_dict)) {
        __PYX_PY_DICT_LOOKUP_IF_MODIFIED(
            use_cline, *cython_runtime_dict,
            __Pyx_PyDict_GetItemStr(*cython_runtime_dict, __pyx_n_s_cline_in_traceback))
    } else
#endif
    {
      PyObject *use_cline_obj = __Pyx_PyObject_GetAttrStrNoError(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback);
      if (use_cline_obj) {
        use_cline = PyObject_Not(use_cline_obj) ? Py_False : Py_True;
        Py_DECREF(use_cline_obj);
      } else {
        PyErr_Clear();
        use_cline = NULL;
      }
    }
    if (!use_cline) {
        c_line = 0;
        (void) PyObject_SetAttr(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback, Py_False);
    }
    else if (use_cline == Py_False || (use_cline != Py_True && PyObject_Not(use_cline) != 0)) {
        c_line = 0;
    }
    __Pyx_ErrRestoreInState(tstate, ptype, pvalue, ptraceback);
    return c_line;
}
#endif

/* CodeObjectCache */
#if !CYTHON_COMPILING_IN_LIMITED_API
static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line) {
    int start = 0, mid = 0, end = count - 1;
    if (end >= 0 && code_line > entries[end].code_line) {
        return count;
    }
    while (start < end) {
        mid = start + (end - start) / 2;
        if (code_line < entries[mid].code_line) {
            end = mid;
        } else if (code_line > entries[mid].code_line) {
             start = mid + 1;
        } else {
            return mid;
        }
    }
    if (code_line <= entries[mid].code_line) {
        return mid;
    } else {
        return mid + 1;
    }
}
static PyCodeObject *__pyx_find_code_object(int code_line) {
    PyCodeObject* code_object;
    int pos;
    if (unlikely(!code_line) || unlikely(!__pyx_code_cache.entries)) {
        return NULL;
    }
    pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
    if (unlikely(pos >= __pyx_code_cache.count) || unlikely(__pyx_code_cache.entries[pos].code_line != code_line)) {
        return NULL;
    }
    code_object = __pyx_code_cache.entries[pos].code_object;
    Py_INCREF(code_object);
    return code_object;
}
static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object) {
    int pos, i;
    __Pyx_CodeObjectCacheEntry* entries = __pyx_code_cache.entries;
    if (unlikely(!code_line)) {
        return;
    }
    if (unlikely(!entries)) {
        entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Malloc(64*sizeof(__Pyx_CodeObjectCacheEntry));
        if (likely(entries)) {
            __pyx_code_cache.entries = entries;
            __pyx_code_cache.max_count = 64;
            __pyx_code_cache.count = 1;
            entries[0].code_line = code_line;
            entries[0].code_object = code_object;
            Py_INCREF(code_object);
        }
        return;
    }
    pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
    if ((pos < __pyx_code_cache.count) && unlikely(__pyx_code_cache.entries[pos].code_line == code_line)) {
        PyCodeObject* tmp = entries[pos].code_object;
        entries[pos].code_object = code_object;
        Py_DECREF(tmp);
        return;
    }
    if (__pyx_code_cache.count == __pyx_code_cache.max_count) {
        int new_max = __pyx_code_cache.max_count + 64;
        entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Realloc(
            __pyx_code_cache.entries, ((size_t)new_max) * sizeof(__Pyx_CodeObjectCacheEntry));
        if (unlikely(!entries)) {
            return;
        }
        __pyx_code_cache.entries = entries;
        __pyx_code_cache.max_count = new_max;
    }
    for (i=__pyx_code_cache.count; i>pos; i--) {
        entries[i] = entries[i-1];
    }
    entries[pos].code_line = code_line;
    entries[pos].code_object = code_object;
    __pyx_code_cache.count++;
    Py_INCREF(code_object);
}
#endif

/* AddTraceback */
#include "compile.h"
#include "frameobject.h"
#include "traceback.h"
#if PY_VERSION_HEX >= 0x030b00a6 && !CYTHON_COMPILING_IN_LIMITED_API
  #ifndef Py_BUILD_CORE
    #define Py_BUILD_CORE 1
  #endif
  #include "internal/pycore_frame.h"
#endif
#if CYTHON_COMPILING_IN_LIMITED_API
static PyObject *__Pyx_PyCode_Replace_For_AddTraceback(PyObject *code, PyObject *scratch_dict,
                                                       PyObject *firstlineno, PyObject *name) {
    PyObject *replace = NULL;
    if (unlikely(PyDict_SetItemString(scratch_dict, "co_firstlineno", firstlineno))) return NULL;
    if (unlikely(PyDict_SetItemString(scratch_dict, "co_name", name))) return NULL;
    replace = PyObject_GetAttrString(code, "replace");
    if (likely(replace)) {
        PyObject *result;
        result = PyObject_Call(replace, __pyx_empty_tuple, scratch_dict);
        Py_DECREF(replace);
        return result;
    }
    #if __PYX_LIMITED_VERSION_HEX < 0x030780000
    PyErr_Clear();
    {
        PyObject *compiled = NULL, *result = NULL;
        if (unlikely(PyDict_SetItemString(scratch_dict, "code", code))) return NULL;
        if (unlikely(PyDict_SetItemString(scratch_dict, "type", (PyObject*)(&PyType_Type)))) return NULL;
        compiled = Py_CompileString(
            "out = type(code)(\n"
            "  code.co_argcount, code.co_kwonlyargcount, code.co_nlocals, code.co_stacksize,\n"
            "  code.co_flags, code.co_code, code.co_consts, code.co_names,\n"
            "  code.co_varnames, code.co_filename, co_name, co_firstlineno,\n"
            "  code.co_lnotab)\n", "<dummy>", Py_file_input);
        if (!compiled) return NULL;
        result = PyEval_EvalCode(compiled, scratch_dict, scratch_dict);
        Py_DECREF(compiled);
        if (!result) PyErr_Print();
        Py_DECREF(result);
        result = PyDict_GetItemString(scratch_dict, "out");
        if (result) Py_INCREF(result);
        return result;
    }
    #endif
}
static void __Pyx_AddTraceback(const char *funcname, int c_line,
                               int py_line, const char *filename) {
    PyObject *code_object = NULL, *py_py_line = NULL, *py_funcname = NULL, *dict = NULL;
    PyObject *replace = NULL, *getframe = NULL, *frame = NULL;
    PyObject *exc_type, *exc_value, *exc_traceback;
    int success = 0;
    if (c_line) {
        (void) __pyx_cfilenm;
        (void) __Pyx_CLineForTraceback(__Pyx_PyThreadState_Current, c_line);
    }
    PyErr_Fetch(&exc_type, &exc_value, &exc_traceback);
    code_object = Py_CompileString("_getframe()", filename, Py_eval_input);
    if (unlikely(!code_object)) goto bad;
    py_py_line = PyLong_FromLong(py_line);
    if (unlikely(!py_py_line)) goto bad;
    py_funcname = PyUnicode_FromString(funcname);
    if (unlikely(!py_funcname)) goto bad;
    dict = PyDict_New();
    if (unlikely(!dict)) goto bad;
    {
        PyObject *old_code_object = code_object;
        code_object = __Pyx_PyCode_Replace_For_AddTraceback(code_object, dict, py_py_line, py_funcname);
        Py_DECREF(old_code_object);
    }
    if (unlikely(!code_object)) goto bad;
    getframe = PySys_GetObject("_getframe");
    if (unlikely(!getframe)) goto bad;
    if (unlikely(PyDict_SetItemString(dict, "_getframe", getframe))) goto bad;
    frame = PyEval_EvalCode(code_object, dict, dict);
    if (unlikely(!frame) || frame == Py_None) goto bad;
    success = 1;
  bad:
    PyErr_Restore(exc_type, exc_value, exc_traceback);
    Py_XDECREF(code_object);
    Py_XDECREF(py_py_line);
    Py_XDECREF(py_funcname);
    Py_XDECREF(dict);
    Py_XDECREF(replace);
    if (success) {
        PyTraceBack_Here(
            (struct _frame*)frame);
    }
    Py_XDECREF(frame);
}
#else
static PyCodeObject* __Pyx_CreateCodeObjectForTraceback(
            const char *funcname, int c_line,
            int py_line, const char *filename) {
    PyCodeObject *py_code = NULL;
    PyObject *py_funcname = NULL;
    #if PY_MAJOR_VERSION < 3
    PyObject *py_srcfile = NULL;
    py_srcfile = PyString_FromString(filename);
    if (!py_srcfile) goto bad;
    #endif
    if (c_line) {
        #if PY_MAJOR_VERSION < 3
        py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
        if (!py_funcname) goto bad;
        #else
        py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
        if (!py_funcname) goto bad;
        funcname = PyUnicode_AsUTF8(py_funcname);
        if (!funcname) goto bad;
        #endif
    }
    else {
        #if PY_MAJOR_VERSION < 3
        py_funcname = PyString_FromString(funcname);
        if (!py_funcname) goto bad;
        #endif
    }
    #if PY_MAJOR_VERSION < 3
    py_code = __Pyx_PyCode_New(
        0,
        0,
        0,
        0,
        0,
        0,
        __pyx_empty_bytes, /*PyObject *code,*/
        __pyx_empty_tuple, /*PyObject *consts,*/
        __pyx_empty_tuple, /*PyObject *names,*/
        __pyx_empty_tuple, /*PyObject *varnames,*/
        __pyx_empty_tuple, /*PyObject *freevars,*/
        __pyx_empty_tuple, /*PyObject *cellvars,*/
        py_srcfile,   /*PyObject *filename,*/
        py_funcname,  /*PyObject *name,*/
        py_line,
        __pyx_empty_bytes  /*PyObject *lnotab*/
    );
    Py_DECREF(py_srcfile);
    #else
    py_code = PyCode_NewEmpty(filename, funcname, py_line);
    #endif
    Py_XDECREF(py_funcname);  // XDECREF since it's only set on Py3 if cline
    return py_code;
bad:
    Py_XDECREF(py_funcname);
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(py_srcfile);
    #endif
    return NULL;
}
static void __Pyx_AddTraceback(const char *funcname, int c_line,
                               int py_line, const char *filename) {
    PyCodeObject *py_code = 0;
    PyFrameObject *py_frame = 0;
    PyThreadState *tstate = __Pyx_PyThreadState_Current;
    PyObject *ptype, *pvalue, *ptraceback;
    if (c_line) {
        c_line = __Pyx_CLineForTraceback(tstate, c_line);
    }
    py_code = __pyx_find_code_object(c_line ? -c_line : py_line);
    if (!py_code) {
        __Pyx_ErrFetchInState(tstate, &ptype, &pvalue, &ptraceback);
        py_code = __Pyx_CreateCodeObjectForTraceback(
            funcname, c_line, py_line, filename);
        if (!py_code) {
            /* If the code object creation fails, then we should clear the
               fetched exception references and propagate the new exception */
            Py_XDECREF(ptype);
            Py_XDECREF(pvalue);
            Py_XDECREF(ptraceback);
            goto bad;
        }
        __Pyx_ErrRestoreInState(tstate, ptype, pvalue, ptraceback);
        __pyx_insert_code_object(c_line ? -c_line : py_line, py_code);
    }
    py_frame = PyFrame_New(
        tstate,            /*PyThreadState *tstate,*/
        py_code,           /*PyCodeObject *code,*/
        __pyx_d,    /*PyObject *globals,*/
        0                  /*PyObject *locals*/
    );
    if (!py_frame) goto bad;
    __Pyx_PyFrame_SetLineNumber(py_frame, py_line);
    PyTraceBack_Here(py_frame);
bad:
    Py_XDECREF(py_code);
    Py_XDECREF(py_frame);
}
#endif

/* CIntFromPyVerify */
#define __PYX_VERIFY_RETURN_INT(target_type, func_type, func_value)\
    __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 0)
#define __PYX_VERIFY_RETURN_INT_EXC(target_type, func_type, func_value)\
    __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 1)
#define __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, exc)\
    {\
        func_type value = func_value;\
        if (sizeof(target_type) < sizeof(func_type)) {\
            if (unlikely(value != (func_type) (target_type) value)) {\
                func_type zero = 0;\
                if (exc && unlikely(value == (func_type)-1 && PyErr_Occurred()))\
                    return (target_type) -1;\
                if (is_unsigned && unlikely(value < zero))\
                    goto raise_neg_overflow;\
                else\
                    goto raise_overflow;\
            }\
        }\
        return (target_type) value;\
    }

/* CIntFromPy */
static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *x) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const int neg_one = (int) -1, const_zero = (int) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if ((sizeof(int) < sizeof(long))) {
            __PYX_VERIFY_RETURN_INT(int, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (int) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            if (unlikely(__Pyx_PyLong_IsNeg(x))) {
                goto raise_neg_overflow;
            } else if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_DigitCount(x)) {
                    case 2:
                        if ((8 * sizeof(int) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) >= 2 * PyLong_SHIFT)) {
                                return (int) (((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) >= 3 * PyLong_SHIFT)) {
                                return (int) (((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) >= 4 * PyLong_SHIFT)) {
                                return (int) (((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                            }
                        }
                        break;
                }
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (int) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if ((sizeof(int) <= sizeof(unsigned long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int) <= sizeof(unsigned PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_SignedDigitCount(x)) {
                    case -2:
                        if ((8 * sizeof(int) - 1 > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
                                return (int) (((int)-1)*(((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                    case 2:
                        if ((8 * sizeof(int) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
                                return (int) ((((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                    case -3:
                        if ((8 * sizeof(int) - 1 > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
                                return (int) (((int)-1)*(((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
                                return (int) ((((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                    case -4:
                        if ((8 * sizeof(int) - 1 > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 4 * PyLong_SHIFT)) {
                                return (int) (((int)-1)*(((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int) - 1 > 4 * PyLong_SHIFT)) {
                                return (int) ((((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                            }
                        }
                        break;
                }
            }
#endif
            if ((sizeof(int) <= sizeof(long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int) <= sizeof(PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
            int val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
#if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
#endif
            if (likely(v)) {
                int ret = -1;
#if !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                ret = _PyLong_AsByteArray((PyLongObject *)v,
                                           bytes, sizeof(val),
                                           is_little, !is_unsigned);
#else
                PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
                int bits, remaining_bits, is_negative = 0;
                long idigit;
                int chunk_size = (sizeof(long) < 8) ? 30 : 62;
                if (unlikely(!PyLong_CheckExact(v))) {
                    PyObject *tmp = v;
                    v = PyNumber_Long(v);
                    assert(PyLong_CheckExact(v));
                    Py_DECREF(tmp);
                    if (unlikely(!v)) return (int) -1;
                }
#if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                if (Py_SIZE(x) == 0)
                    return (int) 0;
                is_negative = Py_SIZE(x) < 0;
#else
                {
                    int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                    if (unlikely(result < 0))
                        return (int) -1;
                    is_negative = result == 1;
                }
#endif
                if (is_unsigned && unlikely(is_negative)) {
                    goto raise_neg_overflow;
                } else if (is_negative) {
                    stepval = PyNumber_Invert(v);
                    if (unlikely(!stepval))
                        return (int) -1;
                } else {
                    stepval = __Pyx_NewRef(v);
                }
                val = (int) 0;
                mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
                shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
                for (bits = 0; bits < (int) sizeof(int) * 8 - chunk_size; bits += chunk_size) {
                    PyObject *tmp, *digit;
                    digit = PyNumber_And(stepval, mask);
                    if (unlikely(!digit)) goto done;
                    idigit = PyLong_AsLong(digit);
                    Py_DECREF(digit);
                    if (unlikely(idigit < 0)) goto done;
                    tmp = PyNumber_Rshift(stepval, shift);
                    if (unlikely(!tmp)) goto done;
                    Py_DECREF(stepval); stepval = tmp;
                    val |= ((int) idigit) << bits;
                    #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                    if (Py_SIZE(stepval) == 0)
                        goto unpacking_done;
                    #endif
                }
                idigit = PyLong_AsLong(stepval);
                if (unlikely(idigit < 0)) goto done;
                remaining_bits = ((int) sizeof(int) * 8) - bits - (is_unsigned ? 0 : 1);
                if (unlikely(idigit >= (1L << remaining_bits)))
                    goto raise_overflow;
                val |= ((int) idigit) << bits;
            #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
            unpacking_done:
            #endif
                if (!is_unsigned) {
                    if (unlikely(val & (((int) 1) << (sizeof(int) * 8 - 1))))
                        goto raise_overflow;
                    if (is_negative)
                        val = ~val;
                }
                ret = 0;
            done:
                Py_XDECREF(shift);
                Py_XDECREF(mask);
                Py_XDECREF(stepval);
#endif
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
            return (int) -1;
        }
    } else {
        int val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (int) -1;
        val = __Pyx_PyInt_As_int(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to int");
    return (int) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to int");
    return (int) -1;
}

/* CIntToPy */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const int neg_one = (int) -1, const_zero = (int) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(int) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(int) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(int) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
#if !CYTHON_COMPILING_IN_LIMITED_API
        return _PyLong_FromByteArray(bytes, sizeof(int),
                                     little, !is_unsigned);
#else
        PyObject *from_bytes, *result = NULL;
        PyObject *py_bytes = NULL, *arg_tuple = NULL, *kwds = NULL, *order_str = NULL;
        from_bytes = PyObject_GetAttrString((PyObject*)&PyInt_Type, "from_bytes");
        if (!from_bytes) return NULL;
        py_bytes = PyBytes_FromStringAndSize((char*)bytes, sizeof(int));
        if (!py_bytes) goto limited_bad;
        order_str = PyUnicode_FromString(little ? "little" : "big");
        if (!order_str) goto limited_bad;
        arg_tuple = PyTuple_Pack(2, py_bytes, order_str);
        if (!arg_tuple) goto limited_bad;
        kwds = PyDict_New();
        if (!kwds) goto limited_bad;
        if (PyDict_SetItemString(kwds, "signed", __Pyx_NewRef(!is_unsigned ? Py_True : Py_False))) goto limited_bad;
        result = PyObject_Call(from_bytes, arg_tuple, kwds);
        limited_bad:
        Py_XDECREF(from_bytes);
        Py_XDECREF(py_bytes);
        Py_XDECREF(order_str);
        Py_XDECREF(arg_tuple);
        Py_XDECREF(kwds);
        return result;
#endif
    }
}

/* CIntFromPy */
static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *x) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const long neg_one = (long) -1, const_zero = (long) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if ((sizeof(long) < sizeof(long))) {
            __PYX_VERIFY_RETURN_INT(long, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (long) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            if (unlikely(__Pyx_PyLong_IsNeg(x))) {
                goto raise_neg_overflow;
            } else if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(long, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_DigitCount(x)) {
                    case 2:
                        if ((8 * sizeof(long) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) >= 2 * PyLong_SHIFT)) {
                                return (long) (((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(long) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) >= 3 * PyLong_SHIFT)) {
                                return (long) (((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(long) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) >= 4 * PyLong_SHIFT)) {
                                return (long) (((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                            }
                        }
                        break;
                }
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (long) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if ((sizeof(long) <= sizeof(unsigned long))) {
                __PYX_VERIFY_RETURN_INT_EXC(long, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(long) <= sizeof(unsigned PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(long, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(long, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_SignedDigitCount(x)) {
                    case -2:
                        if ((8 * sizeof(long) - 1 > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
                                return (long) (((long)-1)*(((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                    case 2:
                        if ((8 * sizeof(long) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
                                return (long) ((((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                    case -3:
                        if ((8 * sizeof(long) - 1 > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
                                return (long) (((long)-1)*(((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(long) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
                                return (long) ((((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                    case -4:
                        if ((8 * sizeof(long) - 1 > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 4 * PyLong_SHIFT)) {
                                return (long) (((long)-1)*(((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(long) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(long) - 1 > 4 * PyLong_SHIFT)) {
                                return (long) ((((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                            }
                        }
                        break;
                }
            }
#endif
            if ((sizeof(long) <= sizeof(long))) {
                __PYX_VERIFY_RETURN_INT_EXC(long, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(long) <= sizeof(PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(long, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
            long val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
#if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
#endif
            if (likely(v)) {
                int ret = -1;
#if !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                ret = _PyLong_AsByteArray((PyLongObject *)v,
                                           bytes, sizeof(val),
                                           is_little, !is_unsigned);
#else
                PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
                int bits, remaining_bits, is_negative = 0;
                long idigit;
                int chunk_size = (sizeof(long) < 8) ? 30 : 62;
                if (unlikely(!PyLong_CheckExact(v))) {
                    PyObject *tmp = v;
                    v = PyNumber_Long(v);
                    assert(PyLong_CheckExact(v));
                    Py_DECREF(tmp);
                    if (unlikely(!v)) return (long) -1;
                }
#if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                if (Py_SIZE(x) == 0)
                    return (long) 0;
                is_negative = Py_SIZE(x) < 0;
#else
                {
                    int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                    if (unlikely(result < 0))
                        return (long) -1;
                    is_negative = result == 1;
                }
#endif
                if (is_unsigned && unlikely(is_negative)) {
                    goto raise_neg_overflow;
                } else if (is_negative) {
                    stepval = PyNumber_Invert(v);
                    if (unlikely(!stepval))
                        return (long) -1;
                } else {
                    stepval = __Pyx_NewRef(v);
                }
                val = (long) 0;
                mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
                shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
                for (bits = 0; bits < (int) sizeof(long) * 8 - chunk_size; bits += chunk_size) {
                    PyObject *tmp, *digit;
                    digit = PyNumber_And(stepval, mask);
                    if (unlikely(!digit)) goto done;
                    idigit = PyLong_AsLong(digit);
                    Py_DECREF(digit);
                    if (unlikely(idigit < 0)) goto done;
                    tmp = PyNumber_Rshift(stepval, shift);
                    if (unlikely(!tmp)) goto done;
                    Py_DECREF(stepval); stepval = tmp;
                    val |= ((long) idigit) << bits;
                    #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                    if (Py_SIZE(stepval) == 0)
                        goto unpacking_done;
                    #endif
                }
                idigit = PyLong_AsLong(stepval);
                if (unlikely(idigit < 0)) goto done;
                remaining_bits = ((int) sizeof(long) * 8) - bits - (is_unsigned ? 0 : 1);
                if (unlikely(idigit >= (1L << remaining_bits)))
                    goto raise_overflow;
                val |= ((long) idigit) << bits;
            #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
            unpacking_done:
            #endif
                if (!is_unsigned) {
                    if (unlikely(val & (((long) 1) << (sizeof(long) * 8 - 1))))
                        goto raise_overflow;
                    if (is_negative)
                        val = ~val;
                }
                ret = 0;
            done:
                Py_XDECREF(shift);
                Py_XDECREF(mask);
                Py_XDECREF(stepval);
#endif
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
            return (long) -1;
        }
    } else {
        long val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (long) -1;
        val = __Pyx_PyInt_As_long(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to long");
    return (long) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to long");
    return (long) -1;
}

/* CIntFromPy */
static CYTHON_INLINE int64_t __Pyx_PyInt_As_int64_t(PyObject *x) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const int64_t neg_one = (int64_t) -1, const_zero = (int64_t) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if ((sizeof(int64_t) < sizeof(long))) {
            __PYX_VERIFY_RETURN_INT(int64_t, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (int64_t) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            if (unlikely(__Pyx_PyLong_IsNeg(x))) {
                goto raise_neg_overflow;
            } else if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int64_t, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_DigitCount(x)) {
                    case 2:
                        if ((8 * sizeof(int64_t) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) >= 2 * PyLong_SHIFT)) {
                                return (int64_t) (((((int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0]));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int64_t) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) >= 3 * PyLong_SHIFT)) {
                                return (int64_t) (((((((int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0]));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int64_t) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) >= 4 * PyLong_SHIFT)) {
                                return (int64_t) (((((((((int64_t)digits[3]) << PyLong_SHIFT) | (int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0]));
                            }
                        }
                        break;
                }
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (int64_t) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if ((sizeof(int64_t) <= sizeof(unsigned long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int64_t, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int64_t) <= sizeof(unsigned PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int64_t, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int64_t, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_SignedDigitCount(x)) {
                    case -2:
                        if ((8 * sizeof(int64_t) - 1 > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 2 * PyLong_SHIFT)) {
                                return (int64_t) (((int64_t)-1)*(((((int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                    case 2:
                        if ((8 * sizeof(int64_t) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 2 * PyLong_SHIFT)) {
                                return (int64_t) ((((((int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                    case -3:
                        if ((8 * sizeof(int64_t) - 1 > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 3 * PyLong_SHIFT)) {
                                return (int64_t) (((int64_t)-1)*(((((((int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int64_t) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 3 * PyLong_SHIFT)) {
                                return (int64_t) ((((((((int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                    case -4:
                        if ((8 * sizeof(int64_t) - 1 > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 4 * PyLong_SHIFT)) {
                                return (int64_t) (((int64_t)-1)*(((((((((int64_t)digits[3]) << PyLong_SHIFT) | (int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int64_t) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int64_t, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int64_t) - 1 > 4 * PyLong_SHIFT)) {
                                return (int64_t) ((((((((((int64_t)digits[3]) << PyLong_SHIFT) | (int64_t)digits[2]) << PyLong_SHIFT) | (int64_t)digits[1]) << PyLong_SHIFT) | (int64_t)digits[0])));
                            }
                        }
                        break;
                }
            }
#endif
            if ((sizeof(int64_t) <= sizeof(long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int64_t, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int64_t) <= sizeof(PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int64_t, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
            int64_t val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
#if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
#endif
            if (likely(v)) {
                int ret = -1;
#if !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                ret = _PyLong_AsByteArray((PyLongObject *)v,
                                           bytes, sizeof(val),
                                           is_little, !is_unsigned);
#else
                PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
                int bits, remaining_bits, is_negative = 0;
                long idigit;
                int chunk_size = (sizeof(long) < 8) ? 30 : 62;
                if (unlikely(!PyLong_CheckExact(v))) {
                    PyObject *tmp = v;
                    v = PyNumber_Long(v);
                    assert(PyLong_CheckExact(v));
                    Py_DECREF(tmp);
                    if (unlikely(!v)) return (int64_t) -1;
                }
#if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                if (Py_SIZE(x) == 0)
                    return (int64_t) 0;
                is_negative = Py_SIZE(x) < 0;
#else
                {
                    int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                    if (unlikely(result < 0))
                        return (int64_t) -1;
                    is_negative = result == 1;
                }
#endif
                if (is_unsigned && unlikely(is_negative)) {
                    goto raise_neg_overflow;
                } else if (is_negative) {
                    stepval = PyNumber_Invert(v);
                    if (unlikely(!stepval))
                        return (int64_t) -1;
                } else {
                    stepval = __Pyx_NewRef(v);
                }
                val = (int64_t) 0;
                mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
                shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
                for (bits = 0; bits < (int) sizeof(int64_t) * 8 - chunk_size; bits += chunk_size) {
                    PyObject *tmp, *digit;
                    digit = PyNumber_And(stepval, mask);
                    if (unlikely(!digit)) goto done;
                    idigit = PyLong_AsLong(digit);
                    Py_DECREF(digit);
                    if (unlikely(idigit < 0)) goto done;
                    tmp = PyNumber_Rshift(stepval, shift);
                    if (unlikely(!tmp)) goto done;
                    Py_DECREF(stepval); stepval = tmp;
                    val |= ((int64_t) idigit) << bits;
                    #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                    if (Py_SIZE(stepval) == 0)
                        goto unpacking_done;
                    #endif
                }
                idigit = PyLong_AsLong(stepval);
                if (unlikely(idigit < 0)) goto done;
                remaining_bits = ((int) sizeof(int64_t) * 8) - bits - (is_unsigned ? 0 : 1);
                if (unlikely(idigit >= (1L << remaining_bits)))
                    goto raise_overflow;
                val |= ((int64_t) idigit) << bits;
            #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
            unpacking_done:
            #endif
                if (!is_unsigned) {
                    if (unlikely(val & (((int64_t) 1) << (sizeof(int64_t) * 8 - 1))))
                        goto raise_overflow;
                    if (is_negative)
                        val = ~val;
                }
                ret = 0;
            done:
                Py_XDECREF(shift);
                Py_XDECREF(mask);
                Py_XDECREF(stepval);
#endif
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
            return (int64_t) -1;
        }
    } else {
        int64_t val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (int64_t) -1;
        val = __Pyx_PyInt_As_int64_t(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to int64_t");
    return (int64_t) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to int64_t");
    return (int64_t) -1;
}

/* CIntToPy */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int32_t(int32_t value) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const int32_t neg_one = (int32_t) -1, const_zero = (int32_t) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(int32_t) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(int32_t) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int32_t) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(int32_t) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int32_t) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
#if !CYTHON_COMPILING_IN_LIMITED_API
        return _PyLong_FromByteArray(bytes, sizeof(int32_t),
                                     little, !is_unsigned);
#else
        PyObject *from_bytes, *result = NULL;
        PyObject *py_bytes = NULL, *arg_tuple = NULL, *kwds = NULL, *order_str = NULL;
        from_bytes = PyObject_GetAttrString((PyObject*)&PyInt_Type, "from_bytes");
        if (!from_bytes) return NULL;
        py_bytes = PyBytes_FromStringAndSize((char*)bytes, sizeof(int32_t));
        if (!py_bytes) goto limited_bad;
        order_str = PyUnicode_FromString(little ? "little" : "big");
        if (!order_str) goto limited_bad;
        arg_tuple = PyTuple_Pack(2, py_bytes, order_str);
        if (!arg_tuple) goto limited_bad;
        kwds = PyDict_New();
        if (!kwds) goto limited_bad;
        if (PyDict_SetItemString(kwds, "signed", __Pyx_NewRef(!is_unsigned ? Py_True : Py_False))) goto limited_bad;
        result = PyObject_Call(from_bytes, arg_tuple, kwds);
        limited_bad:
        Py_XDECREF(from_bytes);
        Py_XDECREF(py_bytes);
        Py_XDECREF(order_str);
        Py_XDECREF(arg_tuple);
        Py_XDECREF(kwds);
        return result;
#endif
    }
}

/* CIntToPy */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const long neg_one = (long) -1, const_zero = (long) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(long) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(long) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(long) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(long) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(long) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
#if !CYTHON_COMPILING_IN_LIMITED_API
        return _PyLong_FromByteArray(bytes, sizeof(long),
                                     little, !is_unsigned);
#else
        PyObject *from_bytes, *result = NULL;
        PyObject *py_bytes = NULL, *arg_tuple = NULL, *kwds = NULL, *order_str = NULL;
        from_bytes = PyObject_GetAttrString((PyObject*)&PyInt_Type, "from_bytes");
        if (!from_bytes) return NULL;
        py_bytes = PyBytes_FromStringAndSize((char*)bytes, sizeof(long));
        if (!py_bytes) goto limited_bad;
        order_str = PyUnicode_FromString(little ? "little" : "big");
        if (!order_str) goto limited_bad;
        arg_tuple = PyTuple_Pack(2, py_bytes, order_str);
        if (!arg_tuple) goto limited_bad;
        kwds = PyDict_New();
        if (!kwds) goto limited_bad;
        if (PyDict_SetItemString(kwds, "signed", __Pyx_NewRef(!is_unsigned ? Py_True : Py_False))) goto limited_bad;
        result = PyObject_Call(from_bytes, arg_tuple, kwds);
        limited_bad:
        Py_XDECREF(from_bytes);
        Py_XDECREF(py_bytes);
        Py_XDECREF(order_str);
        Py_XDECREF(arg_tuple);
        Py_XDECREF(kwds);
        return result;
#endif
    }
}

/* CIntFromPy */
static CYTHON_INLINE int32_t __Pyx_PyInt_As_int32_t(PyObject *x) {
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic push
#pragma GCC diagnostic ignored "-Wconversion"
#endif
    const int32_t neg_one = (int32_t) -1, const_zero = (int32_t) 0;
#ifdef __Pyx_HAS_GCC_DIAGNOSTIC
#pragma GCC diagnostic pop
#endif
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if ((sizeof(int32_t) < sizeof(long))) {
            __PYX_VERIFY_RETURN_INT(int32_t, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (int32_t) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            if (unlikely(__Pyx_PyLong_IsNeg(x))) {
                goto raise_neg_overflow;
            } else if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int32_t, __Pyx_compact_upylong, __Pyx_PyLong_CompactValueUnsigned(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_DigitCount(x)) {
                    case 2:
                        if ((8 * sizeof(int32_t) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) >= 2 * PyLong_SHIFT)) {
                                return (int32_t) (((((int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0]));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int32_t) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) >= 3 * PyLong_SHIFT)) {
                                return (int32_t) (((((((int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0]));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int32_t) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) >= 4 * PyLong_SHIFT)) {
                                return (int32_t) (((((((((int32_t)digits[3]) << PyLong_SHIFT) | (int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0]));
                            }
                        }
                        break;
                }
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030C00A7
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (int32_t) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if ((sizeof(int32_t) <= sizeof(unsigned long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int32_t, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int32_t) <= sizeof(unsigned PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int32_t, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            if (__Pyx_PyLong_IsCompact(x)) {
                __PYX_VERIFY_RETURN_INT(int32_t, __Pyx_compact_pylong, __Pyx_PyLong_CompactValue(x))
            } else {
                const digit* digits = __Pyx_PyLong_Digits(x);
                assert(__Pyx_PyLong_DigitCount(x) > 1);
                switch (__Pyx_PyLong_SignedDigitCount(x)) {
                    case -2:
                        if ((8 * sizeof(int32_t) - 1 > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 2 * PyLong_SHIFT)) {
                                return (int32_t) (((int32_t)-1)*(((((int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                    case 2:
                        if ((8 * sizeof(int32_t) > 1 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 2 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 2 * PyLong_SHIFT)) {
                                return (int32_t) ((((((int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                    case -3:
                        if ((8 * sizeof(int32_t) - 1 > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 3 * PyLong_SHIFT)) {
                                return (int32_t) (((int32_t)-1)*(((((((int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                    case 3:
                        if ((8 * sizeof(int32_t) > 2 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 3 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 3 * PyLong_SHIFT)) {
                                return (int32_t) ((((((((int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                    case -4:
                        if ((8 * sizeof(int32_t) - 1 > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 4 * PyLong_SHIFT)) {
                                return (int32_t) (((int32_t)-1)*(((((((((int32_t)digits[3]) << PyLong_SHIFT) | (int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                    case 4:
                        if ((8 * sizeof(int32_t) > 3 * PyLong_SHIFT)) {
                            if ((8 * sizeof(unsigned long) > 4 * PyLong_SHIFT)) {
                                __PYX_VERIFY_RETURN_INT(int32_t, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                            } else if ((8 * sizeof(int32_t) - 1 > 4 * PyLong_SHIFT)) {
                                return (int32_t) ((((((((((int32_t)digits[3]) << PyLong_SHIFT) | (int32_t)digits[2]) << PyLong_SHIFT) | (int32_t)digits[1]) << PyLong_SHIFT) | (int32_t)digits[0])));
                            }
                        }
                        break;
                }
            }
#endif
            if ((sizeof(int32_t) <= sizeof(long))) {
                __PYX_VERIFY_RETURN_INT_EXC(int32_t, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if ((sizeof(int32_t) <= sizeof(PY_LONG_LONG))) {
                __PYX_VERIFY_RETURN_INT_EXC(int32_t, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
            int32_t val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
#if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
#endif
            if (likely(v)) {
                int ret = -1;
#if !(CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_LIMITED_API) || defined(_PyLong_AsByteArray)
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                ret = _PyLong_AsByteArray((PyLongObject *)v,
                                           bytes, sizeof(val),
                                           is_little, !is_unsigned);
#else
                PyObject *stepval = NULL, *mask = NULL, *shift = NULL;
                int bits, remaining_bits, is_negative = 0;
                long idigit;
                int chunk_size = (sizeof(long) < 8) ? 30 : 62;
                if (unlikely(!PyLong_CheckExact(v))) {
                    PyObject *tmp = v;
                    v = PyNumber_Long(v);
                    assert(PyLong_CheckExact(v));
                    Py_DECREF(tmp);
                    if (unlikely(!v)) return (int32_t) -1;
                }
#if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                if (Py_SIZE(x) == 0)
                    return (int32_t) 0;
                is_negative = Py_SIZE(x) < 0;
#else
                {
                    int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                    if (unlikely(result < 0))
                        return (int32_t) -1;
                    is_negative = result == 1;
                }
#endif
                if (is_unsigned && unlikely(is_negative)) {
                    goto raise_neg_overflow;
                } else if (is_negative) {
                    stepval = PyNumber_Invert(v);
                    if (unlikely(!stepval))
                        return (int32_t) -1;
                } else {
                    stepval = __Pyx_NewRef(v);
                }
                val = (int32_t) 0;
                mask = PyLong_FromLong((1L << chunk_size) - 1); if (unlikely(!mask)) goto done;
                shift = PyLong_FromLong(chunk_size); if (unlikely(!shift)) goto done;
                for (bits = 0; bits < (int) sizeof(int32_t) * 8 - chunk_size; bits += chunk_size) {
                    PyObject *tmp, *digit;
                    digit = PyNumber_And(stepval, mask);
                    if (unlikely(!digit)) goto done;
                    idigit = PyLong_AsLong(digit);
                    Py_DECREF(digit);
                    if (unlikely(idigit < 0)) goto done;
                    tmp = PyNumber_Rshift(stepval, shift);
                    if (unlikely(!tmp)) goto done;
                    Py_DECREF(stepval); stepval = tmp;
                    val |= ((int32_t) idigit) << bits;
                    #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
                    if (Py_SIZE(stepval) == 0)
                        goto unpacking_done;
                    #endif
                }
                idigit = PyLong_AsLong(stepval);
                if (unlikely(idigit < 0)) goto done;
                remaining_bits = ((int) sizeof(int32_t) * 8) - bits - (is_unsigned ? 0 : 1);
                if (unlikely(idigit >= (1L << remaining_bits)))
                    goto raise_overflow;
                val |= ((int32_t) idigit) << bits;
            #if CYTHON_COMPILING_IN_LIMITED_API && PY_VERSION_HEX < 0x030B0000
            unpacking_done:
            #endif
                if (!is_unsigned) {
                    if (unlikely(val & (((int32_t) 1) << (sizeof(int32_t) * 8 - 1))))
                        goto raise_overflow;
                    if (is_negative)
                        val = ~val;
                }
                ret = 0;
            done:
                Py_XDECREF(shift);
                Py_XDECREF(mask);
                Py_XDECREF(stepval);
#endif
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
            return (int32_t) -1;
        }
    } else {
        int32_t val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (int32_t) -1;
        val = __Pyx_PyInt_As_int32_t(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to int32_t");
    return (int32_t) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to int32_t");
    return (int32_t) -1;
}

/* FormatTypeName */
#if CYTHON_COMPILING_IN_LIMITED_API
static __Pyx_TypeName
__Pyx_PyType_GetName(PyTypeObject* tp)
{
    PyObject *name = __Pyx_PyObject_GetAttrStr((PyObject *)tp,
                                               __pyx_n_s_name);
    if (unlikely(name == NULL) || unlikely(!PyUnicode_Check(name))) {
        PyErr_Clear();
        Py_XDECREF(name);
        name = __Pyx_NewRef(__pyx_n_s__78);
    }
    return name;
}
#endif

/* FastTypeChecks */
#if CYTHON_COMPILING_IN_CPYTHON
static int __Pyx_InBases(PyTypeObject *a, PyTypeObject *b) {
    while (a) {
        a = __Pyx_PyType_GetSlot(a, tp_base, PyTypeObject*);
        if (a == b)
            return 1;
    }
    return b == &PyBaseObject_Type;
}
static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b) {
    PyObject *mro;
    if (a == b) return 1;
    mro = a->tp_mro;
    if (likely(mro)) {
        Py_ssize_t i, n;
        n = PyTuple_GET_SIZE(mro);
        for (i = 0; i < n; i++) {
            if (PyTuple_GET_ITEM(mro, i) == (PyObject *)b)
                return 1;
        }
        return 0;
    }
    return __Pyx_InBases(a, b);
}
static CYTHON_INLINE int __Pyx_IsAnySubtype2(PyTypeObject *cls, PyTypeObject *a, PyTypeObject *b) {
    PyObject *mro;
    if (cls == a || cls == b) return 1;
    mro = cls->tp_mro;
    if (likely(mro)) {
        Py_ssize_t i, n;
        n = PyTuple_GET_SIZE(mro);
        for (i = 0; i < n; i++) {
            PyObject *base = PyTuple_GET_ITEM(mro, i);
            if (base == (PyObject *)a || base == (PyObject *)b)
                return 1;
        }
        return 0;
    }
    return __Pyx_InBases(cls, a) || __Pyx_InBases(cls, b);
}
#if PY_MAJOR_VERSION == 2
static int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject* exc_type2) {
    PyObject *exception, *value, *tb;
    int res;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&exception, &value, &tb);
    res = exc_type1 ? PyObject_IsSubclass(err, exc_type1) : 0;
    if (unlikely(res == -1)) {
        PyErr_WriteUnraisable(err);
        res = 0;
    }
    if (!res) {
        res = PyObject_IsSubclass(err, exc_type2);
        if (unlikely(res == -1)) {
            PyErr_WriteUnraisable(err);
            res = 0;
        }
    }
    __Pyx_ErrRestore(exception, value, tb);
    return res;
}
#else
static CYTHON_INLINE int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject *exc_type2) {
    if (exc_type1) {
        return __Pyx_IsAnySubtype2((PyTypeObject*)err, (PyTypeObject*)exc_type1, (PyTypeObject*)exc_type2);
    } else {
        return __Pyx_IsSubtype((PyTypeObject*)err, (PyTypeObject*)exc_type2);
    }
}
#endif
static int __Pyx_PyErr_GivenExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
    Py_ssize_t i, n;
    assert(PyExceptionClass_Check(exc_type));
    n = PyTuple_GET_SIZE(tuple);
#if PY_MAJOR_VERSION >= 3
    for (i=0; i<n; i++) {
        if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
    }
#endif
    for (i=0; i<n; i++) {
        PyObject *t = PyTuple_GET_ITEM(tuple, i);
        #if PY_MAJOR_VERSION < 3
        if (likely(exc_type == t)) return 1;
        #endif
        if (likely(PyExceptionClass_Check(t))) {
            if (__Pyx_inner_PyErr_GivenExceptionMatches2(exc_type, NULL, t)) return 1;
        } else {
        }
    }
    return 0;
}
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject* exc_type) {
    if (likely(err == exc_type)) return 1;
    if (likely(PyExceptionClass_Check(err))) {
        if (likely(PyExceptionClass_Check(exc_type))) {
            return __Pyx_inner_PyErr_GivenExceptionMatches2(err, NULL, exc_type);
        } else if (likely(PyTuple_Check(exc_type))) {
            return __Pyx_PyErr_GivenExceptionMatchesTuple(err, exc_type);
        } else {
        }
    }
    return PyErr_GivenExceptionMatches(err, exc_type);
}
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *exc_type1, PyObject *exc_type2) {
    assert(PyExceptionClass_Check(exc_type1));
    assert(PyExceptionClass_Check(exc_type2));
    if (likely(err == exc_type1 || err == exc_type2)) return 1;
    if (likely(PyExceptionClass_Check(err))) {
        return __Pyx_inner_PyErr_GivenExceptionMatches2(err, exc_type1, exc_type2);
    }
    return (PyErr_GivenExceptionMatches(err, exc_type1) || PyErr_GivenExceptionMatches(err, exc_type2));
}
#endif

/* CheckBinaryVersion */
static int __Pyx_check_binary_version(void) {
    char ctversion[5];
    int same=1, i, found_dot;
    const char* rt_from_call = Py_GetVersion();
    PyOS_snprintf(ctversion, 5, "%d.%d", PY_MAJOR_VERSION, PY_MINOR_VERSION);
    found_dot = 0;
    for (i = 0; i < 4; i++) {
        if (!ctversion[i]) {
            same = (rt_from_call[i] < '0' || rt_from_call[i] > '9');
            break;
        }
        if (rt_from_call[i] != ctversion[i]) {
            same = 0;
            break;
        }
    }
    if (!same) {
        char rtversion[5] = {'\0'};
        char message[200];
        for (i=0; i<4; ++i) {
            if (rt_from_call[i] == '.') {
                if (found_dot) break;
                found_dot = 1;
            } else if (rt_from_call[i] < '0' || rt_from_call[i] > '9') {
                break;
            }
            rtversion[i] = rt_from_call[i];
        }
        PyOS_snprintf(message, sizeof(message),
                      "compile time version %s of module '%.100s' "
                      "does not match runtime version %s",
                      ctversion, __Pyx_MODULE_NAME, rtversion);
        return PyErr_WarnEx(NULL, message, 1);
    }
    return 0;
}

/* FunctionImport */
#ifndef __PYX_HAVE_RT_ImportFunction_3_0_2
#define __PYX_HAVE_RT_ImportFunction_3_0_2
static int __Pyx_ImportFunction_3_0_2(PyObject *module, const char *funcname, void (**f)(void), const char *sig) {
    PyObject *d = 0;
    PyObject *cobj = 0;
    union {
        void (*fp)(void);
        void *p;
    } tmp;
    d = PyObject_GetAttrString(module, (char *)"__pyx_capi__");
    if (!d)
        goto bad;
    cobj = PyDict_GetItemString(d, funcname);
    if (!cobj) {
        PyErr_Format(PyExc_ImportError,
            "%.200s does not export expected C function %.200s",
                PyModule_GetName(module), funcname);
        goto bad;
    }
    if (!PyCapsule_IsValid(cobj, sig)) {
        PyErr_Format(PyExc_TypeError,
            "C function %.200s.%.200s has wrong signature (expected %.500s, got %.500s)",
             PyModule_GetName(module), funcname, sig, PyCapsule_GetName(cobj));
        goto bad;
    }
    tmp.p = PyCapsule_GetPointer(cobj, sig);
    *f = tmp.fp;
    if (!(*f))
        goto bad;
    Py_DECREF(d);
    return 0;
bad:
    Py_XDECREF(d);
    return -1;
}
#endif

/* InitStrings */
#if PY_MAJOR_VERSION >= 3
static int __Pyx_InitString(__Pyx_StringTabEntry t, PyObject **str) {
    if (t.is_unicode | t.is_str) {
        if (t.intern) {
            *str = PyUnicode_InternFromString(t.s);
        } else if (t.encoding) {
            *str = PyUnicode_Decode(t.s, t.n - 1, t.encoding, NULL);
        } else {
            *str = PyUnicode_FromStringAndSize(t.s, t.n - 1);
        }
    } else {
        *str = PyBytes_FromStringAndSize(t.s, t.n - 1);
    }
    if (!*str)
        return -1;
    if (PyObject_Hash(*str) == -1)
        return -1;
    return 0;
}
#endif
static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
    while (t->p) {
        #if PY_MAJOR_VERSION >= 3
        __Pyx_InitString(*t, t->p);
        #else
        if (t->is_unicode) {
            *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
        } else if (t->intern) {
            *t->p = PyString_InternFromString(t->s);
        } else {
            *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
        }
        if (!*t->p)
            return -1;
        if (PyObject_Hash(*t->p) == -1)
            return -1;
        #endif
        ++t;
    }
    return 0;
}

static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char* c_str) {
    return __Pyx_PyUnicode_FromStringAndSize(c_str, (Py_ssize_t)strlen(c_str));
}
static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject* o) {
    Py_ssize_t ignore;
    return __Pyx_PyObject_AsStringAndSize(o, &ignore);
}
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
#if !CYTHON_PEP393_ENABLED
static const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
    char* defenc_c;
    PyObject* defenc = _PyUnicode_AsDefaultEncodedString(o, NULL);
    if (!defenc) return NULL;
    defenc_c = PyBytes_AS_STRING(defenc);
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
    {
        char* end = defenc_c + PyBytes_GET_SIZE(defenc);
        char* c;
        for (c = defenc_c; c < end; c++) {
            if ((unsigned char) (*c) >= 128) {
                PyUnicode_AsASCIIString(o);
                return NULL;
            }
        }
    }
#endif
    *length = PyBytes_GET_SIZE(defenc);
    return defenc_c;
}
#else
static CYTHON_INLINE const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
    if (unlikely(__Pyx_PyUnicode_READY(o) == -1)) return NULL;
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
    if (likely(PyUnicode_IS_ASCII(o))) {
        *length = PyUnicode_GET_LENGTH(o);
        return PyUnicode_AsUTF8(o);
    } else {
        PyUnicode_AsASCIIString(o);
        return NULL;
    }
#else
    return PyUnicode_AsUTF8AndSize(o, length);
#endif
}
#endif
#endif
static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
    if (
#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
            __Pyx_sys_getdefaultencoding_not_ascii &&
#endif
            PyUnicode_Check(o)) {
        return __Pyx_PyUnicode_AsStringAndSize(o, length);
    } else
#endif
#if (!CYTHON_COMPILING_IN_PYPY && !CYTHON_COMPILING_IN_LIMITED_API) || (defined(PyByteArray_AS_STRING) && defined(PyByteArray_GET_SIZE))
    if (PyByteArray_Check(o)) {
        *length = PyByteArray_GET_SIZE(o);
        return PyByteArray_AS_STRING(o);
    } else
#endif
    {
        char* result;
        int r = PyBytes_AsStringAndSize(o, &result, length);
        if (unlikely(r < 0)) {
            return NULL;
        } else {
            return result;
        }
    }
}
static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
   int is_true = x == Py_True;
   if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
   else return PyObject_IsTrue(x);
}
static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject* x) {
    int retval;
    if (unlikely(!x)) return -1;
    retval = __Pyx_PyObject_IsTrue(x);
    Py_DECREF(x);
    return retval;
}
static PyObject* __Pyx_PyNumber_IntOrLongWrongResultType(PyObject* result, const char* type_name) {
    __Pyx_TypeName result_type_name = __Pyx_PyType_GetName(Py_TYPE(result));
#if PY_MAJOR_VERSION >= 3
    if (PyLong_Check(result)) {
        if (PyErr_WarnFormat(PyExc_DeprecationWarning, 1,
                "__int__ returned non-int (type " __Pyx_FMT_TYPENAME ").  "
                "The ability to return an instance of a strict subclass of int is deprecated, "
                "and may be removed in a future version of Python.",
                result_type_name)) {
            __Pyx_DECREF_TypeName(result_type_name);
            Py_DECREF(result);
            return NULL;
        }
        __Pyx_DECREF_TypeName(result_type_name);
        return result;
    }
#endif
    PyErr_Format(PyExc_TypeError,
                 "__%.4s__ returned non-%.4s (type " __Pyx_FMT_TYPENAME ")",
                 type_name, type_name, result_type_name);
    __Pyx_DECREF_TypeName(result_type_name);
    Py_DECREF(result);
    return NULL;
}
static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x) {
#if CYTHON_USE_TYPE_SLOTS
  PyNumberMethods *m;
#endif
  const char *name = NULL;
  PyObject *res = NULL;
#if PY_MAJOR_VERSION < 3
  if (likely(PyInt_Check(x) || PyLong_Check(x)))
#else
  if (likely(PyLong_Check(x)))
#endif
    return __Pyx_NewRef(x);
#if CYTHON_USE_TYPE_SLOTS
  m = Py_TYPE(x)->tp_as_number;
  #if PY_MAJOR_VERSION < 3
  if (m && m->nb_int) {
    name = "int";
    res = m->nb_int(x);
  }
  else if (m && m->nb_long) {
    name = "long";
    res = m->nb_long(x);
  }
  #else
  if (likely(m && m->nb_int)) {
    name = "int";
    res = m->nb_int(x);
  }
  #endif
#else
  if (!PyBytes_CheckExact(x) && !PyUnicode_CheckExact(x)) {
    res = PyNumber_Int(x);
  }
#endif
  if (likely(res)) {
#if PY_MAJOR_VERSION < 3
    if (unlikely(!PyInt_Check(res) && !PyLong_Check(res))) {
#else
    if (unlikely(!PyLong_CheckExact(res))) {
#endif
        return __Pyx_PyNumber_IntOrLongWrongResultType(res, name);
    }
  }
  else if (!PyErr_Occurred()) {
    PyErr_SetString(PyExc_TypeError,
                    "an integer is required");
  }
  return res;
}
static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
  Py_ssize_t ival;
  PyObject *x;
#if PY_MAJOR_VERSION < 3
  if (likely(PyInt_CheckExact(b))) {
    if (sizeof(Py_ssize_t) >= sizeof(long))
        return PyInt_AS_LONG(b);
    else
        return PyInt_AsSsize_t(b);
  }
#endif
  if (likely(PyLong_CheckExact(b))) {
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(__Pyx_PyLong_IsCompact(b))) {
        return __Pyx_PyLong_CompactValue(b);
    } else {
      const digit* digits = __Pyx_PyLong_Digits(b);
      const Py_ssize_t size = __Pyx_PyLong_SignedDigitCount(b);
      switch (size) {
         case 2:
           if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -2:
           if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case 3:
           if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -3:
           if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case 4:
           if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -4:
           if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
      }
    }
    #endif
    return PyLong_AsSsize_t(b);
  }
  x = PyNumber_Index(b);
  if (!x) return -1;
  ival = PyInt_AsSsize_t(x);
  Py_DECREF(x);
  return ival;
}
static CYTHON_INLINE Py_hash_t __Pyx_PyIndex_AsHash_t(PyObject* o) {
  if (sizeof(Py_hash_t) == sizeof(Py_ssize_t)) {
    return (Py_hash_t) __Pyx_PyIndex_AsSsize_t(o);
#if PY_MAJOR_VERSION < 3
  } else if (likely(PyInt_CheckExact(o))) {
    return PyInt_AS_LONG(o);
#endif
  } else {
    Py_ssize_t ival;
    PyObject *x;
    x = PyNumber_Index(o);
    if (!x) return -1;
    ival = PyInt_AsLong(x);
    Py_DECREF(x);
    return ival;
  }
}
static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b) {
  return b ? __Pyx_NewRef(Py_True) : __Pyx_NewRef(Py_False);
}
static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
    return PyInt_FromSize_t(ival);
}


/* #### Code section: utility_code_pragmas_end ### */
#ifdef _MSC_VER
#pragma warning( pop )
#endif



/* #### Code section: end ### */
#endif /* Py_PYTHON_H */
